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DEPARTMENT OF CARDIOTHORACIC ANAESTHESIA FREEMAN HOSPITAL NEWCASTLE UPON TYNE HANDBOOK Revised August 2016 INTRODUCTION The Department of Cardiothoracic Anaesthesia welcomes you to the Cardiothoracic Centre at Freeman Hospital. The Northern Regional Health Authority has two established cardiothoracic centres, one at Freeman Hospital in Newcastle on Tyne and the other at South Cleveland Hospital in Middlesbrough. Freeman Hospital is one of the most comprehensive centres in the country with integral cardiological, thoracic and intensive care services and a case mix that includes all types of adult and paediatric cardiac and thoracic surgery including heart and lung transplantation, VADs and ECMO as well as dysrhythmia surgery. The Department in association with the Directorate of Cardiothoracic Surgery and the Directorate of Cardiology and Respiratory Medicine provide the medical services for the Cardiothoracic Centre. This handbook is intended as a guide to maximise your learning during the limited period that you have with us. The Consultant staff are still learning things every day and we do not expect you to master cardiothoracic anaesthesia during your rotation. However, you will come in close contact with cardiovascular and pulmonary physiology and various methods of controlling and altering pathological states. This will provide you with a sound base applicable beyond the cardiothoracic centre. Some of you who desire to become specialists in cardiothoracic anaesthesia may take the opportunity of spending a year as a Fellow in the speciality at a national training centre such as ours. The opportunity for obtaining knowledge and “mastering” new skills depend on how energetically you take advantage of our resources. We can guide you towards reference articles, textbooks and meetings to support your efforts. Whatever your level of training, we are glad to have you as a colleague and welcome you to our training programme in cardiothoracic anaesthesia. We hope you will enjoy working in the department. The Department is situated in the Cardiothoracic Centre. We have a suite of 4 operating theatres and 6 radiological laboratories in close proximity to the adult and paediatric cardiac ITU’s. The adult cardiac intensive care unit (ward 21) is sited on level 3 of the Cardiothoracic Centre of Freeman Hospital. It has 21 ITU beds consisting of a main bay with 15 beds and 6 cubicle. At present, there is not enough nursing staff for all 21 beds but the staff is used flexibly to make maximum use of these facilities. The unit is comprehensively equipped with modern haemodynamic monitors, ventilators, blood gas apparatus etc. The old cardiac ITU is now called 25a and is used as a level 2 step down but mainly for post op thoracic patients. It is staffed by the same nurses as adult ITU but the first line medical cover is the surgical team. It frequently closes at the weekend. The Paediatric ITU has 6 beds and is staffed for 4-6 beds at present. Equipment is similar to that in the adult ITU. We use Th19 several times a week in the Institute of Transplantation notably for the robot assisted cases. The pre and postoperative cardiothoracic patients are housed in Ward 23 (paediatric), Wards 24, 24A (CCU), 25, 30 (adults) in the cardiothoracic block. Occasionally patients may be in 29 but this is a respiratory ward. PERSONNEL ADULT CONSULTANT STAFF: Dr Hazel Powell, Rota-maker Dr Kevin Brennan, Head of Adult ITU Dr Chandrika Roysam, TAVI lead Dr Deirdre Timon Dr Leena Pardeshi, Flexible Training Advisor for SHO & SpR Dr Mahesh Prabhu, Echocardiography Lead Dr Orathi Sanjay Dr Abraham Samuel, Acute Pain Lead & Audit Lead Dr Denis O’Leary ,Head of Department, VAD Lead Dr Henning Pauli ,Deputy College Tutor Dr Anthony George, ECMO lead Dr Francesca Caliandro Dr Jim Park Dr Shabana Anwar, Consultant Intensivist Dr Mostafa Eladawy (Locum) PAEDIATRIC CONSULTANTS Dr Simon Haynes, Anaesthetist and Intensivist Dr Jon H-Smith, Anaesthetist and Intensivist, Lead for all Paediatric Intensive Care Units in the Trust, Lead Clinician for ECMO Dr Thesesa Chila, Anaesthetist Dr Alan McCheyne, Anaesthetist Departmental Secretary TBIC - Direct Line 0191 2137488 Trainees – The department has nine Cardiothoracic Fellows and five ST Trainees from the Northern School of Anaesthesia. There are also two adult critical care practitioners ACCPs on the ST rota Other Key Personnel: Mrs Liz Bailey - Speciality Manager Dr Simon Haynes– Clinical Director Lorna Charlton – Matron, Adult ITU (ward 26) Karen Mason – Anaesthetic Sister Billy Watson – Chief Perfusionist David Kinnersley- Theatre Matron Cardiothoracic Module The aim is to expand a trainee’s understanding of the peri-operative management of patients suffering from advanced pathology of the cardiovascular and respiratory systems. A wide spectrum of age, pathology and therapy are covered from preoperative assessment to postoperative management. Relevance to everyday practice comes from the fact that such patients may present for anaesthesia in nonspecialist hospitals. Many centres will be able to undertake the training of sub specialists who wish to become consultants in a particular field. Such training should be an extension of training on offer to UK anaesthetic trainees. It should not be restricted to UK trainees but also be available to candidates from other countries. National Training Centres for Sub-specialities, particularly highly specialised facets such as anaesthesia for paediatric cardiac surgery, intensive care and transplantation is a concept for the future. It is generally felt that the period of training for a consultant with a special interest in cardiothoracic anaesthesia should be a minimum of twelve months cardiothoracic anaesthesia in addition to the basic anaesthesia training. For overseas trainees or fellows, a similar period is appropriate. The training programme includes a series of guidelines and emphasis in the following areas: Cardiac Anaesthesia; Cardiothoracic ITU; Perfusion Techniques and ECMO; Cardiothoracic Transplantation; Thoracic Anaesthesia; Echo Cardiography; Paediatric Cardiac Anaesthesia and Intensive Care; Presentation Skills. Formal Teaching 1. 2. 