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Digestive System Azami PHD Digestive System Anatomy • Digestive tract – Alimentary tract or canal – GI tract • Accessory organs – Primarily glands • Regions – – – – – – – Mouth or oral cavity Pharynx Esophagus Stomach Small intestine Large intestine Anus Oral Cavity • Mouth or oral cavity – Vestibule: Space between lips or cheeks and alveolar processes – Oral cavity proper • Lips (labia) and cheeks • Palate: Oral cavity roof – Hard and soft • Palatine tonsils • Tongue: Involved in speech, taste, mastication, swallowing Salivary Glands • Produce saliva – Prevents bacterial infection – Lubrication – Contains salivary amylase • Breaks down Starch • Three pairs – Parotid: Largest – Submandibular – Sublingual: Smallest Teeth • Two sets – Primary, deciduous, milk: Childhood – Permanent or secondary: Adult (32) • Types – Incisors, canine, premolar and molars Tooth structure: Pharynx and Esophagus • Pharynx – Nasopharynx – Oropharynx: Transmits food – Laryngopharynx: Transmits food • Esophagus – Transports food from pharynx to stomach – Passes through esophageal hiatus (opening) of diaphragm and ends at stomach (Swallowing) • Three phases – Voluntary – Pharyngeal • Reflex – Esophageal • Reflex Digestive Tract Histology Digestive System Regulation • Nervous regulation – Involves enteric nervous system • Types of neurons: sensory, motor, interneurons – Coordinates peristalsis and regulates local reflexes • Chemical regulation – Production of hormones – Production of paracrine chemicals Digestive Tract Anatomy serous membranes Peritoneum • Peritoneum – Visceral: Covers organs – Parietal: Covers interior Retroperitoneal surface of body wall – Retroperitoneal: Behind peritoneum as kidneys, pancreas, duodenum • Mesenteries – Routes which vessels and nerves pass from body wall to organs Mesenteries • Mesenteries – Routes which vessels and nerves pass from body wall to organs Mesenteries Mesenteries Lesser omentum from ventral mesentery Lesser omentum from ventral mesentery greater omentum from dorsal mesentery greater omentum from dorsal mesentery greater omentum Greater sac Lesser sac Stomach Anatomy • Openings – Gastroesophageal : To esophagus – Pyloric: To duodenum • Regions – – – – Cardiac Fundus Body Pyloric Stomach Histology: • Layers – Serosa or visceral peritoneum: Outermost – Muscularis: Three layers • Outer longitudinal • Middle circular • Inner oblique – Submucosa – Mucosa Stomach Histology • Rugae: Folds in stomach when empty • Gastric pits: Openings for gastric glands – Contain cells Small Intestine anatomy and Histology • Site of greatest amount of digestion and absorption • Divisions – Duodenum – Jejunum – Ileum: Peyer’s patches or lymph nodules • Modifications – Circular folds or plicae circulares, villi, microvilli • Cells of mucosa – Absorptive, goblet, granular, endocrine Small Intestine Secretions • Mucus – Protects against digestive enzymes and stomach acids • Digestive enzymes – Disaccharidases: Break down disaccharides to monosaccharides – Peptidases: Hydrolyze peptide bonds – Nucleases: Break down nucleic acids • Duodenal glands – Stimulated by vagus nerve, secretin secretin increases water and bicarbonate secretion from duodenal (Brunner's) glands Duodenum