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PROCELL’s Transdermal
Cosmeceuticals : pII SKIN™
Oct.
23.
2014
Brand Competitiveness of pII-SKIN™
Fusion with
innovative
biotechnology
 Innovativeness of ProCell’s
platform technology
 Uniqueness and high
performance of cosmeceutical
active ingredients
ProCell’s top notch
technology
1
 Worldwide IP application
and registration
 Publication in peer-reviewed
top scientific journals
 Global Partner
: co-development of
cosmeceutical active
ingredients and PCT
application
2
 Collaboration with
global cosmetic giants and
partnership with domestic
- based cosmetic companies
Collaboration with
outstanding Global
partners
 Development of unique and highperformance active ingredients
 Efficient transdermal
 Production of highly purified
delivery of active ingredients
materials
 Maximizing efficacy through
skin cell activation
 Efficacy and safety validated
 Diverse application of active
ingredients to cosmetics
 Product safety is verified by
certified clinical test
institution
3
4
 Top quality and safety-guaranteed
active ingredients
Self supply of cosmeceutical active ingredients
ProCell’s Platform Technology : MITT
Basic Technology (MITT)
Cargo (active ingredients)
▷ Antibodies
▷ Recombinant Proteins
▷ Peptides
▷ siRNA or DNA
▷ Low MW chemicals
▷ Nanoparticles
MTD
Macromolecule Transduction Domain
MITT
Macromolecule Intracellular Transduction Technology
Skin and Skin Cell Permeable MTD
Delivery of MTD-conjugated FITC into artificial skins
Delivery of MTD-conjugated FITC into skin cells
3
Keratinocyte
Melanocyte
Fibroblast Cells
pII SKIN™ The novel platform for Cosmetics
Anti-aging
Anti-wrinkle
Skin penetrating
MTDs
Whitening
Growth Factors
Skin-lifting
Elasticity
Moisturization
Skin nourishment
Pure to Skin
siRNAs
Premium to Skin
Precious to Skin
 Paraben free
 Mineral oil free
Functional
Peptides
Natural Materials
ProCell’s Platform Technology
- MITT for Transdermal Delivery-
MTD enhances skin permeability of cosmeceutical ingredients
1st action

MTD efficiently delivers active ingredients into stratum corneum and dermis
2nd action

MTD maximizes efficacy of active ingredients by intercellular or intracellular delivery
MTD-EGF Effect on
Dermal Fibroblast Proliferation
(% of control)
Cell proliferation
200.00
Human Dermal Fibroblast (NHDF)
NHDF (Human)
150.00
control
100.00
50.00
0
0.01
0.1
1
10
Procell MTD-EGFs (ng/mL)
(% of control)
Cell proliferation
200.00
0.1 ng/mL
Mouse Fibroblast (NIH3T3)
150.00
100.00
1.0 ng/mL
50.00
0
0.01
0.1
1
Procell MTD-EGFs (ng/mL)
10
NIH3T(Mouse)
(% of donor protein conc.)
permeation rate
Skin Permeability of MTD-EGF
0.3%
0.35
0.30
6h
24h
0.25
0.20
0.15
0.10
0.05
0.01%
0.00
GF
EGF
MTD-GF1
MTD-EGF
Skin permeability of MTD-conjugated EGF is 30 times more
than that of EGF after 24 hour treatment on artificial skin.
4
MTD-FGF2 Effect on
Dermal Fibroblast Proliferation
Human Dermal Fibroblast (NHDF)
control
125.0
(% of control)
Cell Proliferation
150.0
100.0
0.8 ng/mL
75.0
50.0
0
0.1
1
10
100
Procell MTD-FGF2 (ng/mL)
3.0 ng/mL
Skin Permeability of MTD-FGF2
0.60
(% od donor protein conc.)
Permeation rate
1h
24h
0.5%
0.50
0.40
0.25%
0.30
0.20
0.186
0.163
0.10
0.00
FGF2
GF2
MTD-FGF2
MTD-GF2
Skin permeability of MTD-conjugated FGF is 2 times more
than that of FGF after 24 hour treatment on cadaver skin.