3. Formal Combined Anaesthetic Teaching- as per departmental programme, Anaesthetic Seminar Room, Level 1, General Anaesthetic Department Monthly Audit – Mandatory (Dates available from Secretary), Cardiothoracic Lecture Theatre, Level 2 Every Thursday Evening 17:00 – 18:00 Teaching, Cardiothoracic Seminar Room Level 3 Portakabins Alternating Journal Club and Teaching (all welcome) ADULT CARDIAC ATTACHMENT 1. Adult ITU (WARD 21) If you are rostered for Ward 21 during the day (0800-2000), you are expected to take a hand over from the on-call anaesthetic trainee of the previous night, with the ITU consultant at 0800. You are also one of the designated bleep holders for cardiac arrests in the cardiothoracic centre. Only the top of the ‘green sheet’ need be done for this. The transplant VAD and ECMO patients will be done by the tx fellow. Subsequently full patient reviews are organised with the team on ITU, examining all systems of the patient in depth. In this time, the previous day’s patients are reviewed and either discharged or the decision made to retain in ITU – these are usually done by the ITU2 consultant. After coffee (!), a formal ward round with trainees presenting the findings occurs at 11.00 and then clinical plans are formulated. Progress notes and plans are documented in the patient’s notes and the “Daily Instructions” sheets completed. All chest X-rays must be reviewed daily either during or immediately after the morning round. Following the ward round, the trainees complete the various tasks allocated to them during the round. At the end of your shift, you are expected to hand over to the incoming anaesthetic trainees who are on-call for the night. The trainees accept patients as they come from the operating theatre. An admission note needs to be completed (yellow form). Of particular importance are any problems preoperatively, any specific management instructions from the theatre anaesthetic or surgical teams especially in relation to cardiovascular support, ventilation and sedation. First Day Patients are looked after overnight by the Anaesthetic ST. Cardio-anaesthetic fellow and the anaesthetic ST needs to be familiar with all patients.. The 730pm handover round will be done together with the fellows Trainees should frequently review patients to ensure optimal progress over the course of the day. If you have any uncertainties about the management of a patient, discuss this with the duty consultant anaesthetist. The consultants are used to having a close patient involvement and like to be aware of any concerns about a patient’s progress Any early post op problems that may be surgical must involve the surgical team on call. Vad and TX are often complex and may need MDT discussion. Educational Aims of Cardiothoracic ITU Experience 1. To become familiar with pharmacological control of the cardiovascular system and comfortable with managing the failing heart using all modes of pharmacological support. To see the roll of mechanical support of the failing heart. 2. To gain experience of the ITU management of patients with multi-organ failure with the background of an impaired heart. IT IS CUSTOMARY FOR THE DUTY CONSULTANT TO INFORM YOU WHEN HE/SHE IS LEAVING THE HOSPITAL. IF YOU ARE UNABLE TO CONTACT THE DUTY CONSULTANT, PLEASE CONTACT ONE OF THE OTHER ADULT ANAESTHETIC CONSULTANTS. THE ON CALL CONSULTANT WILL USUALLY DO A WARD ROUND AT 10pm OR SO. SUMMARY OF OVERNIGHT WARD 26 RESPONSIBILITIES Anaesthetic SpR - Care of First day cardiac surgical patients. Share the management of all long term (>24hr) patients with the cardio-anaesthetic fellow Cardio-Anaesthetic Fellow – Care of Transplant patients, support for and supervision of Anaesthetic SpRs ITU. Surgical SpRs – Available on the ward for “surgical issues” on CITU such as bleeding problems, chest re-opening and IABP insertion. A guide for managing emergencies in Cardiac Surgical Patients Bleeding Coagulation problems in cardiac surgical patients can differ from the other surgical patients. Pre-op risk factors for bleeding can be compounded by post-CPB coagulopathy and surgical bleeding. Fluid replacement is dictated by the patient’s hemodynamic state, urine output, haematocrit and ongoing blood losses. Consider extra Protamine, TEG. If mediastinal and chest tube drainage suddenly stops, the tubes should be examined for clots with concern for impending tamponade. If bleeding exceeds 150mls/hour, please repeat coagulation profile and correct as necessary. (2mls/kg in a small stature patient).If bleeding exceeds 200mls/hr with hemodynamic compromise, involve the cardiac surgical registrar as re-exploration may be necessary. Please inform the consultant anaesthetist on call. The cardiac surgical registrar should inform the consultant surgeon about any re-exploration. Cardiac tamponade Accumulation of fluid around the heart can produce a severe restriction of atrial and ventricular filling with drop in stroke volume. The classic signs of cardiac tamponade in a post-op ventilated cardiac patient might not be obvious. The clinical suspicion should be raised in patients with hypotension, acidosis, oliguria and elevated CVP (consider the rate of rise of CVP rather than an absolute number).This is a clinical diagnosis and may not be clear cut. Echocardiography should be considered. Remembering Transthoracic echo can diagnose but cannot 100% exclude. TOE is better. Please inform the consultant anaesthetist on call, the cardiac surgical registrar and the cardiac anaesthetic fellow. The treatment is re-exploration, occasionally to exclude it as a treatable cause. Depending on the patient’s haemodynamic status, this is usually done in the cardiac theatre. The cardiac surgical registrar will organise getting the theatre team in. Rarely the pt may be reopened in ITU. If general anaesthesia is required in an extubated patient with cardiac tamponade, be aware induction can precicipate acute CVS collapse. Continue administering IV fluids/ inotropes until the team arrives. Higher Heart rate must be maintained to preserve cardiac output. Consider turning the pacing rate up. The primary problem is reduced ventricular pre-load and not failure of myocardium. Give 100% O2 via face mask. Allow spontaneous breathing as long as possible. If spontaneous breathing is not possible, use low tidal volumes with a higher respiratory rate. Be cautious with PEEP. Be cautious with anaesthetic induction doses. Avoid drugs that can depress the myocardium. Antibiotic prophylaxis for chest re-exploration is 2g Aztreonam. CARDIAC ARREST The guidelines for CPR after cardiac surgery were reviewed by the Clinical Guideline Committee of the European Association for Cardio-Thoracic Surgery (EACTS). These guidelines will be followed in the event of cardiac arrest. Infection control issues The Newcastle Upon Tyne Hospitals NHS Trust’s policy on Infection Prevention and Control is the responsibility of all staff within their own sphere of work. The Newcastle Upon Tyne Hospitals NHS Trust has adopted the WHO guidelines on hand