Download Pharmacology Exams for Grade 2003 Pakistan students

Pharmacology Exam for Grade 2003(A) Pakistan Students
(Exam 1) — Nov 10th,2005
Part Ⅰ Choice Questions （60 points）
Type A (only one answer is correct)
1. Which of the following statements is correct?
A. weak bases are absorbed efficiently across the epithelial cells of the
stomach
B. coadministration of atropine speeds the absorption of a second drug
C. drugs showing large Vd can be efficiently removed by dialysis of the
plasma.
D. stressful emotions can lead to a slowing of drug absorption.
E. if the Vd for a drug is small, most of the drug is in the extraplasmic space.
2. The drugs that can pass across the blood brain barrier are
A. small in molecular weight and ionized drugs
B. small in molecular weight and nonionized drugs
C. large in molecular weight and ionized drugs
D. large in molecular weight and nonionized drugs
E. all of above are not true
3. Which of the following statements is correct?
A. if 10mg of drug A produces the same response as 100mg of drug B, drug A
is more efficacious than drug B.
B. the greater the efficacy, the greater the potency of a drug
C. in selecting a drug, potency is usually more important than efficacy
D. a competitive antagonist increases ED50
E. variation in response to a drug among different individuals is most
likely to occur with a drug showing a large therapeutic index
4. Which of the following is true for a drug whose elimination from plasma shows
first-order kinetics?
A. the half-life of the drug is proportional to the drug concentration in
plasma
B. the amount eliminated per unit time is constant
C. the rate of elimination is proportional to the plasma concentration
D. elimination involves a rate-limiting enzyme reaction operating at its
maximal velocity
E. a plot of drug concentration versus time is a straight line
5. Which of the following drugs has the largest therapeutic index ?
A. Drug A LD50=150mg, ED50=100mg
B. Drug B LD50=100mg, ED50=50mg
C. Drug C LD50=250mg, ED50=100mg
D. Drug D LD50=300mg, ED50=50mg
E. Drug E LD50=300mg, ED50=150mg
6. A drug eliminated with first-order kinetics, the concentration of the drug in
plasma is 100mg/L at 9 am after administration of a single dose, and at 6 pm
the drug plasma concentration is 12.5 mg/L. So, its t1/2 is
A. 4h
B. 5h
C. 6h
D. 3h
E. 12h
7. The maximal effect of a drug is called
A. potency
B. efficacy
C. affinity
D. toxic effect
E. margin of safety
8. Among the following drugs, which will be excreted most quickly in acidic
urine？
A. a weak acid drug with pKa of 5.5
B. a weak base drug with pKa of 7.5
C .a weak base drug with pKa of 4.5
D. a weak acid drug with pKa of 3.5
E. a weak base drug with pKa of 6.5
9. The mechanism of treating phenobarbital poisoning with bicarbonate sodium
is that it
A. neutralizes Phenobarbital
B. stimulates Phenobarbital transference from the brain to the plasma
C. alkalinizes urine fluid, prevents Phenobarbital from reuptaking, and
stimulates excretion of drug
D. both B and C are right
E. both A and C are right
10. The half-life is
A. the time that the concentration of the drug in plasma declines by 50%
B. the time that the amount of the drug in the body declines by 50%
C. the time that half amount of the drug in the body are metabolized
D. the time that the effects of the drug decline in a half
E. all of above are wrong
11. After repeated administration of phenobarbital sodium, the patients complain
the drug is less useful, this phenomenon is called
A. tolerance
B. resistance
C. dependence
D. side reaction
E. residual effect
12. The study of the time course of absorption, distribution, metabolism and
excretion of drugs in the body is called
A. pharmacology
B. pharmacokinetics
C. pharmacodynamics
D. pharmacy
E. pharmaceutics
13. The bioavailability is
A. the quantity of drug absorbed after oral administration
B. the rate of drug absorbed after oral administration
C. the ratio of AUC(oral)/AUC(intravenous)
