Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Fourth AACR International Conference on FRONTIERS IN BASIC CANCER RESEARCH October 23-26, 2015 • Philadelphia, PA Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m. Cancer Stem Cells and/or Tumor Dormancy B01 Cyclin D1 integrates G9a-mediated histone methylation and nuclear lamina association with lamina-associated domains. Zhiping Li, Xuanmao Jiao, Mathew C Casimiro, Sanjay Katiyar, Ke Chen, Xiaoming Ju, Adam Ertel, Debra Klopfenstein, Aydin Tozeren, Richard Pestell. Tumor Microenvironment and/or Inflammation B02 Honokiol attenuates stemness, growth and metastasis of pancreatic tumor cells: A novel natural agent for therapy and prevention. Courey A Averett, Arun Bhardwaj, Sumit Arora, Sanjeev Srivastava, Seema Singh, JE Carter, Ajay P Singh. B03 HURP and ZEB1: Novel prognostic biomarkers in colorectal carcinomas. Logan Fair, Ingrid Espinoza, Xu Zhang, Abdelouahid Elkhattouti, Tangeng Ma, Joy King, Elizabeth Tarsi, Richard Whitlock, Vijay Kannuthurai, Ryan Jimenez, Tara Craft, Mary Graichen, Sharon Lobert, Roy Duhe, Charulochana Subramony, Christian R Gomez, Christopher Lahr. B04 A role for EphA3 in angiogenesis in vivo and in vitro exploration. Rae H Farnsworth, Mary E Vail, Magdaline Costa, Linda Hii, Ross A Dickins, Andrew G Elefanty, Edouard G Stanley, Martin Lackmann. B05 Invadopodium formation is enriched in perivascular niches and leads to cancer cell intravasation. Aviv Bergman, John Condeelis, Bojana Gligorijevic. B06 Cancer associated fibroblasts in the activated stroma and their interaction between ERM proteins in breast cancer progression. Sreelatha Krishnakumar Hemalatha, Arun Peter Mathew, Thara Somanathan, Jithin Dev, Reshma R S, Satheesh Kumar S, Revathy Nadhan, Priya Srinivas. B07 Tumor promoting activity of SLC13A3 in metastatic prostate cells. Aigul Zhunussova, Zhanar Irgebayeva, Bhaswati Sen, Leah Friedman, Saniya Ossikbayeva, Sultan Tuleukhanov, Ari Brooks, Richard Sensenig, Zulfiya Orynbayeva. B08 Inflammasome components caspase-1, IL1β, IL18 and NLRP3 (NOD-like receptor family, pyrin domain containing 3) are increased in a spontaneous model (chicken: Gallus gallus) of human ovarian cancer. Judith Luborsky, Seara Edassery, Seby L Edassery, Animesh Barua, Janice M Bahr. B09 Differential effect of microenvironment on tumor phenotype using an immature T cell lymphoma mouse model. Philip J Lucas, Ronald E Gress. B10 Cyclin D1 restrains oncogene-induced autophagy via phosphorylation of LKB1. Mathew Casimiro, Gabriele Di Sante, Emanuele Loro, Timothy Pestell, Sara Bisetto, Marco Velasco-Velázquez, Xuanmao Jiao, Zhiping Li, Chenguang Wang, Daniel Ly, Bin Zheng, Shen Che-Hung, Adam Ertel, Richard G Pestell. B11 Characterization of human effectors in the tumor microenvironment of NSCLC patients and lung tumor xenograft models. Hyun-Jeong Ra, Gisela Brake-Silla, Evgeniy Eruslanov, Michael Sharp, Charuhas Deshpande, Michael D Feldman, Amy Ziober, Li-Ping Wang, Manuel A Sepulveda, Linda A Snyder, Gwenn Danet-Desnoyers. B12 Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer. Lalita A Shevde, Kyle Adam Morrow, Shamik Das, Rajeev S Samant. Fourth AACR International Conference on FRONTIERS IN BASIC CANCER RESEARCH October 23-26, 2015 • Philadelphia, PA Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m. Technologies Used in Basic Cancer Research B13 In vitro animal cancer model for assessment of sulfated polysaccharides extract of Ulva lactuca as colon cancer therapeutic and chemopreventive agents. Marwa Abu-Serie, Maha El Demellawy, Mohamed El-Sayed, Fatma El-Rashidy. B14 Nanoparticles as potential therapeutic treatments for Inflammatory breast cancer (IBC) by disassociation of