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to Our Stakeholders The Question We Face: What is New Value? We are now in the midst of unprecedented change. In particular, However, no matter what type of changes we face, we must in the past several years the management environment in the always remember the starting point for all our business activities— domestic pharmaceutical industry has worsened rapidly. Major “Everything we do is for the patients.” Remicade, a core product, trends include lower success rates in new drug creation and was launched in 2002 as a treatment agent for Crohn’s disease. changes in the market. In addition, the Japanese government has After its launch, we steadily took steps to promote post-marketing taken steps to limit health care spending, including stepped up development. These steps included additional indications for rheu- measures to reduce spending on pharmaceuticals. Initiatives to matoid arthritis (RA) and ulcerative colitis and dose escalation for promote the use of generics have had a rapidly increasing influ- RA and Crohn’s disease. Through these initiatives, Remicade has ence on long-listed products. Many domestic companies that grown into a drug that makes a contribution to many patients. As make new drugs have relied on long-listed drugs as an important a result, in fiscal 2013 combined sales of Remicade and Simponi, source of revenues, but the industry is now entering a stage in a new RA treatment agent, surpassed ¥100.0 billion on a national which that business model no longer functions. health insurance (NHI) drug price basis. I believe this success was In this environment, Mitsubishi Tanabe Pharma is working to the result of the value of the product itself and the value accumu- implement the Medium-Term Management Plan 11–15, which has lated by the Company together with health care professionals, “New Value Creation” as its key concept. Implementing reforms patients, and their families. to become a “company that can continue to create new value” No matter how superior a drug is, without the process of post- is nothing more than implementing reforms to a new business marketing development that establishes effectiveness and safety, model. In the first three years of the plan, we have launched it cannot make a contribution to patients. Our business activities a number of new products and royalty revenues from out-licensed do not end with the creation of a new drug. They continue on in products have become a pillar of our revenues. In addition, the nurturing of that drug. we have implemented reforms targeting the establishment of Moving forward, we will continually return to our starting point a new business model that addresses the changes in the business of “Everything we do is for the patients” and work to contribute environment. These steps have included reorganizations and other to the health of patients around the world by repeating the restructuring initiatives. processes of drug discovery and post-marketing development. To In June 2014, the Company transitioned to a new management that end, the Company’s managers and all other employees will system. Michihiro Tsuchiya, who served as president for five years, ask themselves “What is value for the patient?” and continually became chairman, and Masayuki Mitsuka was appointed president. take on the challenge of creating new value. In addition, we will Under the new system, we will further accelerate initiatives strive to increase management transparency and achieve sustained targeting these reforms. growth. I would like to ask our shareholders, investors, and other stakeholders for their continued understanding and support for Mitsubishi Tanabe Pharma in the years ahead. August 2014 06 Mitsubishi Tanabe Pharma Corporate Report 2014 michihiro tsuchiya masayuki mitsuka Chairman of the Board & Representative Director President & Representative Director OVERViEW OF mEDiUm-tERm manaGEmEnt PLan 11–15 Key Concept: New Value Creation Period: April 2011 to March 2016 (five years) Strategic Challenges: Objectives that Will be Realized under the medium-term management Plan 11–15: 1 Bolstering Our ability to Discover new Drugs Becoming a Company that Can Continue to Create New Value 2 advancing Domestic Operations, Centered on new Drugs 3 Building a Foundation for the Expansion of Overseas Operations 4 accelerating Operational and Structural Reforms Building a Foundation for Future Growth • Taking on the challenge of unmet medical needs* • Discovering drugs and building a foundation to provide them around the world • Investing aggressively in future growth Steadily nurturing and Providing new Products and Priority Products, Centered on Remicade * Unmet medical needs: Medical needs that are not addressed adequately by existing therapies. Mitsubishi Tanabe Pharma Corporate Report 2014 07