4
MTD-FGF2 Effect on
Dermal Fibroblast Proliferation
Human Dermal Fibroblast (NHDF)

Cell migration by MTD-FGF2
125.0
100.0
75.0
150
0.1
1
10
100
Procell MTD-FGF2 (ng/mL)
125
(% of control)
0
Cells/Fields
50.0
Number of Migrating
Cell Proliferation
(% of control)
5 ng/mL
control
150.0
100
75
50
control
control
1 ng/mL
3.0 ng/mL
Cell proliferation was stimulated in human dermal
fibroblast after 72 hrs treatment of MTD-FGFs.
MTD-FGF2
MTD-FGF2 treatment greatly enhanced the migration
of HUVEC cell compared to control.
MTD-VEGF Effect on
HUVEC Cell Proliferation and Migration
180
 Cell migration by MTD-VEGF
HUVEC cell
25 ng/mL
control
(% of control)
140
120
100
control
0
3 ng
3
6 ng
6
12 ng
12
25 ng
25
Pcocell MTD-VEGF (ng/mL)
(% of control)
80
Cells/Fields
175
Number of Migrating
Cell Proliferation
160
150
125
100
75
50
control
control
5 ng/mL
25 ng/mL
Increased cell proliferation of HUVEC cells was
observed after 72 hrs treatment of MTD-VEGF.
MTD-VEGF
MTD-VEGF treatment greatly enhanced the migration
of HUVEC cell compared to control.
Skin Permeability & Collagen synthesis
Efficacy of acetylpentapeptide-MTD
 Cadaver skin permeability of
acetylpentapeptide-MTD
 In vitro collagen synthesis efficacy
of acetylpentapeptide-MTD
20
14.2
15
10
5
0.5
Collagen synthesis (% of control)
Human Cadaver Skin Flux rate (%)
120.0
115.0
Conc. : 10 ppm
Cell-line : NHDF
110.0
105.0
100.0
95.0
90.0
0
Acetyl pentapeptide
(AP)
IntoSkinCell-AP®
MTD-AP
control
AP
MTD-AP
pII SKIN™ Solutions
Products
functions
Regenerative Antiwrinkle Cream
Anti-wrinkle
Characteristics
Advanced skin permeability of growth factors and
peptides effective for skin elasticity : MEGF. MFGF,
MVEGF, P2Skin-AP, P2Skin-AH
Exceptional efficacy of anti-wrinkle and skin
elasticity, compared to any other brand’s products
New concept whitening ingredient by the
collaboration with Institut Curie
Bright Whitening
Serum
Whitening
IP co-application and registration in
International Cosmetic Ingredient Dictionary(ICID)
New concept whitening serum strengthened with
anti-wrinkle and skin elasticity
Multi-factors Double
Action
High-performance
-
skin regeneration
anti-aging
anti-wrinkle
whitening
Development of high-performance ampule
containing highly purified and concentrated
ingredients
Outstanding efficacy of anti-wrinkle and elasticity
via customized ampule application
Strengthened skin regeneration and elasticity with
the simultaneous use of anti-wrinkle cream
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The main ingredients of pII-SKIN™ solutions
Skin penetrating
MTDs
Skin penetration
Intracellular delivery
ProCell patented MTDs
M085, M1067, M2173A etc.
Growth Factors
Anti-aging/wrinkle
Hair regrowth
EGF, FGF-2, KFG, VEGF,
IGF-1, SCF, PDGD etc.
Functional proteins
Hormones
Anti-oxidation
Slimming
SOD, Irisin, FGF21 etc.
Functional Peptides
Anti-wrinkle
Whitening
Acetyl & Amidated
Di, Tri, Penta-peptides
Natural Materials
Moisturization
Skin nourishment
Plant extracts
Natural origin proteins
PROCELL Anti-wrinkle Cream
PROCELL Regenerative Anti-wrinkle Cream contains ProCell’s platform technology-applied human growth factors such as
EGF, FGF, and VEGF designed for efficient transdermal delivery and high-performance peptides for anti-wrinkle, and
efficient delivery of these active ingredients into skin fibroblast cells helps skin regeneration and lifting.
