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Curriculum Vitae of Dr. L.H. du Plessis 1. General information Title, name and surname: Date of birth: Citizenship: Professional registrations: 2. Contact details Organisation where based: Faculty or School: Work telephone number: Work fax number: E-mail address: Website address: Work postal address: Work physical address: Dr. Lissinda du Plessis 1981/01/03 RSA none North-West University (NWU) Faculty of Health Sciences: School of Pharmacy +27 (0)18 299 4246 +27 (0)18 299 2251 [email protected] http://www.nwu.ac.za North-West University (NWU) Potchefstroom Campus Private Bag x6001 Potchefstroom 2520 North-West University (NWU) Potchefstroom Campus 11 Hoffman Street Building G02, room 107 2531 3. Qualifications (Start with most recent) Qualification type: PhD Field of study: Biochemistry Institution: North-West University (PU for CHE) Year obtained: 2007 Qualification type: Field of study: Institution: Year obtained: MSc Physiology North-West University (PU for CHE) 2005 4. Employment history (From current backwards. Not more than five) Position: Organisation Appointed from – to: Senior Lecturer School of Pharmacy 2010 - Current Potchefstroom Campus of the North-West University (NWU) Senior Subject Specialist Unit for Drug Research and 2008-2010. Development NWU. 5. Research expertise Scientific domain: Main research field: Fields of specialisation: NRF rating and year rated: 6. Publications International publications: Health Sciences Pharmaceutics Cell and Molecular biology; Drug delivery; Infectious diseases - Steyn, J.D., du Plessis, L.H. and Kotzé, A.F. 2010. Nasal delivery of recombinant human growth hormone: in vivo evaluation with Pheroid™ technology and N-trimethyl chitosan chloride. Journal of Pharmacy and Pharmaceutical Sciences,13(2):263-273. Du Plessis, L.H., Kotze, A.F. and Junginger, H.E. 2010. Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride. Drug Delivery, Aug;17(6):399-407. Du Plessis, L.H., Laubscher, P.J., Jooste, J., du Plessis, J.L., Franken, A., van Aarde, M.N. and Eloff, F.C. 2010. Flow cytometric analysis of the oxidative status in human peripheral blood mononuclear cells of workers exposed to welding fumes. Journal of Occupational and Environmental Hygiene, 7:367-374. Du Plessis, L.H., Lubbe, J., Strauss, T., Kotze, A.F. 2010. Enhancement of nasal and intestinal calcitonin delivery by the TM novel Pheroid fatty acid based delivery system, and by Ntrimethyl chitosan chloride. International Journal of Pharmaceutics, 385:181–186. Keretetse, G.S., Laubscher, P.J., Du Plessis, J.L., Pretorius, P.J., Van der Westhuizen, F.H., van Deventer, E., Van Dyk, E., Eloff, F.C., Van Aarde, M.N. and Du Plessis, L.H. 2008. DNA damage and repair detected by the comet assay in lymphocytes of African petrol attendants: A pilot study. Annals of occupational hygiene, 52(7):653-662. Du Plessis, L.H., Elgar, D. and Du Plessis, J.L. 2008. Southern African scorpion toxins: an overview. Toxicon, 51:1-9. Du Plessis, L.H., Van der Westhuizen, F.H. and Kotze, H.F. 2008. The protective effect of plasma antioxidants during ozone autohemotherapy. African Journal of Biotechnology, 7(14):24722477, July 2008. 7. Papers delivered International papers: th Oral presentation at IOHA 2008 7 International Scientific Conference February 18-22, 2008, Taipei, Taiwan, R.O.C. Title: DNA damage and repair detected by the comet assay in a lymphocytes of African petrol attendants. Goitsemang Keretetse , a a Petrus Johannes Laubscher , Johannes Lodewykus du Plessis , b a a Piet Pretorius , Elmarie van Deventer , Frederik Christoffel Eloff , a b Michiel Nicolaas van Aarde , Etrisia van Dyk , Lissinda du b Plessis . st Poster presented at the 1 International Conference on Drug Design & Discovery, February 3-6, Dubai, UAE.2008. Title: An in vitro evaluation of the enhancement in efficacy of anti-malarial drugs by Pheroid™ technology. Langley, N., Grobler, A., Du Plessis, L., Kotze, A. & Liebenberg, W. Poster presented at the Pathogenesis and Control of Emerging Infections and Drug-Resistant Organisms, Keystone Symposia Global Health Series, Bangkok, Thailand (22-27 October 2008). Title: Enhancement of the in vitro efficacy of chloroquine with Pheroid™ technology. Langley, N., du