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From: Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma
Invest. Ophthalmol. Vis. Sci.. 2015;56(2):893-907. doi:10.1167/iovs.14-15008
Figure Legend:
rAAV-CMV-Brn3b administration increased expression of GAP-43, abLIM, and neurofilament-M proteins following IOP
elevation in Brown Norway rats. (A) Intraocular pressure was elevated in the left eye of Brown Norway rats while the
contralateral right eye served as the corresponding control. Immunoblots of whole optic nerves extracts, obtained 3
weeks following rAAV-CMV-GFP or rAAV-CMV-Brn3b virus injection into IOP-elevated left eye (IOP↑) of Brown Norway
rats. Blots were probed with specific antibodies against GAP-43, abLIM, and neurofilament-M (NF-M). Calnexin served
as a loading control. (B) Intraocular pressure–elevated Left(L)/Contralateral Right (R) ratio of densitometry readings
(normalized
to corresponding
calnexin
levels)
representing
ratio in
between
IOP-elevated
and Copyright
contralateral
eye All
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Date
of download:
5/14/2017
The
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© 2017.
presented as mean ± SD.