hygiene and will carry out regular audits to ensure that all staff comply with these guidelines. Lack of hand hygiene was highlighted in the resent Department of Health visit. We scored very low on cleanliness!! The following points will be closely monitored and audited. Hand hygiene. Wash your hands or use alcohol gel for decontamination Before patient contact, Before an aseptic procedure, After patient contact, After body fluid exposure After contact with patient surroundings. The last point means that we have to clean our hand after touching any object or furniture in the patient’s immediate surroundings even if the patient is not touched (such as trolley, beds etc.) We don’t do well on that score. All wrist watches and jewellery (particularly stoned rings) should be removed before hand decontamination. Cuts and abrasions must be covered with waterproof dressings. Please refer to the WHO guidelines attached. Gloves are single-use items and should be removed and discarded immediately afterwards. Patients with MRSA and C Diff: On entering the infected area, all staff should Wash their hands with soap and water (not alcohol gel) Put on disposable apron and clean gloves for protection. When leaving the infected area, discard the apron and gloves in a yellow or orange bag. Wash hands with soap and water (not alcohol gel). Peripheral venous cannula insertion: Wash hand and use gloves for protection. Clean the insertion site with 2% Chlorhexidine Gluconate spray and allow to dry. Complete the peripheral venous cannula record. This applies to all lines inserted in the wards, theater and ITU. The only patients exempted are those having day case procedures. All cannula ports must be cleaned with 2% chlorhexidine before and after giving iv fluids or injections. All giving sets should be changed Immediately after giving blood and blood products 24hrs after giving TPN (if it contains lipids) After 72hrs for all infusions. Ventilated patients: Equipment should be visibly clean with filters in the proper places. Tubing should be free from excessive condensation and fluid. Staff should wear gloves and decontaminate hands before and after airway suctioning. Goggles should be used when suctioning infected patients. Head of bed should be elevated to 30-450 unless contraindicated. Theatre : Gowns should not be worn from Theatre to theatre or from ITU to Theatre. Gowns should be bare below the elbow unless they are sterile Caps and masks are a prerequisite in the operating theatre. PRE-OPERATIVE ASSESSMENT Each patient coming for cardiothoracic surgery will be seen pre-operatively, in most cases, one to two weeks prior to surgery in the pre-assessment clinic. A COPY OF EVERY PREASSESSMENT FORM WILL BE AVAILABLE IN THE SECRETARIES OFFICE IN THE WEEK BEFORE THE OPERATION. The first cardiac patient will be on the ward, the evening before the operation. The second patient might arrive from home on the day of operation at 07:30 AM. Some unstable patients will be transferred from other hospitals or may be admitted on the coronary care unit (ward24A) or cardiology wards (usually ward 24). It is customary for the Consultant to perform the pre-operative visit but the trainee should also see all patients on his list pre-operatively even if already assessed by the Consultant. The aim is to identify high risk patients such as Emergencies especially following failed angiographic procedures Severe left main stem stenosis Severe aortic stenosis Preoperative left ventricular decompensation Cardiac disease in combination with other systemic disease The following should be noted: 1. Present and past history 2. Type of medications used and allergies. Sensitivities. Be familiar with each drug and dosage that the patient uses. 3. Cath. Lab data, angiographic, echo and radionucleide studies if performed. 4. Haematological and microbiological data. 5. ASA and NYHA classification should be made. 6. Anaesthetic considerations a. Airway – intubation difficulty Teeth – poor repair, are extractions required prior to surgery. b. Neck – mobility, dizziness on extreme flexion, carotid bruits, jugular venous access. c. Pulses – equal bilaterally, evidence of vascular disease, previous shunts or dissecting aortic aneurysm. d. Heart – Can the patient tolerate lying flat? Can PA catheter be inserted safely? Danger of air embolism from a R to L shunt. e. Lungs – Bronchospasm, preop pulmonary hypertension, pneumonia. f. Neurological – There is a high incidence of neurological sequelae following cardiopulmonary bypass, hence a brief evaluation of carotid and cerebrovascular disease must be made. Previous stroke, TIA, muscle weakness, blurred vision and dizziness should be noted. 7. Pre-medication for adults individual consultants have preferences please liaise with them. Antibiotics Flucloxacillin 1 gram or Clindamycin 300 mg (for patients allergic to penicillin) is given orally with the pre-medication. If MRSA+ve, teicoplanin is used as antibiotic prophylaxis Other drugs Familiarity with cardiac drugs and their dose regimes should be undertaken at an early stage. Warfarin should be discontinued at the earliest opportunity – check INR on morning of surgery if patient is on warfarin. Ace inhibitors For the most part ACE inhibitors should be withheld from the evening before surgery until postoperatively Aspirin and anti platelet agents They should be usually discontinued before surgery. Routine patients approx 7 days preop, sometimes they are continued in ‘unstable’ patients or if stents have been placed. ALL OPEN HEART AND OTHER COMPLEX CASES MUST BE DISCUSSED WITH YOUR SUPERVISING CONSULTANT PRIOR TO ANAESTHESIA Intra-operative Care Physiological Monitoring Technicians (PMT) They are highly trained in this field and are good trouble-shooters when necessary. They are there to support you if you wish to use monitoring equipment, pacemakers, defibrillators, insert a pulmonary artery catheter or an intra-aortic balloon catheter in the cardiac theatres and ITU’s. Defibrillators A. External defibrillator (unsterile) is always connected at start of the case. B. Connect internal defibrillator (sterile) when chest opened. C. External pads if patient is having separate cardiac surgery or a “redo” or is a major risk of arrest prior to sternotomy. Trained Anaesthetic Nurses/Operating Department Assistants will help the anaesthetist(s) during the operation. An on-call nurse/ODA will assist you during out of hour’s operations. They are responsible for: Checking and connecting the anaesthetic machines and suction apparatus in the theatre and anaesthetic rooms. This includes pulse oximeters and capnographs. Checking