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Name
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SU ID
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Of Last Name
BIO 501 Biology of Cancer
Second Exam, March 31, 2015
Exam 2
100 Points
I.
Matching (25 Points)
Filename: 50115Xm2Key.doc
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II. Meaning of Graphics (75 Points)
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Exam Total:
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(100 Pts)
_______________________________________________________________________________________
I. Matching. (25 Pts). The 25 items in column A have a best matching item in Column B. Insert next to the
number in Column A the letter for the item from Column B that best matches the item in Column A. Each item in
Column B can be used only once. If an item is used more than once it will be marked incorrect wherever it
appears. You are looking for the optimal match, not for one that just comes close. If you use an item that only
comes close, you won't have it available when you need it for a best matching response.
Column A
Column B
1
Radioactive Iodine labelled Antibody
A. Dividing blood cell
2
Immortality
B. Controlled by telomere length
3
lymphoblast
C. Inhibition can promote immortalization
4
IV
D. Exhibited by normal epithelial cells in culture
5
DCIS
E. A measure of cancer growth during treatment
6
Apoptosis
F. can help to spread a primary cancer
7
Epithelial-mesenchymal transition
G. Might inhibit invasion
8
aneuploidy
H. Can accept human tumor grafts
9
Host survival time
I. An important outcome of heterogeneity during treatment
10
Senescence in dividing cells
J. Can support cancer growth when mutated
11
Extravasation
K. Adenocarcinoma
12
Multidrug-Resistance
L. about 1 mm diameter tumor
13
Biopsy and palpation
M. A brain cancer
14
Primary glioblastoma
15
Genomic instability and selection
N. Phenotypic characteristic of many cancer cells in
culture
O. Over-production of cells
16
Lower dietary fat and body mass
P. Still localized
17
NK Deficient and SCID mice
Q. Can induce stomach cancer
18
Helicobacter pylori infection
R. Leads to progression in cancers
19
pathfinder cells
S. A route of challenge with experimental metastases
20
Anchorage-dependent growth
T. Abnormal number and form of chromosomes
21
Epidermal growth factor receptor
U. show that invasion can be actively directed
22
V. Decreases risk of breast cancer
23
Sac-like histology of neoplasm of
Epithelial origin
Protease inhibitors
24
One million cancer cells
X. getting out of the circulation
25
Hyperplasia
Y. Used to locate metastases
W. Allows primary cancer to become invasive
II. Meaning of Graphics (75 pts)
A. (15 Pts Total)
Endothelial cell
1. (3 Pts) The picture on the left is illustrating the attachment of a melanocyte to a keratinocyte. What cell
type are these, or what kind of cell attachment is this uillustrating?
2. (3 Pts) The picture on the right is showing melanoma cells attached to an endothelial cells or to a
fibroblast. What kind of cells are endothelial cells and fibroblasts?
3. (3 Pts) What key feature of cancer biology are these two pictures demonstrating?
4. (3 pts) How does this process contribute to cancer pathobiology?
5. (3 pts) What are E-________ and N- ____________ ?
B. (15Pts) From the Folder Inv&Mets:
1. (5 pts) The picture below of a renal adenocarcinoma in cell culture at the left is showing two important
features about cancer invasion.
(2 pts) What is it showing about how cancer invasion proceeds?
(3 pts) What is the cell or cell mass that is moving in panels b, c, and d called other than merely an invasive
cell?
2. (5
Pts)
(3 pts) What important process involving tumor growth and spread is this sequence of pictures showing?
(2pts) There is an important cancer treatment that is directed against this pathological process. What is the
treatment or what is the agent called that is used for the treatment?
3. (5 Pts)
What is this showing? (5 Pts)
C. (15 Pts Total)
1. (5 Pts) What general property of cancers in patients is the graphic below demonstrating? (One word will do
it!)
______________________________________ (your response)
Pleural
effusion,
non-small
cell lung
carcinoma
in a patient.
Figure 11.19 The Biology of Cancer (© Garland Science 2007)
p. 422
Chromosome 11 is Blue-Green. Chromosome
17 is pink by FISH with DNA Probes
2. (5 Pts) Why does this feature of cancer biology help to promote the development of cancers?
3. (5 Pts) Why does this feature of cancer biology present problems in cancer treatment in patients?
D. (15 Points total)
(3 Pts Each)
1. What specific biochemical process is the anti-PARP drug inhibiting?
2. Why do the cells shown in the red line give such a different response to the anti-PARP drug?
3. What does “BRCA” stand for?
4. How could you further enhance the chemotherapeutic effects of the anti-PARP agent in patients?
5. We list ten different pathological effects that a growing cancer can have on a patient.
List three of those: 1) ________________________
2) ________________________
3) ________________________
E. (15 Pts Total) A graphic presented in class appears below. Please identify the cell-types or
processes marked with the boxes 1 to 7. You should need only single words for each box. Mark
your responses in the table below the figures marked 1 to 7.
1
2
3
5
4
6. What is happening here?
7. What is happening here?
.
1. ____________________________________________________________ (2 pts)
2. ____________________________________________________________ (2 pts)
3. ____________________________________________________________ (2 pts)
4. ____________________________________________________________ (2 pts)
5. ____________________________________________________________ (2 pts)
6. ____________________________________________________________ (2 pts)
7. ____________________________________________________________ (3 pts)