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CV Litvinova Larisa Full Name: Office Address: Date of Birth: Marital status: Citizenship: Tel: e-mail: Larisa Sergeevna Litvinova Immanuel Kant Baltic Federal University, Laboratory of Immunology and Cell Biotechnologies, 3 Botkina str., Kaliningrad, 236016, Russia November 21, 1975 Single Russia +79114820489 (mobile) +7 (4012) 595-595 (6631) (work) [email protected] EDUCATION: 1993-1999 1999-2002 2004-2007 Siberian State Medical University, Department of Pathophysiology, Faculty of Biology and Medicine, Tomsk, Russia (Diploma of Specialist) PhD, Siberian State Medical University, Department of Pathophysiology, Tomsk, Russia (Scientific Advisor - MD, Professor Ryazantseva Natalia, thesis "Cytogenetic status of peripheral blood lymphocytes in children with infectious mononucleosis") MD, Siberian State Medical University, Department of Pathophysiology, Tomsk, Russian Federation (Scientific Advisor MD, Professor Ryazantseva Natalia, thesis "Mechanisms of dysregulation of cooperation between eosinophils and immune cells in blood eosinophilia") PROFESSIONAL EXPERIENCE: 2007-2008 2008- up to date Research fellow, Head of the inter-chair Laboratory of Molecular Medicine, Siberian State Medical University, Tomsk, Russia Projects: Mechanisms of dysregulation of cooperation between eosinophils and immune cells in blood eosinophilia Head of Laboratory Immunology and Cell Biotechnologies, Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation. Projects: 1. Study the mechanisms of regulation of the immunological memory in normal and pathological conditions: Molecular mechanisms of violations of the structure, metabolism and function of blood cells in pathology; Development of new technologies to obtain individual universal T cell vaccines that are effective in treating autoimmune diseases; Study of molecular biological mechanisms of modulation of the immunological memory in norm and autoimmune diseases; Study of cellular and endocrine mechanisms of regulation of immunological memory; The influence of steroid hormones on the functional activity and processes of self-maintenance of T-cell immune memory. (Topicality was confirmed by obtaining federal destination grants) 2. The study of molecular and immunological mechanisms of the pathogenesis of the metabolic syndrome: Investigation of immunopathological reactions in metabolic syndrome; Study of the variability of mitochondrial DNA of adipocytes in metabolic syndrome; Investigation of molecular and cellular mechanisms of formation of chronic inflammation in metabolic disorders; Search and identification of prognostic significance of molecular and cellular markers in socially significant diseases; Molecular and genetic mechanisms of metabolic abnormalities in insulin resistance; Study of the association of endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome in Russian population; Study of gene expression of proinflammatory cytokines and adipokines in metabolic syndrome. (Topicality was confirmed by obtaining federal destination grants) 3. The study of molecular-genetic, morphological and functional properties of multipotential mesenchymal stem cells (MMSCs): The study of the regenerative capacity of multipotential mesenchymal stem cells in various types of tissues; Development of 3D tissue-engineering constructs. International scientific collaboration with Laboratory of Experimental Modeling, Department of Cell and Tissue Technologies, Institute of Genetic and Regenerative Medicine of National Academy of Medical Sciences of Ukraine in Kiev, Ukraine. LABORATORY SKILLS AND COMPETENCES: Basic skills: Methods of isolation, cultivation, expansion, purification, processing, cultivation, differentiation of cells, storage and characterization culture of T-cells, eosinophils and mononuclear cells. Isolation, primary culture and expansion of mesenchymal stromal cells from human adult adipose tissue, dermis. Comparative analysis of the proliferation rate, and differentiation capacities of cells from different sources, using qualitative and quantitative methods. Immunophenotypic flow cytomery analysis of cells during subculturing. Low temperature banking of cells. Clonal analysis of mesenchymal stromal cells, using CFU-f assays. Differentiation of isolated clones. Isolation and primary culture of Technical skills: Skills profile: MSC from human adipose tissue and from rat bone marrow and skin. Hematologic research methods, methods of separation (density gradient, the direct and indirect penning, immunomagnetic separation), the definition of surface markers on different types of cells (flow cytometry), coagulometry, agregatometry, biochemical and enzyme immunoassay (all kinds), microscopy, Bio-Plex assay, xCelligence and Cell-IQ system et al. Fluent PC: OS Windows, all programs of package Microsoft Office, Opera, Google et al., statistical software. Knowledge of languages: English, Deutsch (understanding, reading, speaking and writing) Personal qualities: Ability to collaborate, perseverance, efficiency, analytical thinking. Good communication skills. CURRENT RESEARCH INTERESTS: Humoral and cellular regulation of adaptive immunity; immunopathological reactions in socially significant diseases (metabolic syndrome, cardiovascular diseases, etc.). Regenerative medicine, cell-based therapy (multipotent adipose-derived stem cells), 3D tissue engineered constructs for experimental and medical use.