Download 2010 Annual Research Report, Princess Alexandra Hospital

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2010 Annual
Research Report
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Centres for
Health Research
NS L AT
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Translating discoveries
to better health
T1 – Translation to first in humans:
Findings from basic research are tested for clinical effect and/or applicability.
T1 research yields knowledge about human physiology and the potential for
intervention.
T2 – Translation to patients (refer page 17)
T3 – Translation to clinical practice (refer page 23)
T4 – Translation to population health (refer page 134)
Translation to
Community
T4
T1
Practice to
Population
Translation
to Patients
Translation
to Practice
Application to
Evidence
Evidence to
Health Practice
T2
T3
© Centres for Health Research Annual Research Report 2010.
This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part of
this publication may be reproduced by any process without prior written permission from the Princess
Alexandra Hospital Centres for Health Research. Enquiries should be directed to the Director, Research
Development & Ethics, Centres for Health Research, Princess Alexandra Hospital.
ISSN 1833-6574
Contents
02
Message from the District
CEO and PAH Executive
Director
04 Message from the Director
Research Development & Ethics
06 Translating our research
into practice
10 The University of
Queensland at the Princess
Alexandra Hospital
12 Queensland University of
Technology at the Princess
Alexandra Hospital
14 Postgraduate Research
17 Committee Reports
18
20
22
Human Research Ethics
Committee
Health Practitioner
Research Collaborative
The PA Research
Foundation
23 Group Reports
24
26
27
28
32
33
35
37
39
Acquired Brain Injury
Outreach Service
Alcohol and Drug Research
Anaesthetic Department
Australian Prostate
Cancer Research Centre Queensland
Brain Injury Rehabilitation Unit
Breast & Endocrine Surgery Unit
Cardiology
Cardiothoracic Surgery
Cardiovascular Imaging
Research Centre
41
44
46
52
54
57
59
61
64
66
69
71
72
75
77
81
82
84
86
88
90
91
92
94
98
101
102
103
105
Centre for Functioning and Health Research
Centre for Integrative
Clinical and Molecular
Medicine
Centre for Kidney Disease Research
Centre for Liver Disease Research
Centre for Research in
Geriatric Medicine
Clinical Governance
Clinical Pharmacology
Dermatology Research
Centre
Diabetes & Endocrinology
Diamantina Institute
Ear Nose Throat
Emergency
Endocrine Hypertension
Research Centre
Gastroenterology &
Hepatology
Haematology
Infection Management
Services
Intensive Care Unit
Internal Medicine & Clinical
Epidemiology
Medical Oncology
Mental Health
Microbiology
Neurosurgery
Nursing Practice
Development Unit
Nutrition & Dietetics
Occupational Therapy
Older Persons Mental
Health
Ophthalmology
Pathology Queensland
Pharmacy
107 Physiotherapy
109 Plastics & Burns
110 Queensland Clinical Trials & Biostatistics Centre
112 Queensland Melanoma
Project
114 Queensland Spinal Cord
Injuries Service
117 Radiation Oncology (PAH)
119 Radiation Oncology (Mater)
120 Radiology
122 Respiratory and Sleep
Medicine
124 Speech Pathology
126 Therapeutics Research
Centre
129 Trauma Service
131 Upper Gastrointestinal & Soft Tissue
133 Vascular Medicine
134 Publications, Major
Grants & People
135 Journal Articles
156 Books & Book Chapters
158 Abstracts & Conference
Proceedings
163 Accepted for Publication (In Press)
167 Summary of Publications
and Postgraduate Students
168 Major Grants
172 Committees
173 Research Staff by
Department
179 Postgraduate Students
Message from the District CEO
and the PAH Executive Director
It is with great pleasure that we present the Princess Alexandra Hospital
(PAH) Centres for Health Research Annual Research Report for 2010. We
are delighted to reflect on another year of outstanding achievements.
The year has been productive for researchers on the campus with a large
proportion of translational research undertaken.
David Theile
Richard Ashby
This translation of research into better patient health is what we are
all aspiring to and, indeed, expecting. We are committed to continuing
to achieve this by working in partnership with our universities and in
collaboration securing and growing a critical mass of high-calibre scientists
and clinicians, and contributing to state-of-the art infrastructure.
All achievements in research should
Increase in Research Performance
be celebrated. This report showcases
As highlighted in this report our research
the breadth of achievements and
performance on campus continues
commitment of researchers on
to increase. The NHMRC awarded
this campus. These are evidenced
grants totalling over $8.8M to twelve
by prestigious grants, research
chief investigators based at the PAH.
breakthroughs and awards. The benefits
In addition, eight PAH Private Practice
of our academic health partners are
Grants; four Smart State Grants and
becoming evident and will be further
four Health Research Fellowships were
amplified with the opening of the
awarded. This funding is vital for our
Translational Research Institute in 2012.
investigators to continue their valuable
In this annual report, we are delighted to
reflect on the extraordinary success and
achievements of our research scientists
and clinicians.
2
research - key to health
research. The number of world-class
publications featured in high calibre
journals such as Nature Genetics also
increased.
Awards and Recognition
Increase in Collaborations
is a vital part of the commitment Awards and recognition for researchers
It is truly pleasing to see the number
of the hospital to further strengthen based at the hospital is reflected
of examples of our researchers and facilitate the integration of throughout this report. Professor
collaborating with local, national and
research and teaching with clinical Ian Frazer, Director, University of
international experts to achieve world-
care through our partnership in the
Queensland Diamantina Institute,
class research outcomes.
academic health centre.
PAH Week – Leading Health in a
Professor Ken Ho has been appointed
Changing World
as the new Chair of the Centres for
The Princess Alexandra Hospital
Health Research. He will join us full-
has been in existence for 54 years
time from St. Vincent’s Hospital and
and during this time has reached
the Garvan Institute in Sydney in early
international stature in many
2011. As a successful and influential
areas, including liver and kidney
clinical researcher, he will make a strong
transplantation, melanoma treatment,
contribution to the research efforts
laparoscopic surgery, gout research
at the PAH. We look forward to his
Professor Matt Brown from the
and treatment, cardiovascular disease
leadership.
University of Queensland's Diamantina
management and the development of
Institute was awarded the prestigious
the vaccine for cervical cancer.
was awarded the 2010 Ernst & Young
Champion of Entrepreneurship
(Northern Region) Award in recognition
of his discoveries that led to the
development of the world’s first cervical
cancer vaccine. With immunisation
programs initiated across the world, this
is a true indicator of translating scientific
discoveries to the patient.
2010 Parr Prize from The Australian
Rheumatology Association recognises
outstanding achievement in
