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Prepared by: Ibrahim Tawhari. Scernario:    Khalid 14 years old come to the clinic c/o shortness of breath for one day duration. He is a known asthmatic patient for more than 8 years, he visits clinic frequently. His school performance is below average, with frequent absence from school due to his illness. What is Bronchial Asthma??  It is a chronic inflammatory disorder of the airways resulting in EPISODES of:  Reversible  bronchospasm  airflow obstruction. Associated with airway HYPER-RESPONSIVENESS to endogenous or exogenous stimuli. Asthma in KSA:   A common problem especially in children. The prevalence of asthma among school children in KSA:  Range: 4%-23%.  Riyadh: 10%.  Jeddah: 12% PATHOPHYSIOLOGY:  During an acute asthmatic attack: Airways obstruction V/Q mismatch Hypoxemia Hyperventilation PCO2 PH (Respiratory Alkalosis) PATHOPHYSIOLOGY: Muscle Fatigue Ventilation PCO2 PH (Respiratoty Acidosis) TRIGGERS TRIGGERS:   URTIs. Allergens / Irritants: Mould Pet dander Feather House Dust Smoking Air Pollution Pollens TRIGGERS:  Drugs: Aspirin  Emotion & Anxiety: NSAIDs -Blockers TRIGGERS:  Others: Cold Air Exercises GERD SIGNS & SYMPTOMS… SYMPTOMS & SIGNS:     Tachypnea, Wheezing, Chest tightness, Cough (especially nocturnal), sputum production. RED FLAGS… RED FLAGS: Fatigue Silent Chest Expiratory Effort Cyanosis  LOC Respiratory Distress:     Nasal flaring, tracheal tug Inability to speak Accessory muscle use, intercostal indrawing Pulsus paradoxus DIAGNOSIS DIAGNOSIS:  History:  Is it the first time??? Recurrent???  If first attack  Hyperactive airway disease.  SOB, Cough, sputum,…  Nocturnal attacks?  Effect on daily activities??  Frequency?  Look for any triggers…  Family History…  Drug History… DIAGNOSIS:  History:  Atopic manifestation: Atopy Triad DIAGNOSIS:  P/E:  General Appearance,  Vital signs: Tachypnea, pulsus paradoxus, fever,…???  General Examination:  Cyanosis,  Local eczema, nasal polyps, URTI, … Examinations:  Inspection:  Palpation:  Auscultation:  Percussion DIAGNOSIS:  Investigations:  O2 saturation.  ABGs:  PO2 during attack (V/Q mismatch).   PCO2 in mild asthma (hyperventilation)…  But, normal or PCO2 ominous sign (resp. muscle fatigue).   PFTs: May not be possible during attacks…  Done when patient is stable…  DIAGNOSIS:  Investigations:  PFTs:  Spirometry:  FEV1:  Improvement with medications.. MANAGEMENT Management:  Non-Pharmacologic Management:  Avoid allergens…  Education  Features of the patient: of disease…  Goal of management…  How to do self monitoring…  Red flags… Management:  Pharmacologic Management:  Symptomatic relief in ACUTE ATTACKS: acting 2-agonists: albuterol, terbutalin, mataprotrenol,…  Anticholinergic bronchodilators…  Steroids…  Long acting 2-agonists: Salmetrol, formetrol,…  Short Management:  Pharmacologic Management:  CHRONIC  Long MANAGEMENT: Term Prevention of Attacks…  Inhaled or oral steroids…  Anti-allergic: Na chromoglycate, Nidocromile,..  Long acting 2-agonists: Salmetrol, Formetrol,…  Aminophyllins…  LT receptors antagonists: zileuton, zafirlukast, montilukast,.. Management: FOLLOW UP Criteria of Controlled Asthma: Assessment of Control: THE END…. Thanks…