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The informed patient Normalization of bowel function in constipation and diarrhea (Plantago ovata seed shells) Publisher: www.drfalkpharma.com © 2008 Dr. Falk Pharma GmbH All rights reserved. 9th edition 2008 The informed patient Normalization of bowel function in constipation and diarrhea (Plantago ovata seed shells) 1 The informed patient Contents Foreword 4 Our digestion: how does it work? 6 What causes constipation? 15 Laxatives: how they work – Irritant laxatives – Osmotically active laxatives 24 24 27 Lubricants and bulking agents: how they work 28 What can you do if bowel movements remain irregular despite – or because of – laxative use? 30 What causes diarrhea? 36 Mucofalk® 38 3 Foreword Dear reader, You may be one of the large number of people who suffer, often over a period of many years, from chronic constipation. This disorder is often accompanied by other symptoms, such as distended abdomen, bloating, feeling of fullness, pain and/or increased passage of intestinal gas. These complaints can be unpleasant, to say the least, and can significantly affect your general health and quality of life. Many people are reluctant to talk about constipation and its related complaints and therefore do not consult their physician. Instead, they may try to help themselves by the use of supposedly healthy laxative teas and laxatives that are universally available without a prescription. For a while, this may be adequate. More often, however, one find that after only a short period of using these agents one needs ever increasing doses or must switch to a different, usually stronger, preparation to achieve the desired effects. This, in turn, also becomes inadequate in short course and it is only a matter of time before the constipation and its symptoms again worsen, the stools become irregular and hard, and other problems, such as painful bloating, occur. It is usually at this time that people overcome their reluctance and consult a physician for advice. How will your doctor advise you? First and foremost, you should stop taking the laxatives that you have become more or less dependent on! Your physician will tell you that your bowel may actually have been damaged by these drugs and that this will not help you in the long run. Instead, you need to make 4 The informed patient changes in your life (dietary habits, fluid intake, activity and stress management). If this alone does not help, you should use only bulking or high-fiber agents that do not negatively affect bowel function but actually promote normal bowel activity. This brochure also provides information on diarrhea, the treatment of certain forms of which can be supported with bulking agents such as psyllium. It will not always be easy to follow these recommendations. Why it is important to do so will be explained in this brochure, which will also provide you with suggestions that can make your compliance more successful. 5 Our digestion: how does it work? After initial intake and chewing in the mouth, food and beverages pass into the esophagus on swallowing and reach the stomach. In the stomach, the food is reduced further in size and mixed with gastric juices, after which the mixture is passed in measured portions into the small bowel. Nutrients such as carbohydrates, proteins, fats, together with minerals and vitamins are predominantly absorbed in the upper segments of the small bowel and pass into the blood. The remaining, indigestible components of food, especially vegetable fiber, are mixed with digestive juices from the small bowel, pancreas and gallbladder, and pass from the small bowel into the large bowel, or colon. Anatomy of the small and large intestines Stomach Duodenum Transverse colon Ileum Cecum Appendix Jejunum Descending colon Sigmoid colon Rectum Anatomy of the small bowel and colon. 6 The informed patient About 1.5 to 2 liters of small bowel contents pass into the colon each day. The colon consists of three segments: the right (ascending) and left (descending) colon are connected by a transverse segment. The fluid contents of the small bowel first reach the ascending colon, where they remain for up to two days. During this time, water and important mineral substances are extracted and made available to the organism. This also results in an increasing concentration of the bowel content and the transformation to stool begins. At this point, usually after a meal, the stool is propelled by forward movements of the bowel from the right into the left colon and further thickened. Once it has reached the rectum, the final segment of the bowel, the urge to defecate sets in and a bowel movement occurs. 