rheumatologic research. Matt's research concentrates on identifying
the genetic causes of common forms
of arthritis, osteoporosis and multiple
sclerosis, providing avenues for future
treatment options.
Another highlight was the Australian
Society of Medical Research awarding
Dr Maher Gandhi, Clinician Researcher
of the Year for his work on understanding
the biological features of lymphoma.
In 2010, the hospital successfully hosted
PAH Week bringing together experts
from all manner of clinical professions to
present their knowledge and experience
thereby promoting quality care for
patients and improved staff training.
Professor David Theile
CEO, Metro South Health
Service District
AO, PhD (Hon), MBBS (Hons) (Qld), MS, FRACS,
FRCS (Eng), FRCS (Ed) (Hon), FANZCA (Hon)
Additionally, PA Week showcased the
considerable achievements of research
conducted on campus.
Dr Richard Ashby
Executive Director,
Princess Alexandra Hospital
Centres for Health Research
The PAH Centres for Health Research, established by the Princess Alexandra Hospital in 1998, AM, MBBS (Qld), BHA (NSW), FRACGP, FRACMA,
FACEM, FIFEM
Centres for Health Research 2010 Annual Research Report
3
Message from the Director
Research Development & Ethics
Areti Gavrilidis
2010 has been an outstanding year noteworthy on a number of fronts.
We have continued to build on growing achievements in parallel with
major developments on the PAH campus. The new Translational Research
Institute (TRI) building is emerging from the ground and is on schedule for
occupancy in late 2012. A forum held in September provided an update
on the plans of the development. The TRI is a joint venture between
The University of Queensland, Queensland University of Technology,
Mater Medical Research Institute and the Princess Alexandra Hospital
(Queensland Health). We are poised to leverage the many opportunities of
our partnerships within the TRI.
The Princess Alexandra Hospital is
appeals to ensure their continuation.
committed to excellence in patient care
We congratulate all our researchers and
supported by world’s best research
wish and thank the dedicated work of
practice led by the world’s best
the foundation and funding team.
researchers. This is truly an exciting time
for us working here in an environment
of strengthening of academic health
partnerships.
The research groups at the hospital
garnered greater success in securing
competitive peer review grant funding
(see Group Reports section) in particular
NHMRC funded fellowships and project
grants. The PA Research Foundation and
Private Practice boosted their support
of research to $900,000 in 2010 for
research (in 2011), again ensuring that
high quality research is supported. In
addition, over $200,000 was provided to
current research projects through direct
4
research - key to health
We have also been very encouraged that
the estimated total research income for
2010 has increased by over 30%.
Publications are vital for research to
be translated into improved health
outcomes for our community. Our
researchers published over 590 papers
and book chapters, representing about
a 25% increase to the 2009 output. The publication profile is likely to
continue to increase based on a
25% increase in investigator initiated
applications to our Human Research
Ethics Committee this year.
This year has also seen an increase in
doctoral appointment at the University
the number of postgraduate students
of Sydney. We wish her all the best with
350
totalling 220 students on campus
her academic career. We express our
300
from our local and other collaborating
appreciation to Associate Professor
universities.
Carl Kirkpatrick, Dr Eleanor Milligan, Dr
for Functioning and Health Research
in mid-2010 and the launch in October
Scott Campbell and Associate Professor
200
Richard Roylance for assisting with
150
the Chairing of the HREC meetings
100
following Dr Fleming’s departure.
of the Health Practitioner Research
Our appreciation to all those who Collaborative (formerly the Allied Health
helped to enhance the research
Research Collaborative) which should
performance on the campus particularly
be a further stimulus to enhance
the staff of the Centres for Health
research activities across the district.
Research. The Centres for Health
There were a number of achievements
in Nursing including Professor Leanne
Aitken's membership to the team who
gained Australia's first nursing-focused
NHMRC Centre of Research Excellence.
The NHMRC Centre of Research
add services to support our research
community. We look forward to working
with our academic, research and health
care partners in 2011.
for Hospitalised Patients (NCREN) will
leadership and experience when he
focus on generating and implementing
moves to Brisbane to take on the
evidence into clinical practice. In
leadership role of Chair of the Centres
addition the nursing team is leading
for Health Research in early 2011.
will commence a second RCT on the
management of facial suture lines.
We thank the Human Research Ethics
centre research. Jennifer stepped down
2008
2010
2000-2010
500
400
300
200
100
0
‘00 ‘01 ‘02 ‘03 ‘04 ‘05 ‘06 ‘07 ‘08 ‘09 ‘10
Year
Higher Degrees
2000-2010
250
which is a summary of what has been
200
PhD
Masters
achieved in 2010 through a wealth of
partnerships and collaborations.
of research applications. Under the
conduct single ethical reviews of multi-
2004
2006
Year
600
this thirteenth Annual Research Report,
efforts in reviewing the large load
HREC was certified by the NHMRC to
2002
Total Publications
It gives me great pleasure to present
Committee (HREC), for their tireless
leadership of Dr Jennifer Fleming, the
2000
700
facilitates research and will continue to
We look forward to Professor Ho’s
the management of skin grafts and
0
Research fosters an environment that
Excellence in Nursing Interventions
a randomised-control trial (RCT) on
50
Number of Publications
Health was the founding of the Centre
2000-2010
250
Total Number
A significant achievement for Allied
New Submissions to the HREC
150
100
50
Ms Areti Gavrilidis
0
MBA, Grad Dip Bus Admin, BSc, BAppSc, Churchill Fellow
‘00 ‘01 ‘02 ‘03 ‘04 ‘05 ‘06 ‘07 ‘08 ‘09 ‘10
Year
as Chair in July 2010 to take up a post-
Centres for Health Research 2010 Annual Research Report
5
Translating our research
into practice
Vaccine development leading to
public health policy
HPV vaccine development started with basic research on how HPV works
as a virus to cause cervical cancer, undertaken by Professor Harald zur
Hausen and his colleagues in the early 1980s. Discovery of the technology
for HPV virus like particle production by Jian Zhou and myself in 1991,
which arose from studies on how the virus assembled itself, lead to
preclinical studies of their immunogenicity in animals, to see if they might
form the basis of a vaccine to protect against cervical cancer.
Ian Frazer
Vaccination to prevent cervical cancer
has now become public health policy
in at least 20 countries world-wide
with over 70 million doses of vaccine
delivered to date.
By 1995 clinical trials of vaccines based
in the developing world, and programs
on HPV Virus like particles in human
of education on vaccine use.
subjects were showing immunogenicity
and safety. These findings lead to larger
scale vaccine trials over the next 8 years
to prove efficacy and safety, conducted
