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Prepared by: Ibrahim Tawhari. Scernario: Khalid 14 years old come to the clinic c/o shortness of breath for one day duration. He is a known asthmatic patient for more than 8 years, he visits clinic frequently. His school performance is below average, with frequent absence from school due to his illness. What is Bronchial Asthma?? It is a chronic inflammatory disorder of the airways resulting in EPISODES of: Reversible bronchospasm airflow obstruction. Associated with airway HYPER-RESPONSIVENESS to endogenous or exogenous stimuli. Asthma in KSA: A common problem especially in children. The prevalence of asthma among school children in KSA: Range: 4%-23%. Riyadh: 10%. Jeddah: 12% PATHOPHYSIOLOGY: During an acute asthmatic attack: Airways obstruction V/Q mismatch Hypoxemia Hyperventilation PCO2 PH (Respiratory Alkalosis) PATHOPHYSIOLOGY: Muscle Fatigue Ventilation PCO2 PH (Respiratoty Acidosis) TRIGGERS TRIGGERS: URTIs. Allergens / Irritants: Mould Pet dander Feather House Dust Smoking Air Pollution Pollens TRIGGERS: Drugs: Aspirin Emotion & Anxiety: NSAIDs -Blockers TRIGGERS: Others: Cold Air Exercises GERD SIGNS & SYMPTOMS… SYMPTOMS & SIGNS: Tachypnea, Wheezing, Chest tightness, Cough (especially nocturnal), sputum production. RED FLAGS… RED FLAGS: Fatigue Silent Chest Expiratory Effort Cyanosis LOC Respiratory Distress: Nasal flaring, tracheal tug Inability to speak Accessory muscle use, intercostal indrawing Pulsus paradoxus DIAGNOSIS DIAGNOSIS: History: Is it the first time??? Recurrent??? If first attack Hyperactive airway disease. SOB, Cough, sputum,… Nocturnal attacks? Effect on daily activities?? Frequency? Look for any triggers… Family History… Drug History… DIAGNOSIS: History: Atopic manifestation: Atopy Triad DIAGNOSIS: P/E: General Appearance, Vital signs: Tachypnea, pulsus paradoxus, fever,…??? General Examination: Cyanosis, Local eczema, nasal polyps, URTI, … Examinations: Inspection: Palpation: Auscultation: Percussion DIAGNOSIS: Investigations: O2 saturation. ABGs: PO2 during attack (V/Q mismatch). PCO2 in mild asthma (hyperventilation)… But, normal or PCO2 ominous sign (resp. muscle fatigue). PFTs: May not be possible during attacks… Done when patient is stable… DIAGNOSIS: Investigations: PFTs: Spirometry: FEV1: Improvement with medications.. MANAGEMENT Management: Non-Pharmacologic Management: Avoid allergens… Education Features of the patient: of disease… Goal of management… How to do self monitoring… Red flags… Management: Pharmacologic Management: Symptomatic relief in ACUTE ATTACKS: acting 2-agonists: albuterol, terbutalin, mataprotrenol,… Anticholinergic bronchodilators… Steroids… Long acting 2-agonists: Salmetrol, formetrol,… Short Management: Pharmacologic Management: CHRONIC Long MANAGEMENT: Term Prevention of Attacks… Inhaled or oral steroids… Anti-allergic: Na chromoglycate, Nidocromile,.. Long acting 2-agonists: Salmetrol, Formetrol,… Aminophyllins… LT receptors antagonists: zileuton, zafirlukast, montilukast,.. Management: FOLLOW UP Criteria of Controlled Asthma: Assessment of Control: THE END…. Thanks…