7 The path of nutrition Food and beverages Daily intake: ca. 1 kg of food and 2 liters of beverages Retention time Mouth Tips: Seconds Chew your food completely Esophagus Take adequate fluids with each meal Stomach Eat a lot of high-fiber foods Small bowel Seconds 1-4 hours 2-8 hours Colon 10-40 hours Anus Bowel movement (100-200 g/day) 8 The total duration of gastrointestinal transit ranges between 30 and 100 hours The informed patient The frequency of bowel movements and the amount of stool are affected by different factors: The larger the amount of indigestible vegetable fiber in the diet, the higher the stool volume. The stool also does not become hard and therefore it can pass more quickly through the colon, be concentrated and finally evacuated. The effects of dietary fiber depend on adequate amounts of fluid, which typically means a daily fluid intake of at least 2 liters. The VFED beverage column 4 cups of tea or coffee 600 ml 1 glass of a low-fat dairy 200 ml product (e.g. buttermilk) 1 large glass of fruit juice 250 ml 1 large glass of vegetable 250 ml juice (e.g. tomato juice) 1 bottle of mineral water 700 ml Recommended daily fluid intake 2000 ml Remember, you should drink at least 2 liters of fluid every day! 9 High-fiber foods include whole grain products such as whole grain bread (finely milled whole grain bread is recommended for persons with diverticular disease) and muesli, vegetables, salads, legumes, fruit, linseed and bran. These foods contain the indigestible substances collagen and elastin. Whole grain bread with aromatic tomatoes, delicious spices and herbs, and fresh cottage cheese is just as appealing to you as to your gut. Advantages of high-fiber foods: – Prevention and treatment of constipation – Prevention of intestinal diseases such as diverticulosis and possibly even cancer – Improvement in important intestinal flora – Satiety without “empty calories” 10 The informed patient “Eat more vegetables and less animals” That is a motto for bowel health. Healthy nutrition for the bowels is high in essential vitamins and minerals and keeps or makes the body fit and trim. Whole grain muesli with fruit is the right way to start a bowelhealthy, active day (Source: Dr. Grandel). 11 When the diet is low in fiber too little fiber reaches the colon. As a result, the stool becomes too concentrated and hard and its transport is delayed. Typically, a low fiber diet consists of food made from bleached flour, pudding, sauces and sweets. Meats and cheese contain very little fiber and may divert you from better, more reliable sources of fiber. Low-fiber foods (Not bowel-healthy) White bread Biscuits and rolls Crackers Pudding High-fiber foods (Bowel-healthy) Whole grain bread Whole grain rolls Crisp bread Fruit groats Beverages may also affect the activity of the colon. While mineral water, juices and herbal teas have a positive effect, large amounts of strong black tea and cocoa may cause constipation or make it more severe. You should not drink more than four cups of black tea or cocoa each day. Sour dairy products such as buttermilk or kefir, as well as coffee promote good bowel function. In the morning, a glass of mineral water, possibly mixed with some prune juice, helps get the bowels moving. 12 The informed patient What happens in the colon? In the colon, water is extracted from the mass of digested food, or chyme, which is kneaded by the action of the bowel musculature. If transit is prolonged, these effects on the chyme may be excessive, resulting in the extraction of too much water. As a result, the stool becomes harder and more difficult to transport to the rectum. Normal digestion: Water and important salts are extracted from the chyme and made available to the organism. The bowel contents become thicker and stool forms. Constipation: The chyme is over-processed and too much water is extracted. The stool becomes hard and more difficult to transport to the rectum. 13 Because the muscular movements in the colon are regulated by the vegetative nervous system and, hence, outside the scope of voluntary control, psychic (e.g. stress), emotional (e.g. anxiety) and environmental factors also play an important role for well-regulated digestion and bowel movements. For example, changes in location when traveling or pregnancy can lead to constipation, while anxiety and feelings or helplessness or insecurity tend to cause constipation. Who has not experienced changes in stool frequency and/or consistency before an examination, a dentist visit or a long-distance flight? These issues should also be considered when you are evaluated for constipation and treatment options are explored. 14 The informed patient What causes constipation? Before we consider this question, we must first be clear on what constipation is and at what point it begins. The widely held belief that daily bowel movements are necessary is not shared by physicians. Daily bowel movements are not required and a person who has a bowel movement only every two days is not necessarily sick. As discussed above, the food, depending on its composition, may remain for a shorter or longer time in the bowel. A low-fiber diet generally requires much more time to transit the bowel than does a diet high in fiber taken with adequate liquids. Finally, no one must fear being “poisoned” if a bowel movement is delayed for one or two days. Physicians generally apply the term “constipation” to those cases in which bowel movements occur less than three times per week, is accompanied by significant complaints or is associated with complaints such as abdominal pain and flatulence. Constipation may be due to organic causes, such as scar tissue formation in the bowel, as may occur as a result of inflammation, or thickening of the bowel wall, due, for example, to a tumor. Other diseases, which have nothing to do with the bowel, such as reduced function of the thyroid gland, may also cause constipation. Similarly, diabetes that has been poorly 15 controlled over a number of years may be associated with constipation. The physician will look for these causes before he starts any treatment. It may be advisable to consult a gastroenterologist, who specializes in diseases of the stomach and intestinal tract, in this search for the causes of constipation. In many cases, however, such organic causes may not be present. These cases are called functional constipation. There are convincing reasons to believe that the main cause of functional constipation lies in the profound changes in diet common to developed Western industrial nations. For many years, the content of carbohydrates and dietary fiber has decreased in favor of fats, refined sugars and proteins. Our bowels, however, are dependent for normal function on an adequate supply of carbohydrates and fiber. 