that there is an adequate supply of syringe pumps in working order. Preparing the airway equipment and intravascular trays. Drawing and checking the anaesthetic drugs required by the anaesthetist. Making sure that the patient’s blood is available in the theatre blood fridge. Providing help during the operation in obtaining various medications, blood or other types of fluid. Helping in the safe transport of the patient to the ITU following surgery. Anaesthetic Record These are important medicolegal documents and care must be taken to ensure accuracy. The open-heart surgery record is comprehensive and well laid out. It comes in duplicate, the first copy is attached to the patient’s notes by the anaesthetist if required. If you are unsure about its use, discuss it with your consultant. The anaesthetic record for non-open heart surgery is a two-page document, which is also comprehensive and is used across Freeman Hospital. There is only one copy, which must be attached to the patient’s notes. Pre-Induction The anaesthetic nurse is there to help you and has checked the equipment and prepared the medication needed for your anaesthetic. Please double check. When patient arrives in the anaesthetic room: 1. 14G Intravenous cannula inserted into a large vein on hand/forearm under local anaesthesia (LA). 2. 20G cannula inserted into radial artery under LA. Connect to transducer system. Record baseline haemodynamic parameters. Obtain room air blood gas sample. For thoracic patients discuss plan with the consultant. 3. Oxygen administered via a face mask and pulse oximeter attached. ECG leads attached. In redo cases, external defibrillator pads are attached. PLEASE NOTE THAT SMALLER GAUGE CANNULAE ARE USED FOR PAEDIATRIC PATIENTS. Induction 1. Appropriate anaesthetic and antibiotic drugs. 2. Intubate and connect to the ventilator using O2/air/volatile if using. CVP line is generally inserted into right internal jugular vein usually after induction (left side if heart transplant). The CVP line should be stitched into the skin in two places and then covered with a sterile dressing. Three way taps are attached to each limb of the CVP catheter and capped. If PA catheter is to be used, insert sheath and catheter at the same time. 3. Oesophageal or nasal temperature probe is sited. 4. Foley catheter inserted into the bladder by the surgical trainee and connected to a urometer. Post-Induction 1. Transfer patient to the operating room and connect to ventilator using 02/air and volatile agent mixture if using. Connect to pulse oximeter and Capnograph. 2. PMT will connect the haemodynamic monitoring. 3. Confirm that all the monitors are connected and working properly before allowing the scrub nurse to prepare the patient for surgery. 4. After chest is opened, the scrub nurse will pass the defibrillator cables over. Connect them to the defibrillator. Pre-bypass Management 1. Deflate lungs if requested and inform surgeon that the “lungs are down” prior to sternotomy. 2 units of concentrated donor blood are available in the theatre transfusion store for routine bypass operations, 4 units for ‘urgent’ procedures and 4-6 units for redo procedures. For redo procedures ensure that at least 2 units of blood are available in the theatre before reordering. Be aware of sudden, massive haemorrhage during sternotomy or subsequent 2. dissection. Loss of functioning graft during this procedure may result in ischaemia. Follow anticoagulation protocol. The surgeon usually requests Heparin to be administered prior to cannulation . Give heparin slowly via the CVP line and inform surgeon and perfusionist that heparin has been given. ACT is performed 2-3 minutes later. Patients on pre-op heparin may be resistant and require further doses. ACT > 300 can use the pump suction but Please ensure that the ACT is > 400 secs prior to commencing bypass. Cardiopulmonary Bypass Management Cardiopulmonary bypass is managed mainly by the perfusionist. The anaesthetist is responsible for the composition of the prime and any additions during the procedure, the administration of volatile, other anaesthetic drugs and vasoactive agents into the bypass apparatus. The anaesthetist must prescribe and sign for pump ingredients and parameters for CPB such as pressure and HCT. 1. 2. 3. 4. 5. 6. 7. The perfusionist goes onto bypass slowly. Watch blood pressure carefully for any unusual rise or fall in systemic, central or cpb line pressure. It may indicate improper cannulation. Inform the surgeon immediately. It is important to make sure that SVC drainage is good and the CVP is low. Check eyes for pupillary size and conjunctival oedema, face for development of plethora during bypass and differential cooling of the two sides of the face (Watson’s sign). Check carotid arteries for thrills. These features act as a further screen of improper cannulation. Stop ventilation when full bypass is established. Turn off unneeded infusions; administer additional anaesthetic agents if required. Withdraw PA catheter 57 cms (if used). Maintain mean arterial pressure between 50-70mm Hg using a volatile anaesthetic agent or a vasoconstricter agent as required. An infusion of a vasodilator may be administrated during cooling and rewarming. Measure ACT when working temperature has been reached and repeat every half-hour. Maintain ACT above 400 seconds (600 seconds when Trasylol is used) To wean off bypass, the following conditions should be met: a. Nasal temperature > 36.5 degrees b. Blood gas, potassium and ionised calcium within normal limits. c. Normal sinus rhythm is preferable with a rate 70-100 depending on the case. Use atrial pacing or AV sequential pacing if necessary. Maintain perfusion pressure around 70 mm Hg. d. Start ventilation, initially by hand to expand noncompliant, atelectatic areas, which have developed during bypass. Switch over to the ventilator and check that the correct tidal volume, gas concentration and volatile agent are being delivered. Avoid stretching the IMA graft during initial expansion of the lungs. Restart the pulse oximeter and capnograph if disabled. 8. The surgeon, perfusionist and anaesthetist will wean the patient off bypass together. Check that the heart does not overfill. Observe the monitors and the heart directly. Post Bypass Management 1. The anaesthetist takes over the management of cardiovascular haemodynamics and circulation blood volume. The use of vasodilator and inotropic therapy should be considered. Pump blood should be returned in aliquots of 50 - 100mls at a time based on filling pressure and condition of the heart. 