Download Drugs to be Avoided or Used With Caution In Pregenancy

Drugs to be Avoided or Used
With Caution In Pregnancy
Introduction
• Drugs can have harmful effects on the
foetus at any time during pregnancy.
During first trimester they may produce
congenital malformations (teratogenesis)
and the period of greatest risk is from the
third to eleventh week of pregnancy. All
drugs should be avoided if possible during
the first trimester.
• During the second and third trimesters.
drug may affect the growth and functional
development of the foetus or have atoxic
effects on foetal tissues.
• Drugs should be prescribed in pregnancy
only if the expected benefit to mother is
thought to be greater than the risk to the
foetus.
Drugs
Gastrointestinal
stimulant
laxatives
Trimester of
Risk
1,2,3
Sulphasalazine 3
Adverse Effect
Best avoided.
As they may
increase uterine
activity in
susceptible
patients.
Theoretical risk
of neonatal
haemolysis and
of kemicterus in
jaundiced
neonates
Drugs
Trimester of
Risk
Adverse Effect
Cardiovascular; 3
Amiodaron
(cordaron)
Release iodine
with possible
risk of neonatal
goiter.
B-Adrenoceptor 3
Blocking Drug
Neonatal
hypoglycemia
and bradycardia
Drugs
Trimester of
Risk
Adverse Effect
Diuretics
3
Reduce plasma volume
and placental
perfusion Thiazides
may cause neonatal
thrombocytopenia
Oral anticoagulants
1,2,3
Congenital
malformation. Foetal
neonatal haemorrhage
.
Subcutaneous heparin
can be used in the last
few weeks of
pregnancy in deep vein
thrombosis