by the pharmaceutical companies
who were developing the commercial
vaccines. Positive findings from these
studies were presented to the US and
Australian regulatory authorities in
2005, resulting in release of a licenced
vaccine in 2006. Since then we have
been conducting studies in Vanuatu of
uptake and field efficacy of the vaccines
6
research - key to health
Vaccination to prevent cervical cancer
has now become public health policy
in at least 20 countries world-wide
with over 70 million doses of vaccine
delivered to date. Large scale studies
to measure the impact of the vaccine
programs on cervical cancer and
genital wart incidence in Australia and
elsewhere are now underway.
Professor Ian Frazer
Director, University of Queensland
Diamantina Institute
Measuring activity of older patients
to reduce cost of hospitalisation
Older patients in hospital quickly
of activity of their patients, most often
become deconditioned when they spend
over-estimating by 100%.
long periods of inactivity. A common
strategy to “prevent” and “treat” this
deconditioning is to encourage regular
sitting out of bed and walking throughout
Len Gray
the day. Even though this activity is often
“we plan larger scale studies
to examine whether an activity
intervention might either improve the
patient outcomes or reduce the cost
of hospitalisation”
“prescribed”, no one can be sure that
anything actually happens. At the Centre
Project Grant, we are conducting a
study to investigate if accurate activity
information about activity (derived
from accelerometers) is offered daily
to patients and their treatment team
together with daily targets, then the level
for Research in Geriatric Medicine, we
of activity increases (T3 translation). We
are using accelerometers to monitor
plan larger scale studies to examine
patients’ daily activities. First we needed
whether this intervention might either
to demonstrate that these devices
improve patient outcomes or reduce the
actually measure activity accurately
cost of hospitalisation (T4 translation).
(lying, sitting, standing, walking) in older
patients, with abnormal gait patterns (T2
With the support of an NHMRC
translation). We also demonstrated that
clinicians have little idea about the level Professor Len Gray
Director, Centre for Research in
Geriatric Medicine
Director, Centre for Online Health
Genetics of common and
rare human diseases
Matthew Brown
”My main research interest for
the past 15 years has been the
genetics of ankylosing spondylitis...
gene-mapping programs that have
identified all 13 non-MHC genes
thus far robustly associated with
the disease”
We research genetics of common and
ankylosing spondylitis, where I have led
rare human diseases, and investigate
the gene-mapping programs that have
the mechanisms by which genes
identified all 13 non-MHC genes thus
associated with disease operate in
far robustly associated with the disease.
those conditions. We have a particular
My group have been at the forefront
focus on bone and joint diseases,
of development of new methods for
but research quite a diverse range
mapping human diseases including
of conditions including neurological
during the genomewide association
diseases such as multiple sclerosis,
study era, and more recently with the
schizophrenia, intracranial haemorrhage
advent of sequencing based gene-
and motor neurone disease, ocular
mapping approaches.
diseases, and asthma.
Our main research interest for the past
15 years has been the genetics of
Professor Matthew Brown
Research Leader Musculoskeletal
Genetics Group, Diamantina Institute
Centres for Health Research 2010 Annual Research Report
7
Detection of primary aldosteronism
Michael Stowasser
Excessive aldosterone (PA) findings
in hypertensive patients have
“closed the circle” in supporting our
recommendation that all hypertensive
patients should be screened for PA, so
that those found to have this important
condition can benefit from the effects of
specific, optimal treatment approaches.
With hypertension being the commonest
around the world. Not only has this
chronic condition affecting Western
meant improved health outcomes for
countries and usually requiring lifelong
those patients, but it has facilitated
medications to prevent complications
a flurry of clinical research studies
such as stroke, heart and kidney
assessing causes and effects of PA.
disease, detection of underlying causes
Examples are work by our Centre and of
such as primary aldosteronism (PA) can
others demonstrating that aldosterone
be a major breakthrough for patients,
excess has harmful effects that go
bringing with it the chance of more
beyond just raising blood pressure,
effective, specific treatment and but which are ameliorated by specific
even cure.
surgical and medical treatments
Our work demonstrated a previously
unrecognised, high prevalence of PA
of up to 5-10% among hypertensive
patients, and its efforts to raise
awareness of this nationally and
internationally, have had major and
targeting excessive aldosterone action.
These findings have “closed the
circle” so that those found to have this
important condition can benefit from
the effects of specific, optimal treatment
approaches.
widespread clinical impacts, with
Professor Michael Stowasser
thousands of patients (who would
Director, Endocrine Hypertension
otherwise have been missed) being
Research Center
diagnosed among dozens of centres
Asthma and other chronic lung
diseases
workings of the immune system in
John Upham
Understanding what is going wrong (in
people with asthma and other chronic
lung diseases) is a first step to keeping
people well and avoiding the need to
spend time in hospital.
Our ultimate goal is to improve the
existing influenza vaccines and to
develop a new vaccine for rhinoviruses
that could be used in people with lung
diseases.
research - key to health
lung diseases. Understanding what is
going wrong is a first step to keeping
people well and avoiding the need to
spend time in hospital. Our ultimate
People with asthma and other chronic
goal is to improve the existing influenza
lung diseases can become very unwell
vaccines and to develop a new vaccine
when they develop infections caused
for rhinoviruses that could be used
by rhinoviruses (the common cold virus)
in people with lung diseases.” (T1
and influenza. We think this happens
translation)
because the immune system does
Professor John Upham
Director, Lung and Allergy Research
Centre
not function as well as it should. We
are performing a detailed study of the
8
people with asthma and other chronic
Understanding and Reducing the
Burden of Kidney Disease
Carmel Hawley
“Our investigation across the spectrum
of basic and translational studies is
aimed to reducing the burden of kidney
disease in Australia and internationally”
Kidney disease contributes directly or
The Department of Transplant Surgery
indirectly to at least 10% of deaths in
at Princess Alexandra Hospital has
Australia. Despite a rapid improvement
recently become the first transplant unit
in treatment options during the last 20
in Australia to use a machine perfusion
years, the mortality rate remains high in
organ preservation system. This system
end-stage kidney disease patients. We
has the potential to lead to a reduction
are currently undertaking clinical studies
in tissue damage caused by lack of
examining interventions to improve
