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ADHD Research Program Newsletter November 2012 – Volume 1, Issue 1 Julie Schweitzer, Ph.D. ADHD Program Director Dr. Schweitzer is a licensed Clinical Psychologist whose research aims to develop novel treatments of ADHD for adults and children using a variety of behavioral and psychological techniques. In addition to directing the ADHD Program at the MIND Institute, Dr. Schweitzer is an Associate Professor in the Dept. of Psychiatry and Behavioral Sciences and is highly involved in the mentorship of new researchers and faculty at the UC Davis School of Medicine. J. Faye Dixon, Ph.D. Clinic Director Dr. Dixon is an assistant clinical professor of psychiatry and behavioral sciences and is the Director of the UC Davis MIND Institute ADHD Clinic. She is a Licensed Clinical Psychologist. Her clinical and research interests include ADHD, learning differences, and anxiety and mood disorders in children. She also has a long history of educating and training psychology graduate students and interns, medical students and child psychiatry fellows. Catherine Fassbender, Ph.D. Assistant Professional Researcher Dr. Fassbender is a cognitive neuroscientist. She studies cognitive impairments in individuals with ADHD, patterns of brain and behavior in individuals vulnerable to substance dependence and cognitive impairment related to long-term substance dependence. A. Murat Pakyurek, M.D. Medical Director Dr. Pakyurek is a board certified General Psychiatrist and Child and Adolescent Psychiatrist. Dr. Pakyurek is Medical Director of the UC Davis ADHD Program and the Dept. of Psychiatry and Behavioral Sciences outpatient clinic. Our Mission Attention Deficit/Hyperactive Disorder (ADHD) is the most common childhood behavioral disorder affecting 3-5% of school-age children and 4% of adults. Individuals with ADHD may act quickly without thinking and interrupt others (impulsivity), fidget, have difficulty sitting still and staying on-task (hyperactivity), or daydream and get easily sidetracked (inattention). ADHD impacts school, work, friendships and daily functioning. It requires lifelong management and can be paired with depression or learning disorders. The UC Davis MIND Institute ADHD Team is leading the field with research into the causes of ADHD and its impact on the lives of individuals, families and society. We bring hope and help to families experiencing ADHD by researching more accurate diagnoses and expanding treatment options for ADHD. Our goals are to better understand and treat impulsivity, to improve attention, and to help individuals with ADHD succeed in school and work. We know that those affected by ADHD have amazing potential and it is our mission to enable each patient to achieve their best. Recent findings by the ADHD team include… Telemedicine methods can effectively be used for parent training in ADHD—a breakthrough for parents without local access to therapists Children with ADHD work just as hard, but use increased and less efficient brain activity in working memory problems 1/3 of adolescents with ADHD are likely to drop out of high school Computerized cognitive training games can improve attention during academic tasks for children with ADHD Khyati Brahmbhatt, M.D. ADHD Program Psychiatrist Dr. Brahmbhatt is a board certified Child Psychiatrist. In addition to working with the ADHD Program, Dr. Brahmbhatt is an Assistant Clinical Professor in the Dept. of Psychiatry and Behavioral Sciences at UC Davis School of Medicine and director of the pediatric consultation-liaison service at the UC Davis Medical Center. Kyle Rutledge, M.S. Graduate Student Researcher Mr. Rutledge is a Ph.D. candidate in the Dept. of Human Development, UC Davis. His research interests include ADHD in children and adults, cognition and behavior, and treatment effectiveness. Tadeus Hartanto, B.S. Mr. Hartanto has a degree in Psychobiology from UC Davis and research interests in developmental disorders and clinical psychology. Erin Calfee, B.A. Ms. Calfee has a degree in History from Brown University and assists with data collection and research recruitment. ADHD Program Volunteers Elizabeth Bisi Kathryn Dulla Adam Petchers Caitlin Critz Ayla Kapahi How to get involved 2012 is an exciting time for the ADHD program as we continue current treatment trials and begin new ones. Our innovative research depends on community support. Please consider participating in a study, referring others, or making a donation to help us find answers for families living with ADHD. Contact (916) 703-0294 [email protected] Current clinical research studies by the ADHD team include… Cognitive Control and Reward Processing in ADHD: We are conducting the largest, longitudinal functional neuroimaging study of brain development of impulsivity in ADHD and typical development adolescents and young adults in the U.S. This project will recruit 200 teenagers and young adults and study how brain development relates to self-control, risk-taking, academic and occupational functioning in youths with and without ADHD to provide clues for intervention. Individuals will be assessed using cognitive and achievement testing, behavioral computer tasks, and brain imaging (fMRI). All participants (ages 12-25) will be compensated for their time. (NIMH/NIH-PI: Schweitzer) Identifying Cognitive and Neural Risk Factors for Substance Dependence in ADHD: We are studying behavior and related neural activity in adults with ADHD and adults that have been dependent on methamphetamine in the past to help us understand how to prevent illicit drug dependence in ADHD. The study compares attention and memory brain activity in adults with ADHD, past methamphetamine dependence, both, and neither. Participants (ages 18-50) complete computer tasks and fMRI scans. (NIDA/NIH-PI: Fassbender) Comparison between Parent Training and Computerized Cognitive Training in ADHD: We are testing the effectiveness of a parent training and a home-based computer program, both designed to improve attention and memory in children with ADHD. All participants (ages 6-12) complete both 6-8 week treatments. Recent research publications by the ADHD team include… Fassbender, C., Schweitzer, J.B., Cortes, C.R., Tagamets, M.A. Windsor, T.A., Reeves, G.M. & Gullapalli, R. (2011). Working Memory in Attention Deficit/Hyperactivity Disorder is Characterized by a Lack of Specialization of Brain Function. PLoS ONE, 6(11):e27240. Green, C.T., Long, D.L., Gree, D., Iosif, A.M., Dixon, J.F., Miller, M.R., Fassbender, C. & Schweitzer, J.B. (2012). Will Working Memory Training Generalize to Improve Off-Task Behavior in Children with Attention-Deficit/Hyperactivity Disorder? Neurotherapeutics, 9(3): 639648. Rutledge, Kyle J., van den Bos, Wouter, McClure, Samuel M. & Schweitzer, Julie B. (2012). Training Cognition in ADHD: Current Findings, Borrowed Concepts, and Future Directions. Neurotherapeutics, published online 22 August 2012. Salo, R., Gabay, S., Fassbender, C. & Henik, A. (2011). Distributed Attentional Deficits in Chronic Methamphetamine Abusers: Evidence from the Attention Network Task (ANT), Brain and Cognition, 77(3): 446-452. Xie, Y., Dixon, J.F., Yee, O.M., Zhang, J., Chen, A., DeAngelo, S., Yellowlees, P., Hendren, R., Schweitzer, J.B. (in press). A Preliminary Study on the Effectiveness of Videoconferencing on Teaching Parent Training Skills to Parents of Children with ADHD. Accepted with minor revisions, Telemedicine and e-Health. Schweitzer, J.B., Pakyurek, A.M., Dixon, J.F. (in press). AttentionDeficit/Hyperactivity Disorder. APPI Clinical Manual of Neurodevelopmental Disorders. American Psychiatric Association Press.