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LACTOSE INTOLERANCE Lactose intolerance is defined as the development of gastrointestinal symptoms associated with incomplete digestion of the milk sugar, lactose. Lactose intolerance is caused by a relative deficiency of lactase, an enzyme normally found in the brush border of the mucosal cells of the proximal small intestine that hydrolyzes lactose into its monosaccharide constituents, glucose and galactose. The condition can be congenital or acquired, lifelong or transient. SYMPTOMS OF LACTASE DEFICIENCY Symptoms include bloating, cramps, diarrhea and flatulence, occuring 30 minutes to 4 hours after ingesting lactose-containing foods. The symptoms are caused by the fermentation of unabsorbed lactose by colonic bacteria to produce hydrogen gas and lactic acid. The severity of symptoms is dependent on the degree of enzyme deficiency, the amount of lactose ingested, and the presence of superimposed bowel disease. Acquired Lactose Deficiency Acquired lactose deficiency accounts for most cases of lactose intolerance. The condition is found in most adult populations throughtout the world. (50 million Americans) Population Prevalence of Lactose Deficiency in Adults Thias 97% Filipinos 95% Chinese 90% Japanese 90% Greeks 85% Arabs 80% Ashkenazic Jews 80% Mexicans 75% Black Americans 70% Israeli Jews 60% African Bantus 50% White Americans 5-20% British 5-8% West Europeans (Danes, Swiss) 2-8% In genetically predisposed persons, intestinal lactase begins to decline at about age 4 to 5 years of age. Most susceptible individuals become symptomatic by early adulthood. DIETARY MANAGEMENT OF LACTOSE INTOLERANCE In most cases, symptoms can be controlled easily by avoiding large amounts of lactose-containing foods. Enlisting the aid of a dietitian can be helpful in determining each individual's particular tolerance level. Most adults with acquired lactase deficiency are able to tolerate 3-8 gm of lactose at a given time. The lactose restricted diet limits intake of lactose to 8-10 gms/day. The diet limits the qualities of milk and milk products consumes. Lactose-Containing Food Serving Size Lactose Content Whole milk 1 cup 11 gm Low fat, skim milk 1 cup 9-14gm Yogurt (plain) 1 cup 12 gm Cottage cheese 1 cup 5-6 gm Ice cream 1 cup 9 gm Ice milk 1 cup 10 gm Sherbet 1 cup 4 gm Whipped cream 1 tbls .4gm Sour cream 4 oz 5 gm Cheeses 1 oz .5-1 gm Butter 1 tbls .15 gm Food labels should be read carefully. The following ingredients signal lactose-containing foods: milk, milk products, milk sugar, lactose, whey, curds, caseinate. Lactose is also used as a base in certain prescription and over-the-counter drugs. In very sensitive individuals, a pharmacist should be consulted. Hidden sources of lactose may be found in a variety of foods, including: bread and other baked goods, processed breakfast cereals, instant potatoes, soups, breakfast drinks, margarine, luncheon meats, salad dressings, candies and other snacks, mixes for pancakes, biscuits and cookies. NUTRITIONAL CONSIDERATIONS Lactose restricted diets may be deficient in calcium, vitamin D, and riboflavin, particularly in persons with increased nutritional requirements (children, adolescents, pregnant and lactating women). The RDA for calcium can usually be met by consuming low-lactose foods that are high in calcium, by eating cultured yogurt (contains both lactose and lactase, the latter produced by bacterial cultures), by taking calcium supplements, or by eating specially prepared dairy products to which lactase is added. Examples of foods with high calcium but no lactose include broccoli, kale, turnip greens and other green vegetables, tofu, molasses, shrimp, salmon and oysters. Vitamin D and riboflavin replacement are not necessary in persons who otherwise are exposed to the sun and who are eating otherwise wellbalanced diets. LACTASE ADDITIVES Lactase enzyme can be added to milk to predigest the lactose. The contents from 1 or 2 lactase capsules (e.g., Lactrase) or 5 drops of "Lactaid" liquid can be added to one quart of milk and stored in the refrigerator for 24 hours. This can reduce the lactose content by 70% without lowering its nutrient value. More complete breakdown can be achieved with 2 to 4 Lactrase capsules or 15 drops of Lactaid. Lactase supplements can also be ingested with meals containing lactose. One to two Lactrase capsules, or 1/2 to 3 Lactaid caplets can be taken just befor meals or snacks. In most supermarkets, there are also availabe specially prepared lowlactose foods. Lactaid Milk is 70% lactose reduced. Other pretreated foods include lactose-reduced ice cream, cottage cheese, and American process cheese food. The milk may be slightly sweeter than untreated milk but is palatable and well tolerated. Unpasturized cultured yogurt, is high in lactose content, but also contains sufficient lactase produced by the bacterial cultures. Pasturized yogurt is poorly tolerated because the lactase is inactivated by the pasturization process.