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Transcript
NT2
Indications:
Type 2 diabetes
Syndrome x
Insulin resistance
Hyperglycaemia
Hyperinsulimia
Also Indicated for:
Distal neuropathies
Fatigue
High triglycerides
BSL fluctuations
Depression due to insulin resistance
Weight gain around waist (1 to 1 or greater waist to hip ratio)
Habitual constipation.
Contents: 60x500mg Capsules
Ingredients:
Jin-Qi formula:
Flos Lonicerae
Rhizome Coptidis
Radix Astragali
Ren Shen Berry
Ou Jie- Nelumbo nucifera
Momoridica
Chromium
Theaflavin 3-O-gallate, Thealavin 3'-O-gallate, Theaflavin 3, 3'di-O-gallate
Action:
NT2 combines European and Oriental herbs with the latest natural molecular extracts to raise satiation levels and
regulate insulin levels. (in other words you find you are satisfied with less food). NT2 also helps regulate blood
sugar and insulin levelse. NT2 works by changing the way the hypothalamus (part of the brain that controls
appetite) sees the body. When someone is overweight the hypothalamus signals that there is enough energy and
appetite is reduced but for many people the signal is not strong enough and they feel hungry even when full. NT2
corrects the message and the appetite is controlled.
Regulates blood sugar levels (BSL);Bi-directional regulation of pancreatic insulin production, increases or
decreases as needed; regulates liver glycogen storage; Stimulates thyroid function and increases metabolism;
Decreases cortisol levels and up regulates hypothalmic sensitivity; Protects tissues from oxidant stress.
Combinations:
With ZLIM TRIM for weightloss.
Dosage:
4 capsules daily
Contraindications:
During first trimester pregnancy; thereafter daily dosage of no more than 3 capsules.
Note:
Chromium/Diabetes
Diabetes & Chromium
Evidence shows that taking chromium picolinate orally can decrease fasting blood glucose, insulin levels, and
glycosylated hemoglobin (HbA1c) and increase insulin sensitivity in people with type 2 diabetes (1,2,6,12). Some
evidence also suggests that chromium picolinate might decrease weight gain and fat accumulation in type 2
diabetes patients who are taking a sulfonylurea (12).
Higher chromium doses might be more effective and work more quickly (2). Higher doses might also reduce
triglyceride and total serum cholesterol levels in some patients (1,2).
Preliminary evidence also suggest that chromium picolinate might have the same benefits in patients with type 1
diabetes (5) and in patients who have diabetes secondary to corticosteroid use (3).
Some evidence also shows that a specific combination of biotin and chromium (Diachrome, Nutrition 21) might
lower blood glucose levels and HbA1C levels in type 2 diabetes patients who are poorly controlled despite
treatment with oral hypoglycaemic agents (10, 11, 16). However, there is no reliable evidence that this
combination is more effective than taking chromium alone.
Epidemiological research also links lower toenail chromium levels to increased risk of diabetes and cardiovascular
disease, but there is no clinical evidence to suggest that chromium supplements can lower disease risk (9).
But not all evidence is positive (7,8,13,14,15). An analysis of pooled results from previous studies found
inconclusive results due to the small number of trials, small study size and inconsistent patient population
studied (8). One of the largest studies that found benefit enrolled patients in China where poor nutritional status
is more likely, and therefore, benefit from supplementation is also more likely, compared to Western populations
(2,14). There is speculation that chromium supplements might primarily benefit patients with poor nutritional
status or low chromium levels. Chromium levels can be below normal in patients with diabetes (4, 14).
Phytotherapy Research
Drug products that can reduce insulin resistance
Many type II diabetic patients have normal levels of insulin in the blood. The diabetes is not caused by the
destruction of beta cells in the pancreas but by other mechanisms, such as insulin resistance, related to downregulation of insulin receptors, defects in insulin secretion from the pancreatic beta cells and other changes to the
glucose transporter system. Jin-qi was reported to have the pharmacological effect of restoring sensitivity to
insulin and therefore, reducing insulin resistance (Cui, 2000). Jin-qi’s composition comprises extracts from
honeysuckle flower, milkvetch root and coptis root. Honeysuckle flower is a vinelike shrub that grows to a height
of 6-9m, with slender, prickly branches and flowers that bloom white then turn yellow, hence the Chinese name
meaning ‘gold and silver flower’. The flower, stem and leaves contain inositol, saponin, and tannin. Honeysuckle
flower is routinely used for detoxication and thirst. Coptis root is a perennial herb with long trifoliated leaves,
small yellowish white flowers and a reddish brown root covered with fine rootlets. This plant is cultivated
throughout China and also in parts of northern India. The root is yellowish orange on the inside, the inner pith
being deeper in colour, and contains berberine, alkaloids coptisine, palmatine, jatrorrhizine and magnoflorine,
etc. among these ingredients, berberine is the most popular and well-characterized compound with demonstrated
antidiabetic effects (Xiao, 2002).
