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Download 0073 Characteristics of Malignant Ocular Tumors in a Japanese
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0073 Characteristics of Malignant Ocular Tumors in a Japanese Cohort: A Review of 194 Cases Managed at the Shizuoka Cancer Center Hiroya Kashiwagi1, Tetsro Onitsuka2, Masahiro Nakagawa3, Shusuke Yoshikawa4, Ichiro Ito5 1 Division of Ophthalmology in Shizuoka Cancer Center, Nagaizumi, Japan, 2Division of Head and Neck Surgery in Shizuoka Cancer Center, Nagaizumi, Japan, 3Division of Plastic Surgery in Shizuoka Cancer Center, Nagaizumi, Japan, 4Division of Dermatology in Shizuoka Cancer Center, Nagaizumi, Japan, 5Division of Pathology in Shizuoka Cancer Center, Nagaizumi, Japan Purpose: To report the clinical and histopathological features of malignant ocular tumors treated at our hospital. Methods: We retrospectively examined the records of 194 cases of malignant ocular tumors that were managed at the Shizuoka Cancer Center over the last 8years (2007–2014). Cases of secondary tumors from head and neck cancers were excluded from this analysis. Results: The study population included 89 male and 105 female patients, with a mean age of 62.12 years (range, 0.5–97 years). With regard to tumor site, there were 82cases of eyelid tumors (including sebaceous gland carcinoma [n=28], basal cell carcinoma [n=27], and squamous cell carcinoma [n=11]), 35 cases of conjunctival tumors (including malt type lymphoma [n=17] and squamous cell carcinoma [n=10]), 41 cases of intraocular tumors (including malignant melanoma [n=13], metastatic tumor [n=13], and diffuse large B-cell lymphoma [n = 10]), and 36 cases of orbital tumors (including malt type lymphoma [n=12] and metastatic disease [n=7]). Of the 194 patients, 27 died (13.9%); these patients had malignant melanoma [n=2], metastatic tumor [n=23], or primary intraocular lymphoma [n=2]. Adenoid cystic carcinoma of the lacrimal sac [n=2] were the rare tumors that were observed. Proton beam therapy or carbon beam therapy was administered for this carcinoma, however the clinical course following treatment was not good. Conclusion: Sebaceous gland carcinoma accounted for most cases of eyelid tumors, in agreement with previously reported data on Asian populations. In addition, we should consider that the feasibility of proton or carbon beam therapy for lacrimal sac carcinoma.
