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Action – Target ADVERSE/se: Dose Metered-dose broncodilator PARADOXICAL inhaler--2-3 Beta2 BRONCHOSPASM inhalations q 3-4 hr Agonist/short- (EXCESSIVE USE OF term control INHALERS). nervousness, (not to exceed 12 inhalations/day). agent./inhibits restlessness, tremor release of SHORT ACTING mediators from mast cells. Nursing considerations: • use other inhalation meds first-wait 5 min. rinse w/water. Adequate fluid intake2-3L. Drug Metaproter enol (Alupent) O= 1 min P=1 D = 1-5 Drug Action – Target ADVERSE/se: Dose Metered-dose Ipratropium Anticholinergic no major adverse/se. inhaler--2 bromide s- not beta2, Quick Relief medication inhalations 4 x (Atrovent) but added daily (not to O= 1-3 min benefit in exceed 12 P = 1-2 hr severe inhalations/day). D = 4-6 exacerbations of asthma – more frequently used in COPD Nursing considerations: assess for allergy to atropine, belladonna alkaloids. Assess RR, breath sounds, Dyspnea, HR. Rinse mouth, oral hygiene. Drug Action – Target ADVERSE/se: Dose PO 2-4 mg 3-4 x daily broncodilator nervousness, (not to exceed Beta2 restlessness, tremor, Agonist/shortchest pain, palpitations. 32mg/day) Geriatric: not exceed 2mg 3term control In O= 5-15 min 4xday 2 Inhalations q agent./inhibits SHORT ACTING P = 1-1.5 hr 4-6 hr or 2 inhalations release of D = 3-6 PO O=15-30 min mediators from 15 min before exercise P=2-3 hr (90 mcg/spray); mast cells. D=4-6 hr Nursing considerations: •Assess lung sounds, pulse, BP before admin and during peak. Note amount, color and character of sputum. •Advise patients to use albuterol first if using other inhalation medications and allow 5 min to elapse before administering other inhalant medications unless otherwise directed. •Advise patient to rinse mouth with water after each inhalation dose to minimize dry mouth. albuterol (Proventil, Ventolin, Volmax) Drug Action – Target ADVERSE/se: Dose Diskus-50 mcg Salmeterol Bronchodilator/ headache (one inhalation as (Serevent Adrenergic. LONG... ACTING dry powder) twice Diskus) LONG Term O= 10-15 min control of daily P = 3-4 (approximately 12 reversible D = 12 hr apart) airway obstruction. Nursing considerations: maintenance treatment of COPD. Not for acute asthma attacks. Drug Action – Target Solu-Medrol intermediatemethyipredn acting corticosteroids – isolone suppresses O= UNK P = 1-2 hr inflammation D = 1.25 – 1.5 days ADVERSE/se: Dose 2-60 mg/day as a single dose or in 24 divided doses. Asthma exacerbations-120-180 mg/day in divided doses 3-4 times/day for 48 hr, then 60-80 mg/day in 2 Intermediate ACTING divided doses. Nursing considerations: monitor I/O, electrolytes/glucose/WBC. Admin in morning to coincide w/normal secretions of cortical. stress/surgery may increase need. PEPTIC ULCERATION, THROMBOEMBOLISM, anorexia, nausea, acne, decreased wound healing, ecchymosis, fragility, hirsutism, petchiae, adrenal suppression, muscle wasting, osteoporosis, cushingoid appearance Drug Action – Target Prednisone (Sterapred) O= UKN P = UKN D = 1.25 – 1.5 days Oral Glucocorticoid s acting as antiinflammatory agents reducing edema of the airways. ADVERSE/se: PEPTIC ULCERATION, THROMBOEMBOLISM, anorexia, nausea, acne, decreased wound healing, ecchymosis, fragility, hirsutism, petchiae, adrenal suppression, muscle wasting, osteoporosis, cushingoid appearance Dose Most uses--560 mg/day as a single dose or in divided doses. Quick Relief!! (intermed. acting) med Nursing considerations: monitor I/O, electrolytes/glucose/WBC. Admin in morning to coincide w/normal secretions of cortical. stress/surgery may increase need.w/water. Drug Action – Target Advair Comb. Beta 2 & (salmeterol/ Corticosteroid fluticasone) fluticasone – antiasthmatic/ antiinflammatory (steroidal)/ corticosteroid (inhalation). Prophylactic therapy Nursing considerations: ADVERSE/se: headache Dose Drug Action – Target Theophylline (Sloe-bid, Theo-Dur) Aminophylline theo O= rapid P = 1-2 hr D = 6 hr Xanthines bronchodilator amino O=15-60 min P=1-2 hr D=6-8 hr ADVERSE/se: Dose SEIZURES, PO (Adultswith CHF, Cor ARRHYTHMIAS anxiety, Pulmonale, or Liver tachycardia, nausea, Dysfunction): Loading dose--5 vomiting mg/kg, followed by 5 mg/kg/day divided q 8-12 hr Long-term control of (not to exceed 400 mg/day). reversible airway obstruction by asthma or geri (not exceed 400mg/day) COPD drink +2L water/day, minimize intake caffine. Nursing considerations: Monitor theophylline serum level therapeutic 10-15 asthma, 6-14 apnea. Increases the risk of digoxin toxicity and decreases the effects of lithium and phenytonin (Dilantin). If theoophylline and B2 adrenergic agonist are administered together, cardiac dysrhythmias may result. cimetidine (Tagamet) and erythromycin increase the effects of theophylline. used in addition to inhaled corticosteroids, mainly for relief of NIGHTIME astha symptoms. Barbituarates and carbamazepine (Tregretol) decrease the effects of theophylline.) Drug Action – Target Montelukast (Singulair) O= within 24 hr P = 3-4 D = 24 leukotriene antagonist prevents bronchoconstriction. ADVERSE/se: EOSINOPHILIC CONDITIONS, CHURG-STRAUSS SYNDROME nervousness, restlessness, tremor Dose ASTHMA – PO 10 mg once daily. Exercise induced - 10 mg at least 2 hrs before exercise. Do not take within 24 hrs of another dose; if taking daily doses, do not take dose for EIB. take 1 daily in evening. alternative to inhaled corticosteroids for mild persistent asthma or added to regime in severe asthma. Nursing considerations: assess lung sounds and resp function. Drug Action – Target Zafirlukast Leukotriene (Accolate) inhibitor Long term control O= UKN agent. Not for P = 1 week acute asthma D = UKN attacks ADVERSE/se: CHURG-STRAUSS SYNDROME headache Long term control Dose 20 mg twice daily. PO: Administer at regular intervals on an empty stomach, 1 hr before or 2 hr after meals Nursing considerations: Blood levels are increased by aspirin. Blood levels are decreased by erythromycin and theophylline. Increases effects and risk of bleeding with warfarin. Drug Action – Target Zileuton (Zyflo) O= UKN P = 1.7 hr D = UKN broncodilator headache Beta2 Agonist/shortterm control Long Term Control of agent./inhibits Asthma release of mediators from mast cells. Nursing considerations: ADVERSE/se: Dose PO (Adults and Children ≥12 yr): 600 mg 4 times daily or two 600 mg extended release tablets twice daily with meals and at bedtime. Administer extended release tablets within 1 hr after morning and evening meals ↑ blood levels and effects of theophylline, beta blockers, propranolol, and warfarin. Drug-Food: Food slows but does not alter extent of absorption.