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FASEB Hematologic Malignancies Conference July 23-28, 2017 Saxtons River, Vermont Organizers: Iannis Aifantis, Ph.D. New York University New York, NY Kimberly Stegmaier, M.D. Dana-Farber Cancer institute and Boston Children’s Hospital Boston, MA Sunday, July, 23, 2017 4:00 p.m. – 9:00 p.m. 6:00 p.m. – 7:00 p.m. 7:00 p.m. – 8:00 p.m. 8:00 p.m. – 9:30 p.m. Conference Registration Welcome Reception DINNER Opening Keynote Speaker Targeted Therapies and Leukemia James Bradner Monday, July, 24, 2017 7:30 a.m. – 1:00 p.m., 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. 7:30 a.m. – 12:00 p.m. 9:00 a.m. – 12:00 p.m. 27 January 2017 Conference Registration BREAKFAST Conference Registration Regulation of Transcription and Signaling in Hematological Malignancies: Part I Adolfo Ferrando (Chair) Application of Functional and Cancer Genomics to Dissect Mechanisms of Leukemogenesis Scott Lowe Aberrant Transcription in AML Ruud Delwel New Discoveries in Childhood B-ALL Shai Izraeli Transcriptional Dysregulation in TALL Adolfo Ferrando 10:00 a.m. – 10:15 a.m. 12:00 p.m. – 1:00 p.m. (at the end, the session will include short presentations selected from abstracts, aka “poster teasers”) FASEB Sponsored Coffee Break LUNCH 1:00 p.m. – 2:30 p.m. Career Development Workshop 2:30 p.m. – 4:00 p.m. 4:00 p.m. – 6:00 p.m. Finding a Job/ Starting an Academic Ross Levine Lab Free time Poster Session 6:00 p.m. – 7:00 p.m. 6:00 p.m. – 7:00 p.m. 7:00 p.m. – 9:00 p.m. Conference Registration DINNER Regulation of Transcription and Signaling in Hematological Malignancies: Part II Michelle Kelliher (Chair) Targeting Dysfunctional Gene Expression Control in Leukemia Christopher Vakoc Mechanisms of T-ALL Leukemogenesis Michelle Kelliher Mechanisms of T-ALL Leukemogenesis Thomas Look Aberrant Splicing in Hematopoietic Malignancies Omar Abdel-Wahab Tuesday, July, 25, 2017 7:30 a.m. – 1:00 p.m., 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. 7:30 a.m. – 12:00 p.m. Conference Registration BREAKFAST Conference Registration Targets, Drugs and Mechanisms of Resistance: Part I Mechanisms of Resistance to Signaling Inhibitors in Leukemia Kevin Shannon Targeting Transcription Factorfusion Driven Leukemia Jolanta Grembecka In Vivo Functional Genomic 27 January 2017 Tanja Gruber (Chair) Screening to Drug Identify Resistance Mechanisms New Targets in High-risk Pediatric Leukemias 10:00 a.m. – 10:30 a.m. 12:00 p.m. – 1:00 p.m. 1:00 p.m. – 2:30 p.m. 1:00 p.m. – 4:00 p.m. 4:00 p.m. – 6:00 p.m. 6:00 p.m. – 7:00 p.m. 6:00 p.m. – 7:00 p.m. 7:00 p.m. – 9:00 p.m. New Approaches to Measure Drug Response FASEB Sponsored Coffee Break and *Group Photo LUNCH Michael Hemann Tanja Gruber David Weinstock Meet the Experts Session Work-life Balance Free time Poster Session Conference Registration DINNER Targets, Drugs and Mechanisms of Resistance: Part II Jonathan Licht, Kimberly Stegmaier & Jane Skok Functional Genomic Screening Approaches to Identify New Targets in Leukemia Johannes Zuber Targeted Approaches to Childhood Leukemia Mignon Loh Drugging the "Undruggable" John Bushweller Dissecting the Underpinnings of MDS: Molecular Origins and Therapeutic Response Benjamin Ebert Mignon Loh (Chair) Wednesday, July 26, 2017 7:30 a.m. – 1:00 p.m., 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. 