blood supply before transplantation.
outcomes in chronic kidney disease
patients (T2 translational research). Our
researchers are identifying molecular
biomarkers to aid in improved diagnosis
for kidney disease with the ultimate goal
of improved prognosis. The CKDR is
actively involved in understanding the
clinical implications of the higher risk
of cardiovascular disease for patients
with chronic kidney disease (CKD).
Our investigators are examining the
Our researchers are examining the
clinical outcomes of kidney damage
between kidneys which were placed on
ice prior to transplantation and kidneys
that were machine perfused. This clinical
trial will enhance the understanding of
the risk factors and health cost benefit
of machine perfusion and may aid in
clinical decision making regarding organ
perfusion and allocation.
prevalence, severity and relationship
Associate Professor Carmel Hawley
between bone disease and vascular
Centre for Kidney Disease Research
disease in early CKD aimed at earlier
detection of abnormalities to ensure
better treatment.
Centres for Health Research 2010 Annual Research Report
9
The University
of Queensland
at the Princess Alexandra Hospital
Faculty of Health Sciences, UQ
Many schools and centres within the Faculty of Health Sciences have a
long history of collaborative research with the Princess Alexandra Hospital.
The sustained impact of outcomes obtained from projects conducted by
School of Medicine research groups with the Princess Alexandra Hospital is a reflection of this illustrious history.
Gregory Monteith
David Wilkinson
10
research - key to health
In addition to the growing research
Excellence in Research for Australia
links with other units within the Faculty
(ERA) initiative saw the University of
of Health Sciences such as the School
Queensland ranked at the highest
of Health and Rehabilitation Sciences
level (well above world standard)
and the School of Population Health,
for Biomedical and Clinical Health
new opportunities are now emerging.
Sciences. The quality of research
The opening of the Pharmacy Australia
conducted at Princess Alexandra
Centre of Excellence (PACE) which
Hospital across a diverse array of
houses the UQ School of Pharmacy and
fields (from liver disease to e-health
the soon to be completed Translational
delivery and occupational therapy
Research Institute will see a further
to cardiovascular disease) was a
strengthening of research links between
contributor to this excellent result.
the University of Queensland and
Princess Alexandra Hospital. The 2010
Associate Professor Gregory Monteith
Associate Dean (Research)
School of Medicine
As Australia’s global medical school,
education our medical students receive
awarded nine project grants totalling
The University of Queensland’s School
is absolutely up to date and inspires
over $4.75 million to commence in 2011,
of Medicine offers a variety of clinical
research curiosity and endeavour in
along with two prestigious fellowships
and research training experiences within
the next generation of the medical
with many of these based at PAH. Our
Australia and internationally, and the
workforce. In 2010, nearly 500 of
largest grant was awarded to a team
research activity at PAH campus is a
our year 2, 3 or 4 medical students
led by Associate Professors Andrew
critical element in our success and our
spent some of their placements at the
Barbour and Mark Smithers, in the
international reputation for excellence
research-rich PAH campus.
Discipline of Surgery at PA-Southside.
and quality in medical research and
education.
The School of Medicine research activity
at PAH has major focus in ten research
The School of Medicine operates over
centres, which in 2010 include the Centre
a number of different sites including
for Research in Geriatric Medicine,
Queensland Health and private hospitals.
Dermatology Research Centre, Centre for
There are 10 Clinical schools, including
Liver Disease Research, and a node of
schools in Brunei and New Orleans,
the Liver Research Centre (Greenslopes
and 11 Academic disciplines that have
Private Hospital), the Cardiovascular
an overarching role in promoting and
Imaging Research Centre, Centre for
supporting teaching and research in
Kidney Disease Research, Centre for the Clinical Schools: Anaesthesiology &
Integrative Clinical and Molecular
Critical Care, General Practice, Medical
Medicine, Lung and Allergy Research
Imaging, Medical Education, Molecular
Centre, Therapeutics Research Centre
& Cellular Pathology, Obstetrics &
and the Endocrine Hypertension
Gynaecology, Medicine, Paediatrics &
Research Centre.
Child Health, Rural & Remote Medicine,
Their team have been awarded
nearly $792,000 over 5 years for their
appropriately named DOCTOR trial,
studying DOCetaxel with or without
radiation therapy for resectable
oesophageal adenocarcinoma. Other
NHMRC grants to commence at PAH
were awarded to Professor Len Gray,
Director of the Centre for Research
in Geriatric Medicine and Acting
Director of the Centre for Online Health;
Professor Peter Soyer, Director of
the Dermatology Research Centre;
Associate Professors Elizabeth Powell,
Julie Jonsson and Andrew Clouston of
the Liver Disease Research Centre; Dr
Beyond these school centres, research
Tarl Prow and Professor Michael Roberts
is conducted by our academics
of the Therapeutics Research Centre;
The School of Medicine offers
integrated in the hospital’s clinical
and Professor David Johnson of the
opportunities and encouragement for
departments. Professor Jenny Martin,
Centre for Kidney Disease Research.
staff members to engage in research
as Head of the PA-Southside Clinical
A prestigious NHMRC Practitioner
projects that meets local, national
School has actively encouraged
Fellowship was also awarded to the
and global needs and to disseminate
collaboration between the School
Centre for Liver Disease Research’s
the results through prestigious peer-
of Medicine and PAH medical staff,
Associate Professor Elizabeth Powell
reviewed journals. The School’s close
supporting joint positions and academic
adding to the outstanding list of
integration into the hospital community
titles with the School of Medicine and
successes by groups at the PA-
means that our research is relevant
multiple partnerships with research
Southside Clinical School in 2010.
and the outcomes of that research is
groups, other universities and hospitals.
Psychiatry and Surgery.
swiftly translated into improved health
practices and real clinical outcomes.
Our clinical and research academics’
engagement in research means that the
The end of 2010 brought outstanding
Professor David Wilkinson
Head School of Medicine
success with NHMRC funding, with
School of Medicine researchers being
Centres for Health Research 2010 Annual Research Report
11
Queensland University
of Technology
at the Princess Alexandra Hospital
Cooperation between researchers from the Queensland University of
Technology’s Institute of Health and Biomedical Innovation (IHBI) and the
Princess Alexandra Hospital contributes to IHBI’s goal of relevant, high
priority research to benefit patients in the near future.
QUT researchers are active members of the PAH, with trauma, prostate
cancer, and nursing practice research being conducted at the PAH campus.
Trauma
Ross Young
The QUT Trauma Research Group
12

