Download NIH Roadmap to the Future - The Medical University of South Carolina

Medical University of South Carolina
NIH Roadmap
November 1, 2004
Dr. Patricia A. Grady
Director, National Institute of Nursing Research
NIH Roadmap
NIH Roadmap
www.nihroadmap.nih.gov
• Conception
• Infrastructure
• Progress
• Implications
2
Roadmap Questions
• What are today’s scientific
challenges?
• What are the roadblocks to progress?
• What do we need to do to overcome
roadblocks?
• What can’t be accomplished by any
single Institute – but is the
responsibility of NIH as a whole?
4
Imperatives for NIH
• Accelerate pace of discoveries in
life sciences
• Translate research more rapidly
from laboratories to patients and
back
• Develop novel approaches in
orders of magnitude never before
undertaken
• Develop new strategies: NIH
Roadmap
5
The Problem
Bench
Bedside
Practice
6
NIH Roadmap Theme:
New Pathways to Discovery
Bench
Bedside
Practice
New Pathways to
Discovery
• Building Blocks
and Pathways
• Molecular Libraries
• Bioinformatics
• Computational
Biology
• Nanomedicine
7
NIH Roadmap Theme:
Research Teams of the Future
Research Teams of the Future
Interdisciplinary Research Teams
Pioneer Awards
Public-Private Partnerships
Bench
Bedside
Practice
•New
Building
Blocks to
and
Pathways
Pathways
Discovery
•Building
Molecular
Libraries
Blocks
and
Pathways
• Bioinformatics
Libraries
•Molecular
Computational
Bioinformatics
Biology
•Computational
Nanomedicine
Biology
Nanomedicine
8
NIH Roadmap Theme:
Re-engineering Clinical Research
Research Teams of the Future
Interdisciplinary Research Teams
Pioneer Awards
Public-Private Partnerships
Bench
Bedside
Practice
New Pathways to
Discovery
Integrated Research Networks
Building Blocks and
Pathways
Clinical Research Informatics
Molecular Libraries
NIH Clinical Research Associates
Clinical outcomes
Bioinformatics
Clinical Research Policy
Computational
Translational Research
Training
Biology
Initiatives
Nanomedicine
Re-Engineering the
Clinical Research Enterprise
9
Criteria for Roadmap Initiatives
• Is it ‘transforming’ -- will it change how or what
biomedical research is conducted in the next
decades?
• Would its outcome enhance the ability of all
Institutes and Centers to achieve their
missions?
• Can the NIH afford NOT to do it?
• Will it be compelling to our stakeholders,
especially the public?
• Is it something that no other entity can or will
do?
10
NIH Roadmap for Medical
Research
New Pathways
to Discovery
NIH
Research Teams
of the Future
Re-engineering the
Clinical Research Enterprise
11
NIH Roadmap for Medical Research
FY2004 Funding
New Pathways
to Discovery
$64.1
$26.6
Research Teams
of the Future
NIH
$37.6
Re-engineering the Clinical
Research Enterprise
12
Roadmap Funding
FY04
FY05
FY06
FY07
FY08
FY09
Total
Pathways
to
Discovery
64
137
169
182
209
188
948
Research
Teams
27
39
44
92
96
93
390
Clinical
Research
38
61
120
174
214
227
833
128
237
332
448
520
507
2172
Total
13
Integrating the NIH Roadmap
at NINR
NINR
Themes
• Identifying effective strategies to
reduce health disparities
• Changing lifestyle behaviors for
better health
• Managing the effects of chronic
illness to improve quality of life
• Harnessing advanced
technologies to serve human
needs
• Enhancing the end-of-life
experience for patients and their
families
NIH Roadmap
Themes
• New research
teams
• New paths to
discovery
• Re-engineering the
clinical research
enterprise
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Integrating the NIH Roadmap
at NINR
• What are the science gaps that nurse
researchers in particular can fill?
• What areas of the Roadmap are we
already addressing?
• What directions should we take to be
Roadmap leaders?
• What will spur the community to be a
part of the Roadmap?
15
NINR Roadmap Integration
NIH Roadmap Link
NINR Roadmap Integration
16
NIH Roadmap
October 14th Briefing:
NIH Roadmap for Medical Research
One Year Later
“Early success claimed for
Zerhouni's NIH roadmap”
17
Research Teams of the Future:
A Closer Look
New Pathways to Discovery
Building Blocks, Biological Pathways, and Networks
Molecular Libraries & Imaging
Structural Biology
Bioinformatics & Computational Biology
Nanomedicine
Research Teams of the Future
High-Risk Research
Interdisciplinary Research
Public Private Partnerships
Re-Engineering the Clinical Research Enterprise
Clinical Research Policy Analysis and Coordination
Integration of Clinical Research Networks
Enhance Clinical Research Workforce Training
Enabling Technologies for Improved Assessment of Clinical Outcomes
Regional Translational Research Centers
Translational Research Service Cores
Clinical Center’s Clinical Research Training Program
18
Research Teams of the Future:
Working Groups and Co-Chairs
•
Interdisciplinary Research
– Patricia Grady, NINR
– Ken Olden, NIEHS
– Larry Tabak, NIDCR
•
High-risk Research
– Ellie Ehrenfeld, NIAID
– Stephen Straus, NCCAM
•
Public-Private Partnerships
– Andy von Eschenbach, NCI
– Richard Hodes, NIA
19
Research Teams of the Future
NIH Director's
Pioneer Award
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Research Teams of the Future
Pioneer Award
Criteria:
– Evidence of scientific innovation and creativity;
– Testimony of intrinsic motivation, enthusiasm and
intellectual energy; and
– Potential for scientific leadership and evidence of, or
potential for, effective communication skills.
