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Nature’s Materia Medica Page #717 DOLICHOS PRURIENS (Cowhage) PHARMACY - dol. Dolichos pruriens. Cowhage. Mucuna pruriens. Cow-itch. N. O. Leguminosae. Papilionoideae. Trituration or tincture of whole pod. Historical dose: Tincture and all potencies. CLINICAL - Bedwetting. Bloated, abdomen. Colic. Constipation. Cough. Dentition. Gums, pain. Hemorrhoids. Hepatitis. Herpes, zoster. Hodgkin’s disease. Itching. Jaundice. Jaw, pain. Neuralgias. Pruritus. Senile, pruritus. Sore, throat. Worms. 1 Monday, March 18, 13 Lotus Health Institute DOLICHOS PRURIENS A right-sided medicine with liver and skin symptoms Intense itching without eruption Yellow spots all over. Jaundice. As if a splinter in throat Itching is better from cold water, Exalted nervous sensibility Neuralgia following herpes zoster Lotus Health Institute 8 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic 3 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic MUCUNA PRURIENS (Velvet Bean) Botanical name: Mucuna Pruriens Common name: Velvet Bean, Cow-itch, Cowhage, Cow-itch, Buffalo bean Latin name: Mucuna Pruriens Part used: Seeds, Root, Legumes Mucuna pruriens is a tropical legume known as velvet bean or cowitch and by other common names (see below), found in Africa, India and the Caribbean. The plant is infamous for its extreme itchiness produced on contact, particularly with the young foliage and the seed pods. It has value in agricultural and horticultural use and has a range of medicinal properties. 4 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute TRIBAL AND HERBAL MEDICINE USES In Central America, velvet beans have been roasted and ground to make a coffee substitute for decades; its goes by the common name of "nescafé" in these regions, as well as in Brazil. It is still grown as a food crop by the Ketchi indigenous people in Guatemala; the bean is cooked as a vegetable. In Brazil the seed has been used internally for Parkinson's disease, edema, impotence, intestinal gas, and worms. It is considered a diuretic, nerve tonic, and aphrodisiac. Externally it is applied to ulcers. 5 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic TRIBAL AND HERBAL MEDICINE USES Mucuna has a long history of use in Ayurvedic medicine, where it is used for worms, dysentery, diarrhea, snakebite, sexual debility, cough, tuberculosis, impotence, rheumatic disorders, muscular pain, sterility, gout, menstrual disorders, diabetes, and cancer. In India it is considered an aphrodisiac, menstrual health promoter, uterine stimulant, nerve tonic, diuretic, and blood purifier. 6 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute TRIBAL AND HERBAL MEDICINE USES The Mucuna plant and its extracts have been long used in tribal communities as a toxin antagonist for various snakebites. Research on its effects against Naja (Cobra), Echis (Saw scaled viper), Calloselasma (Malayan Pit viper) and Bangarus (Krait) have shown that it has potential use in the prophylactic treatment of snakebites. Mucuna pruriens seeds have also been found to have antidepressant properties in cases of depressive neurosis when consumed. and formulations of the seed powder have shown promise in the management and treatment of Parkinson disease. Dried leaves of M. pruriens are sometimes smoked. Mucuna has also recently become popular among lucid dreaming enthusiasts: when combined with other supplements it stimulates the cholinergic system. 7 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic TRIBAL AND HERBAL MEDICINE USES Mucuna is an Ayurvedic remedy in nervous and sexual diseases. Traditionally, Mucuna pruriens is commonly used as carminative, hypertensive and hypoglycemic agent. Traditional Preparation: One half to one cup of a seed decoction twice daily. Alternatively 1-2 g twice daily of seed powder (tablets or capsules) daily can be substituted. For tinctures take 5 to 10 drops in water or juice, three times a a day. For standardized extract products: follow the labeled dosages provided. Suggested Use: Take 1 teaspoon 1 - 3 times daily. Mix 1 teaspoon with water, juice, yogurt, add to a smoothie, or infuse into a tea. 8 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute Mucuna pruriens has been found to contain L-DOPA, 40 mg/g of the plant. The plant/seeds contain the bioactive alkaloids mucunine, mucunadine, mucuadinine and pruriendine, besides B-sitosterol, glutathione, lecithin, oils, venolic and gallic acids. Studies in experimental model show L-Dopa also helps in the reduction of cholesterol and blood sugar levels. 9 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute Pharmacology M.pruriens seeds contain high concentrations of levodopa, a direct precursor of the neurotransmitter dopamine. It has long been used in traditional Ayurvedic Indian medicine for diseases including Parkinson's Disease. In large amounts (e.g. 30 g dose) it has been shown to be as effective as pure levodopa/carbidopa in the treatment of Parkinson's Disease, but no data on long-term efficacy and tolerability is available. 10 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic Pharmacology In addition to levodopa, it contains serotonin (5-HT), 5-HTP, N,N-DMT (DMT), bufotenine, and 5-MeO-DMT. As such, it could potentially have psychedelic effects, and it has purportedly been used in ayahuasca preparations. The mature seeds of the plant contain about 3.1-6.1% L-DOPA, with trace amounts of 5-hydroxytryptamine (serotonin), nicotine, DMT-n-oxide, bufotenine, 5-MeO-DMTn-oxide, and beta-carboline. One study using 36 samples of the seeds found no tryptamines present in them. The leaves contain about 0.5% L-DOPA, 0.006% dimethyltryptamine (DMT), 0.0025% 5-MeO-DMT and 0.003% DMT n-oxide. 11 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute Pharmacology L-Dopa Research discovered the body converts the amino acid tyrosine into L-dopa. L-dopa is then converted into dopamine. Dopamine is formed by the decarboxylation of L-DOPA. Dopamine is an essential component of our body and it's required for proper functioning of the brain. Without the neurotransmitter dopamine to serve a damping effect on neural transmissions, muscles become tense and tremble. 