16 The informed patient What does this mean? Functional constipation is due in large part to our civilized lifestyle. Five factors in particular have bad effects: The composition of the diet Tip: Eat more vegetables and less animals! Our diet is weighted too heavily in favor of animal proteins at the cost of vegetable components. The average German consumes too much fat, alcohol and refined sugar. The proportion of meat and cured meat products in the German diet is also too high. On the other hand, the average intake of dietary fiber stands at about 22 grams per day, which is far below the minimum recommended daily allowance of 30 grams. Your consumption of dietary fiber is adequate when your daily diet includes at least 500 grams of vegetables and potatoes, 250 grams of fruit (for example, two apples) and four slices of whole-grain bread. If you orient your diet to the VFED nutrition pyramid (see page 20/21), you will always be in the safe zone. 17 In addition, our food is so highly processed that little is left for the bowel to do. Many foods today are essentially pre-digested. Fast food, sweets and soft drinks are not good for the gastrointestinal tract. The proportion of vegetable fiber is so low that little indigestible matter is left to be excreted from the bowel. Drinks, too, are often loaded with calories (sugar, alcohol) and also do not leave behind any indigestible remains. The colon is inadequately filled and the stool is excessively thickened, resulting in a lengthened transit time. This leads to constipation. Regular bowel movements depend on adequate filling of the bowel and a soft consistency of the chyme. This stimulates the bowel by stretching, resulting in forward propulsion of the stool and, finally, an easy bowel movement. Bowel-healthy foods such as vegetables can only preserve their healthy effects when they are fresh and correctly prepared (i.e., not overcooked; Source: Fissler). 18 The informed patient Inadequate physical activity Tip: Get regular exercise! Many people work at a desk and sit the entire day, something for which our body was not designed. Elevators, escalators, automobiles, busses and trains serve our transportation needs, and there is almost no need for further motion. At night and on the weekends, there is often time only for household chores and any remaining free time is spent in front of the television set. In the household, actual physical work is made increasingly superfluous by mixers, washing machines and clothes driers, dishwashers and other kitchen gadgets. The less you move, the less your bowel moves and this results in a slowing-down of the rate at which the chyme is transported through the bowel. As this happens, too much water is extracted and the stool becomes less soft and less voluminous, which makes bowel movements difficult. Optimum bowel function requires more physical activity. This is not only good for the bowel: Your cardiovascular system will also thank you for more activity in the form of walks of increasing length, swimming, jogging, dancing or bicycle riding and reward you with improved function and well-being. This will help you remain or become fit and trim. 19 The informed patient The nutrition pyramid of the VFED e.V. (VFED – Verband für Ernährung und Diätetik e.V.) Choose wisely when it comes to eating and drinking daily: small amounts Iodized salt with fluor daily: in moderation daily: 3 low-fat servings K Rapseed Olive OIL OIL weekly: no more than 2–3 low-fat servings of meat/sausage, 2 eggs weekly: 1–2 servings of ocean fish daily: at least 4 servings Wholemeal flour Whole wheat pasta Wholemeal rice daily: at least 3–4 servings daily: 2 servings WAT E R daily: at least 1.5–2 liters m o re daily: moderate activity, weekly: 3 x physical exercise/sports 20 21 Inadequate fluid intake Tip: Drink at least 2 liters daily Because water is extraordinarily important and the body must keep itself safe from desiccation, water is extracted from the chyme in the colon. This liquid comes not only from food and beverages but also from digestive juices. The colon absorbs up to 2 liters every day. If the fluid intake in food and beverages is inadequate, however, the stool becomes firm, then hard. You should drink at least 2 liters of liquid every day. Mineral water has no calories but contains large amounts of the minerals and trace elements required for life. The body requires 2 liters of fluid from beverages (Source: IDM). 