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Management of Patients with Renal Disorders Glomerular Diseases Acute Glomerulonephritis Chronic Glomerulonephritis Nephrotic Syndrome Glomerulonephritis Acute Glomerulonephritis Preceded (10 days) by an infection Assess for: Lesions Signs of circulatory overload Change in urine color and amount Mild to moderate hypertension Interventions: Treat cause: antibiotics, corticosteroids, immunosuppressants Restrict sodium, water, potassium, protein Dialysis, plasmapheresis Client education Nursing ManagementAcute Glomerulonephritis Patient assessment Maintain fluid balance Fluid and dietary restrictions Patient education Follow-up care Chronic Glomerulonephritis 20-30+ years to develop Diagnostics: Causes: Urine with fixed specific gravity, casts, and proteinuria Electrolyte imbalances hypoalbuminemia Repeated episodes of acute glomerulonephritis, hypertensive nephrosclerosis, hyperlipidemia, Manifestations: Mild proteinuria and hematuria, hypertension, and occasional edema Nursing Management: Chronic Glomerulonephritis Assessment Potential fluid and electrolyte imbalances Cardiac status Neurologic status Emotional support Teaching self-care Nephrotic Syndrome Increased glomerular permeability Severe loss of protein into urine Treatment: Immunosuppresive agents ACE Inhibitors Heparin Diet changes Mild diuretics Nephrotic Syndrome Nephrosclerosis Narrowing of vessel lumen from thickening in blood vessels of the nephron Occurs with hypertension, atherosclerosis and diabetes mellitus Collaborative management: Control hypertension Preserve renal function Renal Failure Results when kidney’s cannot remove wastes or perform regulatory functions Systemic disorder resulting from many different causes Acute renal failure- reversible syndrome that results in decreased GFR and oliguria Chronic renal failure- progressive; irreversible deterioration of renal function resulting in azotemia Acute Renal Failure Pathophysiology Types of acute renal failure include: Prerenal Intrarenal Postrenal Phases of Acute Renal Failure Phases of rapid decrease in renal function lead to the collection of metabolic wastes in the body. Phases include: Onset Diuretic Oliguric Recovery Acute syndrome may be reversible with prompt intervention. Assessment History Clinical manifestations Laboratory assessment Radiographic assessment Other diagnostic assessments such as renal biopsy Drug Therapy Cardioglycides Vitamins and minerals Biologic response modifiers Phosphate binders Stool softeners and laxatives Monitor fluids Diuretics Calcium channel blockers Treatment Diet therapy Dialysis therapies Hemodialysis Peritoneal dialysis Renal Replacement Therapy Standard treatment Dialysate solution Vascular access Continuous arteriovenous hemofiltration Continuous venovenous hemofiltration Posthospital Care If renal failure is resolving, follow-up care may be required. There may be permanent renal damage and the need for chronic dialysis or even transplantation. Temporary dialysis is appropriate for some clients. Chronic Renal Failure Progressive, irreversible kidney injury; kidney function does not recover Azotemia Uremia Uremic syndrome Stages of Chronic Renal Failure Diminished renal reserve Renal insufficiency End-stage renal disease Changes R/T CRF • • Kidney Metabolic – • Electrolytes – – • • Urea and creatinine Sodium Potassium Acid-base balance Calcium and phosphorus (Continued) Changes R/T CRF (Continued) • Cardiac – – – – • • Hypertension Hyperlipidemia Congestive heart failure Uremic pericarditis Hematologic Gastrointestinal Clinical Manifestations Neurologic Cardiovascular Respiratory Hematologic Gastrointestinal Urinary Skin Imbalanced Nutrition: Less Than Body Requirements Interventions include: Dietary evaluation for: Protein Fluid Potassium Sodium Phosphorus Vitamin supplementation Excess Fluid Volume Interventions: Monitor client’s intake and output. Promote fluid balance. Assess for manifestations of volume excess: Crackles in the bases of the lungs Edema Distended neck veins Drug therapy includes diuretics. Decreased Cardiac Output Interventions: Control hypertension with calcium channel blockers, ACE inhibitors, alpha- and beta-adrenergic blockers, and vasodilators. Instruct client and family to monitor blood pressure, client’s weight, diet, and drug