C. the ratio of AUC (intravenous)/AUC(oral)
D. the area under curve of oral administration
E. the area under curve of intravenous administration
14. The pharmacological mechanism of side effect is
A. overdose
B. low in selectivity
C. hypersensitivity
D. administration of drug for a long time
15. Property of a partial agonist is
A. high affinity and high intrinsic activity
B. low affinity and low intrinsic activity
C. high affinity and low intrinsic activity
D. low affinity and high intrinsic activity
E. high affinity and no intrinsic activity
16. The effect of pilocarpine on eye is
A. miosis, increase intraocular pressure, accommodation of paralysis
B. miosis, decrease intraocular pressure, accommodation of spasm
C. mydiasis , decrease intraocular pressure, accommodation of paralysis
D. mydiasis , increase intraocular pressure, accommodation of spasm
E. mydiasis , increase intraocular pressure, accommodation of paralysis
17. Patients with myasthenia gravis are more effectively treated with
A. epinephrine
B. propranolol
C. neostigmine
D. atropine
E. pilocarpine
18. β-antagonists can NOT be used in the treatment of
A．hypertension
B．bronchial asthma
C．tachycardia
D．angina pectoris
E．hyperthyroidism
19. The released norepinephrine is disposed mainly by
A．the metabolism in the liver
B．enzymatic inactivation
C．reuptake by the neuronal terminal
D．hydrolysis
E. MAO and COMT in the circulation
20. Which of the following drugs can be used in treatment of glaucoma?
A. neostigmine
B. pilocarpine
C. phentolamine
D. norepinephrine
E. atropine
21. Which of the following therapeutic projects would be used in the treatment of
patient with serious organophosphate intoxication?
A．atropine + norepinephrine
B．atopine+ neostigmine
C．atropine + pralidoxime iodide
D．atropine + epinephrine
E．atropine + morphine
22. The main route of inactivation of Ach is that
A．it is destroyed by MAO
B．it is destroyed by COMT
C．it is retaken into the cytoplasm
D．it is hydrolyzed by cholinesterase
E．it is retaken into the vesicle
23. The elevated blood pressure caused by epinephrine may be reversed by
A．propranolol
B．phentolamine
C．norepinephrine
D．nicotine
E．atropine
24. Scopolamine is contraindicated in patients with
A．glaucoma
B．gastrospasm
C．organophosphate poisoning
D．infectious shock
E．parkinsonism
25. Which of the following does NOT belong to muscarinic actions caused by
M-receptor activation?
A. Heart depression
B. Vessel dilation
C. Smooth muscle contraction
D. Glands secretion increased
E. Mydriasis
26. Which of the following can inhibit the acetylcholinesterase
A. Pilocarpine
B. Organophosphate
C. Epinephrine
D. Timolol
E. Atropine
27. Which of the following is NOT correct in the treatment of acute
organophosphate poison
A. supporting respiration
B. gastriclavage
C. blocking the muscarinic effect by atropine
D. blocking the nicotinic effect by succinylcholine
E. reactivating the inhibited cholinesterase by PAM
28. The intoxication of tubocurarine can be antagonized by
A. atropine
B. adrenaline
C. neostigmine
D. dopamine
E. ephedrine
29. Which of the following is the drug of choice in the treatment of cardiac
arrest?
A. Atropine
B. Epinephrine
C. Norepinephrine
D. Isoprenaline
E. Lidocaine
30. The dilation of bronchial smooth muscle can be caused by
A. α1 -receptor activation
B. α2 -receptor activation
C. β1 -receptor activation
D. β2 -receptor activation
E. M-receptor activation
PART Ⅱ Please explain the following pharmacological terms（20 points）
1. Agonist
2. First-pass elimination
3. Side reaction
4. First-order Elimination Kinetics
5. Therapeutic index (TI)
PART Ⅲ Assay Questions （20 points）
1. Please describe the pharmacological action of atropine.
2. Why is epinephrine used as the drug of choice in the treatment of allergic
shock?
ANSWERS:
1.D 2.B 3.A 4.C 5.D 6.D 7.B 8.B 9.D 10.A 11.A 12. B 13. C
14.B 15.C 16.B 17.C 18.B 19.C 20.B 21.C 22.D 23.B 24.A 25. E
26.B 27.D 28.C 29.B 30.D