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WRITE WITH BLACK BALL POINT INK ONLY USING FIRM PRESSURE. DOCTOR WRITING ORDER IS TO RECORD DATE AND TIME WITH EACH SET OF ORDERS WRITTEN. AUTHENTICATE WITH FULL SIGNATURE AND BEEPER NUMBER. MR FORM 1C 8/96 PHYSICIAN ORDERS DIAGNOSIS: DRUG SENSITIVITY: Patient Identification Patient’s Weight____________ kg DIAGNOSIS: _______________________________________________________________________ Hematology/Oncology Hospital Orders Adult High-Dose Aldesleukin (Proleukin, Interleukin-2, IL-2) Orders RESPONSIBLE SERVICE/PHYSICIANS: Please notify oncology fellow (pager # 762-2166) of room number. CONDITION: G stable G guarded G severe G critical VITALS: Baseline and Q 4 hours; Pulse oximetry baseline and Q 4 hours Notify physician systolic B/P less than 90 ACTIVITY: As tolerated NUTRITION: _______________________________________________________________________ NURSING ORDERS: Strict I & O; Daily weights Ensure that CBC, Comprehensive Metabolic Profile, Phos, Mg, and Urinalysis have been done and results are acceptable values prior to initiating therapy. Ensure that, prior to 1st course of therapy, Thallium Stress Test, EKG and PFT’s are done and results are acceptable values prior to initiating therapy. Heart Monitor Patient to be placed on monitor while receiving aldesluekin (IL-2) therapy. DIAGNOSTIC ORDERS: Daily Labs: CBC with diff, Comprehensive Metabolic Profile, Phos, Mg MISCELLENOUS ORDERS: O2 at 2 L via NC prn dyspnea ___________ Initials Rev. 2/16 JH 2/10/16 Page 1 of 3 Distribution: White - Chart Copy WRITE WITH BLACK BALL POINT INK ONLY USING FIRM PRESSURE. DOCTOR WRITING ORDER IS TO RECORD DATE AND TIME WITH EACH SET OF ORDERS WRITTEN. AUTHENTICATE WITH FULL SIGNATURE AND BEEPER NUMBER. MR FORM 1C 8/96 PHYSICIAN ORDERS DIAGNOSIS: DRUG SENSITIVITY: Patient Identification Hematology/Oncology Hospital Orders Adult High-Dose Aldesleukin (Proleukin, Interleukin-2, IL-2) Orders New medication for this admission: IVF: NS 1L with 20 mEq KCl at 50 mL/hr OR ________________________________________________________ mL/hr (type of fluid) 1. Diphenhydramine 25 mg PO every 4 hours prn pruritis 2. Meperidine 25 mg IV every hour for rigors 3. Lorazepam 1 mg PO every 8 hours prn anxiety 4. Lorazepam 1 mg PO QHS prn insomnia 5. Prochloroperazine 10 mg PO every 4 hours prn nausea 6. Promethazine 25 mg IV every 6 hours prn vomiting 7. Loperamide 4 mg PO after initial loose stool followed by 2 mg after each loose stool (max 16 mg/day) 8. Pantoprazole 40 mg PO every AM 9. Moisturizing lotion prn to affected skin Aldesleukin (IL-2) Scheduled Pre-medications: 1. Acetaminophen 650 mg PO 30 minutes prior to first IL-2 dose, followed by every 4 hours scheduled until 12 hours after final dose of IL-2. If unable to take PO, may give acetaminophen 650 mg PR every 4 hours until 12 hours after last IL-2 dose. 2. Ibuprofen 200 mg PO every 4 hours prn fever not relieved by acetaminophen; hold if serum creatinine doubles from baseline or if serum creatinine 1.5 mg/dL or greater 3. Granisetron 1 mg IVP every 24 hours starting before the first IL-2 dose; DC on the day of final IL-2 dose Aldesleukin (IL-2): 600,000 units/kg/dose = _______________ units/dose in 50 mL D5W. Give IV over 15 minutes every 8 hours (administer at 0800, 1600, and 2400 hours). Give no more than 14 doses. Piggyback in to D5W flush bag only; flush before and after each dose before resuming IVF – incompatible with NS