Improvement of fracture healing,
headed by Professor Michael Schuetz,
including mechanobiology;
orthopaedic and trauma surgeon,
biomechanics; and biology of The Institute of Health and Biomedical
Innovation (IHBI) is a collaborative
institute based at QUT, devoted to
improving the health of individuals
through research innovation. We
combine high quality health research
with a commitment to social justice. This
means that we do more than develop
innovative solutions to health issues. We
also apply our solutions to real world
experiences to make sure that they are
effective. Through our work, we seek to
improve the health of individuals and of
communities.
includes engineers and computer
fracture healing
IHBI's researchers focus on three
broad health areas - prevention;
mind and body health; and recovery.
IHBI's researchers are clustered
into five flexible research domains
that emphasise multidisciplinary
collaboration:
defined the group’s research strengths

Cells & Tissue

Human Health & Wellbeing

Injury Prevention & Rehabilitation

Medical Device

Vision Improvement
research - key to health
scientists, working with surgeons, and
emergency specialists at the PAH. This
Group improves community capacity
to respond to trauma and creates more
effective clinical services for severely

Optimisation of implant design,
incorporating musculoskeletal
imaging; variability in bone shapes;
implant fit assessment/optimisation
injured patients. It focuses on bone
In August, the Trauma Research
fracture healing through computer
Group held a successful showcase of
modelling, developing bone substitutes
their research at the PAH, providing
and infection resistant implant coatings.
an overview of current projects. The
Strategic planning in early this year
and the group was structured around
the themes of:

Complications in fracture healing,
incorporating infection/inflammation;
soft tissue trauma; and bone nutrition
showcase targeted medical students
and doctors in training who were
interested in participating in clinical and
experimental research projects. There
was a strong show of interest from third
year medical students with several now
participating on research projects.
Nursing Practice
QUT is conducting multiple

Identifying the relationship between

Health promotion and risk-
nursing-specific research projects
biochemical markers and healing
reduction behaviours of younger
in collaboration with PAH. Led by
in chronic leg ulcers treated with
female survivors of breast and
Professor Patsy Yates, the QUT School
compression
haematological cancers
of Nursing’s Director of Research,
Professor Helen Edwards, Head of
School, and Dr Alexandra McCarthy,
Senior Lecturer, the collaboration
incorporates a variety of projects
examining key health issues including:

Prevalence and determinants of
health promotion and risk reduction of
younger female cancer survivors

Evaluating novel methods for
This year, the group received an
delivering non-pharmacological
Australian Government Department
interventions for dyspnoea in cancer
of Health and Ageing grant to develop
patients
and trial cancer survivorship plans.

Evaluating a prescribed exercise
intervention for patients with venous
leg ulcers
Dr McCarthy was awarded PAH
Private Practice Funding to evaluate a
cryotherapy intervention for docetaxelinduced hand and nail toxicities.

