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The Use of Mibolerone (Cheque Drops) in Dogs
1/4/14 2:13 PM
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Mibolerone (Cheque Drops)
Veterinary & Aquatic Services Department, Drs. Foster & Smith
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Generic Name
Mibolerone
Brand Name
Cheque Drops
Type of Drug
Androgenic steroid
Form and Storage
Drops
Store at room temperature unless otherwise specified by the
manufacturer.
Indication for Use
Prevention of estrus, infertility, false pregnancy
Summary
Mibolerone is used to prevent
dogs from coming into heat, and
in the treatment of some causes
of infertility and false
pregnancy. Do NOT use in cats.
Do NOT use in dogs with or
predisposed to liver or kidney
disease. Contact your
veterinarian if your dog
experiences aggression, urinary
incontinence, lethargy, lack of
appetite, weight loss, vomiting,
or yellow gums while taking
mibolerone.
General Information
FDA approved for use in dogs for estrus suppression. Mibolerone is an androgenic steroid which
opposes the effects of estrogen and other hormones which cause ovulation and subsequent
production of progesterone. Need to start the medication at least 30 days before proestrus to
prevent the female from coming into heat. It is about 90% effective. Do not use in dogs which are to be
bred in the future, as start of the next cycle may vary from 7-200 days from discontinuation of Cheque
Drops. It has been used to lengthen short cycles which cause infertility and to treat false pregnancies. The
false pregnancy may recur when the medication is discontinued. Because of this and the fact that most
false pregnancies resolve on their own, no treatment is usually given. The most effective way to prevent
these problems in dogs who are not showing in the breed ring and are not going to be used for breeding is
by an ovariohysterectomy (spay).
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Nylabone Durable Shapes
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Usual Dose and Administration
Contact your veterinarian.
Side Effects
May see increase in clitoral size which may resolve after treatment is discontinued, vaginal discharge,
mounting other dogs, aggression, change in voice, increase in oily skin and body odor, reproductive tract
lesions, tearing, or urinary incontinence. May also cause liver disease or death especially in cats.
Contraindications/Warnings
Do not use in Bedlington Terriers or other breeds predisposed to kidney or liver disease.
Do not use in patients with liver or kidney disease.
Do not use in patients with androgen-dependent cancers such as perianal adenocarcinomas
(malignant tumors that occur near the anus).
Do not use before the first estrus cycle, in pregnant or nursing dogs, or for more than 24 months.
Do not use in cats, as it has a very narrow therapeutic range.
Booda Bones
As low as $5.99
Drug or Food Interactions
Do not use with progestins or estrogens.
May decrease effect of phenytoin.
No known food interactions.
Overdose/Toxicity
May see increased tearing, lethargy, lack of appetite, weight loss, muscle pain, or liver, pancreatic, or
thyroid disease. May cause death.
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The Use of Mibolerone (Cheque Drops) in Dogs
1/4/14 2:13 PM
Keep this and all other medications out of the reach of children and pets.
If you think your pet has been poisoned...
Contact your veterinarian or one of the Animal Poison Hotlines (listed below) if you think your pet may have
accidentally received or been given an overdose of the medication.
**ASPCA National Animal Poison Control Center
1-888-4ANI-HELP (1-888-426-4435). $65.00 per case, billed to caller's credit card.
Follow-up calls can be made for no additional charge by dialing 888-299-2973.
There is no charge when the call involves a product covered by the Animal Product Safety Service.
**Pet Poison Helpline - 24-hour service available throughout North America for pet owners and veterinary
professionals who require assistance with treating a potentially poisoned pet.
1-800-213-6680 ($35.00 per incident). Staffed 24-hours a day.
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