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Tentative Outline Special Issue for Current Topics in Medicinal Chemistry Title of Thematic Issue: Natural Leads in Drug Discovery against Metabolic Disorders and Related Infectious Diseases Guest Editors: Rajeev K Singla, Luciana Scotti, Marcus Tullius Scotti Aims & Scope: Treatment for metabolic disorders like diabetes, inflammation, obesity and related infectious diseases using modern medicines is not effective, as modern medicines offers only the means to manage these diseases and disorders for the life of patients. Moreover, long term therapy using these medicines is not advisable as side effects are many a times more dangerous than the targeted disease for which the drug was being used. Resistance with the existing drugs is also a major issue in the infectious diseases. According to International Diabetes federation, around 382 million people are suffering from diabetes mellitus and expected to be two folded by year 2035. Infections are of particular concern for diabetics. People with diabetes are more susceptible to developing infections, as high blood sugar levels can weaken the patient's immune system. According to recent reports released by WHO in 2014, at least 2.8 million people are dying each year as a result of being overweight or obese. Moreover, obesity may leads to other metabolic disorders also. So keeping this in view, scientists are now extensively exploring natural source to have leads against metabolic disorders and related infectious diseases. Natural source like plants and microbes are now considered as potential reservoirs for bioactive leads. Their in silico studies like docking, QSAR etc further facilitates scientists in doing lead optimization. In this special issue, we will cover natural products isolated from all sources like plant/animal/microbes and their significance in treating metabolic disorders and infectious diseases related to it. Research and review articles which emphasizing on the role of computational studies in the lead optimization are preferred. Keywords: Natural Products; Diabetes; Hyperlipidemia; Fungal Infections; Antioxidants Subtopics: (This is tentative list only. Final published issue may have different titles) The subtopics to be covered within this issue are listed below: 1. Deciphering the Inactivation of Human Pancreatic Alpha Amylase, an Antidiabetic Target, by Bioactive Isolated by Cocos nucifera bioactives 2. Insights on the Important Aspects of Post Prandial acting Alpha Glucosidase Inhibitor, Acarbose 3. Recent Advances in the Treatment of Hyperlipidemia: Role of Natural Products 4. Isolation, Characterization and Docking Studies of Antifungal Agents isolated from Cocos nucifera Linn. Endocarp 5. Combined Approach of 2D-QSAR and 3D-QSAR in Design of Antioxidant Agents 6. Medicinal Plants as Potential Source in Deriving Antidiabetic Leads 7. Emerging leads from Microbial Sources as Antidiabetic agents & their QSAR studies 8. Utilization of eclectic data as basis for rational drug discovery 9. Recent Research Progress in Natural Bioactive Constituents against Lipid Metabolic Disorder Schedule: Manuscript submission deadline: August 31, 2015 Peer Review Due: October 30, 2015 Revision Due: November 20, 2015 Announcement of acceptance by the Guest Editors: November 28, 2015 Final manuscripts due: November 30, 2015 Contacts: Rajeev K Singla, Division of Biotechnology, Netaji Subhas Institute of Technology, Sec-3,Dwarka, New Delhi-110078, India. Email: [email protected] ResearchGate Profile: https://www.researchgate.net/profile/Rajeev_K_Singla CTMC Link: http://benthamscience.com/journal/editorial-board.php?journalID=ctmc#top Dr. Luciana Scotti, Health Sciences Center, Federal University of Paraíba, Campus I, João Pessoa, CEP: 58051-900, Brazil. Email: [email protected] ResearchGate: https://www.researchgate.net/profile/Luciana_Scotti?ev=hdr_xprf FB page https://www.facebook.com/luciana.scotti?ref=tn_tnmn Prof. Marcus Tullius Scotti, Engineering and Environment Department, Federal University of Paraíba, Campus IV, Rio Tinto, 58297-000, PB, Brazil. Email: [email protected] LinkedIn: http://br.linkedin.com/pub/marcus-scotti/9/4b0/243 ResearchGate: http://www.researchgate.net/profile/Marcus_Scotti/ Any queries should be addressed to [email protected].