2. Following removal of venous lines and discussion with the surgeon, protamine is administered slowly. Inform surgeon and perfusionist when protamine commences so they can discontinue suction and when all the protamine has been given. 3. Non-heparinised blood sample taken for estimation of ACT and a heparinised sample taken for blood gas 5-10 minutes after protamine administration. If ACT is not within 10-15 seconds of control, an additional 50 mg of protamine should be given and ACT checked again. If ACT still abnormal, check coagulation screen. Condsider heparinase TEG. (ACT is affected by temperature and hct as well as heparin) 4. It is desirable to keep the MAP between 70-80 mm Hg, recognising the patients pressure range may be higher. Hypertension is treated with additional opiates, volatile agents or a vasodilator either as a bolus or infusion. Hypotension is usually treated with colloid replacement if under filled or inotropic agent if heart is full and sluggish. 5. There may be “pump blood” that is bagged after weaning off bypass. Remember this is heparinised and consider further protamine. Routine use of cell salvage is now in practice and this pump blood may be washed. 6. Complete ICU short order form in full. 7. Transfer patient to the ICU with a nurse and a monitoring technician. If inotropic or vasodilator infusions are being used in theatre, they should be continued during transfer. The patient is hand ventilated and connected to a monitor, which displays ECG, heart rate, BP and pulse oximetry during transfer. 8. Arrival at the ITU bed space, connect your patient to the ventilator with appropriate settings and switch on the disconnect alarm. Hand over your patient to the ITU resident and nurse. They will be interested in any surgical or anaesthetic problems, haemodynamics, inotropic and vasodilator therapy, blood gas exchange, fluid balance and critical incidents in theatre if any. INOTROPIC AGENTS Intravenous infusion dose guide In Freeman Hospital, concentration of inotropic agents is based on the “0.3 x kg body wt in 50mls” formula. A “Standard” solution is adjusted to economise on the amount of drug used by diluting to 60mls instead of 50mls, and by avoiding the use of a second ampoule by diluting to a smaller volume, e.g. by using 200 mg in 48 mls of solution (200/48) of dopamine instead of 210/50. A standard solution contains 1 mcg/kg/minute in 1 ml of solution of Dopamine/Dobutamine and 0.01 mcg/kg/minute of adrenaline, isoprenaline or noradrenaline in 1 ml of solution. WEIGHT (kg) DOPAMINE DOBUTAMINE 30 32 34 36 38 40 42 44 46 48 50 52 54 56 58 60 62 64 66 68 70 72 74 76 78 80 82 84 86 88 90 110/60 115/60 120/60 130/60 140/60 140/60 150/60 160/60 170/60 170/60 180/60 190/60 190/60 200/60 200/57 200/56 200/54 200/52 200/51 200/49 200/48 200/46 200/45 200/44 200/43 200/42 200/41 200/40 200/39 200/38 200/37 110/60 120/60 120/60 130/60 140/60 140/60 150/60 160/60 170/60 170/60 180/60 190/60 190/60 200/60 210/60 220/60 550/60 230/60 240/60 250/60 250/58 250/56 250/55 250/53 250/52 250/52 250/51 250/50 250/48 250/47 250/46 ADRENALINE/ ISOPRENALINE NORADRENALINE 1.1/60 1.2/60 1.2/60 1.3/60 1.4/60 1.4/60 1.5/60 1.6/60 1.7/60 1.7/60 1.8/60 1.9/60 1.9/60 2.0/60 2.0/57 2.0/56 2.0/54 2.0/52 2.0/51 2.0/49 2.0/48 2.0/46 2.0/45 2.0/44 2.0/43 2.0/42 2.0/41 2.0/40 2.0/39 2.0/38 2.0/37 GENERAL DEPARTMENTAL INFORMATION 1. On-call Rooms – on Ward 21 2. Catering -> sandwich trolley with food in Cardio Theatres at Lunchtime 11301330. When on call if you place your order with the kitchen it will be delivered to Ward 25 on their dinner trolley - Various vending machines 3. Registrar Room Level 3 -> Mail boxes – computer – (very slow and virus-laden!!) 4. Anaesthetics Department Secretary Level 3 Portakabins – Diane Robson Annual Leave Forms, Rota Requests etc. LOG BOOK There is a departmental logbook for you to use during your stay. It has been designed with Cardiothoracic experience in mind. Feel free to use it, any comments are welcome. This is on the hard drive of the computer in the Trainees Room. ACUTE PAIN SERVICE This handout is intended to give you some background information on the role of our Acute Pain Service and more specific information about the analgesic techniques you are likely to encounter in this hospital. If you feel that the information could be usefully amended or expanded, please pass on your suggestions to any of the Pain Team. Acute Pain Service staff The Pain Team at Freeman Hospital consists of Consultant Anaesthetists and Nursing Sisters: Consultant Anaesthetists: Sameena Ahmed (Lead Consultant), Abraham Samuel and Leena Pardeshi. Pain Nurses: Angela Knight, Stewart Keenan, Jenny Houston and Susan Breen. The Acute Pain Service conducts daily pain rounds commencing at 9am in Recovery. A weekly pain round is carried out in conjunction with an Anaesthetist (Thursday) All Consultants are available for teaching advice and help. Acute Pain Service information All up to date Acute Pain Service Guidelines can be found on the trusts intranet site. Please refer to them if you are unsure about any aspect of pain management. Acute Pain Service routine We review all patients using Epidural infusion analgesia (EIA) twice a day and see patients with nerve catheters and PCA’s once a day. The majority of patients will be postoperative, but we also take referrals from ward staff for patients with acute non-operative pain. You will be allocated pain round sessions. The official hours for the APS Nursing staff are 08.00 - 17.30 Monday to Friday. There is no nursing cover from Friday evening until Monday morning. As 1st on call you will be expected to review any patients with EIA on Saturday morning and evening and Sunday morning and evening, you will also be required to cover bank holidays. If you are busy in theatre you must contact the 2nd on call or Consultant to cover you while you review the EIA patients. When reviewing the patients you must document on the prescription chart that you have seen the patient and on the Saturday, Sunday and Bank Holiday morning you must carry out and document a full set of epidural observations. Ward staff are instructed to contact 1 st call for acute pain problems out of hours. Epidural infusion analgesia (EIA) Please ensure that you reserve EIA for patients undergoing significant upper abdominal/chest surgery, major pelvic surgery, or in whom medical conditions warrant regional rather than opiate analgesia e.g. severe COAD. You should discuss any such patients with one of the Consultant staff pre-operatively. The following wards will accept patients with EIA 23, 25, 25a, 26, 38 and PICU but you should always check in advance with the nurse in charge to