Plessis, L., Liebenberg, W. & Kotze, A. Poster presented at the Drug Discovery for Protozoan Parasites, Keystone Symposia Global Health Series, Breckenridge, Colorado (22-26 March 2009). Title: Enhancement of the in vitro efficacy of mefloquine and artesunate with Pheroid technology. Du Plessis, L.H., Slabbert, C., Steyn, J.D., van Huyssteen, E., Kotzé, A.F. 2009. Invited Lecture presented at the International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), NorthWest University, Potchefstroom South Africa (23-26 September 2009). Title: Topical and/or transdermal growth factors in cosmetics Minja Gerber, Berenice Campbell, Lize van Niekerk, Anne Grobler, Lissinda du Plessis and Jeanetta du Plessis. Poster presented at the International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), NorthWest University, Potchefstroom South Africa (23-26 September 2009). Title: An in vitro evaluation of triclosan in combination with Pheroid technology for antimalarial treatment Lissinda du Plessis, Dewald Steyn, Awie Kotze. Poster presented at the International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), NorthWest University, Potchefstroom South Africa (23-26 September 2009). In vitro antimalarial efficacy enhancement of mefloquine and ertemther with Pheroid technology RW Odendaal, Lissinda du Plessis, Awie Kotze. Poster presented at the International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), NorthWest University, Potchefstroom South Africa (23-26 September 2009).Title: Enhancement of the in vitro efficacy of chloroquine with Pheroid technology on multi-drug resistant malaria parasites. N Langley, LH du Plessis, AF Kotze th Poster presented at the 6 European Congress on Tropical Medicine and International Health, Verona Italy, 6-10 September 2009. Title: Enhancement of the in vitro antimalarial efficacy of artemisinins and quinolines by Pheroid™ vesicles. L.H. du Plessis, N. Langley, C. Slabbert, R.W. Odendaal, E. van Huysteen, A.F. Kotze th Poster presented at the 6 European Congress on Tropical Medicine and International Health, Verona Italy, 6-10 September 2009. Title: Assessment of the in vitro efficacy of selected artemisinin derivatives in combination with the Pheroid™ drug a a a delivery system. A.F. Kotzé , L.H. du Plessis , J.D. Steyn , A.F. a b Grobler , R.K. Haynes Oral presentation presented at the CRS Denmark 2009 Title: The use of alternative formulation strategies to enhance the efficacy of antimalarials Anne Grobler, Lissinda du Plessis, Marina Rautenbach, Natasha Langley, Dewald Steyn, Richard Haynes, Wilna Liebenberg, Awie Kotze. Poster presented at the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Malta 8-11 March 2010. Title: Size characterisation of Pheroid™ technology and liposomes. C. Slabbert, L.M. Nieuwoudt, L.H. du Pelssis, A.F. Kotzé. Poster presented at the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Malta 8-11 March 2010. Entrapment ability of Pheroid™ technology and liposomes., L.M. Nieuwoudt, C. Slabbert, L.H. du Pelssis, A.F. Kotzé National papers: Poster presented at the Perspectives in Percutaneous th Penetration, 12 International conference, 7-10 April 2010. Title: Topical delivery of selected growth factors. Van Niekerk, L., Campbell, B., Gerber, M., Du Plessis, L.H., Du Plessis, J. th Poster presented at the 29 Annual Conference of the Academy of Pharmaceutical Sciences of South Africa, Hunter’s Rest, Rustenburg, North-West Province (22 – 26 September 2008). Title: Enhancement of the In vitro Efficacy of Chloroquine with Pheroid™ Technology. Langley N., Du Plessis L., Liebenberg W. & Kotze, A. th Poster presented at the 29 Annual Conference of the Academy of Pharmaceutical Sciences of South Africa, Hunter’s Rest, Rustenburg, North-West Province (22 – 26 September 2008). Title: Alternative methods to determine Malaria parasitemia levels for drug efficacy tests. Slabbert,C., Du Plessis, L. & Kotze, A. Oral presentation at the Joint Workshop on Nanaotechnology, Drug delivery and Poverty related diseases. May 2009, CSIR Pretoria South –Africa Title: The use of alternative formulation strategies to enhance the efficacy of antimalarials Anne Grobler, Lissinda du Plessis, Marina Rautenbach, Natasha Langley, Dewald Steyn, Richard Haynes, Wilna Liebenberg, Awie Kotze.