Cryotherapy for docetaxel-induced
nail toxicities: Case control study
Prostate Cancer
The QUT Prostate Cancer Program,
tissue microarrays elucidating pathways
The program has a significant presence
directed by Professor Colleen Nelson
associated with poor response to
on the PAH campus, and aspires to trial
and Professor Judith Clements at the
treatment.
new potential prognostic biomarkers
Australian Prostate Cancer Research
Centre – Queensland (APCRC-Q),
examines therapeutic and biomarker
development for prostate cancer and
involves geneticists, protein chemists,
urologists, oncologists and clinical
pharmacologists.
The program is working collaboratively
with commercial partners in the US and
UK, and has established the national
Australian Prostate Cancer Bio-resource.
and therapeutics at PAH. The group
continues to create and evaluate new
methods for more effective diagnosis
and treatment of prostate cancer.
This year saw the recruitment of Dr
Preparations for the move into the TRI in
Derek Richard, an ARC Future Fellow,
2012 will intensify during 2011.
and his team to IHBI at Kelvin Grove, to
It employs high throughput bioprofiling
continue their successful research into
of prostate cancer tissues to
on the interactions between genes and
characterize the molecular mechanisms
proteins and their effect on prostate
underlying disease progression.
cancer. Program senior researcher,
The research validates the relevance
Professor Pamela Russell was awarded
of potential targets through the
the Prostate Cancer Foundation of
expression of candidate genes on
Australia Researcher of the Year award.
Professor Ross Young
Executive Director IHBI
Centres for Health Research 2010 Annual Research Report
13
Postgraduate
Research
Nigel completed his PhD “Androgen receptor, caveolin-1 and androgen self-sufficiency in prostate cancer” at The University of Queensland, supervised
by Associate Professor Glenda Gobe.
Nigel Bennett
Prostate cancer is the third most
by the steroids, testosterone and
common cancer and the second
dihydrotestosterone. Its activity is
leading cause of male cancer deaths
further modulated by co-regulators,
in Western countries. With an aging
proteins that directly interact with the
population, prostate cancer incidence
androgen receptor. Nigel’s PhD project
continues to rise. More research is
investigated the relationship between
needed, to develop accurate early
caveolin-1, a membrane bound protein
detection assays, and to successfully
that is reported to have androgen
treat patients suffering from advanced
receptor co-regulator functions, and
castrate-resistant disease.
the steroidogenic potential of prostate
The androgen receptor is an integral
protein in the development and
The group have already had two invited
prostate cancer. Blocking androgen
review articles published (IUBMB Life
receptor activity causes atrophy of
and Int J Biochem Cell Biol).
The androgen receptor is activated
research - key to health
steroids of the androgen receptor.
maintenance of the prostate and
both the prostate and prostate cancer.
14
tissue for synthesising the activating
Dr Adam Frankel
Adam is completing his PhD as part
an attempt at curative treatment. For
of his training in General Surgery
those who are, treatment is very invasive
under the supervision of Associate
and aggressive, usually involving
Professor Andrew Barbour and Dr Derek
chemo- and radiotherapy, as well as
Nancarrow, investigating “Genome-wide
surgery. Adam is investigating whether
analysis of oesophageal cancer towards
molecular markers in the DNA of these
biomarkers of response and outcomes
patients can help to determine who will
of therapy”. Adam recognised early
receive a long term benefit from such
on that the academic side of medicine
treatment. His research is generously
is the means by which the profession
supported by the Paul Mackay Bolton
advances, and wanted to be part of
Scholarship (Royal Australasian College
that evolution. He also thinks a clinical/
of Surgeons).
academic mix will bring better long term
job satisfaction.
In November he presented a poster at
the Surgical Research Society meeting
Oesophageal adenocarcinoma, a cancer
in Adelaide “Copy number in stage
of the food pipe, has the fastest rising
III oesophageal adenocarcinoma –
incidence of any malignancy in the
towards biomarkers for staging and
western world. Survival rates are dismal,
prognostication”.
and many patients are not suitable for
Amy Lubic
Amy started prostate cancer often gives way to recurrent disease.
research because her father is a
There are many side effects including
prostate cancer survivor, and she
metabolic syndrome/hyperinsulinemia
wanted to make a difference with her
onsets rapidly in 55% of men. The
career. She worked under Professor
group hypothesized that this metabolic
Colleen Nelson in Canada before
syndrome/hyperinsulinemia may
commencing her PhD with the
exacerbate CaP progression by initiating
Australian Prostate Cancer Research
cancer survival pathways, specifically
Centre-Queensland investigating “The
steroidogenesis and lipogenesis.
Role of Insulin and IGF2 Signalling on
Possible suppression of these pathways
Metabolic Pathways in Prostate Cancer
by metabolic syndrome drugs,
Progression” at QUT and supervised by
metformin and simvastatin, is also being
Professors Colleen Nelson and Adrian
investigated. Insulin-like growth factor
Herington. The project investigates the
2 is highly upregulated in CaP during
extremely important interaction between
progression, and the group have shown
metabolic syndrome and prostate
that it upregulates steroidogenesis.
cancer progression.
This project has fostered much
Androgen deprivation therapy is
international collaboration. Posters have
the most widely used treatment for
been presented at four conferences,
advanced prostate cancer (CaP),
and a presentation was given at one
which is initially successful, but most
conference.
Centres for Health Research 2010 Annual Research Report
15
Matthew commenced his PhD
glare eliminated. It allows us to view
investigating “Novel approaches to the
colours and structures within a mole
self detection of melanoma: the role
which are not visible to the naked
of dermoscopy” at The University of
eye. Dermoscopy is currently being
Queensland under the supervision of
used by GPs and dermatologists to
Professor Peter Soyer.
identify moles which are suspicious
Matthew has been interested in
dermatology since he was 12, when he
Matthew Luttrell
be captured and sent to a specialist
(teledermoscopy). This research aims to
which is curable if detected early. This
see whether dermoscopy can be used
research aims to give people a tool
by people without a medical background
for identifying moles which need to be
to identify early melanomas.
Matthew has published the results
Matthew has been investigating a new
of his honours study, the AC Rule for
technology called dermoscopy. This
Melanoma, as a research letter in the
is a handheld device which creates
Journal of the American Academy of
a magnified image with surface
Dermatology.
Dr Skoien is undertaking his PhD at pro-inflammatory factors, may represent
The University of Queensland
a key mechanism in disease progression
supervised by Associate Professors
and is being studied using an in vitro
Andrew Clouston, Julie Jonsson and
model of hepatocyte senescence and
Elizabeth Powell
findings validated in vivo. Using liver
(NAFLD) is increasingly common and
patients are at risk of progression to
cirrhosis, liver failure and death. The
development of fibrosis, particularly
portal fibrosis, is more complex than
biopsy specimens from NAFLD patients,
the portal inflammatory response and
its relationship to hepatic progenitor cell
expansion and an associated ductular
reaction are also being investigated for
potential roles in mediating fibrogenesis.
previously thought and the mechanisms
An abstract on heterogeneity fibrosis
that mediate its progression are
patterns and their associations was
incompletely understood.
presented at the 2010 AASLD Liver
Fibrosis patterns in NAFLD are
heterogeneous. Fibrosis in different
areas, such as portal tracts, and their
histological associations are being
examined to investigate whether
multiple fibrogenic pathways may exist.
Cellular senescence, a permanent
replicative arrest where cells still secrete
research - key to health
technology, such that images can
mole. Melanoma is a serious disease
Non-alcoholic fatty liver disease
16
incorporated into mobile phone
visited a specialist with a funny looking
shown to a doctor.
Dr Richard Skoien
for melanoma. It has recently been
Meeting in Boston. Dr Skoien was
awarded the best abstract submitted
by a Research Fellow. His presentation
of the in vitro hepatocyte senescence
model won the Young Investigator
Award at the 2010 Queensland
Gastroenterology Society Update.
Committee Reports
T2 – Translation to patients:
Knowledge from T1 studies is translated to patients. Testing new interventions under controlled
environments to form the basis for clinical application and evidence-based guidelines. Moving new
medical discoveries into clinical practice. T2 research yields knowledge about the efficacy of the
interventions in optimal settings.
T4
Population
Health
T1
Basic
Research
Practice
T2
T3
Human Research
Ethics Committee
Metro South Health Service District
The Metro South Health Service District encompasses Redland and
Wynnum Hospital, Logan and Beaudesert Hospitals, Queen Elizabeth
II Jubilee Hospital and Princess Alexandra Hospital as well as various
Community, Oral and Mental Health facilities.
Jennifer Fleming
The work of the Human Research Ethics Committee continued to be
significant even with the introduction of the Queensland Health single
ethical review of multi-centre research in July. The Committee reviewed
263 new ethics applications in 2010. Investigator-led research applications
increased by 25% whilst pharmaceutical sponsored trials decreased by the
same proportion.
Dr Jennifer Fleming, Chair, HREC
Dr Eleanor Milligan, Acting Chair
Certification
Eleanor Milligan
The Metro South Health Service
interventional studies other than clinical
District’s ethical review processes
trials; Population and/or public health;
were assessed in June and certified
Qualitative health research; Mental
by the NHMRC National Certification
health; Paediatric research
Scheme for single ethical review
This initiative is expected to significantly
for multi-centre research under the
Harmonisation of Multi Centre Ethical
Review (HoMER) Scheme. The Ethics
Committee is now certified to undertake
single ethical review for multi-centre
that can be conducted anywhere in
Australia for the following categories:
Clinical trials Phase I, II, III & IV; Clinical
18
research - key to health
reduce the work loads of researchers
who under HoMER will need to receive
one ethics approval by a certified
committee to conduct the research in
any number of sites across Australia.
HoMER is expected to begin in January 2012.
Monitoring
Program
Professional
Development
Communication
Development
The implementation of a pilot monitoring
Several members of the Committee
To assist researchers navigate through
program allowed the successful
and the Ethics Secretariat attended a
the application process a number of web
monitoring of a number of research
number of professional development
site updates occurred during the year.
projects on site. The program has been
meetings including the following
The Committee under the leadership
established to enhance current monitoring
training and education forums:
of Dr Milligan developed and published
activities. Researchers are still required
to submit Annual Progress Reports, Final
Reports, Serious Adverse Event Reports
and reports from independent agencies
(such as a data and safety monitoring
board) for all ongoing approved research
“Submission Tips” in the December

