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PROSTATE SCREENING Patient Information What is the prostate? That sounds good, what are the disadvantages? The prostate is a chestnut-sized organ that sits under your bladder. It has an important role in the production of semen. The blood test that we use to check the prostate is not specific for cancer. Other conditions such as benign prostatic hypertrophy (the age-related swelling of the Prostate gland) can cause it to be elevated also. At moderately raised levels we know that only approximately one quarter of men will have cancer diagnosed on subsequent biopsy. Why do I hear all this discussion about the prostate? In a significant amount of men, as they age, cancer can develop in the prostate. In fact, it is the commonest male cancer in Ireland. What are my chances of getting it? Statistics suggest that once you reach 50 years of age you have over a 50% chance of developing it. How dangerous is it? Again, taking a 50 year old man, he has a 3% chance of dying from prostate cancer over his lifetime. That seems like a low figure, I thought all cancers were the same? Prostate cancer behaves very differently from other cancers, for example lung or bowel cancer. The majority of prostate cancers are slow growing and will rarely impact on a man’s health or life-expectancy. It is said that most men will die with it rather than from it. Should I have my prostate checked? This is primarily a personal choice that should be made in consultation with your GP. At this point in time we simply do not know if men are better off from having regular checks on their prostate. The indirect evidence seems to suggest that they are, but we are waiting for 2 large research trials to conclude, within the year, and hopefully get a definite answer. What are the advantages of having my Prostate checked? Regular checking or “screening” of your prostate can provide reassurance that there is no evidence of cancer. We also know that prostate cancer, if caught early, can be cured. Surely it’s a good thing if you identify the cancer early? In general it is, but where prostate cancer differs is that we actually identify a large number of cancers that would never have caused any problems. Statistics suggest that only 1 in 8 screening-detected cancers is likely to cause death if left untreated. We are therefore giving a significant number of men a diagnosis of a cancer that they would otherwise never have known about. Isn’t it better to over-diagnose the condition? We will certainly identify more cancers but bear in mind that we will also expose a large number of men to unnecessary worry about abnormal blood test results and cancer that may not have led to any health problems. We find it difficult to distinguish slowgrowing cancers from aggressive, fast-growing ones. Is screening right for me? You need to decide if you want to know about your prostate and be willing to submit to regular screening and biopsy, if indicated from your tests. If you are between 50 and 70 years of age the consensus is that you would be more likely to benefit from screening. The rationale is that because prostate cancer is a comparatively slow-growing cancer it is generally younger men whose life-expectancy will be increased if early cancers are cured. If you have a first degree relative with prostate cancer or if you are of Afro-Caribbean origin then screening should be considered at 45. How often should I be screened? This is based on your results. If your PSA blood test is low, then screening every 2 years should be fine. Your GP may decide on yearly screening if your results are closer to the upper limit of normal. Published April, 2008, © ICGP 2008 How is my Prostate checked? I cannot decide. What should I do? The prostate gland is checked in 2 ways. Firstly a blood test called PSA is done. We know that there is an association between elevated PSA and Prostate cancer. Also, your GP will examine your prostate directly by means of a rectal exam. He or she will insert a finger in your back passage and feel the prostate gland. The aim is to identify any lumps or abnormalities on the gland that could indicate cancer. If you are of an age where screening will most likely benefit you, i.e. between 50 and 70, consider whether you would prefer knowing your risk of having prostate cancer. Understand that while an early, aggressive cancer can be cured you may be exposed to ongoing monitoring and investigation of a cancer that ultimately may not have impacted on your health. If you are over 70 you are far less likely, in terms of life-expectancy, to benefit from even curative treatment. Testing at this stage is much more likely to introduce unnecessary worry which may impact on your quality of life. In all cases discuss your options with your GP and he or she will aid you in coming to a decision that is right for you. What happens if my blood test is raised or my doctor finds a lump? Your doctor will refer you for specialist opinion from an urologist. The urologist will decide on what further steps need to be taken. They may decide to keep your blood tests under active monitoring or to proceed to biopsy. Useful links / contacts: What does the biopsy involve? Irish Cancer Society A small probe is inserted into the rectum which uses ultrasound, a form of imaging, to identify the prostate gland. Once identified, the doctor will collect a number of samples from the prostate using a biopsy needle. The procedure is generally safe, though some men find it uncomfortable and minor symptoms such as blood in the urine can occur. 43/45 Northumberland Road, Dublin 4 Telephone: E-mail: Website: 01 2310500 [email protected] www.cancer.ie Action Prostate Cancer Prostate Cancer Information Service What if the biopsy is negative? If the biopsy is negative the urologist will consider this along with blood test results and findings on rectal examination. If your urologist’s index of suspicion is low that you have a significant cancer, based on all these criteria, he or she will be able to reassure you accordingly and advise about routine follow-up and screening. If, however, he or she remains suspicious that they have not identified a significant cancer they will devise a schedule for further investigation which may include a further biopsy. 43/45 Northumberland Road, Dublin 4 Telephone: E-mail: Website: 1800 380 380 (free phone) [email protected] www.cancer.ie Men Against Cancer (MAC) c/o Irish Cancer Society, 43/45 Northumberland Road, Dublin 4 What if the biopsy is positive? If cancer is identified then the urologist will consider all the criteria. Detailed treatment options are beyond the scope of this document because of the variability of practice in different treatment centres. Broadly speaking a decision will be made whether to treat or to actively monitor the cancer. Treatment options include the removal of the prostate (radical prostatectomy), radiotherapy (using radiation to destroy the cancer) and hormonal treatment. If the cancer is confined to the prostate, there is a good chance of cure with surgery or radiotherapy. All these treatments have side effects including urinary incontinence, impotence and the risk of cancer recurrence and these must be carefully weighed up before proceeding. Telephone: E-mail: Website: Published April, 2008, © ICGP 2008 1800 200 700 (free phone) [email protected] www.cancer.ie