ensure the ward is adequately staffed to cope with the additional monitoring. Our routine mixture for adult EIA is 0.1% bupivacaine with 5-40 mg Diamorphine per 500ml. Paediatric patients usually do not require Diamorphine. The EIA is delivered via dedicated Hospira Gemstar pumps, which are used only for Epidurals, Intrathecals and occasionally Nerve Catheters. Analgesia should be maintained with 0.1% bupivacaine and routine top ups of stronger concentrations are not recommended. EIA must be prescribed on the dedicated yellow prescription forms. Nursing staff on the ward are not authorised to programme epidurals or change bags, it is the responsibility of the on-call Anaesthetist to do this. EIA should be continued until the patients’ use has declined and he/she can convert to oral analgesia. The exit site must be inspected daily for signs of infection and to ensure that the IV3000 dressing remains intact; if any disconnection occurs in the epidural line between patient and filter then the epidural must be removed as contamination of the catheter is inevitable. Ward staff do not routinely discontinue EIA without reference to the Pain Service or 1st on-call Anaesthetist. Patient Controlled Analgesia We use Morphine PCAs (50 mgs/50 ml – pre-filled syringes). If Morphine is contraindicated then Fentanyl (neat 50mcg per ml) may be used. We have a large supply of Graseby 3300 PCA pumps. PCA information leaflets are available on all surgical wards. PCA is usually started in the Recovery Room, and the nursing staff will load and programme the pump for you, provided that you have completed the dedicated prescription chart (available in all Theatres / Recovery / Wards). Please ensure that a Codan non-return valve is included in the IV line whenever you set up a PCA - this is particularly likely to be missed when you are setting one up on the wards. All patients with PCA are only nursed on surgical wards, where the nursing staff are familiar with the pumps and can change the syringes. The Nurses are not qualified to programme pumps or administer loading doses. Most ward staff are sufficiently familiar with PCA management that they are able to decide when the patient can reasonably be weaned from the technique. Mild opiates are prescribed for any patients whose PCA is discontinued (please see PCA discontinuation guidelines). Setting up PCAs /Epidurals Before removing a PCA / Epidural pump from the theatre equipment store the pump log must be completed (situated in recovery). Also please inform the Pain Service if you set up a PCA / Epidural out of hours (leave a message on their office answer phone – ext 27379). PCA and EIA equipment is not routinely stocked on all the wards, so take everything with you from Theatre for ease. Ketamine Ketamine is occasionally used for chronic pain / palliative care patients; please refer to separate guidelines (intranet). Paravertebral catheters in cardio-thoracic patients Paravertebral infusions are routinely used post-operatively on any patient undergoing Thoracotomy (including single lung transplants). The standard prescription used is 500ml bag of Bupivercaine 0.1% running continuously at 10-15mls per hour via the grey Hospira Gemstar pumps. Patients must be nursed on Wards 23, 25, 25a, 26, 38, PICU or 30; Nursing staff cannot change the bags of local anaesthetic agents. The 1st on call is expected to change the local anaesthetic infusion bags as required. The Acute pain sisters usually change the bags during the day to avoid disturbing the 1st on call at night. However, you may be called over to replace the bags during the day at weekends and Bank Holidays. PAEDIATRICS Orthopaedic patients admitted to PICU (Freeman ward 28) Patients are admitted to ward 28 from theatres with a prescription for a morphine infusion. This will be prescribed on a ward 28 drug chart, together with any additional analgesics, antibiotics etc that may be needed. The nursing staff can prepare this infusion prior to the patient’s arrival on the ward. Typical prescription will be (patient’s weight in mg of morphine) made up to 50 mls with 0,9% saline. This should run at up to 2 mls/hr with 1ml boluses of the solution as required. Maximum amount of morphine 50 mg in 50 mls. The following morning, assuming the patient has been extubated (ie in the majority of cases), they will be converted to a PCA (with additional enteral/rectal analgesia as needed). This will be a ‘standard’ PCA in most cases, commonly with boluses but almost invariably with no background infusion. The prescription will be written on a standard PCA chart in theatres the preceding day, and the solution will be prepared and the pump programmed by (band 6) PICU nursing staff prior to discharge. If there is no prescription available, it will be completed by a consultant (JC/YT/MG or JHS/SH/MR/TM) and NOT a trainee. The solution will however be made up, and the pump programmed, by (band 6) PICU nursing staff. The APS have kindly offered to facilitate any necessary training and help troubleshoot while this system becomes established. Once the patient is ‘established’ on ward 17 ongoing troubleshooting and pain management issues will be dealt with by anaesthetists on the ‘general’ side together with the APS. Paediatric/congenital cardiac patients requiring PCAs on discharge from ward 28 If a patient is to be discharged from Ward 28 but requires a morphine PCA this should be prescribed by a consultant (JC/YT/MG or JHS/SH/MR/TM) and the solution will be prepared and the pump programmed by (band 6) PICU nursing staff prior to discharge. It will almost invariably be a bolus/lockout programme with no background infusion. Management and troubleshooting of epidurals (plus paravertebrals and PCAs) on wards 23 and 28 Initial troubleshooting should be referred to the cardiac anaesthetic registrar who is first on call (or occasionally the trainee on the ward). Simple problems can be dealt with by that person. On PICU, particularly at night, the resident doctor on the unit will troubleshoot pain problems. If there are to be any significant changes to a prescription, or if problems are complex or difficult to resolve, a consultant paediatric cardiothoracic anaesthetist should be contacted by telephone for advice at an early opportunity. They may either give telephone advice or come to see the patient. Changes to PCA or epidural/paravertebral prescriptions should not be made without the knowledge and approval of a consultant paediatric cardiothoracic anaesthetist. In reasonable daytime hours, the APS will kindly continue to provide input and help with ongoing acute pain management for all patients