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Pacemakers and AICDs: Short Circuit of the Electronic Heart The expanding use of technology for acute and chronic electrical therapy of dysrhythmias is complex. Emergency physicians must have an understanding of the various devices that utilize electrical therapy for either rate-related control or cardioversion/defibrillation for malignant dysrhythmias. Using a casebased approach, the presenter will review the identification and management of normal and abnormal function of implantable electronic devices. Discuss the normal and abnormal function of permanent pacemakers. Discuss the normal and abnormal function of the implanted cardioverter-defibrillator. Review potential non-electrical complications that can occur with both pacemakers and ICDs. Describe the process by which pacemakers are interrogated. Discuss newer cardiac pacemakers and MRI compatibility. MO– 13 10/27/2014/ 11:30 AM– 12:20 PM W178ab– McCormick Place (+) No significant financial relationships to disclose (+) Tarlan Hedayati, MD, FACEP Assistant Professor, Associate Program Director, Department of Emergency Medicine, Cook County(Stroger) Hospital Chicago, Illinois 10/21/2014 Pacemakers and ICDs: Short Circuit of the Electronic Heart Tarlan Hedayati, MD Associate Program Director Assistant Professor Cook County Hospital Chicago, Illinois Goals of the lecture Review normal pacemaker / ICD function Recognize pacemaker / ICD complications Manage pacemaker / ICD malfunction 1 10/21/2014 Disclaimer I have no financial interest in any pharmaceutical, device, or other healthcare companies The Numbers >250, 000 new permanent PM implanted annually in the U.S. >750,000 worldwide 5 million patients in the U.S. with permanent PM 2 10/21/2014 The Numbers 16-year trends in the infection burden for pacemakers and implantable cardioverter-defibrillators in the United States 1993 to 2008.Greenspon AJ, JACC 2011 Aug 30;58(10):1001-6. The Numbers 16-year trends in the infection burden for pacemakers and implantable cardioverter-defibrillators in the United States 1993 to 2008.Greenspon AJ, JACC 2011 Aug 30;58(10):1001-6. 3 10/21/2014 Pacemaker Indications Sick sinus syndrome Complete AV block Cardiomyopathy (hypertrophic or dilated) Neurocardiogenic syncope Atrial fibrillation with sinus node dysfunction Manufacturers Guidant/ Boston Scientific 1800 CARDIAC Medtronic 1800 MEDTRONIC St. Jude 1800 PACER QI 4 10/21/2014 5 10/21/2014 6 10/21/2014 Pacemaker Terminology “PaSeR” Position 1 Position 2 Position 3 Position 4 Position 5 Paced Sensed Response Program Function O O O O O A A T P P V V I M S D D D C D R Pacemaker Terminology VVI - most common worldwide Ventricle paced Ventricle sensed Inhibition of pacing activity if normal ventricular activity occurs 7 10/21/2014 Pacemaker Terminology DDD - most common in U.S. Dual chamber paced Dual chamber sensed Dual response = inhibit or trigger pacing Pacemaker Anatomy Kusumoto, F. M. et al. JAMA 2002;287:1848-1852. 8 10/21/2014 9 10/21/2014 Pocket complications Hematoma Infection Wound dehiscence Erosion Pacemaker migration Ann Emerg Med. 2014 Apr;63(4):391, 403 Images in emergency medicine. An unusual swelling at the pacemaker pocket site. Pacemaker pocket infection caused by Stenotrophomonas maltophilia. Aktuerk D1, Lutz M2, Luckraz H1 Pocket complications Shapiro M et al. A Rare, Late Complication after AICD Placement, Indian Pacing Electrophysiol. J. 2004;4(4):213216 Tex Heart Inst J. 2012;39(1):156-7. Total extrusion of a normally functioning pacemaker. Yuksel S1, Demir S, Sahin M. 10 10/21/2014 Infection Rates 16-year trends in the infection burden for pacemakers and implantable cardioverter-defibrillators in the United States 1993 to 2008.Greenspon AJ, JACC 2011 Aug 30;58(10):1001-6. Sohail, M. R. et al. J Am Coll Cardiol 2007;49:1851-1859 11 10/21/2014 Lead Complications Hemothorax Pneumothorax Venous thrombosis Lead infection Dislodged lead Electrode penetration Perforation Exit block 12 10/21/2014 13 10/21/2014 Cardiac Resynchronization Therapy Biventricular pacing Synchronized pacing of