therapy. Risk for Infection Interventions include: Meticulous skin care Preventive skin care Inspection of vascular access site for infection Monitoring of vital signs for manifestations of infection Risk for Injury Interventions include: Drug therapy Education to prevent fall or injury, pathologic fractures, bleeding, and toxic effects of prescribed drugs Fatigue Interventions: Assess for vitamin deficiency, anemia, and buildup of urea. Administer vitamin and mineral supplements. Administer erythropoietin therapy for bone marrow production. Give iron supplements as needed. Anxiety Interventions include: Health care team involvement Client and family education Continuity of care Encouragement of client to ask questions and discuss fears about the diagnosis of renal failure Potential for Pulmonary Edema Interventions: Assess the client for early signs of pulmonary edema. Monitor serum electrolyte levels, vital signs, oxygen saturation levels, hypertension. Hemodialysis Client selection Dialysis settings Works using passive transfer of toxins by diffusion Anticoagulation needed, usually heparin treatment Vascular Access Arteriovenous fistula, or arteriovenous graft for long-term permanent access Hemodialysis catheter, dual or triple lumen, or arteriovenous shunt for temporary access Precautions Complications Permanent Vascular Access Hemodialysis Nursing Care Postdialysis care: Monitor for complications such as hypotension, headache, nausea, malaise, vomiting, dizziness, and muscle cramps. Monitor vital signs and weight. Avoid invasive procedures 4 to 6 hours after dialysis. Continually monitor for hemorrhage. Complications of Hemodialysis Dialysis disequilibrium syndrome Infectious diseases Hepatitis B and C infections HIV exposure—poses some risk for clients undergoing dialysis Peritoneal Dialysis Procedure involves siliconized rubber catheter placed into the abdominal cavity for infusion of dialysate. Types of peritoneal dialysis: Continuous ambulatory peritoneal Automated peritoneal Intermittent peritoneal Continuous-cycle peritoneal Complications Peritonitis Pain Exit site and tunnel infections Poor dialysate flow Dialysate leakage Other complications Nursing Care During Peritoneal Dialysis Before treating, evaluate baseline vital signs, weight, and laboratory tests. Continually monitor the client for respiratory distress, pain, and discomfort. Monitor prescribed dwell time and initiate outflow. Observe the outflow amount and pattern of fluid. Nursing Management of Hospitalized Client on Dialysis Protect vascular access Monitor fluid balance indicators Monitor IV carefully Assess for s/s uremia Monitor cardiopulmonary status carefully Monitor BP Monitor medications Address pain and discomfort Infection control measures Monitor dietary e-lytes and fluids Skin care CAPD catheter care if appropriate Renal Transplantation Candidate selection criteria Donors Preoperative care Immunologic studies Surgical team Operative procedure Postoperative Care Assessment all body systems Pain Fluid and electrolyte status Urologic management Assessment of system patency Assessment of urine output hourly for 48 hours. Complications Rejection Acute tubular necrosis Thrombosis Renal artery stenosis Other complications Immunosuppressive drug therapy Psychosocial preparation Post-transplantation Intervetions Pain relief measures and analgesics Promote airway clearance and effective breathing pattern Strict asepsis Monitor for signs/symptoms of bleeding Encourage leg exercises, early ambulation, and monitor for signs of DVT Renal Cell Carcinoma Healthy kidney tissue damaged and replaced by cancer cells Paraneoplastic syndrome: Anemia Erythrocytosis Hypercalcemia Liver dysfuntion Hormonal effects Increased sedimentation rate Hypertension Renal Cell Carcinoma Management Nonsurgical Radiofrequency ablation Chemotherapy Biological response modifiers and tumor necrosis factor lengthen survival time Renal artery embolization Surgical Pre-op care Nephrectomy Post-op care: Monitoring for hemorrhage and adrenal insufficiency Pain management Prevention of complications Renal Trauma Minor injuries: Major injuries: Lacerations to cortex, medulla, or branches or renal artery Nonsurgical management: Contusions, small lacerations Drug and fluid therapy Surgical management: Nephrectomy or partial nephrectomy