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Sagittal section of the brainstem. The riMLF and the PPRF act as brainstem centers for the generation of saccades. The riMLF mediates vertical saccades and the PPRF mediates the horizontal. Lesions of these regions or their cortical input pathways impair the saccadic actions necessary for volitional vertical and horizontal gaze. PPRF = paramedian pontine reticular formation; riMLF = rostral interstitial nucleus of the medial longitudinal fasciculus. (Reproduced with permission from Kennard C, Crawford TJ, Henderson L. A pathophysiological approach to saccadic eye movements in neurologic and psychiatric disease. J Neurol Neurosurg Psychiatry. 1994;57:881-885.) Source: Examination of the Central Ocular Motor Systems, DeMyer's The Neurologic Examination: A Programmed Text, 7e Citation: Biller J, Gruener G, Brazis PW. DeMyer's The Neurologic Examination: A Programmed Text, 7e; 2016 Available at: http://mhmedical.com/ Accessed: May 13, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
