Download Name: Saverio Bellusci

Name: Saverio Bellusci
Position: Professor, Chair of Extracellular Matrix Remodelling.
Excellence Cluster Cardio-Pulmonary System. Justus Liebig
University.
Address: Excellence Cluster Cardio Pulmonary System
University Justus Liebig Giessen, Aulweg 130, 35392 Giessen,
Germany.
Phone: 49 (0) 641 99 46 730; E-mail:
[email protected]
web site: www.belluscilab.com
Research area:
Developmental Biology and stem cells. Lung development and
disease (Idiopathic Pulmonary Fibrosis, Chronic Obstructive Pulmonary Disease, Bronchopulmonary dysplasia)
Expertise:
Phenotypic analysis of mutant embryos with all the techniques attached to this (in situ
hybridization for gene expression, organotypic culture, proliferation and apoptosis, etc..).
Genetically modified mouse (transgenic and knock out). Complex allele breeding (double
condtional ko with reporter and Cre line). Expert on Fibroblast Growth factor signaling.
Key equipment:
BD FACS Area III cell sorter, Confocal microscope SP5 (Leica), Laser capture microscope
(Leica), Inverted microscope for long-term live imaging Leica, Hyperoxia chambers, smoke
chambers. Small animal imaging (FMT), gene arrays (agilent platform), mouse facility
Top 5 publications:
 Bellusci, S., Grindley, J., Emoto, H., Itoh, N. and Hogan, B.L.M. (1997) Fibroblast growth
factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development
124, 4867-4878
 Mailleux, A. A., Kelly, R. G., Veltmaat, J. M., De Langhe, S. P., Zaffran, S., Thiery, J. P. and
Bellusci, S. (2005). Fgf10 expression identifies parabronchial smooth muscle cell progenitors
and is required for their entry into the smooth muscle cell lineage. Development 132: 2157-2166
 Gupte, V.V., Ramasamy, S.K., Reddy, R., Lee, J., Weinreb P. H., Violette S. M., Guenther
A., Warburton, D., Driscoll, B., Minoo, P. and Bellusci, S. (2009) Overexpression of Fibroblast
Growth Factor 10 (FGF10) both during the inflammatory and the fibrotic phases attenuates
bleomycin-induced pulmonary fibrosis in mice. AJRCCM 180(5):424-36.
 Tiozzo, C., Carraro, G., Al Alam, D., Baptista, S., Danopoulos, S., Li, A., Lavarreda-Pearce,
M., Li, C., De Langhe, S., Chan, B., Borok, Z., Bellusci, S.#, and Minoo, P#. (2012)
Mesodermal Deletion of Pten leads to Alveolar Capillary Dysplasia-like phenotype. Journal of
Clinical Investigation, pii: 61334. 10.1172/JCI61334 (#: equal contribution)
 El Agha, E., Herold, S. Al Alam, D., Quantius, J., MacKenzie, B., Carraro, C., Minoo, P.,
Seeger, W., and Bellusci, S. (2014) Fgf10-positive cells represent a multipotent progenitor cell
population during lung development and postnatally. Development 141(2):296-306
Editorial and expert responsibilities:
•
PLoSOne
•
BMC Developmental Biology