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SEMINAR ON WORLD WIDE DANGER OF ARSENIC POISONING IN WATER AND SUSTAINABLE SOLUTIONS ORGANIZED BY ACADEMY OF HEALTHY WATER, ECOSYSTEM AND ENVIRONMENT DERBY, KANSAS, USA CANCER RISKS FROM ARSENIC IN DRINKING WATER Environmental exposures Cancer risks: Tobacco smoke Radon in homes Arsenic Lifetime risks of dying from cancer due to environmental exposures Tobacco smoke: Low exposure = 4/1000 High exposure = 10/1000 Radon in homes: Average exposure = 3/1000 High exposure = 20/1000 Arsenic in drinking water: U.S. estimated average = 1/1000 U.S. water standard = 21/1000 ARSINIC Organic form Inorganic forms More toxic Drinking water contaminated with Arsenic Skin Lung Liver Kidney Other organs SKIN CANCER First described in 1888 in patients treated with arsenical mixtures for skin conditions Arsenic from water supplies and drugs is known to cause skin cancer Prevalence among highly exposed males aged >60 reached 25% Liver cancer Liver Cancer Angiosarcoma Supported by a series of case reports Winegrowers in Germany Taiwan Lung Cancer Ingestion: Water supplies Comparable to tobacco smoke and radon Inhalation: Smelters Kidney and Bladder Cancer There is a clear relationship between arsenic water levels and bladder and kidney cancer CONCLUSION Results from epidemiological studies, showed persuasive evidence that inorganic arsenic is a cause of human cancer at several sites. There is strong evidence supporting a causal relationship between ingested arsenic and cancer of skin, liver, lung cancer. There is some evidence from Taiwan supporting a causal relationship between ingested arsenic and cancer of kidney and bladder cancer. Is Arsenic Useful? Industry Medicine Leukemia (Arsenic Trioxide, Trisenox) Autoimmune diseases