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I.V. bolus injection The I.V. bolus injection method allows rapid drug administration. It can be used in an emergency to provide an immediate drug effect. It can also be used to administer drugs that can’t be given I.M., to achieve peak drug levels in the bloodstream, and to deliver drugs that can’t be diluted, such as diazepam, digoxin, and phenytoin. The term bolus usually refers to the concentration or amount of a drug. I.V. push is a technique for rapid I.V. injection. Bolus doses of medication may be injected directly into a vein, through an existing I.V. line, or through an implanted vascular access port (VAP). The medication administered by these methods usually takes effect rapidly, so the patient must be monitored for an adverse reaction, such as cardiac arrhythmia and anaphylaxis. I.V. bolus injections are contraindicated when rapid drug administration could cause life-threatening complications. For certain drugs, the safe rate of injection is specified by the manufacturer. Some facilities permit only specially trained nurses (such as emergency department, critical care, and chemotherapy nurses) to give bolus injections. EQUIPMENTPatient’s medication record and chart gloves prescribed medication 20G needle and syringe diluent, if needed tourniquet povidone-iodine or alcohol sponge sterile 2" × 2" gauze pad adhesive bandage tape optional: winged-tip needle with catheter and second syringe (and needle) filled with normal saline solution; noncoring needle if used with a VAP; heparin flush solution. Winged-tip needles are often used for this purpose because they can be quickly and easily inserted. They’re ideal for repeated drug administration, as in weekly or monthly chemotherapy. Another useful dosage form is the ready injectable. (See Using a ready injectable.) EQUIPMENTUSING A READY INJECTABLE A commercially premeasured medication packaged with a syringe and needle, the ready injectable allows for rapid drug administration in an emergency. Usually, preparing a ready injectable takes only 15 to 20 seconds. Other advantages include the reduced risk of breaking sterile technique during administration and the easy identification of medication and dose. When using a commercially prefilled syringe, be sure to give the precise dose prescribed. For example, if a 50 mg/ml cartridge is supplied but the patient’s prescribed dose is 25 mg, you must administer only 0.5 ml — half of the volume contained in the cartridge. Be alert for potential medication errors whenever dispensing medications in premeasured dosage forms. PREPARATION OF EQUIPMENTVerify the order on the patient’s medication record by checking it against the doctor’s order. Know the actions, adverse effects, and administration rate of the medication to be injected. Draw up the prescribed medication in the syringe and dilute it if necessary. IMPLEMENTATIONConfirm the patient’s identity, wash your hands, put on gloves, and explain the procedure. Giving direct injections Select the largest vein suitable for an injection. The larger the vein, the more diluted the drug will become, minimizing vascular irritation. Apply a tourniquet above the injection site to distend the vein. Clean the injection site with an alcohol or a povidone-iodine sponge, working outward from the puncture site in a circular motion to prevent recontamination with skin bacteria. If you’re using the drug syringe’s needle, insert it into the vein at a 30-degree angle with the bevel up. The bevel should reach 1/4" (0.6 cm) into the vein. If you’re using a winged-tip needle, insert the needle (bevel up), tape the butterfly wings in place when you see blood return in the tubing, and attach the syringe containing the medication. Pull back on the syringe plunger and check for blood backflow, which indicates that the needle is in the vein. Remove the tourniquet and inject the drug at the appropriate rate. Pull back slightly on the syringe plunger and check for blood backflow again. If blood appears, this indicates that the needle remained in place and all the injected medication entered the vein. Flush the line with the normal saline solution from the second syringe to ensure delivery of all the medication. Withdraw the needle and apply pressure to the injection site with the sterile gauze pad for at least 3 minutes to prevent hematoma formation. Apply the adhesive bandage to the site after bleeding has stopped. Giving injections through an existing I.V. line Check the compatibility of the drug with the I.V. solution. Close the flow clamp, wipe the injection port with an alcohol sponge, and inject the medication as you would a direct injection. (Some I.V. lines have a secondary injection port or a T-connector; others have a latex cap at the end of the I.V. tubing where the needle is attached.) Open the flow clamp and readjust the flow rate. If the drug isn’t compatible with the I.V. solution, flush the line with normal saline solution before and after the injection. (For additional information, see the section on intermittent infusion devices.) Giving a bolus injection through a VAP Wash your hands, put on gloves, and clean the injection site with an alcohol or povidone-iodine sponge, starting at the center of the port and working outward in a circular motion over a 4" to 5" (10- to 12.7-cm) diameter. Do this three times. Palpate the area over the port to locate the port septum. Anchor the port between your thumb and the first two fingers of your nondominant hand. Then, using your dominant hand, insert the needle into the appropriate area of the device and deliver the injection. (See the section on vascular access device maintenance.) SPECIAL CONSIDERATIONSBecause drugs administered by I.V. bolus or push injections are delivered directly into the circulatory system and can produce an immediate effect, an acute allergic reaction or anaphylaxis can develop rapidly. If signs of anaphylaxis (dyspnea, cyanosis, seizures, and increasing respiratory distress) occur, notify the doctor immediately and begin emergency procedures, as necessary. Also watch for signs of extravasation, redness, or swelling. If extravasation occurs, stop the injection, estimate the amount of infiltration, and notify the doctor. If you’re giving diazepam or chlordiazepoxide hydrochloride through a winged-tip needle or I.V. line, flush with bacteriostatic water instead of normal saline solution to prevent drug precipitation resulting from incompatibility. COMPLICATIONSExcessively rapid drug administration may cause adverse effects, depending on the medication administered. DOCUMENTATIONRecord the amount and type of drug administered, time of injection, appearance of the site, duration of administration, and patient’s tolerance of the procedure. Also note the drug’s effect and any adverse reactions.