Patient should NOT receive steroids (systemic or topical) during IL-2 therapy Hold scheduled dose of IL-2 if 1-3 relative criteria have been met and notify physician. Once corrective measures have been taken and physician has determined therapy can continue, administer the next dose of IL-2 at the next scheduled time (0800, 1600, or 2400 hours). Permanently discontinue IL-2 if 4 or more relative criteria or if any absolute criteria have been met and notify physician. Permanently discontinue IL-2 if patient does not receive two consecutive IL-doses due to toxicities. Notify physician. _________________________________ __________________ ______________________________________________ _________________________ Staff Physician Name (Print) Pager Staff Physician Signature Date/Time G Pregnancy test negative or N/A _________________________________ __________________ ______________________________________________ _________________________ Fellow (Print) Pager Fellow signature Date/Time _________________________________ __________________ ______________________________________________ _________________________ Oncology RN/CNS or PharmD (Print) Pager Oncology RN/CNS or PharmD signature Rev. 2/16 JH 2/10/16 Page 2 of 3 Distribution: White - Chart Copy Date/Time WRITE WITH BLACK BALL POINT INK ONLY USING FIRM PRESSURE. DOCTOR WRITING ORDER IS TO RECORD DATE AND TIME WITH EACH SET OF ORDERS WRITTEN. AUTHENTICATE WITH FULL SIGNATURE AND BEEPER NUMBER. MR FORM 1C 8/96 PHYSICIAN ORDERS DIAGNOSIS: DRUG SENSITIVITY: Patient Identification Hematology/Oncology Hospital Orders Adult High-Dose Aldesleukin (Proleukin, Interleukin-2, IL-2) Orders System Cardiac Relative Criteria Absolute Criteria Sinus tachycardia 120-130 bpm SBP less than 90 mmHg Sinus tachycardia greater than 130 bpm EKG changes consistent with ischemia Atrial fibrillation Supraventricular tachycardia Ventricular arrhythmias Elevated CPK-MB Dermatologic Moist desquamation Gastrointestinal Diarrhea 1 L or more in 8 hours Ileus Abdominal distention Diarrhea 1 L or more in 8 hours x 2 Vomiting unresponsive to medication Severe abdominal distension affecting breathing Severe abdominal pain Hemodynamic Max. phenylephrine 1-1.5 mcg/kg/min Min. phenylephrine greater than 0.5 mcg/kg/min Max. phenylephrine 1.5-2 mcg/kg/min Min. phenylephrine greater than 0.8 mcg/kg/min Hemorrhagic Guaiac + sputum, emesis, or stool Platelets less than 50,000/mm3 Frank blood in sputum, emesis, or stool Platelets less than 30,000/mm3 Infectious Documented infection or strong clinical suspicion of infection Neurologic Vivid dreams Emotional lability Pulmonary Resting SOB; 3-4 L O2 via NC for sat greater greater than 4 L O2 via NC for sat greater than 95% than 95% 40% O2 via mask for sat greater than 95% Rales 1/3 up chest Endotracheal intubation Rales 1/2 up chest Pleural effusion requiring tap or chest tube during therapy Renal Urine 80-160 mL/8 hours Urine 10-20 mL/hour Creatinine 2.5-2.9 mg/dL Weight Gain 15% or greater weight gain over baseline weight _________/_________/_________ Date _________________________________ Physician Last Name (Print) Mental status changes not reversible in 2 hours Disorientation Hallucinations Urine less than 80 mL/8 hours Urine less than 10 mL/hour Creatinine 3 mg/dL or greater _____________________ Time ____________________ Pager __________________________________________ Physician Signature Rev. 2/16 JH 2/10/16 Page 3 of 3 Distribution: White - Chart Copy