Pharmacological studies with Jin-qi were performed using genetically diabetic KK mine (female, 20-22g) and
hydrocortisone (HC) induced diabetic mice (Shen et al., 1997). Both groups were insulin-resistant and during the
experiment, were given Jin-qi daily, and were injected with insulin at 23 and 9 days, respectively. Table 14 and
Figs 1 and 2 summarize the experimental results, showing that Jin-qi was able to reduce the insulin resistance in
the two animal models. The blood glucose levels in the Jin-qi group were higher than those in the normal control
groups, upon i.p. injection of insulin, but significantly lower than those in diabetic groups which were insulinresistant. The serum insulin concentration in Jin-qi treated KK mice was 12.1±5.5mU/L in the KK mice control.
A single-blinded, randomised, multicentre clinical investigation of Jin-qi was conducted in 1993 at four major
hospitals in Beijing, in which a total of 442 patients with type II diabetes participated. The clinical dosage was 710 pills (0.42g/pill) of Jin-qi, per dose, and three doses per day (Cui, 2000). A different antidiabetic herbal drug
was used, at eight pills per dose, and three doses per day, as a control. Combined drug treatment using Jin-qi
and chemical hypoglycaemic agents was also used to evaluate the synergistic effect of chemical – herbal
therapeutic drugs. The clinical results are shown in Table 15.
Discussion
There are several review articles (Liu and Lu, 2000; Li, 2000; Jiang and Li, 2001) published in various Chinese
journals discussing traditional antidiabetic agents and pharmacological studies in China. Due to the different
pharmacological roles of those hydro-alcohol extracts, the hypoglycaemic mechanism of drug products containing
a mixture of those extracts becomes complicated. The authors speculated that polysaccharide-containing agents
restored the functions of pancreatic tissues and caused an increase in insulin output by the functional beta cells.
Others attributed the hypoglycaemic effect of many products to their ability to inhibit the intestinal absorption of
glucose, to the increased availability of insulin, or to the facilitation of metabolites in insulin-dependent
processes. However, none of the investigators was able to provide conclusive evidence to ascertain the actual
hypoglycaemic mechanism(s) of a single herbal drug developed in China.
This paper reviews the compositions, pharmacological and clinical effects of seven antidiabetic herbal drugs
commercially available in China. Combination formulas, i.e. mixtures of certain herbal extracts, were used in all
the drug products, and each product possessed significant dose-dependent blood glucose lowering activity in
various animal models as well as in humans. These alterations will further lead to a decrease in atherosclerosis.
The difference between a single-herb formula and a multi-herb combination formula is not merely the addition of
more herbs, but also the interaction between the components of mixtures of herbs. A system of synergistic
interactions among herbal drugs is formed in a combination formula which is believed to take a multi-targeted
therapeutic approach in the treatment.
The treatment of diabetic patients with naturally derived agents has the advantage that it does not cause the
significant side effects as do chemical agents such as sulfonylurea. One of the side effects with sulfonylurea is
that it causes a decreased amount of insulin production by putting too great a strain on the insulin producing
beta cells. Treatment with herbal drugs has an effect of protecting beta cells and smoothing out fluctuations in
glucose levels. Some agents, such as Jin-qi, can reduce the insulin resistance and, hence, improve the apparent
insulin activity. Improved insulin activity leads to decreased circulating insulin, which leads to lower blood
glucose and glycosylated haemoglobin levels as well as total cholesterol, LDL-cholesterol and triglyceride levels,
and increased HDL-cholesterol levels. Additionally, the use of these natural agents in conjunction with
conventional drug treatments such as a chemical agent or insulin permits the use of lower doses of the drug
and/or decreased frequency of administration which decreases the side effects most commonly observed. It was
also widely observed during the clinical studies in China that the mixtures of herbal extracts could lower the
cholesterol and triglyceride levels, in addition to the blood glucose level. This suggests that the long-term use of
herbal drugs may be advantageous over chemical drugs in alleviating some chronic diseases and complications
caused by diabetes, which adverse effects of these herbal extracts are minimal.