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OP39 THEIMPACTOFOBESITYONORTHODONTICTOOTHMOVEMENT:APROSPECTIVECOHORTSTUDY
Hayder Saloom1, Spyridon Papageorgiou2, Guy Carpenter3, Martyn Cobourne4, 1Orthodontic Department,
University of Baghdad, Iraq, 2Department of Orthodontics and Paediatric Dentistry, University of Zurich,
Switzerland,Departmentsof3MucosalandSalivaryBiology,and4Orthodontics,King’sCollegeLondon,U.K.
AIM: Obesity is a widespread chronic inflammatory disorder characterized by an increased overall disease
burdenandsignificantassociationwithperiodontitis.Theaimofthisprospectiveclinicalstudywastoinvestigate
theclinicalandbiochemicaleffectsofobesityonorthodontictoothmovementwithfixed-appliances.
SUBJECTSANDMETHOD:Fifty-fivepatients(27males,28females)meanage15.1(SD,1.7)yearsandamean
bodymassindexof30.2(3.5)inobeseand19.4(2.2)kg/m2innormal-weightgroupswerefollowedfromthe
startoftreatmenttocompletionoftoothalignmentwithfixed-appliances.Theprimary-outcomewasthetime
taken to complete tooth alignment, whilst secondary outcomes included the rate of tooth movement and
changeinclinicalparameters(plaque/gingivalindices,unstimulatedwholemouthsalivaryflowrateandgingival
crevicularfluidbiomarkers).Datacollectiontookplaceatthestartoftreatment;1hourand1weekfollowing
appliance placement; and at completion of alignment on placement of a 0.019 × 0.025-inch stainless steel
archwire. The results were analyzed with descriptive statistics and generalized estimating equation regression
modelling.
RESULTS:Obesepatientsneededlesstimetocompletetoothalignmentcomparedtothoseofnormalweight(–
23.1days;95CI:–65.4,19.2)butthiswasnon-significant(P=0.284).However,afteradjustingforconfounders,
obesepatientshadasignificantlyhigherrateoftoothmovementcomparedtothoseofnormalweight(+0.016
mm/day;95CI:0.007,0.025;P<0.001).Additionally,explorativeanalysesindicatedthatlevelsoftheadipokines
leptin and resistin, the inflammatory-marker myeloperoxidase and the cytokine receptor for nuclear factor
kappa-Bligand(RANKL)weresignificantlydifferentbetweenobeseandnormalweightpatientsandassociated
withtheobservedratesoftoothmovement.
CONCLUSIONS: This investigation provides the first prospective data demonstrating a different response in
obese patients compared to subjects of normal weight during orthodontic tooth movement with fixed
appliances. These differences in the response of periodontal tissues to orthodontic force in the presence of
obesityhavepotentialshortandlong-termclinicalimplications.