Download aow #1- hiv virus - Avon Community School Corporation

Name _________________
AoW #1 HIV drug
Per _______
Highlight confusing sections in one color. Highlight
interesting points-of-discussion, facts, words, phrases,
opinions, etc. in another question.
Annotate – add your comments, questions, and connections,
in the margins.
Web address:
http://www.sciencedaily.com/releases/2012/07/
120725132204.htm
Pioneering Study Shows Drug Can
Purge Dormant HIV
Researchers from the University of North Carolina at
Chapel Hill have published pioneering research
showing that a drug used to treat certain types of
lymphoma was able to dislodge hidden virus in patients
receiving treatment for HIV. (Credit: © rangizzz /
Fotolia)
ScienceDaily (July 25, 2012) — Researchers from the
University of North Carolina at Chapel Hill have
published pioneering research showing that a drug used
to treat certain types of lymphoma was able to dislodge
hidden virus in patients receiving treatment for HIV.
The existence of persistent reservoirs of dormant HIV in the immune system that
are not attacked by anti-AIDS drugs is believed to be a major reason why infection
reemerges once patients stop taking their medication. The disruption and clearance
of these reservoirs is critical to finding a cure for AIDS.
The study was published in the July 25 issue of the scientific journal, Nature.
Researchers at UNC, working in collaboration with scientists from the Harvard
School of Public Health, National Cancer Institute, Merck, and the University of
California at San Diego, undertook a series of experiments designed to evaluate the
potential of the drug vorinostat, a deacetylase inhibitor that is used to treat some
types of lymphoma, to activate and disrupt the dormant virus.
Initially, laboratory experiments measuring active HIV levels in CD4+ T cells,
which are specialized white blood cells that the virus uses to replicate, showed that
vorinostat unmasked the hidden virus in these cells. Subsequently, vorinostat was
administered to eight HIV-infected men who were medically stable on antiretroviral
therapy and the levels of active HIV virus were measured and compared to the
levels prior to administration.
Those patients receiving vorinostat showed an average 4.5-fold increase in the
levels of HIV RNA in CD4+ T cells, evidence that the virus was being unmasked.
This is the first published study to show the potential for deacetylase inhibitors to
attack latency within dormant virus pools in a translational clinical study.
"This work provides compelling evidence for a new strategy to directly attack and
eradicate latent HIV infection," said David Margolis, MD, professor of medicine,
microbiology and immunology, and epidemiology at the University of North
Carolina at Chapel Hill. Targeting latency is the first step on a path that may lead to
a cure.
"Long-term, widespread use of antiretrovirals has personal and public health
consequences, including side effects, financial costs, and community resistance,"
said Margolis, who led the study. "We must seek other ways to end the epidemic,
and this research provides new hope for a strategy to eradicate HIV completely
from the body."
Early results of this study were first presented and reported in March 2012 at the
Conference on Retroviruses and Opportunistic Infections in Seattle, Washington.
The research conducted is part of a UNC-led consortium, the Collaboratory of
AIDS Researchers for Eradication (CARE), funded by the National Institute of
Allergy and Infectious Diseases. The consortium is administered by the North
Carolina Translational and Clinical Sciences (NC TraCS) Institute at UNC, one of
60 medical research institutions in the US working to improve biomedical research
through the NIH Clinical and Translational Science Awards (CTSA) program.
Funding for this research was provided by the National Institutes of Health, Merck
& Co., and the James B. Pendleton Charitable Trust.
**Go on to the next page for the last part, please.
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Comprehension Questions:
Fill in the blank
1.)
2.)
3.)
4.)
What does the acronym HIV stand for? __________________________
What does the acronym AIDS stand for? _________________________
What is dormant HIV? ________________________________________
How do you contract the HIV virus?
a. ___________________
b. ___________________
c. ___________________
Paragraph form- each response must be at least one paragraph in length to receive full credit. 46 sentences.
5.) How have scientist been able to slow down the affects of HIV and AIDS?
6.) Research and describe Ryan White. Who was Ryan White? How did he contract the
AIDS virus? Why was he important to the education of people living with his
condition? (Must be at least one paragraph in length.
Exit ticket task: Describe the history of HIV/AIDS
in your lifespan. Research information about
this disease on your laptop and include research
found/statistics within your response. Must be
at least one page in length and in MLA format.
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