ProCell Regenerative Anti-wrinkle Cream
Anti-wrinkle cream developed using innovative
human growth factors including EGF, FGF, VEGF
effective for anti-wrinkle and cell regeneration
Application
Anti-wrinkle, skin cell regeneration, and anti-aging
• MTD-applied skin permeable human growth factors
Main
Ingredients
- MTD-EGF, MTD-FGF, MTD-VEGF, and other growth factors
• MTD-applied skin permeable cell regenerative peptides
- MTD-conjugated peptides
• EGF(Epidermal Growth Factor): interacts with skin cell receptors
and boosts proliferation of dermal fibroblast cells, and has
function of skin regeneration, anti-aging, and anti-wrinkle
ProCell Regenerative Anti-wrinkle Cream
- Boosting the proliferation of dermal fibroblast
cells – anti-wrinkle effect
- Enhanced skin elasticity through increased
collagen synthesis
- Reduction in transepidermal water loss(TEWL)
* Skin irritation and cytotoxicity test completed
Characteristics
• FGF(Fibroblast Growth Factors) and VEGF(Vascular Endothelial
Growth Factor) induce proliferation and differentiation of
dermal fibroblast cells, and endotherial cells in blood vessel.
Both factors enhance the synthesis of collagen and elastin, finally
elevating skin elasticity.
• Nonapeptide-29 Pentapeptide-4 and Nonapeptide-29
Hexapeptide-8: ProCell’s patented peptides highly effective for
collagen synthesis and skin lifting.
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PROCELL Skin Regenerative Ampule
pII SKIN Multi-factors Double Action System is developed by the aid of ProCell’s innovative platform technology designed
for efficient transdermal delivery of bioactive ingredients, and pII SKIN’s unique and optimized combination ratio of skin
permeable growth factors helps effective skin regeneration and lifting.
pII SKIN Multi-factors Double Action
pII SKIN Multi-factors Double Action contains
highly purified and concentrated skin-permeable
human growth factors effective for anti-aging and
anti-wrinkle. Also, pII SKIN Multi-factors Double
Action helps skin regeneration via prompt and
efficient delivery of human growth factors into
skin
Application
• Anti-wrinkle, collagen synthesis, and improved skin elasticity
• Whitening and moisturization
• MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF2, MTD-VEGF
Main
Ingredients
• MTD-applied skin permeable cell regenerative peptides
- MTD-Acetylpentapeptide, MTD-Acetylhexapeptide
• Niacinamide, Adenosine, Tranexamic acid
• Ampule
- Concentration of growth factors, based on their optimized
combination ratio, and exceptional skin elasticity and
regeneration
- Anti-wrinkle and lifting effects on sagging skins
- Whitening via anti-oxidants and whitening ingredients
pII SKIN Multi-factors Double Action
- Boosting skin elasticity and regeneration
- Anti-wrinkle and lifting effects on sagging skins
- Whitening via anti-oxidants and whitening
ingredients
* Skin irritation and cytotoxicity test completed
Characteristics
• Regenerative Anti-wrinkle Cream
- Improved skin elasticity and regeneration, after application
of Ampule on deeply lined and sagging skins
- Skin protection by reduction of Transepidermal Water Loss
- Improved skin elasticity through collagen synthesis
PROCELL Whitening Serum
Whitening serum was developed by the application of ProCell’s innovation platform technology to Institut Curie’s new
concept whitening ingredient. Its main functions are inhibition of melanin translocation and melanogenesis, and
consequent reduction in melanin pigmentation
ProCell Bright Whitening Serum
ProCell Whitening Cream Serum Fresh
Main ingredient of PROCELL WHITENING SERUM
Was developed by the application of ProCell’s
Innovative platform technology to Curie’s new
Concept whitening ingredient.
Application
Whitening, Anti-oxidant, and moisturizing
• Co-development material with Institut Curie, France
Main
Ingredients
- MTD-Kif13A
• MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF, MTD-VEGF
• Inhibitory effect of melanin translocation
• Melanogenesis inhibition
PROCELL whitening Serum
• Reduction in melanin pigmentation through the
- Inhibitory effect of melanin translocation
deoxidation and removal of produced melanin
- Melanogenesis inhibition
- Reduction in melanin pigmentation
through the deoxidation and inhibition
of melanin synthesis
- Boosting collagen synthesis
Skin irritation and cytotoxicity test
completed
Vol.: 30 mL
Characteristics
• Boosting collagen synthesis
• Strengthened moisturizing effect
• Skin anti-aging effect using Omega ingredient rich in
vegetable oil and lycopene
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Thank you for your attention !