Queensland Clinical Trials
Network - Implement and Monitor
Compliance with Legal and Ethical
Requirements

Intensive Bioethics Course (IBC) at
activities. As part of the certification
Stonelea Estate Alexandra, Victoria,
process a new Monitoring Officer
organised by Monash University,
position was established to assist with
Centres for Human Bioethics 3
the institutional compliance requirements
December 2010

Queensland Health Research
appointment of a Monitoring Officer and
Ethics Governance Unit, Chairs’
the introduction of the self-audit tool
and HREC Member Forums,
designed to help researchers reflect on
facilitated by Professor Colin
their research conduct will further enhance
Thomson, February and July 2010.
the ongoing success of the program.
http://www.health.qld.gov.au/pahospital/
research/publi/newsletters.asp
Committee
Members
The Committee welcomed Dr Sean
for both single and multi site research.
The gradual roll out of the program, the
Centres for Health Research Newsletter
Hatherill (psychiatry representative)
and Dr Adam La-Gaze (toxicology/
pharmacology representative) who
joined as members during the year.
After two and half years of service, Dr Jennifer Fleming resigned as Chair
of the HREC in July 2010 to take up a
postdoctoral research position within
the Sydney Medical School, University
of Sydney. Associate Professor Carl
Kirkpatrick, Deputy Chair resigned in
September to take an academic position
at the University of Melbourne.
Dr Eleanor Milligan was appointed to the
position of Acting Chair during the year.
There is sincere appreciation to all of the
committee members for their selfless
contribution.
Human Research Ethics Committee
Centres for Health Research 2010 Annual Research Report
19
Health Practitioner
Research Collaborative
Metro South
The Health Practitioner Research Collaborative (HPRC-formerly the Allied
Health Research Collaborative) became a Metro South Health Service
District wide group late in the year. The group includes researchers and
health practitioners providing diagnostic, rehabilitative and clinical support
to hospitals and the community through specialised services. The purpose
of the Health Practitioner Research Collaborative is to lead, develop and
support relevant multi-disciplinary translational research and its application
into practice across the continuum of care which is recognised at state,
national and international levels.
Jenny Lethlean
Activities
The HPRC continued to:

facilitate, encourage and support high
quality research conducted by health
practitioners and research students.

facilitate, coordinate and advocate for
the dedicated allocation of resources
and training to increase research
capacity in allied health.

provide the support to increase the
number of postgraduate students,
research proposals, publications,
presentations and successful grant
applications in allied health.

foster multidisciplinary collaborations
to maximise relevance, scope and
impact of findings on service delivery.

increase the profile of health
practitioner involvement in Metro
South Health Service District research
endeavours.
20
research - key to health

ensure health practitioner research
needs were represented and
considered in strategic planning at
facility, district and state levels.

encourage networking and
collaborations with nursing and
medical researchers and universities.

liaise with Evidence Based Practice
Networks to encourage the uptake of
research findings into clinical practice
and facilitate clinically relevant
research.