within the cardiothoracic directorate and those patients cared for on ward 28. Chronic pain patients You will also encounter occasional chronic pain patients with a long history of opiate use and / or abuse. If you are planning PCA or EIA in a patient with a history of chronic opiate use, please discuss the management with a member of the Pain Service prior to commencing the infusion. Entonox Entonox analgesia is available for patient use on Wards under the supervision of the Acute Pain Service. Some Ward staff have been trained to administer entonox. You can gain access to extonox via the Acute Pain Service. Protocols for Peri-operative Care The following aspects of peri-operative care will be applied to all patients under the care of all Consultants. Unless specific, clear and documented instructions are given to the contrary by senior medical staff (Registrar/Consultant level), the following should occur: Thromboembolism Prophylaxis THORACIC major cases - All patients to receive Tinzaparin 3500u SC OD evening before surgery and continuing until discharge. TED stockings to be placed at same time and prescribed alongside the Tinzaparin. Continue until discharge only. CARDIAC – All patients to receive Tinzaparin 3500u SC OD post operatively until discharge. TED stockings until discharge only – remember to prescribe these alongside the Tinzaparin. Not to be continued after leaving hospital. Antimicrobial Chemoprophylaxis WEIGHT NOT ALLERGIC TO PENICILLIN PENICILLIN ALLERGY < 80Kg 1g Flucloxacillin at induction* 500mg x 3 doses 6 hourly 600mg Clindamycin* 300 x 3 doses 6 hourly MRSA POSITIVE OR STATUS UNKNOWN 400mg Teicoplanin* 400mg 12 hours later >80Kg <120Kg 2g Flucloxacillin at induction* 1g x 3 doses 6 hourly 900mg Clindamycin* 600mg x 3 doses 6 hourly 600mg Teicoplanin* 400mg 12 hours later >120Kg 3g Flucloxacillin at induction* 1.5g x 3 doses 6 hourly 1.2g Clindamycin* 900mg x 3 doses 6 hourly 800mg Teicoplanin* 400mg 12 hours later *Consider repeating dose if blood loss >4L Endocarditis patients : treat according to microbiologist recommendations Aztreonam usually used for patients returning to theatre for reopening. Seek Microbiology advice if patient returning to theatre due to an infected wound. THORACIC Patients – No antibiotics with pre-medication unless specifically for a preoperative infection as per microbiology advice. - Prophylactic antibiotics are given as one single dose at induction unless specified by Microbiology Team. No need to give postoperative doses All other postoperative infections and sepsis related diseases (lung infections or other systemic infections) should be treated as per Microbiology advice. At induction No antibiotics for bronchoscopies For mediastinoscopies/open thoracotomies/lobectomies/ pneumonectomy/thoracoplastys and for all VAT’s Only one dose at induction - Single dose of Flucloxacillin at induction Flucloxacillin 1 Gm IV if weight < 80Kg Flucloxacillin 2 Gm IV if weight > 80Kg - If patient is allergic to Penicillin: - Clindamycin 300 mg IV if weight < 80Kg Clindamycin 600 mg IV if weight > 80Kg For Empyema/rib resection or other thoracic sepsis, please discuss with the surgeon or the Microbiology team if necessary If patient has received penicillin-related antibiotics in the recent past, please use Clindamycin at Induction. Routine Investigations Cardiac Patients No immediate post-op CXR or blood tests Day 1 and Day 4 Day 4 Thoracic Patients Day 1 and day 4 FBC, U&E, Creatinine, CXR (or post-drain), ECG ECG FBC & U&E CXR daily while chest drain in situ. After drains removed only CXR when indicated if post drain removal CXR satisfactory. Immediate Postoperative fluids All patients 1ml/kg/hour crystalloid until drinking normally except pneumonectomy 0.5ml/kg/hr If urine output less than 0.5ml/kg/hr for 2 hours notify on call doctor or nurse practitioner. Haemoglobin Transfuse only if Hb < 8.0 Blood transfusions or blood products to be discussed with, and sanctioned by, Consultant Surgeon Consider Ferrous Sulphate if anaemic on Day 3 onwards Radial Artery Grafts No anti-spasmodics need be prescribed routinely. Nitrates (ISMN, GTN) or Calcium channel blockers (Diltiazem) may be requested by the Consultant Surgeon however. GI prophylaxis All CARDIAC patients to receive Lansoprazole 30mg OD PO. This should be stopped on discharge unless prescribed before admission. Recommence patients on usual medication if documented dyspeptic history. Anticoagulation Valve Patients Mechanical valves – commence full dose (175u/kg) SC Tinzaparin on first post operative day until INR >2. Start Warfarin as per protocol Mr Nair uses IV heparin Act 200-220 INR Targets : Mechanical Aortic Valves 2-3 Mechanical Mitral Valves 2.5 to 3.5 Biological Aortic Valves – No Warfarin – use Aspirin 150mg OD Biological Mitral Valves & Mitral Valve Repairs in sinus rhythm – No Warfarin - use Aspirin 150mg OD. If in AF use Warfarin with target INR of 2.5-3.5. Atrial Fibrillation (de novo): No anticoagulation within 48 hours. If still in AF after 48 hours start full dose (175u/kg) Tinzaparin and Warfarin. Aim for an INR of 2-3. Stop Tinzaparin when therapeutic INR. Antiplatelet therapy All CABG patients to receive 150mg Aspirin at 6 hours post op if chest drainage less than 100mls in previous hour Continue 150mg daily for one year unless demonstrated intolerance of aspirin. Reduce then to 75mg for life. Consider 75mg Clopidogrel if on this preoperatively. Clopidogrel may be needed if the patient has coronary stents in situ. Drug eluting stents should have Aspirin and Clopidogrel for one year after implantation while bare metal stents receive the combination for one month only before continuing on Aspirin alone. Urgent (post NSTEMI) patients to be treated with Aspirin ONLY ie if Clopidogrel started by cardiology only for NSTEMI treatment, then DO NOT restart. Discuss with consultant surgeon. CABG patients who are warfarinised (valve/AF/thrombus/endarterectomy) to receive 75mg Aspirin only. Cardiac patients Atrial Fibrillation Confirm AF with 12-lead ECG.. Sinus tachycardia (>100bpm) may indicate a clinical problem and this should be sought rather than treating this an as an arrhythmia. What appears to be a sinus tachycardia >150bpm may well be atrial flutter and will need control as for AF. Check potassium If potassium and hydration satisfactory, and patient not hypoxic: Give 8mmol Magnesium Sulphate IV. Options: SEEK SENIOR ADVICE IF UNCERTAIN 1. If significantly compromised consider cardioversion. 2. Metoprolol 50-100mg TDS orally. If contraindicated use Diltiazem 180mg BD. Exercise care in patients with poor LV function. 3. 