Download The ｂenefits from ancient Inca civilization

The ｂenefits from ancient Inca civilization
MACA
1. Introduction
MACA(Latin name：Lepidium meyenii Walp ）is indigenous of Peru, which
belongs to Brassicaceae as same as Broccoli and Radish, is cultivating or
growing at the BonBon land which is high altitude (about 3000-4000m) of
Andes region of Bolivia-Chile in South America.
It is said that the cultivation of MACA was started by the Inca’s native 2000
years ago. The raw or dried hypocotyls of MACA are used for food by
Peruvian people for the purpose of nutrition. There is the record of colony of
200 years ago that MACA was used for the purpose of increasing breeding
capability of livestock.
It is around 1994 that MACA was first introduced to USA market, it is using
for the purpose of maintaining and increasing physical strength. In 1998,
Peruvian President FUJIMORI has introduced MACA as souvenir of Peru to
Japan.
Although MACA was focused at the usage as tonic, but now, it is focusing
again since MACA has various effects (ex: improvement menopausal disorders
etc.) from the latest research.
2. Constituents of MACA
•Amino acid (arginine and lysine etc)
•Vitamins
•Minerals
•Isothiocyanate and glucosinolate
analogues
NOSO3H
H2C C
N
SGlc
HO
CH2 C
OSO3H
SGlc
N
H
glucobrassicin
glucosinalbin
4-hydroxybenzyl glucosinolate
Glucosinalbin
Glucosinalbate
Glucobrassicin
N
CH2 C
OSO3H
N
SGlc
glucotropaeolin
Glucotropaeolin
MeO
CH2 C
OSO3H
SGlc
4-methoxybenzyl
p-methoxybenzyl glucosinolate
glucosinolate
3. The pharmacology effect of MACA
•Anti-fatigue：
SWIMMING TIME [sec]
Mouse that intakes MACA extract significantly prolonged swimming time than control. This
data shows that MACA has anti-fatigue effect. (Journal of Health Science, 5582) 178-182
(2009))
300
***
***
*
control
MACA extract 6mg/kg
*
*
200
MACA extract 30mg/kg
Each value represents mean ± SE.
*:p<0.05, **:p<0.01, ***:p<0.005 vs. control.
ddYmouse（４week,♂,n=10）
100
0
0
1
2
3
4
WEEK
•Anti-weight increasing effect:
36
34
#
body weight (g)
32
#
30
###
###
28
#
26
*
*
###
*
*
*
#
24
#
#
###
*
#
*
*
control
High calorie food
High calorie food +MACA extract 6mg/kg
High calorie food + MACA extract 30mg/kg
22
0
3
6
9
12 15 18
day
21 24 27 30 33
Mouse that intakes MACA extract suppressed weight increasing by high calorie food than
control. This data shows that MACA has anti-weight increasing effect. This key component is
Benzyl glucosinolate.
•Reduction of stress
•Supplement for nutrition
•Anti-inflammation
•Sexual improvement
4. The Safety data
Acute toxic test (LD50): more than 2,000mg/kg
5. The recommended dosage & Usage
The recommended dosage
300-600mg/day (as MACA extract contain 0.4% benzylglucosinolate)
50-100mg/day (as MACA extract contain 2.4% benzylglucosinolate)
MACA extract is used for dietary supplement for
Weight loss
Physical strength maintenance
Recovery from fatigue
6. Contact
■
Head Office/Factory/R&D;
158, KINOKO, SAKURA-SHI, CHIBA, 285-0801, JAPAN
Tel; +81-43-498-0007
Fax; +81-43-498-0561
■
Tokyo Office (Sales);
4-4-16, NIHONBASHI, HONCHO, CHUO-KU, TOKYO, 103-0023, JAPAN
Tel; +81-3-5200-1251
Fax; +81-3-5200-1256
■
URL
http://www.tokiwaph.com/
■ E-mail
[email protected]