Right atrium Right ventricle Lateral wall of left ventricle CRT vs medical therapy 30% decreased hospitalization with CRT 24-36% mortality benefit with CRT 14 10/21/2014 On the horizon The Nanostim leadless pacemaker by SJM (VVI) First US implant in Feb 2014 at Mt. Sinai in NYC On the horizon 15 10/21/2014 “LEADLESS” studies Initial results from EU LEADLESS study Prospective, single-arm study Primary endpoint is complication rate at 90d ○ 94% (31/33) U.S. study Goal to enroll 670 pts 50 US sites Primary endpoint is complication rate at 6m Paced ECG: What the heck am I looking at here? 16 10/21/2014 Electrocardiogram Rate: 60-100 bpm Rhythm: Paced atrium Atrial spikes precede P-wave P-wave has a normal morphology Chan et al. Emergency medicine clinics of North America. 2006: 179-194 Electrocardiogram Rhythm: Paced ventricle Ventricular spike precedes QRS complex QRS complex has a LBBB morphology Chan et al. Emergency medicine clinics of North America. 2006: 179-194 17 10/21/2014 Electrocardiogram Axis: Left ST segment “Appropriate discordance” T wave hyperacute or inverted Pacemaker Malfunction Failure to pace Failure to capture Failure to sense 18 10/21/2014 Failure to pace Definition: the pacemaker fails to deliver a stimulus to the heart EKG: no pacer spikes Failure to pace Oversensing - most common cause Pseudomalfunction Electromagnetic interference Component/battery failure Lead problem 19 10/21/2014 Magnet Magnet Reverts the pacemaker to asynchronous mode = turns the sensing function off DDD Chan et al. Emergency medicine clinics of North America. 2006: 179-194 20 10/21/2014 Failure to pace Pacing with magnet? + Oversensing, EMI No pacer spikes present? Native rhythm present? + Slow Fast or normal Rate? Pseudomalfunction Mechanical pacemaker failure Failure to capture Definition: the pacemaker delivers a stimulus but it fails to result in or “capture” myocardial depolarization EKG: pacer spike without subsequent P-wave or QRS 21 10/21/2014 Failure to capture Lead dislodgement Lead fracture Battery depletion Exit block Acute MI Metabolic disturbance Medications External defibrillation Pacemaker problem Myocardial problem Failure to capture ? ? ? Cardall TY et al. J Emerg Med. 1999 Jul-Aug;17(4):697-709. 22 10/21/2014 Failure to capture Pacer spikes present + - Capture present? - - CXR Labs Medications Interrogate pacemaker Lead problem Elevated pacing threshold Mechanical failure Twiddler’s syndrome Patients disrupt pacemaker leads by manipulating or “twiddling” the generator EKG: Failure to pace or capture Children and thin women Diagnosis: CXR Rx=surgery 23 10/21/2014 Failure to sense Also known as undersensing Definition: pacemaker fails to detect, or sense, native cardiac activity and generates inappropriate pacer spike EKG: pacer spike present despite normal P or QRS complex Failure to sense Lead problem Battery end of life Intracardiac signal occurs in PM refractory period Intracardiac signal changes Metabolic/Electrol yte Defibrillation MAGNET! 24 10/21/2014 Failure to sense - atrium Chan et al. Emergency medicine clinics of North America. 2006: 179-194 Failure to sense - ventricle Chan et al. Emergency medicine clinics of North America. 2006: 179-194 25 10/21/2014 Failure to sense Pacer spikes present + - CXR Capture present? + Is pacing appropriate? - - Labs Medications Interrogate pacemaker Pacemaker syndrome Usually occurs in single-chambered pacemakers Due to loss of AV synchrony, or “atrial kick” decreased CO decreased BP increased atrial pressures 26 10/21/2014 Pacemaker syndrome Fatigue or weakness Headache Jaw pain Neck pulsations Syncope Confusion Hypotension Heart failure Canon a waves Drop in BP > 20 mmHg when going from native rhythm to paced rhythm Pacemaker syndrome ED treatment: Supportive Disposition: Depends on the patient and cardiologist Definitive treatment: Dual-chamber pacemaker 27 10/21/2014 PMT Occurs in dual-chambered pacemakers Reentrant tachycardia Rate cannot exceed PM upper limit Usually precipitated by a PVC or removal of a magnet Chan et al. Emergency medicine clinics of North America. 