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BIOLOGY 340 Principles of Genetics Fall 2014 Instructor: M. A. Romano Office Hrs: 3-3:50 pm, Mon: 1-2:50 pm, Tue; Office: Room 240 10-11:50 am, Wed; or by appointment. Lecture: Room 378 Phone: 298-1374, Email: [email protected] Web page: http://www.wiu.edu/cas/biological_sciences/faculty/romano_m.php Objective Genetics is the study of inherited variation and the mechanisms for variation. You should be able to understand and predict patterns of inheritance, understand the basic mechanisms of DNA function and the manipulation of DNA. Finally since genes are the basic units for evolutionary changes at the population level, you should have a grasp of the fundamental evolutionary principles after completing this course. TENTATIVE LECTURE SYLLABUS Week and Date 1 Aug 2 Sep 3 4 5 6 Oct 7 8 9 10 11 Nov Chapter in Text* Lecture Topic 25 27 29 1 3 5 8 10 M W F M W F M W 12 F 15 M 17 19 22 24 25 26 29 1 3 6 8 10 13 15 17 20 W F M W TH F M W F M W F M W F M 22 23 24 27 29 31 3 W TH F M W F M Intro., Review Mitosis Review Mitosis cont., Meiosis Review Meiosis cont. LABOR DAY – NO CLASSES Mendelian Genetics cont./Significance of Meiosis Multiple alleles, Gene Interaction, Complementation Multiple alleles, Gene Interaction, Complementation cont. Sex Chromosomes and Sex Determination Sex Linkage, Phenotypic expression Sex Chromosomes and Sex Determination Sex Linkage, Phenotypic expression cont. Chromosomal mutation (Chromosome Structure and DNA sequence organization) Chromosome mutation cont. Linkage and Mapping in Eukaryotes Linkage and Mapping Continued REQUIRED REVIEW SESSION FOR EXAM HOUR EXAM I - 20% of Grade Mapping in prokaryotes and viruses Mapping in prokaryotes and viruses cont. DNA Structure DNA Replication Chromosome Structure and DNA sequence organization DNA and the Genetic Code FALL BREAK – NO CLASSES DNA and the Genetic Code cont. RNA and Transcription RNA and Transcription cont. Translation and Proteins Mutation, Repair and Transposable Elements REQUIRED REVIEW SESSION FOR EXAM HOUR EXAM II - 20% of Grade Mutation, Repair and Transposable Elements cont. Gene Expression Gene Expression cont. Recombinant DNA Technology Genomics 1,2 2 2 3,2 4 4 4,5 4,5 6 6 7 7 8 8 9 10 11 12 12 12 12 13 14 14 15 15 17 18 5 7 10 12 13 14 17 19 21 12 13 14 15 16 17 Dec W F M W TH F M W F Polygenic Inheritance (Quantitative genetics) Polygenic Inheritance (Quantitative genetics) cont. Population Genetics REQUIRED REVIEW SESSION FOR EXAM HOUR EXAM III - 20% of Grade Population Genetics Cont. Population Genetics Cont. Genetics and Evolution Genetics and Evolution cont. 24-28 1 M No Classes - Thanksgiving Break Genetics and Evolution cont. 3 5 8 10 12 15 W F M W F M Conservation Genetics Conservation Genetics cont. Conservation Genetics cont. Catch Up Catch Up FINAL EXAM - 3:00 pm, Room 378 21 21 22 22 22 22 22, Supplements 22, Supplements 23 23 23 *Klug, W. S. et al. 2013. Essentials of Genetics, 8th Edition. Prentice Hall, Inc., Upper Saddle River, New Jersey. 531 pp. COURSE PREREQUISITES BIOL 330; ENG 280 COURSE REQUIREMENTS AND GRADING Points 200 150 200 550 Hour exams (3, the 2 highest exams count) Final Exam Laboratory Total: 99.0% - 100%+ 91% - 98.99% 90% - 90.99% 89% - 89.99% 81% - 88.99% 80% - 80.99% 79% - 79.99% A A AB+ B BC+ GRADING SCALE 71% - 78.99% 70% - 70.99% 69% - 69.99% 61% - 68.99% 60% - 60.99% <60% C CD+ D DF EXTRA CREDIT There are extra credit assignments which will be given during portions of the course. The optional book by the American National Academy of Sciences forms the basis of an extra credit quiz attached to the third exam worth 25 points. Additionally in an attempt to cultivate your ability to begin teaching yourselves, a given chapter or portions of a given chapter will form 15 points extra credit on each exam. WRITING IN THE DISCIPLINE (WID) This course has been designated to meet the Writing Instruction in the Disciplines (WID) graduation requirement. WID courses provide instruction in the processes and formats for the writing content and style needed to be an effective professional in a student’s chosen field. The lab reports, particularly the first one, will represent training in technical writing in biology. EXAMS Exams will be scheduled on selected Thursday evenings during the course of the semester (September 19th, October 17th, and November 7th). A memo will be distributed in class that must be signed by the student indicating she/he is aware of the situation and will make the necessary adjustments in their schedules to meet the assigned examination period. All labs will be cancelled during the week of exams and students with extenuating circumstances and cannot