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ISTUA 2015
Abstract Form for the 2015 Conference of the ISTUA
Send your abstracts to the Conference Secretariats by e-mail no later
than March 31st, 2015. E-mail: [email protected]
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The paper can be assigned, per authors’ agreement, to □oral presentation and/or
□poster presentation (please tick either or both boxes). Those papers that are not
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ISTUA 2015
[SAMPLE] ASSOICIATION OF TAP GENE POLYMORPHISM WITH
CALCIUM OXALATE UROLITHIASIS
Sheng-Hsien Huang, Wen-Chi Chen1,2, Fuu-Jen Tsai2, Chang-Pao Chang
Divisions of Urology, Department of Surgery, Changhua Christian Hospital,
Changhua, Taiwan; Department of Urology1 and Medical Genetics2, China Medical
University Hospital, Taichung, Taiwan
Purpose: We investigated the potential association between the transporter
associated antigen processing (TAP1 and TAP2) gene polymorphisms and calcium
oxalate urolithiasis in Taiwanese patients.
Methods: A total of 208 calcium oxalate urolithiasis patients and 105 healthy control
subjects were enrolled. We analyzed the single nucleotide polymorphisms of TAP1
and TAP2 genes using the polymerase chain reaction (PCR)-based restriction
fragment analysis.
Results: There was a significant difference in the TAP1 gene codon 333
polymorphism between urolithiasis patients and control subjects (p<0.05). The odds
ratio for the risk of the “A” allele in calcium oxalate urolithiasis patients was 1.44
(95% CI 1.02 to 2.04) compared to controls. There was no statically significant
difference in the TAP2 gene polymorphism between urolithiasis patients and
controls.
Conclusion: TAP1 gene codon 333 polymorphism was associated with calcium
oxalate urolithiasis in Taiwanese people. The “A” allele may confer a higher risk of
calcium oxalate urolithiasis. There was a lack of association between the TAP2 gene
polymorphism and calcium oxalate urolithiasis in Taiwan.
The paper can be assigned, per authors’ agreement, to oral presentation and/or
poster presentation (please tick either or both boxes). Those papers that are not
ticked will be considered intended for both.