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Project 2 proposal based on following paper: Al-Hajj, M., M. S. Wicha, A. Benito-Hernandez, S. J. Morrison, and M. F. Clarke. "Prospective Identification of Tumorigenic Breast Cancer Cells." Proc. Natl Acad. Sci. USA 100 (2003): 3983-3988. Courtesy of Sharon Lawrence. Used with permission. Courtesy of Sharon Lawrence. Used with permission. Sharon Lawrence 7.342 – Cancer Biology Project 2 Topic November 9, 2004 Paper Choice: Prospective identification of tumorigenic breast cancer cells Description: In this paper, the authors studied mouse models of breast cancer, and came to the conclusion that a subset of cells, distinguished by certain cell markers, initiate tumorigenesis and produce both tumorigenic and nontumorigenic cells in breast cancer. They produced these models by either implanting human breast tumor samples or injecting human breast tumor cells into the mammary pads of mice. I think the next step is to determine if their data is supported by autochthonous breast tumors in mice. I propose developing murine mouse models of breast cancer that express the same cell surface markers. These models would allow me to assess the differences and similarities between autochthonous and non-autochthonous models, and to possibly determine if a subset of tumorigenic cells is always found in breast cancers.