Download Oral health and risk for head and neck squamous cell

BILAN DENTAIRE
1- Dent Clin North Am. 2008 Jan;52(1):19-37, vii
Dental treatment planning and management in the patient who has cancer.
Brennan MT, Woo SB, Lockhart PB.
Source
Department of Oral Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.
[email protected]
Abstract
The oral cavity has the potential to be a major source of short-term and long-term complications from
cancer therapy. Appropriate evaluation and elimination of potential sources of oral infection before
cancer therapy is vital because oral bacteria are a known source of bacteremia and septicemia during
cancer therapy. Cancer diagnosis with previous and planned treatment, past medical history, past
dental history, current medications, drug allergies, social history, family history, laboratory values,
extraoral findings, intraoral findings, and radiographic findings must all be evaluated in planning
dental treatment for these complex cases.
2- Cancer Causes Control. 2010 Apr;21(4):567-75. Epub 2010 Jan 5.
Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck
Cancer Study.
Divaris K, Olshan AF, Smith J, Bell ME, Weissler MC, Funkhouser WK, Bradshaw PT.
Source
Department of Epidemiology, CB#7435, Gillings School of Global Public Health, University of North
Carolina, Chapel Hill, NC 27599-7435, USA.
Abstract
OBJECTIVE:
Recent reports have linked oral health and periodontal disease indicators with increased risk of
squamous cell carcinoma of head and neck (SCCHN). Thus far, evidence has been inconclusive; our
objective was to study the association between oral health and SCCHN risk in the context of a large
population-based study.
METHODS:
A population-based case-control study of incident SCCHN, the Carolina Head and Neck Cancer Study
was carried out in 2002-2006 in 46 counties in North Carolina. Controls (n = 1,361) were frequency
matched with cases (n = 1,289) on age, race, and gender. Oral health was assessed using interview
data on tooth loss and mobility, mouthwash use, and frequency of dental visits.
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BILAN DENTAIRE
RESULTS:
Subjects were 26-80 years old (median age = 61). The distribution of tooth loss among controls was 05 teeth = 60%; 5-14 = 15%; and 16-28 = 25%. After controlling for covariates, tooth loss did not yield
any notable association with SCCHN (16-28 vs. 0-5 lost teeth: OR: 1.21, 95% CI: 0.94, 1.56). Selfreported history of tooth mobility was moderately associated with increased SCCHN risk (OR: 1.33,
95% CI: 1.07, 1.65); however, the association did not persist among never smokers. Routine dental
visits were associated with 30% risk reduction (OR: 0.68, 95% CI: 0.53, 0.87).
CONCLUSIONS:
These data provide support for a possible modest association of periodontal disease, as measured by
self-reported tooth loss indicators, but not tooth loss per se, with SCCHN risk.
3- Am J Epidemiol. 2007 Nov 15;166(10):1159-73. Epub 2007 Aug 30. +
Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of
two multicentric case-control studies.
Guha N, Boffetta P, Wünsch Filho V, Eluf Neto J, Shangina O, Zaridze D, Curado MP, Koifman S, Matos
E, Menezes A, Szeszenia-Dabrowska N, Fernandez L, Mates D, Daudt AW, Lissowska J, Dikshit R,
Brennan P.
Source
International Agency for Research on Cancer, Lyon, France.
Abstract
Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on oral
health were ascertained as part of two multicenter case-control studies comprising 924 cases and 928
controls in central Europe and 2,286 cases and 1,824 controls in Latin America. Incident cases of
squamous cell carcinoma of the head and neck (oral cavity, pharynx, larynx) and esophagus, as well as
age (in quinquennia)- and sex frequency-matched controls, were enrolled from 1998 to 2003. Poor
condition of the mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74,
4.81; Latin America: OR = 1.89, 95% CI: 1.47, 2.42), lack of toothbrush use (Latin America: OR =
2.36, 95% CI: 1.28, 4.36), and daily mouthwash use (Latin America: OR = 3.40, 95% CI: 1.96, 5.89)
emerged as risk factors for head and neck cancer, independent of tobacco use and alcohol
consumption. Missing between six and 15 teeth was an independent risk factor for esophageal cancer
(central Europe: OR = 2.84, 95% CI: 1.26, 6.41; Latin America: OR = 2.18, 95% CI: 1.04, 4.59).
These results indicate that periodontal disease (as indicated by poor condition of the mouth and
missing teeth) and daily mouthwash use may be independent causes of cancers of the head, neck, and
esophagus.
Comment in
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Evid Based Dent. 2009;10(1):6-7.
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