22 The informed patient Hectic lifestyle Tip: Don’t let the stress get to you and practice relaxation Many people’s lives have become more hectic than every before. The word stress has become a routine part of their vocabulary. Long drives to work, tension in one’s career, fear about losing one’s job, and no time for anything are frequent reasons for delaying the trip to the bathroom. Bowel movements are something that are under our voluntary control. As a result, the stool stays in the bowel longer, it becomes thicker and at some point one no longer even feels the urge to go. You should always go to the bathroom as soon as you feel the urge: This will help you get used to the urge when it occurs. Drugs Tip: Ask your doctor or pharmacist about the effects of drugs on the bowels Numerous drugs can cause and/or worsen constipation. Among the most common are certain heart medications, analgesics, antacids containing aluminum and calcium, some medications for high blood pressure and psychiatric medications used in depression and other mental disorders. 23 Laxatives: how they work Tip: Laxatives belong in the hand of the physician Laxatives only work where they should work: in the bowel, in particular, in the colon. Basically, all laxatives work by means of similar mechanisms. They increase the water content of the stool, which increases its volume and flexibility, resulting in better transport through the bowel and simpler evacuation. There are, however, differences in how the different laxative achieve this objective and in their specific side effects. Irritant laxatives Tip: Herbal does not automatically mean gentle Herbal laxatives (senna leaves, aloe, rhubarb root) and the substances contained in many laxatives not only prevent the extraction of water in the colon and its absorption by the body but also promote the extraction of water from the body. While this is useful for improving the characteristics of the stool, making it softer and easier to transport, the long-term use of these laxative can result in the body becoming too dry and in the loss of minerals essential for life. 24 The informed patient The word “herbal” makes many people think that these laxatives are gentle. This is not true in every case. Laxatives should be kept in the hand of your doctor, who will in general prescribe them only for a limited time. Laxatives that irritate the bowel prevent the absorption of water from the colon and even promote the excretion of water from the body into the colon. At more than 60% of body weight, water is the main component of our body! As we age, the water content of our bodies declines. Water is necessary for life. Minerals are needed for numerous processes in our bodies. An excessive loss of water and minerals from our body has far-reaching consequences that we cannot ignore. These include malfunctions of the kidneys, nerves and heart. 25 In addition, many laxatives may stimulate the motility of the bowels to such an extent that it may no longer respond adequately to its own control mechanisms and signals. These many-sided effects of bowel-irritating, so-called drastic laxatives may initiate a vicious cycle that soon leads to addiction. Patients may require a higher dose of the laxative because the bowel’s own motility is permanently disturbed and damaged when the control mechanisms and nervous structures in the bowel wall are constantly stimulated by contact with laxatives. The loss of minerals, such as potassium, reduces the motility of the bowel even further. One of the main reasons for constipation is the improper use of laxatives. The wide-spread belief that herbal laxatives, because they are natural products, generally cause no harm is false! Especially in long-term use the choice of laxative must be guided by caution. 26 The informed patient Osmotically active laxatives (Salts and artificial sugars such as lactulose as laxatives) These are laxatives whose exclusive mechanism of action is to retain water in the colon and attract water from the body. Typical examples include sodium bicarbonate, Glauber’s salt (sodium sulfate) or Epsom salts (magnesium sulfate), so-called saline laxatives. Carbohydrates such as lactose, lactulose, lactitol, mannitol and sorbitol also act in this way. The use of these laxatives for a short period of weeks to a few months is harmless, but, when used at too high doses and for too long, they can result in disturbances of the salt and water metabolism of the body and even cause the constipation to become worse. These laxatives also belong exclusively in the hand of the doctor. Osmotic agents retain water in the colon and attract further water into the colon. This can lead to disturbances of the organism’s water and salt metabolism. 27 Lubricants and bulking agents: how they work Lubricants Lubricants such as paraffin and glycerin facilitate bowel movement in that they make the stool more slippery. Paraffin is only rarely used today but the short-term use of glycerin in the form of suppositories is not harmful. Bulking agents Unobjectionable for use over longer periods are vegetable bulking agents, which must not be confused with herbal laxatives, such as senna leaves. Bulking agents are natural substances found in plant products such as linseed, wheat bran or the seeds of ® certain varieties of plantain (such as Mucofalk ). The pods of the plantain variety from which Mucofalk® is obtained is called psyllium. Often the amount of dietary fiber contained in foods such as fresh salads does not suffice to get the bowels moving again. In these cases, the use of bulking agents is necessary (Source: Becel Diet Vegetable Oil, Master-Media). 