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CHEE 3466 (Required) Biological and Physical Chemistry Catalog Data: Biological and Physical Chemistry Cr. 4. (4-0). Introduction to biochemistry. Physical-chemical topics including kinetics and adsorption. Prerequisites: CHEE 3333 and CHEM 3332. Instructor: Dr. Peter G. Vekilov, Professor of Chemical and Biomolecular Engineering Office: S233, phone: (713) 743-4315; e-mail: [email protected] Assistants: Book: Ye Li , Anupam Aich Ivan Liadi S232 [email protected] S232 [email protected] S194 [email protected] Physical Chemistry: With Applications to the Life Sciences by David S. Eisenberg, Donald M. Crothers Addison-Wesley Pub Co; ISBN: 080532402X Additional text: Lehninger's Principles of Biochemistry, Third Edition, by David Nelson, and Michael Cox, W.H. Freeman, NY 2000 Additional text: J. M. Smith, H. C. Van Ness and M. M. Abbot, Introduction to Chemical Engineering Thermodynamics, McGraw-Hill Book Company, Boston Homework: will be assigned every lecture and collected at the beginning of the Monday class in the following week. Work on the homework is a prerequisite for a successful passage of all tests and exams. Tests: three tests on material taught in the class will be given through the semester: Test I – on February 14, Test II – on March 9, Test III – on April 25. Spring Break: March 14-19 Last class: Monday, May 2, 2011 Final Examination: Friday, May 6, 2011, 11 am-2 pm, in this auditorium Grading: 10 % homework, 50 % midterm tests, and 40 % final exam Prerequisites by topics: Theory of chemical bond Fundamentals of organic chemistry Theory of acids and bases Thermodynamics of multicomponent systems Non-ideality Calculus and elementary differential equations Expected Student Outcomes Demonstrate understanding of the physico-chemical principles underlying the structures and functions of biological macromolecules (a). Demonstrate ability to use of techniques for analyzing the response of biological systems to pH changes (a). Demonstrate understanding of the thermodynamic concepts associated with hydrophobicity (a) Demonstrate proficiency with the fundamentals of statistical thermodynamics (a). Demonstrate proficiency with the fundamentals of chemical kinetics (a) Demonstrate understanding (limitations and capabilities) of chemically reacting systems kinetics (a) Planned Lecture Outline 1. Biomolecules: structure and function; chirality 2. Water, weak interactions, acidity and buffers 3. Nucleotides and nucleic acids 4. Biological applications of thermodynamics 5. Chemical and biochemical kinetics 6. Equilibrium constant 7. Reaction mechanisms 8. Entropy and enthalpy of activation 9. Diffusion limited kinetics 10. Catalyses and enzyme kinetics 11. Fundamentals of statistical mechanics 12. The virial expansion 13. Discussion and preparation for final examination Prepared by: Peter Vekilov January 2011 Appendix ABET Outcome, Criterion 3 (a) an ability to apply knowledge of mathematics, science and engineering. (b) an ability to design and conduct experiments as well as to analyze and interpret data. (c) an ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health & safety, manufacturability, and sustainability. (d) an ability to function on multi-disciplinary teams. (e) an ability to identify, formulate and solve engineering problems. Program-Specific Outcomes • Use chemistry and physics concepts to set up and solve chemical engineering problems • Use mathematical tools to solve chemical engineering problems • Select appropriate experimental equipment and techniques necessary to solve a given problem • Evaluate and interpret experimental results using statistical tools and chemical engineering concepts • Apply material and energy balance concepts to design a unit operation • Define objectives and perform the design of an integrated chemical process under realistic constraints • • • • (f) an understanding of professional and ethical responsibility. • • (g) an ability to communicate effectively. • • (h) the broad education necessary to understand the impact of engineering solutions in a global, economic, environmental, and societal context. (i) a recognition of the need for and an ability to engage in lifelong learning. • (j) a knowledge of contemporary issues. • • (k) an ability to use the techniques, skills, and modern engineering tools necessary for engineering practice. • • • • Define roles and responsibilities to align with capabilities of team members and fulfill project requirements Develop and carry out a project plan through team work Translate an engineering problem into a mathematical model or other suitable abstraction Use mathematical model or other suitable abstraction to solve an engineering problem and interpret results Demonstrate knowledge of professional code of ethics. Identify ethical issues and make decisions for a chemical engineering problem. Make presentations that are factual and tailored to the audience Can communicate in writing to non-technical and technical audiences Understand the impact of chemical engineering solutions in a global, economic, environmental, and societal context. Recognize the importance of advanced education and development opportunities Identify, retrieve, and organize information necessary to solve open-ended problems Know the interplay between current technical and societal issues Know the recent history, current status, and future trends of chemical engineering Use modern software to solve chemical engineering problems Understand how to operate equipment relevant to chemical engineering systems