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Focused Ultrasound - Lisa Howe What is Focused Ultrasound? • Early-stage • Non-invasive • Therapeutic technology https://www.youtube.com/watch?v=Y73tVVmOjGg What does that mean? • Depending on the design of the lens and the ultrasound parameters, the target can be as small as 1x1.5mm or as large as 10x16mm in diameter. Effects at focal point • Thermal ablation • Focal drug delivery • Blood-brain barrier opening • Immunomodulation • Neuromodulation • Radiation sensitization • Stem cell delivery Brain Tumors • NO CHEMOTHERAPY! • NO NORMAL TISSUE DAMAGE!! State of the Technology State of the Technology What this means for the future…. • Focused ultrasound could become an alternative to or complement • Focused ultrasound could result in fewer complications such as: • Focused ultrasound could shorten recovery time Risks and Drawbacks • Side effects • http://www.sciencedirect.com/science/article/pii/S1474442213700486 • http://www.fusfoundation.org/ Focused Ultrasound By Lisa Howe • Early-stage • Non-invasive • Therapeutic technology • Focused ultrasound could shorten recovery time • Safer, more effective treatment • Reduce death, disability, and suffering Focused ultrasound could become an alternative to or complement: • Traditional surgery • Radiation therapy • Drug delivery Focused ultrasound could result in fewer complications such as: • Damage to normal tissue • Infection • Hemorrhage • Pain Effects of Focal Point: • Thermal ablation • Focal drug delivery • Blood-brain barrier opening • Immunomodulation • Neuromodulation • Radiation sensitization • Stem cell delivery Risks and Drawbacks • postoperative paraesthesias • deep vein thrombosis • burns to the skin