21
Research Teams of the Future
Interdisciplinary Research
–
–
–
Planning grants for interdisciplinary
research centers (P20 Centers)
Innovative training programs
Development of methodologies aimed at
integrating behavioral and social science
into interdisciplinary research
22
Research Teams of the Future
P20 Exploratory Centers for
Interdisciplinary Research
–
–
Lower organizational barriers that impede
research
Enable scientists to conduct research
across disciplines
23
Research Teams of the Future
P20 Exploratory Centers—Examples
• Behavioral Epidemiology
– Integrate theoretical methodological and analytic
aspects of economic sciences, population sciences,
and behavioral sciences to develop a new approach
to discovery and intervention in youth vulnerable to
HIV/AIDS
• Imaging Genetics
– Draw from genomics, image analysis, statistics, and
neuropsychiatry to improve diagnosis and treatment
of mental illness and other brain disorders
24
Research Teams of the Future
P20 Exploratory Centers—Examples
• Antimicrobial resistance
– Integrate new disciplines to address the fast growing
problem of antimicrobial resistance using novel new
strategies developed by interdisciplinary research
teams using long-term strategies
• Obesity research
– Integrate disciplines of neuroendocrinology, genetics,
and lipid& intermediate metabolism , and clinical
epidemiology to better treat and prevent obesity
25
Research Teams of the Future
Interdisciplinary Training Programs
• New funding mechanisms
–
Support interdisciplinary work from undergraduate
students through postdoctoral researchers
• Provide foundation for diverse interdisciplinary
scientific teams necessary for success of future
endeavors
• Include short and long term:
–
–
–
Training
Curriculum
Methodological development
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Research Teams of the Future
Interdisciplinary Training ProgramsExamples
• Clinical Research Experience for Engineers
– Undergraduate engineers engage in clinical research
projects with clinical and bioengineering mentorship,
• Regenerative Sciences Training Program
– Biologists, engineers, and clinicians augment training via
didactic and research experiences with focus on
musculoskeletal systems
• Clinical Biodetective Training
– Trainees to develop novel methods for detection of disease
states, markers of good health, and therapeutic markers
27
Research Teams of the Future
Private-Public Partnerships
NIH
Private
Industry
Nonprofit
Organizations
28
Public Trust Initiative
Committee Co-Chairs
Dr. Patricia A. Grady
Director, National Institute of Nursing Research
Dr. Yvonne T. Maddox
Deputy Director, National Institute of Child Health
& Human Development
Public Trust Initiative
Goal
–
To improve the public’s health by
promoting public trust in bio/medical
and behavioral research
30
Public Trust Initiative
Defining Public Trust
–
Public
•
–
Individuals, patients, families, and
communities.
Trust
•
“Confidence placed by the people in an
institution or process”
31
Public Trust Initiative
NIH cannot control the public’s
perceptions in the area of research…
…but we at NIH can improve how
we communicate and interact
with the public.
32
The Process of Biomedical
Research
The presence of an
untreatable problem
generates a research
need.
Health problem
in a patient
A safe, effective
drug, device, or
treatment is then
used for treatment
of the problem.
Clinical Trials:
Testing on
volunteers
Studies performed in humans
Where are the Issues
of Public Trust?
Epidemiological studies:
Who is affected? Surveys,
population studies
Basic Research:
What are the
mechanisms?
Information obtained from basic
research generates ideas for
drugs, devices, or techniques to
treat the problem.
Drug/Medical Device
Discovery and
Development
Drug/Medical Device
Testing: Efficacy and
toxicity/complications
Drugs, devices, and treatments
are tested for safety and efficacy,
first in laboratory assays, then in
animals, finally in human
volunteers
Studies performed in the laboratory
Studies performed in animals
The entire process from
initiation of a research project to
development of a treatment
may take many years and cost
hundreds of millions of dollars.
Public Trust Initiative
Obtaining a Baseline: Initial Steps
–
Inventory of current NIH activities
•
•
–
Ongoing and planned activities
Research related to public trust
National survey of the public to
discern issues regarding public trust
and the research enterprise
34
Public Trust Initiative
Categories of Public Trust
–
–
–
–
–
Clinical research involving human
participation
Including the public in IC business
Promoting the visibility of NIH
Teaching and developing course materials
for science education
Education and outreach programs for
extramural and intramural clinical and
research communities
35
Public Trust Website
http://publictrust.nih.gov
36
NIH Roadmap Website
http://nihroadmap.nih.gov/
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