7:30 a.m. – 12:00 p.m. 9:00 a.m. – 12:00 p.m. Conference Registration BREAKFAST Conference Registration Leukemia/Lymphoma Genomics and Genetics The Genomics of Childhood ALL Charles Mullighan Epigenetic Control of Blood Malignancies Scott Armstrong The Molecular Origins of Lymphoma 27 January 2017 Charles Mullighan (Chair) Ricardo Dalla-Favera New Insights Into the Pathogenesis of AML 10:00 a.m. – 10:15 a.m. 12:00 p.m. – 12:30 p.m. 12:30 p.m. – 2:00 p.m. Ross Levine (2 short talks will be added from posters) FASEB Sponsored Coffee Break Business Meeting LUNCH Career Development Session 1:00 p.m. – 2:30 p.m. 1:00 p.m. – 4:00 p.m. 4:00 p.m. – 6:00 p.m. 6:00 p.m. – 7:00 p.m. 6:00 p.m. – 7:00 p.m. 7:00 p.m. – 9:00 p.m. RO1 and Foundation Funding for New Investigators Free time Poster Session Conference Registration DINNER Stem Cells and the Initiation of Blood Malignancies Representative from the Evans Foundation and Iannis Aifantis with Adolfo Ferrando Monica Guzman (Chair) Detection of Initiating Mutations in Pre-leukemic Stem Cells Ravi Majeti Cancer Clonal Evolution and Response to Targeted Therapies Olivier Elemento Novel Drug Options in Targeting Leukemia Stem Cells Monica Guzman Multiple Myeloma Epigenetics Johnathan Licht Thursday, July 27, 2017 7:30 a.m. – 1:00 p.m., 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. 7:30 a.m. – 12:00 p.m. 9:00 a.m. – 12:00 p.m. 27 January 2017 Conference Registration BREAKFAST Conference Registration Tumor Microenvironment Emmanuelle Passegue (Chair) The Effects of Microenvironment in Myeloid Neoplasms Emmanuelle Passegue Targeting the Multiple Myeloma Microenvironment Irene Ghobrial Stem Cell Niches in the Bone Marrow Paul Frenette Dynamic Imaging of Bone Marrow Niches in Acute Leukemia Cristina Lo Celso 10:00 a.m. – 10:15 a.m. 11:30 a.m. – 12:00 p.m. 12:00 p.m. – 1:00 p.m. FASEB Sponsored Coffee Break Business Meeting LUNCH 1:00 p.m. – 2:30 p.m. Meet the Experts Session Finding a Job in Industry Poster Session 4:00 p.m. – 6:00 p.m. 6:00 p.m. – 7:00 p.m. 7:00 p.m. – 9:00 p.m. DINNER Tumor Immunotherapy and Gene Editing Approaches in Blood Malignancies Silvia Buonamici Andrei Thomas-Tikhonenko (Chair) CAR T Cells and their Therapy Promise for Blood Cancers Michel Sadelain Mechanisms of Acquired Resistance to Targeted Immunotherapy Andrei Thomas-Tikhonenko Recent Updates of Chimeric Antigen Receptor Clinical Trials Marcela Maus Designing Targeted CRISPRi Screens Cathy Wu Friday, July 28, 2017 7:30 a.m. – 12:00 p.m. 7:30 a.m. – 9:00 a.m. 7:30 a.m. – 12:00 p.m. 9:00 a.m. – 11:30 a.m. Conference Registration BREAKFAST Conference Registration Epigenetics of Hematologic Malignancies Kathrin Bernt (Chair) DNMT3a, DNA Methylation and the Peggy Goodell Control of the Leukemia Epigenome 3D Chromosomal Structure and Transformation of Blood Cell Stem Cells Jane Skok Understanding DOT1L Function in AML Kathrin Bernt Silvia Buonamici 10:00 a.m. – 10:15 a.m. Regulation of Splicing in Myeloid Leukemia FASEB Sponsored Coffee Break 11:30 a.m. – 12:30 p.m. Closing Keynote Speaker 27 January 2017 12:30 p.m. Lymphoma Epigenetic Therapies LUNCH to Go and DEPARTURES Ari Melnick END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD 20814 www.faseb.org/src 27 January 2017