12 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute The L-DOPA’s drug side effects of may include: ■ Hypotension, especially if the dosage is too high ■ Arrhythmias, although these are uncommon ■ Nausea, which is often reduced by taking the drug with food, although protein interferes with drug absorption ■ Gastrointestinal bleeding ■ Disturbed respiration, which is not always harmful, and can actually benefit patients with upper airway obstruction ■ Hair loss ■ Disorientation and confusion ■ Extreme emotional states, particularly anxiety, but also excessive libido ■ Vivid dreams and/or insomnia ■ Auditory and/or visual hallucinations ■ Effects on learning; there is some evidence that it improves working memory, while impairing other complex functions ■ Somnolence and narcolepsy ■ A condition similar to stimulant psychosis 13 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic Mucuna and Parkinson The seed powder of Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinson. LDopa significantly affects dopamine metabolism in the striatonigral tract. This ability helps improve Parkinsonian symptoms in humans. The seeds of Mucuna pruriens accumulate 0.2% - 2% L-dopa in their dry weight. Parkinson's disease study group evaluated activity of Mucuna pruriens extract v/s Levodopa/ caebidopa in sixty patients and during their 12 weeks treatment, they proved that the extract was effective with less adverse effects. 14 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute Mucuna and Parkinson In a randomized, controlled, double blind crossover trial published on Journal of Neurology, Neurosurgery, Psychiatry, the clinical effects of levodopa L-dopa/carbidopa (LD/CD) are compared with two different doses of mucuna preparation. Eight Parkinson's disease patients were given with single doses of 200/50 mg LD/CD, or 15 and 30g of mucuna preparation in randomized order. This natural source of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of Parkinson's disease. 15 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute Mucuna Pruriens Aphrodisiac Effects Mucuna pruriens can improve sexual behavior, libido, and performance. The research shows that sexually active animals had increased sexual desire and improved sexual performance after 21 to 28 days. Another research shows that Mucuna Pruriens heightened arousal and increased sexual activity to a moderate extent but also sustains it for a longer time as indicated by the increase in below This study show that Mucuna Pruriens can be used to improve libido and performance. Mucuna Increase Sperm Count Traditionally, M. pruriens has been used as an effective aphrodisiac It is still used to increase libido in both men and women due to its dopamine inducing properties and in Ayurvedic medicine it is said to increase sperm count. Dopamine has a profound influence on sexual function. Use of Mucuna pruriens is well documented in Siddha medicine for a host of uses. 16 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic Lotus Health Institute Some benefits of raw Mucuna Pruriens Seed Powder may include: ● Increasing libido & sexual performance for men & women ● Improving mood & sense of well-being / antidepressant ● Increasing energy levels ● Boosting natural release of Human Growth Hormone (HGH) & Testosterone ● Increasing bone density & fighting osteoporosis ● Improving skin texture & appearance ● Improving Parkinson disease ● Supporting healthy blood sugar levels ● Strengthening immune system 17 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic VELVET BEAN VELVET BEAN Main Actions Standard Dosage Main Actions Standard Dosage Capsules: 1-2 g twice daily lowers blood sugar reduces fever is L-Dopa alternative, relieves pain, increases testosterone, reduces inflammation Decoction: 1/2 to 1 cup twice daily increases libido kills parasites reduces spasms calms nerves Standardized extracts: lowers blood pressure lowers cholesterol Follow label instructions increases urination 18 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Some benefits of raw Mucuna Pruriens Seed Powder may include: ● Regeneration of organs (heart, kidney, liver, lungs) ● Improving sleep (promotes deep sleep & lucid dreams) ● Increasing sperm count ● Reducing body fat & decreasing cellulite ● Antioxidant properties ● Decreasing wrinkles ● Improving cholesterol profile ● Increasing lean muscle mass ● Potential use in the prophylactic treatment of snakebites 19 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Benefits of Mucuna Pruriens: • • • • • • • • • • Improved mood and sense of well-being Improved sleep (promotes deep sleep) Increased energy levels Reduced body fat & decreased cellulite Increased lean muscle mass Decreased wrinkles, Improved skin texture & appearance Increased bone density and reversal of osteoporosis Enhanced libido & sexual performance Strengthen the immune system Improved cholesterol profile & regeneration of organs (heart, kidney, liver, lungs) and tissues 20 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Mucuna: Human Growth Hormone L- Dopa contains natural secretagogues which may support the body's ability to stimulate the natural release of growth hormone. The blood carries the dopamine into the brain, where it naturally increases HGH production from the pituitary gland. The increased dopamine levels also optimize the production of other hormones, including testosterone, leading to increased sex drive and improved sexual performance for both men and women, beneficial in stimulating muscle growth, as well as burning fat from fat cells. 21 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds: Brain Supertonic Velvet bean is now being considered as an alternative to the pharmaceutical medication levodopa. In one case study it was given to a Parkinson's patient for 12 years instead of the pharmaceutical L-dopa medication. It was found to slow the progression of Parkinson's symptoms (such as tremors, rigidity, slurring, drooling, and balance), and to have none of the side-effects of the current pharmaceutical L-dopa. 22 Monday, March 18, 13 Lotus Health Institute Mucuna Pruriens Seeds Lotus Health Institute 23 Monday, March 18, 13 Mucuna Pruriens Seeds: Brain Supertonic 24 Monday, March 18, 13 Lotus Health Institute