Chapter 2 Lecture Outline: âThe Four Early River Valley Civilizationsâ City-States in Mesopotamia IV. First EMPIRE Builders A. 3,000 â 2,000 B.C.E. the City-States began to war with each other. These internal struggles meant they were too weak to ward off an attack by an outside enemy. B. Sargon of Akkad (ca. 2,350 B.C.E.) Define 1. Took control of the region, creating worldâs first empire type of when several peoples, nations, or previously independent government states are placed under the control of one ruler. PP Design of T. Loessin; Akins H.S.