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From: Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma Invest. Ophthalmol. Vis. Sci.. 2015;56(2):893-907. doi:10.1167/iovs.14-15008 Figure Legend: rAAV-CMV-Brn3b administration increased expression of GAP-43, abLIM, and neurofilament-M proteins following IOP elevation in Brown Norway rats. (A) Intraocular pressure was elevated in the left eye of Brown Norway rats while the contralateral right eye served as the corresponding control. Immunoblots of whole optic nerves extracts, obtained 3 weeks following rAAV-CMV-GFP or rAAV-CMV-Brn3b virus injection into IOP-elevated left eye (IOP↑) of Brown Norway rats. Blots were probed with specific antibodies against GAP-43, abLIM, and neurofilament-M (NF-M). Calnexin served as a loading control. (B) Intraocular pressure–elevated Left(L)/Contralateral Right (R) ratio of densitometry readings (normalized to corresponding calnexin levels) representing ratio in between IOP-elevated and Copyright contralateral eye All arerights reserved. Date of download: 5/14/2017 The Association for Research Vision and Ophthalmology © 2017. presented as mean ± SD.