28 The informed patient These natural and safe vegetable bulking agents promote bowel movement by the fact that their bulking action in the stool binds water. The indigestible dietary fiber increases the volume of the stool and keeps it soft. These factors combine to naturally stimulate the bowel to evacuation and promote adequate emptying of the bowel. Bulking agents also increase and improve the bacterial flora of the colon, which also increases the stool volume, makes it softer in consistency and improves transport. The intestinal flora is part of the defense system of our body. A good bacterial flora helps keep the organism fit and healthy. The increased filling of the colon promotes improved function and the stool consistency is improved by the binding of water. . Bulking agents by their mechanism of action bind water and the indigestible dietary fiber increases the stool volume. The stool becomes softer and transport is facilitated. 29 What can you do if bowel movements remain irregular despite - or because of - laxative use? A large variety of laxatives is available and can be purchased in many places beside pharmacies. Because they are able, initially at least, to solve a troubling, and often embarrassing problem, many patients consult their physicians only when laxatives, after a long period of use, no longer produce the desired effect. In many cases the cause of constipation is the careless use of laxatives. In many cases this is due to the fact that the body has become tolerant of these agents that irritate the bowel and the above-described vicious cycle has set in. How do you break this vicious cycle? This is not simple - for you or for your doctor! Because the body has become accustomed to laxatives over a long period it will now initially respond with increased symptoms once these laxatives are discontinued. It must go through an actual period of withdrawal if you wish to become permanently free of your complaints. Laxatives must be discontinued slowly and you must carefully start a new diet that emphasizes foods and drinks rich in vegetable components and liquid. Your physician knows this and will review with you the importance of this difficult process. Be aware that, here, patience is a virtue! 30 The informed patient Increasing Stool retention Disturbed bowel function (bowel atonia) Water and salt depletion in the body (low blood pressure) Sodium deficiency Stool retention Use of laxatives Loss of water and salt in the colon Potassium deficiency Disturbed kidney function Disturbances in the function of the nerves, which affect the muscles (e.g. the heart) Dieticians and nutritionists can assist you in making the necessary dietary changes. The results are worth the effort. Your bowel and your entire body will thank you with optimum function, activity, health and fitness. 31 The diet plan is constructed under the motto: “Eat more vegetables and less animals!” (Source: Schneekoppe/Wirths PR). Once the laxatives have been discontinued, one should not believe that he no longer needs to take any other agents. However, you should only use substances that do not damage the bowel even after long-term use. This means in particular the bulking agents, such as Mucofalk®. 32 The informed patient ® Initially, Mucofalk alone may not be enough, because you may have become tolerant of other agents. Therefore, it may be necessary in some cases to add other agents, such as lactose (milk sugar), lactulose or sodium bicarbonate. In cases of refractory constipation, a laxative suppository containing glycerin every three days may be necessary. Always consult your physician when you feel that your current treatment is not sufficient. In no case should you return to the laxatives you may previously have used! The withdrawal from laxatives is not as simple as purchasing a supposedly harmless herbal laxative tea in the supermarket. In preparation for treatment with Mucofalk® your physician may prescribe a solution containing macrogol, which is usually used for bowel cleansing prior to colonoscopy. A low-dose macrogol preparation can also be an alternative in the treatment of refractory constipation. 33 As an adjunct to medical treatment you should also consider how you can change your lifestyle and behavior to eliminate factors that negatively affect your digestion. Primarily, this includes: – Eat a diet high in fiber (whole grain products, much fruit and vegetables), but avoid foods that cause flatulence (e.g. raw cabbage dishes). – Drink enough fluids (juices, buttermilk, mineral water). This is especially important when you are ® using Mucofalk in order that the bulking agents can adequate swell in the bowel. Avoid “constipated” beverages such as black tea, cocoa and red wine. With each dose of Mucofalk® you should take a glass of water or of fruit juice mixed 1:2 with sparkling mineral water. – Get adequate exercise and make time for a daily trip to the toilet. Don’t let your hectic schedule get in the way! With these steps and a little patience your digestion can be adjusted so that in a short time 2-6 sachets or teaspoons of Mucofalk® will be sufficient and you can dispense with laxatives for good. 34 The informed patient Because Mucofalk® regulates bowel function naturally without harming the bowel, use of this bulking agent, even for many years, is not associated with the danger of again getting trapped in the vicious cycle of using laxatives at continually increasing