2006: 179194 PMT ED treatment Vagal maneuvers Precordial thump Adenosine Magnet Definitive treatment: Reprogramming 28 10/21/2014 Runaway Pacemaker True pacemaker malfunction True medical emergency Inappropriately rapid discharges that can lead to VT or VF PMT Rate limited by programmed upper limit Magnet will stop dysrhythmia ED Rx= magnet Runaway PM Rate is higher than programmed upper limit Magnet has little effect Rx = cut the wires 29 10/21/2014 When to use the magnet Symptomatic bradycardia and no pacemaker activity on ECG Asystole no spikes: component or battery failure slow spikes: battery depletion normal spikes: oversensing Pacemaker-mediated tachycardia 30 10/21/2014 Case #1 HPI: 25 year old male with a history of WPW c/o being “shocked” by his ICD while playing soccer PMHx: WPW with episode of sustained VT 1 year ago PSHx: Failed ablation 1 year ago, ICD placement 1 year ago Meds: Amiodarone 31 10/21/2014 Case #2 HPI: 69 yo man with c/o 3 ICD “shocks” in the last 10 minutes. Denies any preceding chest pain, SOB, lightheadedness, palpitations PMHx: CAD s/p MI x 5, HTN, Hyperlipidemia, Paroxysmal atrial fibrillation PSHx: CABG x 4v-1988, PCI-2001, ICD2001 Meds: ASA, clopidogrel, BB, ACE-I, statin What is an ICD? 32 10/21/2014 ICD Indications Primary prevention Structural heart disease at high risk for VT/VF History of MI and LV dysfunction DCM and LV dysfunction Secondary prevention Sudden cardiac death due to VT/VF Syncope with inducible VT Structural heart disease and sustained VT ICD Function Sense and detect “Sudden onset” “Rate stability” Terminate VT or VF Anti-tachycardic pacing Cardiovert/Defibrillate Pace bradycardia 33 10/21/2014 History Why does the patient have an ICD? How many shocks were delivered? What was the patient doing? Any preceding symptoms? Medications? Initial Orders IV access Pulse oximetry Cardiac monitor Apply external defibrillator pads Magnet to the bedside 34 10/21/2014 Magnet Stops VT/VF sensing and detection Stops VT/VF therapy No ATP NO CARDIOVERSION NO DEFIBRILLATION Pacing for bradycardia remains intact! Magnet Use the magnet if the patient: Receives inappropriate shock in ED Needs external defib/cardioversion in ED ICD will emit a continuous tone when the magnet is used in Medtronic and Boston Scientific ICDs Be prepared to externally defibrillate or cardiovert the patient! 35 10/21/2014 More Initial Orders Electrocardiogram Chest radiograph Basic laboratory studies BMP, Calcium, Magnesium, Phosphate, Cardiac enzymes, Drug levels Determine ICD manufacturer Inappropriate •VT/VF Appropriate •SVT •Oversensing •ICD malfunction •EMI Phantom Defibrillate 36 10/21/2014 Interrogation Interrogation - WiFi! 37 10/21/2014 Cardiac monitor Ongoing arrhythmia? YES NO NO Multiple shocks •ACLS •Consider magnet ICD Interrogation Inappropriate Single shock Discuss with patient’s cardiologist Appropriate Discharge home •SVT: Treat, Admit •Oversensing: Admit •ICD lead malfunction: Admit •Admit •Rule out reversible causes •Consider drug therapy Case #1 HPI: 25 year old male with a history of WPW c/o being “shocked” by his ICD while playing soccer Meds: Amiodarone Disposition: Case discussed with his cardiologist Patient discharged home! 38 10/21/2014 Case #2 HPI: 69 yo man with c/o 3 ICD “shocks” in the last 10 minutes. Denies any preceding chest pain, SOB, lightheadedness, palpitations PMHx: CAD s/p MI x 5, HTN, Hyperlipidemia, Paroxysmal atrial fibrillation Case #2 Labs drawn and sent Patient placed on a cardiac monitor ICD delivers a “shock” to the patient VBG returns K=2.1 ICD interrogated 39 10/21/2014 Interrogation Practical tips Wear gloves! Don’t put external pads over the PM/ICD! Need a central line? Femoral! PM/ICDs don’t need antibiotic prophylaxis. Some PM/ICD models delete data after download—SAVE PRINT-OUTS! 40 10/21/2014 Practical tips Use non-depolarizing paralytic agents! Obese patients may need 2 magnets! Just because you removed the magnet doesn’t mean the ICD works! Turn off the cardiac monitor after you “pronounce” the patient! Think about turning off the ICD after you “pronounce” the patient! Thank you! 41