Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
m Aurélie is Associate Professor of Organism Biology and Leader of the SPICI team in the Evo Eco Paleo unit (CNRS UMR8198) at the University of Lille in France. Her research activities rely on comparative immunology i.e. the description and comparison of the processes used by different living organisms to recognize, kill and/or tolerate microbes. More particularly, she has been working on one of the key components of the immune defense, i.e. antimicrobial peptides (AMPs), since her Ph.D. These are small antibiotic molecules naturally produced by bacteria, plants, fungi and animals. She is interested in discovering new ones and understanding their immunological functions in the animals that produce them. These are extremely effective chemical warfare systems to kill bacterial pathogens but also to shape the colonizing bacterial symbionts while coping with specific environmental challenges. Concerning biological models, the main part of her studies focus on annelids because they occupy a very large range of habitats (marine, terrestrial…) including very extreme ones where most animals cannot survive, (hydrothermal vents, coastal mud anoxic and enriched in sulfides, highly polluted habitats…) they can be free or parasites and probably as a consequence, appear to be a source of a very large variety of novel AMPs. She identified seven new AMPs in annelids. She demonstrated their function in the defense against pathogenic bacteria in the blood, the digestive tract and interestingly also in the central nervous system where they are produced by neurons and promote the regenerative process of the injured nerve cord. More recently, she has been working on the adaptive evolution of AMP genes and on understanding how AMPs are selected to allow ringed worms to establish symbiosis that are vital to thrive in extreme habitats. AMP studies give rise to both “fundamental” and “applied” interests. Indeed, because of their mode of action and their spectrum of activities and their small size, some AMPs constitute promising candidates for the development of new antibiotics. For these reasons, three of the AMPs newly found by Aurélie were patented by the CNRS or the University of Lille for their potential application in medicine. Together with Daniela Zeppilli, they have recently obtained a grant support to look for and to understand the role of AMPs in extremophile nematodes, another types of worms ! To know more about Aurélie’s work, visit her websites http://spici.weebly.com and https://www.researchgate.net/profile/Aurelie_Tasiemski or even better, talk to her at the Meioscool!!