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MCB 4211, Basic Immunology
September 20, 2016
Quiz 1 /version 1
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SELECT THE BEST ANSWER FROM THE 5
1. Surgical removal of the thymus from a mouse at birth eliminates T cells. What does surgical
removal of the Bursa of Fabricius in a chicken eliminate?
a. B cells
b. Granulocytes
c. Polymorphoneutrophils (PMNs)
d. Mast Cells
e. All of the above
2. Xenografts are grafts exchanged between
a. Close friends
b. Identical twins
c. Xena the warrior princess and her enemies
d. Different individuals within a species
e. Different species
3. In one of Landsteiner’s experiments, tri-nitrophenyl conjugated to bovine serum albumin
(TNP-BSA) was used to immunize a rabbit, and the resulting antiserum was collected from
that rabbit. What would be the result of mixing this antiserum with TNP-BSA?
a. The haptenated carrier protein will precipitate with antibodies to TNP in the
rabbit serum.
b. Only antibody interactions with the BSA carrier protein epitopes will cause
precipitation because the BSA is large enough to elicit an immune response and the
TNP is not.
c. Only the TNP epitopes will interact with the antiserum because rabbits also have
albumin and thus the BSA is not recognized as non-self by the rabbit's immune
system.
d. The TNP-BSA will precipitate due to the presence of hemoglobin in the serum.
e. None of the above
4. Although congenic mice are a powerful tool for deciphering the function of an unknown gene,
observed phenotypic differences between congenic partner strains are not always due to a
difference in the differential locus used to produce the congenic partner strain. Which of the
following could also explain a phenotypic difference between congenic strain partners?
a. New, spontaneous mutations
b. Differences between sexes
c. Passenger loci
d. All of the above
e. None of the above
5. Adjuvants work in several ways to enhance the immune response. Do you expect an
adjuvant to work if co-injected with the synthetic polymer Teflon as the immune stimulus?
a. Yes, Teflon is highly immunogenic molecules and adjuvant will only enhance the
response further
b. No, Teflon is not of sufficient size to provoke an immune response.
c. No, Teflon is highly immunogenic and adjuvant cannot increase the large response
that they elicit.
d. No, Teflon is not of sufficient molecular complexity to induce an immune
response.
e. No, Teflon is recognized as “self” by the body
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MCB 4211, Basic Immunology
September 20, 2016
NAME____________________________________
Student ID number _________________________________
6. Which antibody-binding assay would you use to detect the presence of an antigen in
tissues?
a. Precipitation
b. Agglutination
c. ELISA
d. Radioimmunoassay
e. Immunohistochemistry
7. An example of a heterogeneous humoral immune response is
a. A helper T cell-mediated response
b. A macrophage-mediated response
c. A complement-mediated response
d. An antibody-mediated response
e. All of the above
8. Predict the results of transplanting normal skin tissue from a Japanese Waltzing Mouse to
an F2 mouse from this original mating (Japanese Waltzing Mouse x BALB/c).
a. All engrafted mice would die
b. A small fraction of the transplanted tissues would survive on individual
recipients
c. All of the transplanted tissues would survive on individual recipients
d. No transplanted tissue would survive the surgery
e. None of the above
9. What is an idiotype?
a. The antigenic shape of the Fc region
b. The name of the most important class of antibody
c. The antigenic shape of the antibody’s antigen combining site
d. The allelic antigens that distinguish one antibody from antibodies of the same class
and subclass in a different individual of the same species
e. The force needed to hold antibodies to antigens
10. The Hayflick limit:
a. Is defined as the number of times a normal human cell population will divide
before cells will stop dividing as their chromosomes become unstable.
b. Limits stem cell division.
c. Is a result of telomere elongation.
d. Is the distance cell pseudopods can extend.
e. Defines the number of antigens an individual can recognize as foreign.
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