emboli formation. Arun Kumar, Sangjucta Barkataki, Kenneth L. van Golen. B15 Morphologically compatible mass spectrometric analysis of lipids in cytological specimens. Aparna Baxi, Mariam ElNaggar, Christopher Umbricht, Alfred L Yergey, William Clarke, Matthew T Olson. B16 High-resolution detection of fitness genes and genotype-specific cancer vulnerabilities with CRISPR-Cas9 screens. Traver Hart, Megha Chandrashekhar, Michael Aregger, Zachary Steinhart, Kevin R Brown, Graham Macleod, Monika Mis, Michal Zimmermann, Amelie Fradet-Turcotte, Song Sun, Peter Driks, Sachdev Sidhu, Frederick P Roth, Olivia S Rissland, Daniel Durocher, Stephane Angers, Jason Moffat. B17 Role of Sall2 transcription factor under genotoxic stress: A transcriptomic approach.. Carlos A Farkas, Francisco Fuentes, Boris Rebolledo, Kateryna Makova, Anton Nekrutenko, Ariel Castro, Roxana Pincheira. B18 A simple method to prepare oligonucleotide-conjugated antibodies for multiplex protein detection. Haibiao Gong, Ilona Holcomb, Aik Ooi, Xiaohui Wang, Daniel Majonis, Marc Unger, Ramesh Ramakrishnan. B19 Functional analysis of oncogenic driver mutations in human cancer cells through CRISPRbarcoding. Alexis Guernet, Dorthe Cartier, Sathish Kumar Mungamuri, Sahil Adriouch, Myriam Vezain, Françoise Charbonnier, Sophie Coutant, Shen Yao, Hassan Ainani, David Alexandre, Olivier Boyer, Stuart A Aaronson, Youssef Anouar, Luca Grumolato. B20 Single-cell profiling of EGFR-regulated protein changes involved in cell cycle, cell proliferation and apoptosis. Ilona Holcomb, Gajalakshmi Dakshinamoorthy, Benjamin Liu, Marc Unger, Ramesh Ramakrishnan, Haibiao Gong. B21 Using computational modeling to quantify targeted agent binding and internalization in pancreatic cancers.. Aleksandra Karolak, Veronica Estrella, Tingan Chen, Amanda Huynh, David Morse, Katarzyna Rejniak. B22 Screening and validation of combination therapy in T cell leukemia. Marsilius Mues, Marthe F Lindenbergh, Michael T McManus, Jeroen P Roose. B23 Chemoproteomic profiling of native kinases during the treatment of cells with kinase inhibitors. Tyzoon K Nomanbhoy, Heidi E Brown, Jiangyue Wu, Subha Vogeti, Arwin Aban, Wendy Grant, Alemayehu Senait, Shuzhen Wu , Christa Dias, Geeta Sharma. B24 The diagnostic power of direct mRNA profiling in breast cancer core biopsy. Indira Prabakaran, Paul J Zhang, Marina Guvakova. Fourth AACR International Conference on FRONTIERS IN BASIC CANCER RESEARCH October 23-26, 2015 • Philadelphia, PA Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m. Mechanisms of Resistance B25 Anti-Mullerian hormone (AMH) supports epithelial identity and survival signaling in lung cancer. Tim N Beck, Vladislav Korobeynikov, Alexander Kudinov, Rachel Georgeopoulos, Emmanuelle Nicolas, Margret B Einarson, Yan Zhou, Yanis Boumber, David A Proia, Ilya G Serebriiskii, Erica A Golemis. B26 S6 kinase constitutes a vulnerability in NRAS mutant melanoma. Hsin-Yi Chen, Patricia ReyesUribe, Minu Samanta, Jessie Villanueva. B27 Involvement of c-MET signaling in BCRP/ABCG2 activation and resistance to doxorubicin and photodynamic therapy. Bo-hyun Choi, Kyeong-Ah Jung, Mi-Kyoung Kwak. B28 Mitogen-activated protein kinase-driven Sprouty2 expression mediates resistance to receptor tyrosine kinase-targeted therapeutics in glioblastoma cells. Evan K Day, Matthew J Lazzara. B29 Characterization of the regulatory feedback program components after HER2 inhibition in breast cancer cells. Nareeza Sakur, Marc Fink. B30 Stress granules integrate KRas-driven cell intrinsic and extrinsic signals to determine tumor drug response. Elda Grabocka, Commisso Cosimo, Yuliya Pylayeva-Gupta, Dafna Bar-Sagi. B31 Establishment of a 5-fluorouracil-resistant esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase gene amplification. Osamu Kikuchi, Kiichiro Baba, Shinya Ohashi, Manabu Muto. B32 Single-cell non-genetic heterogeneity confers drug resistance in melanoma. Sydney M Shaffer, Andrew G Biaesch, Stefan Torborg, Clemens Krepler, Meenhard Herlyn, Arjun Raj. Drug Development and New Therapeutic Modalities B33 The oligoclonal antibody MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancer cells harboring EGFR extracellular domain mutations. Sabrina Arena, Giulia Siravegna, Benedetta Mussolin, Jeffrey D Kearns, Beni B Wolf, Sandra Misale, Luca Lazzari, Andrea Bertotti, Livio Trusolino, Alex Adjei, Clara Montagut, Federica Di Nicolantonio, Rachel Nering, Alberto Bardelli. B34 Quantitative systems pharmacology and immunotherapy: accelerating lead generation and optimization of a PD-1 x TIM-3 biotherapeutic in immuno-oncology. Joshua F Apgar, Jamie Wong, Ryan Phennicie, Mike Briskin, John M Burke. B35 Prevention of colitis-associated colorectal cancer by a novel polypharmacological HDAC inhibitor. Tzu-Tang Wei, Yi-Ting Lin, Ching-Chow Chen. B36 Orally active low molecular weight heparin conjugates as a tumoral lymphangiogenesis inhibitor. Jeong Uk Choi, Youngro Byun. B37 Anti-PD-L1 activity of Nano-diamino-tetrac (Nanotetrac) on cancer cells. Yu-Tang Chin, HsuanYu Lai, Heng-Yuan Tang, Hung-Yun Lin, Shaker A Mousa, Paul J Davis. B38 A Novel (+)-dehydroabietylamine derivative shows activity against triple-negative breast cancer cells. Lekh Nath Sharma Gautam, Taotao Ling, Fatima Rivas. B39 Inhibition of the oncoprotein FUBP1 by SN-38 represents a novel therapeutic option for the treatment of hepatocellular carcinoma. Stefanie Hauck, Sabrina Khageh Hosseini, Josephine Wesely, Dieter Steinhilber, Jörg Schulze, Annabelle Vogt, Maria Gonzalez-Carmona, Christian Strassburg, Stefan Zeuzem, Thomas Vogl, Jörg Trojan, Stephan Zangos, Ricardo Biondi, Eugen Proschak, Martin Zörnig. Fourth AACR International Conference on FRONTIERS IN BASIC CANCER RESEARCH October 23-26, 2015 • Philadelphia, PA Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m. B40 Tuning exosomes to modulate macrophage inflammation: A therapeutic strategy for melanoma. Thomas A Noel, Joshua L Hood. B41 Specific blocking of miR-17-5p guide strand in triple negative breast cancer cells, without amplifying passenger strand activity. Yuan-Yuan Jin, Eric Wickstrom. B42 The sigma-2 receptor as a target for therapeutic drug delivery in triple negative breast cancer. Mehran Makvandi, Estifanos D Tilahun, Brian P Lieberman, Kuiying Xu, Chenbo Zeng, Catherine Hou, Robert H Mach. B43 Quantitative PCR and in-situ-hybridization analysis to determine tissue concentration and localization of MRX34. Desiree Martin, Kevin Kelnar, Andreas G. Bader. B44 Sulfated fucan inhibits tumor interaction with endothelial cells and tumor growth: Possible contribution of an anti-vascular endothelial growth factor (VEGF) neutralizing activity. Viviane Mignone, Camila Castro Figueiredo, Aline Oliveira, Eliene Kozlowski, Lubor Borsig, Mauro Pavão, Paulo Mourão, Veronica Morandi. B45 Piptandenia africana and Nauclea latifolia protect against N -Nitrosodiethylamine induced hepatic tumors in Wistar rats. Queen-Esther E Akinade, Sarah O Nwozo, Olubunmi A Akinwumi, Owumi E Solomon. B46 Rac1 inhibition as a therapeutic strategy in breast cancer. Dana Senderoff, Georges Azzi, Erik Goka, Marc Lippman. B47 A novel mechanism for field-controlled high-specificity targeted anticancer drug delivery and on-demand release using magnetoelectric nanoparticles. Alexandra Rodzinski, Ali Hadjikhani, Tiffanie Stewart, Emmanuel Stimphil, Rakesh Guduru, Ping Liang, Carolyn Runowicz, Sakhrat Khizroev.