doses. Instead, the water-soluble dietary fiber contained in Mucofalk® also lower the cholesterol level, prevent other diseases of the bowel and regulate the colon’s natural flora to improve your immune defenses. The VFED nutrition pyramid shows how easy it is to eat healthy (see page 20/21). Foundation of healthy nutrition are whole grain products, lots of vegetables and potatoes (at least a pound each day), as well as fruit (at least one-half pound per day). These foods are supplemented with healthy, low-fat animal products such as fish, poultry, lean meat, skim dairy products and low-fat cheese. The consumption of sugar, highly sweetened foods, butter, margarine and oil, as well as alcoholic beverages, should be reduced as much as possible in order to keep the body active and fit. The nutrition pyramid also promotes a diet that makes overweight nearly impossible, or, if it exists, promotes slow reduction in weight with adequate supply of essential vitamins and minerals. At the bottom of the pyramid is the intake of at least 2 liters of low-calorie beverages each day. 35 What causes diarrhea? Diarrhea is defined as more than three bowel movements per day that are watery or porridge-like in consistency, with an increased total stool volume. In addition, patients may suffer from bloating, abdominal pains, nausea and vomiting. Acute diarrhea persists less than two weeks. If diarrhea lasts more than two weeks, it is considered chronic. Diarrhea is not a disease. It is a symptom and represents the body’s rational response for cleansing itself of damaging substances as quickly as possible. A common cause of acute diarrhea are bacteria or viruses. In most cases, acute diarrhea is of short duration and resolves by itself. If diarrhea is accompanied by fever or when there is blood in the stool, you should immediately seek medical attention. Because of the associated loss of water and minerals, diarrhea can be dangerous for some persons, especially infants, young children and elderly, debilitated persons. Factors that cause diarrhea include: – Disturbed motility of the bowel associated with accelerated bowel transit. – Too much fluid in the bowel, possibly due to a reduced capacity of the mucosal membrane to absorb water. 36 The informed patient The most common causes of acute diarrhea: – “Intestinal flu” - Infection with viruses or bacteria – Dietary intolerances (e.g. lactose intolerance) – Food poisoning – Travelers’ diarrhea – Drug-induced diarrhea (e.g. antibiotics) – Anxiety, stress The most important causes of chronic diarrhea: – Irritable bowel syndrome – Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) – Gluten allergy (celiac disease, sprue) – Laxative abuse ® What is the action of Mucofalk in diarrhea? It may strike you as odd that the same drug can be used to treat both constipation and diarrhea. The apparently contradictory indications are explained by the actions of psyllium, which are based on the bulking properties of the mucinous components, i.e. its capacity to bind large amounts of water. The same components also responsible for the diarrhea-inhibiting effects of Mucofalk®, which result in the desired thickening of the bowel contents. The stool becomes formed and this simultaneously normalizes intestinal transit. 37 Mucofalk® orange Granules Active ingredient: Indian isphagula husk (Plantago ovata seed shells) Bulking agents in Mucofalk®: The bulking agents in Mucofalk® include seed shells from certain types of plantain (Plantago ovata). These herbal substances encourage regular bowel movements by attracting water as they swell and increase the bulk of the stools with their indigestible fibrous constituents. Furthermore, bulking agents increase the bacterial flora, which also adds to the bulk of the stools.The greater bulk in the bowel stimulates it to function more efficiently and the higher water content makes the stool softer. Herbal bulking agents of this type can be used safely for relative long periods. Indications: Chronic constipation diseases in which easier bowel movements with soft stools are desirable, e.g. anal fissures, hemorrhoids, following surgery in the rectum area. As supportive treatment in diarrhea of various causes and in irritable bowel syndrome. Dosage instructions: Unless otherwise prescribed, adults and adolescents from over 12 years of age take the contents of one ® sachet respectively one teaspoonful Mucofalk orange 2 - 6 times daily after stirring into plenty of liquid (at least 150 ml). 38 The informed patient 1. Please never take the preparation in dry state, as difficulties in swallowing can occur. 2. Pour the contents of one sachet respectively one teaspoonful of the granules into a glass. 3. Slowly fill the glass with cold water (at least 150 ml). 4. Stir with a spoon, ensuring that no lumps form, and drink immediately. Do not take when lying down! 5. Drink another glass of liquid afterwards. Hint: Please also note the instructions for use. Store Mucofalk® orange in a dry place! 39 Further information for patients with bowel diseases: – Colon Diverticula and Diverticulosis 31 pages (M80e) – Discomfort in the anal region What can it be? What can you do? 50 pages (M83e) These brochures can be ordered free of charge from Falk Foundation e.V. or the local Falk partner. FALK FOUNDATION e.V. Leinenweberstr. 5 79108 Freiburg Germany www.falkfoundation.com M81e 9-11/2008/3.000 Bu