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Part Three: Etiology &
Pathophysiology of Chronic
Kidney Disease
By T. Parent Nurse Educator, PHC
Community Hemodialysis Units 2015
Interstitial Diseases
overproduce
monoclonal Ig Bence
Jones proteins
Myeloma obstructive disorders
nephrotoxic drugs
Acute tubular necrosis (ATN)
hypotension
sepsis
Congenital, developmental and genetic
disorders
inherited disorder
sensory loss
Genetic mutation
inherited disorder
buildup of a particular type of fat, called globotriaosylc
Cystic Diseases
Obstructive Disorders
Kidney function during pregnancy
Anatomical positioning
dilation of the upper urinary tract
increase in the creatinine clearance
decrease in the serum creatinine and BUN
electrolytes
glucose
Fluid retention
urea
increasing blood volume and cardiac output
Infectious Diseases
Acute post-streptococcal glomerulonephritis (PSGN)
Bacterial endocarditis
Hemolytic uremic syndrome
Toxic nephropathies
Autoimmune disorders
Good Pasteur's syndr
Scleroderma
autoantibody that
specifically targets
the kidneys and
the lungs
hardening connective tissue
Systemic Lupus Nephritis
autoantibodies form or
are deposited in the
glomeruli, causing
inflammation
Amyloidosis
extracellular tissue deposition of fibr