possibly make the evening exam time will agree to take the exam earlier in the day at a time specified by Dr. Romano. MAKEUPS I do give makeups for extenuating circumstances and I will be the arbiter of whether a given circumstance is extenuating. However, my makeups are all essay and very few students have successfully passed my makeups in core courses. ATTENDANCE POLICY I do not take attendance in lecture in this course; however, it is not a good idea to skip class. Students who skip class rarely pass. Lab is mandatory. Two unexcused absences = automatic F Four missed labs for any reason = automatic F SPECIAL NEEDS In accordance with University policy and the Americans with Disabilities Act (ADA), academic accommodations may be made for any student who notifies the instructor of the need for an accommodation. For the instructor to provide the proper accommodation(s), you must obtain documentation of the need for an accommodation through the Disability Resource Center and provide it to the instructor. It is imperative that you take the initiative to bring such needs to the instructor's attention, as he/she is not legally permitted to inquire about such particular needs of students. Students who may require special assistance in emergency evacuations (i.e. fire, tornado, etc.) should contact the instructor as to the most appropriate procedures to follow in such an emergency. Contact the Disability Resource Center at 298-2512 for additional information and services. STATEMENT ON CHEATING AND PLAGIARISM Cheating will not be tolerated in this course. I do allow students to work on the data for lab reports if they so choose. However, each student must turn in an independently written lab report. Should a student copy another student's exam, she/he will receive a zero and procedures outlined in the academic dishonesty section of WIU webpage will be followed. If a student is caught collaborating with another student on a midterm or final, both students will receive zeros and procedures outlined in the academic dishonesty section of the WIU webpage will be followed. I consider plagiarism more serious than simple cheating on exams. Definition of Plagiarism Several years back faculty of the Department of Biological Sciences defined plagiarism as expressed by V. E. McMillan in Writing Papers in the Biological Sciences (Bedford/St.Martin's Press, New York, pg 16): "Plagiarism is the theft of someone else's words, work, or ideas. It includes such acts as (1) turning in a friend's paper and saying it is yours; (2) using another person's data or ideas without acknowledgement; (3) copying an author's exact words and putting them in your paper without quotation marks; and (4) using wording that is very similar to that of the original source but passing it off as entirely your own even while acknowledging the source." This includes information in textbooks or laboratory manuals, honors and masters theses, all writing assignments, and images. Along with my TA, we attempt to monitor student writing assignments (essay exams, papers, laboratory reports, and other writing assignments or exercises) for incidence of plagiarism. If plagiarism is found, I (or we) will discuss the situation with the student and indicate to the student the penalty for this academic dishonesty. Potential penalties include those cited in the academic dishonesty section of the WIU web page, http://www.wiu.edu/policies/acintegrity.php. An Academic Dishonesty Report will be filled out and forwarded to CAGAS and the Chair of Biological Sciences. Should a student choose to appeal the penalty, the process outlined in Section IV of the University Academic Integrity Policy entitled, ‘Undergraduate and Graduate Procedure, Step Two: Appeals’ will be followed. ADDITIONAL STUDENT RESOURCES It is the student’s responsibility to be familiar with the information (including required forms, definitions, and time lines) contained in the following university web sites. Each student should access these web sites and carefully read the information they contain, your instructors will hold you responsible for knowing this information. If you have questions about any of the information contained in the web sites, ask your instructor: Students Rights and Responsibilities: http://www.wiu.edu/provost/students.php University Final Exam Policy: http://www.wiu.edu/policies/finexam.php Academic Dishonesty Policy: http://www.wiu.edu/policies/acintegrity.php Grade Appeal Policy: http://www.wiu.edu/policies/gradeapp.php Western Online: https://westernonline.wiu.edu/d2l/home Disability Resource Center: http://www.wiu.edu/student_services/disability_resource_center/ Complete Policy site: http://www.wiu.edu/policies/