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This figure illustrates the postgastrulation morphogenetic events involved in the formation of the tubular heart. A. A quail embryo is shown at HamburgerHamilton (H/H) stage 7/8, demonstrating the emergence of endocardial precursor mesenchymal cells, characterized by the expression of the antigen QH1
and the transcription factor NFATc, from the splanchnic mesoderm. This mesoderm is also the source for the future myocardium, which, for instance,
expresses the transcription factor Nkx-2.5. It is proposed that the formation of both endocardium and myocardium are induced by growth factors, such as
transforming growth factor β (TGFβ) isoforms, bone morphogenetic proteins (BMPs), fibroblast growth factors (FGFs), and vascular endothelial growth
factor (VEGF). B. Subsequent to the migration and assembly of endocardial precursor mesenchymal cells during H/H stages 7 to 8, the cellular plexus
Source: Chapter 9. Molecular Development of the Heart, Hurst's The Heart, 13e
coalesces to form the definitive endocardial tube enveloped by the myocardial tube. Note that the endocardium is still in close proximity to the ventral side
Citation:
Fuster
WalshSugi,
RA, Harrington
RA. Hurst's
The Heart,
13e; 2011
Available
http://mhmedical.com/
Accessed: May 12, 2017
of the foregut.
Courtesy
of Dr.V,Yukiko
Cardiovascular
Developmental
Biology
Center,
Medicalat:University
of South Carolina.
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