Download MOLECULAR MECHANISMS OF ER+, PR+, Her

CANCER TREATMENT OPTIONS AND MANAGEMENT INC.
PERSONALIZED DIET PLAN
FOR PRE-MENOPAUSAL
ER (+), PR (+), Her (-) INVASIVE BREAST DUCTAL CARCINOMA
SEPTEMBER 21, 2011
PERSONALIZED NUTRACEUTICAL DIET PLAN - September 21, 2011
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PERSONALIZED NUTRACEUTICAL DIET PLAN - September 21, 2011
TABLE OF CONTENTS
SECTION
PAGE
INTRODUCTION
4
I: MOLECULAR MECHANISMS OF ER+, PR+, Her- BREAST CANCER
6
II: INDICATED NUTRACEUTICALS AND DOSING DETAILS
18
APPENDIX A: REFERENCES
29
APPENDIX B: CANCER PATHWAYS MAP
33
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PERSONALIZED NUTRACEUTICAL DIET PLAN - September 21, 2011
INTRODUCTION
The Purpose of This Booklet:
This booklet was designed to ensure that you are doing all you can on a daily basis to enhance
your life-expectancy in the least invasive, most efficient way possible. It is not essential that you
incorporate every aspect of this booklet, but with each small addition of this knowledge to your
therapy, you statistically increase your chances for long-term remission.
Current cancer research focuses on regulating the genes that are altered in cancer, and assumed
to be driving progression of the disease. The benefits of targeted therapies, such as BRAF
inhibitors for melanoma, have been showing amazing results with each new clinical trial
resulting in a small population of long term remissions (Flaherty et al., 2010). While the
databases are full of both unique and shared genetic alterations that have been identified and
used as a targets for drug development, identifying these unique genetic signatures in every
patient, referred to as personalized medicine, is not yet cost effective and remains a benefit only
to patients that participate in clinical trials.
However, the benefit of targeted drug research and development has an immediate benefit to
cancer patients above and beyond drug development. In order to identify and develop a drug that
targets a specific cancer-causing genetic alteration, extensive and costly research is required to
establish the mechanisms of both the genetic alteration, as well as the drug. The benefit of this
extensive research is that it results in the identification of many substances that regulate the
mechanism, including naturally occurring nutraceuticals. In other words, once the genetic
alterations that cause a specific cancer have been identified, customized diets can be designed to
control them. We refer to these as ‘gene-based nutraceutical diets.’
In This Booklet, We Will:

Identify the genes and mechanisms that cause this cancer;

Identify nutraceuticals that have been shown to have a direct and positive influence
on this mechanism;

Identify other nutraceuticals that improve the performance of the gene regulating
nutraceuticals;

Show you how to create synergistic combinations of nutraceuticals that can both
increase the activity of the nutraceuticals, as well as improve their uptake by the
body and the cancer cells specifically.
Cancer Treatment Options and Management Inc. 778-999-5463 www.ctoam.com
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PERSONALIZED NUTRACEUTICAL DIET PLAN - September 21, 2011
The attached research literature review will cover the latest molecular knowledge on the issues
pertaining to patients with this molecular subtype of breast cancer. This review is structured into
two different sections:
1. In section I, we will cover some of the key molecular processes involved in the
progression of ER+, PR+, and Her - invasive breast ductal carcinoma. We will then
introduce the genes specific to each process.
2. In section III, we will identify nutraceuticals that have the greatest effect on the
molecular processes unique to this case and discuss how they work. And finally, we will
make some dietary recommendations and discuss how to include them in your daily diet
for maximum prevention of cancer recurrence.
Cancer Treatment Options and Management Inc. 778-999-5463 www.ctoam.com
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