5-15mg Metoprolol can be used as an IV loading dose followed by 5mg QDS. Aim for a heart rate below 100bpm. 4. Amiodarone 300mg IV over an hour followed by 900mg over 23 hours if central line present and/or compromised (hypotensive/rate >150). If compromised and no central line, insert line. Move to 25A. Oral Amiodarone 400mg tds loading dose followed by 200mg tds has often been used previously but it takes days to work and is less effective than rate control with beta blockers. Note that Simvastatin should be reduced to 20mg daily when on Amiodarone. Beware potentiation of Warfarin by Amiodarone. Consider and correct surgical complications / other acute precipitants (pain, infection, hypoxia, embolism). These cause sympathetic stimulation which makes HR control difficult and will restart AF after cardioversion. See ANTICOAGULATION SECTION - Start Tinzaparin full dose & Warfarin if still in AF after 48 hours THORACIC PATIENTS – Avoid Amiodarone – seek senior advice. Pacing Wires Remove on Day 3. Check INR is <2.5 if applicable. Patient needs to be 24 hours free of pacing Statins Recommence on the statin on the first post operative day and dose originally taken by patient Diuretics CABG and AVR patients with good ventricles should not routinely be discharged on diuretics. Hypertensive patients on thiazides should remain on them. Prescribe according to clinical status. Use daily weight to guide therapy. Frusemide is the diuretic of choice. Patients taking diuretics pre-op should be discharged on a (reduced) dose of same diuretic. Poor left ventricles should remain on diuretic irrespective of weight. Discuss with consultant if unsure. Chest drains Cardiac – remove if no air leak and drainage less than 25ml/hr for 4 hours. Thoracic – X ray 2 hours post op. Drains to be on suction at 5kPa for the first post operative night, then free drainage pending review of the chest X ray. Drains to be removed only on the instructions of a registrar or consultant. Pneumonectomy – drain clamped and released for 5 minutes on the hour every hour. Drain removed the following morning after review. Beta Blockers Continue any previously prescribed beta blockers at full dose where tolerated. Half dose where indicated. ACE Inhibitors ACE inhibitors should be recommenced at low (half) dose post operatively – check U & E’s. ACE inhibitors should be started if LV dysfunction noted for first time on this admission. Lisinopril is the ACE inhibitor of choice if starting new prescription on this admission. Continue any previously prescribed ACE inhibitor. S.C. Clark March 2010 NEWCASTLE UPON TYNE HOSPITALS NHS TRUST FREEMAN HOSPITAL ACUTE PAIN SERVICE (APS) THE APS QUICK GUIDE FOR TRAINEES – PCA AND EPIDURAL MANAGEMENT AT FREEMAN All patients are routinely prescribed Paracetamol 1g QDS and PRN antiemetics (follow anti-emetic guideline). If not contra-indicated NSAID's should be prescribed. On call Anaesthetist: to cover the Acute Pain Service during out of hour’s periods – weekends and bank holidays. Anti-depressants and sedatives should not routinely be given with PCA'S and epidurals, unless the patient has been taking the drug long term. No other Opioids: patients on PCA or Epidural opioids cannot have any other form of opioids orally, IM, IV, Sub-cut etc. Please cross off opioids on the drug chart or mark "Not with PCA/Epidural" this includes mild opiates – e.g. Co-codamol, Codeine or Tramadol. EPIDURALS Filters: one filter should be used and secured between 2 dressings Only IV3000 Epidural dressing to be used over exit site Diamorphine: the only opioid to be used in the 0.1% bags of Bupivicaine Bolus top-ups of 0.25% or 0.5% Bupivicaine should not routinely be given in ward areas. Epidurals can be used on the following wards:23, 25, 25a, 26,27a and PICU. Anaesthetic responsibilities: patients with an Epidural remain the ultimate responsibility of the initiating Anaesthetist Approximate guide for programme rates: Lumbar Mid thoracic Thoracic L3/4-L1/T12 T12 - T10 T9 - T 7/6 bolus - 6mls bolus - 5mls bolus - 4mls background - 6mls background - 5mls background - 4mls PCA'S Background infusions are only used if the patient is on long term strong opioids or in exceptional circumstances - discuss with Consultant Anaesthetist / Acute Pain Sister Anti-emetics: follow guidelines Respiratory depression: follow protocol (see back of PCA chart). Consider adding oral/rectal NSAID’S, increasing lockout time and/or reducing PCA bolus PCA'S can be used on the following wards: - 23, 25, 25a, 26, 27a, 30 and PICU. HOSPIRA GEMSTAR EPIDURAL PUMP TRAINING AID On completion of this self-assessment training aid the participant will be able to demonstrate the safe and correct use of the Hospira Gemstar epidural pump. Name: Position: ATTAINED DATE 1. State the clinical indication for use for the Gemstar pump. 2. Identify all the equipment required to operate the Gemstar pump. 3. Identify the power source for the Gemstar pump. 4. Load the cassette into the Gemstar pump. 5. Turn on of the Gemstar pump. 6. Clear programme and history from previous patient. 7. Programme the pump for continuous infusion /PCA bolus delivery. 8. Purge the giving set. 9. Start the infusion. 10. Review the programme for epidural observations. 11. Review the patient history for epidural observations. 12. Unlock the keypad. 13. Alter the programme. 14. Deliver a clinician activated loading dose. 15. Change the bag. 16. Stop the infusion. 17. Remove cassette and dispose of correctly. 18. Respond appropriately to alarms. 19. General care, cleaning and storage of the pump. 20. State where programming instructions can be located. GRASEBY 3300 PCA PUMP TRAINING AID On completion of this self-assessment, training aid the participant will be able to demonstrate the safe and correct use of the Graseby PCA pump. Name: Position: ATTAINED 1. State the clinical indication for use for the Graseby 3300 PCA pump. 2. Identify all the equipment required to operate the Graseby 3300 PCA pump. 3. Identify the power source for the Graseby 3300 PCA pump. 4. Load the syringe into the Graseby 3300 PCA pump. 5. Turn on of the Graseby 3300 PCA pump. 6. Clear programme and history from previous patient. 7. Programme the pump for continuous infusion /PCA bolus delivery. 8. Purge the giving set. 9. Start the infusion. 10. Review the programme for PCA observations. 11. Review the patient history for PCA observations. 12. Alter the programme. 13. Deliver a clinician activated loading dose. 14. Change the syringe. 15. Stop the infusion. 16. Remove syringe and dispose of correctly. 17. Respond appropriately to alarms. 18. General care, cleaning and storage of the pump. DATE