liaise with the Centres for Health
Research, Office of Health and
Medical Research and the Allied
Health Clinical Education and Training
Unit – Research Team regarding
research resources and processes.
Achievements
A significant achievement for the year
Hickman commenced as Health
review panel for the Health Practitioner
was the establishment of the Centre
Practitioner Principal Research Fellow, a
Research Grants. They have taken the
for Functioning and Health Research
conjoint appointment with the University
leadership of projects determining
(CFaHR) in the Metro South Health
of Queensland’s Diamantina research capacity in clinical staff and
Service District. The CFaHR strives
Institute. Late in the year, Liz Isenring
in the development of a Research
to generate and translate research
was appointed as Clinical Academic
Capability Framework to engage staff in
evidence in order to strengthen the
Fellow (Senior Clinical and Research
research and its translation into practice.
delivery of health care, at all time
Dietitian), conjoint with the School of
points along the health care continuum.
Human Movements, The University The research focus is underpinned
of Queensland.
by the International Classification of
Functioning, Disability and Health.
Early in the year, Steven McPhail was
appointed as the conjoint Senior
Research Fellow with the School of
Public Health and Institute of Health
and Biomedical Innovation, QUT; and
Pim Kuipers was appointed as the
conjoint Principal Research Fellow with
the Griffith Health Institute, Griffith
University. Mid year, Elizabeth Ward was
appointed as conjoint Professor with
the School of Health and Rehabilitation
Sciences, The University of Queensland.
This team of researchers together with
existing discipline specific conjoint
researchers will contribute significantly
to building health practitioner research
productivity and capacity, and the
translation of evidence into clinical
practice across the district.
Over two million dollars of competitive
the significant investment in dedicated
funding was awarded to members
research positions; the sharing of
of the HPRC across diverse areas of
resources, training and information; and
health practitioner research including
the collaboration of researchers across
innovations in the use of technology
the Metro South Health Service District.
to improve rehabilitation, goal-setting,
work-place injuries, life-style diseases,
service models, exercise therapy,
rehabilitation, ageing, cancer services,
indigenous health services, health
related quality of life and nutrition.
There continues to be a strong health
practitioner post-graduate research
presence on the campus with more
than 20 full-time and part-time higher
degree students enrolled. Over 40
refereed journal articles and book
chapters have been published this year
by the collaborative. Details of funding
attained, postgraduate students and
Dietetics was successful in securing
departmental, service or centre reports.
as a Senior Research Fellow receiving
a OHMR Health Research Fellowship
and a Lions Senior Medical Research
Fellowship. In November, Dr Ingrid
Dr Jenny Lethlean
Chair
spinal cord injury, acquired brain injury
publications can be found in the relevant
positions. Katrina Campbell commenced
research capacity and research
evidence translation is anticipated with
The Department of Nutrition and
funding for dedicated research
An increase in health practitioner
The HPRC participants have contributed
to the Queensland Health statewide research agenda through active
involvement in the Health Practitioner
Research Advisory Group and the
Centres for Health Research 2010 Annual Research Report
21
The PA Research
Foundation
Our Mission:
To bring research to life
Our Vision:
To prevent and cure disease
Robert Bowen
The PA Research Foundation financially supports and promotes health
research conducted on the hospital campus. This includes a research
staff in excess of 600 people from Queensland Health, The University of
Queensland, Queensland University of Technology and Griffith University.
The foundation’s goal is to develop a philanthropic culture within
staff members, former patients, businesses, individuals and external
organisations to provide ongoing funds which support research. Grant
funding is made on an annual basis to a diverse range of world leading, life
saving research projects.
The PA Research Foundation is a
of projects were funded from the PA
the words of Professor Ian Frazer: “As
statutory authority appointed under the
Research Foundation funds and the
individuals and as a nation, we need
Queensland Hospital Foundations Act
Private Practice Trust Fund. In addition
to value ideas. The solution to many of
1982 and is controlled and managed
over $200,000 was provided to current
today’s challenges will start with an idea
by the CEO and an independent Board
research projects through direct appeals
and be driven by a commitment to find
of Directors. The Directors are drawn
to ensure their continuation.
that solution.”
I thank all those who generously invested
Robert Bowen
Chairman, PA Research Foundation
from the local business and medical
community and are appointed by the
Governor of Queensland on advice from
the Minister of Health.
in these projects by making a gift to
the PA research Foundation. This is
not just an investment in the future
In December the PA Research
health and wellbeing of our families and
Foundation announced the successful
communities; it is also an investment
recipients of grants. This year $900,000
in Australian industry and ingenuity. In
22
research - key to health
Group Reports
T3 – Translation to clinical practice:
Translating knowledge into actual clinical practice - once clinical applications have been demonstrated
through the T2 translation, clinicians must find ways to move these findings into the daily care of patient.
Translates results from T2 research into clinical practice. Researchers explore ways of applying
recommendations or guidelines in general practice.
T4
T1
Translation
from the Lab
Translation
to Community
Translation
to Patients
T2
T3
Acquired Brain Injury
Outreach Service
The Acquired Brain Injury Outreach Service is a specialist community
rehabilitation service for people with acquired brain injury, their carers
and service providers. During the year, the unit continued its success in
many research arenas. New funding has been received for collaborative
research projects with the Brain Injury Rehabilitation Unit and Griffith
University looking at efficacy oriented care and family involvement in
rehabilitation. The first pilot year has commenced for the Department
of Communities funded initiative, exploring self-directed funding
support for people with disability. Research continued in the areas of
knowledge translation and consultancy within rehabilitation and aged
Ray Quinn
care settings, models of rehabilitation for Aboriginal and Torres Strait
Islander communities, transition from hospital to home and parenting
following brain injury. New research has been developed in the areas of
psychosocial care following injury with a focus on identity reconstruction and exploration of the training needs of
volunteer workforces to support STEPS (Strategies Teaching Educators Parents Students) programs.
Ray Quinn
Manager
Research Activities
Clinical knowledge translation from
project that aims to develop and
J, Worrall L, Cornwall P, Haines T,
specialist health practitioners to general
evaluate models of service delivery
Ownsworth T, Kendall M, Chenoweth
health practitioners- evaluating a
in community-based rehabilitation
L). This ARC Linkage funded project
consultancy model of service delivery
for people with acquired brain injury
involves a collaborative team of
(Amsters D, Kuipers P, Kendall M,
that are appropriate and relevant for
researchers from The University of
Lindeman M). The project aims to
Aboriginal and Torres Strait Islander
Queensland, Griffith University and
explore the efficacy of consultancy as
communities. This project commenced
Princess Alexandra Hospital. Industry
a means of health service delivery and
in 2007 and resulted in the submission
partners include Disability Services and
clinical capacity building in rehabilitation
of a business case during 2009. Work
ABIOS. Data analysis has commenced
and aged care settings.
has continued on expansion of the
for this multisite project.
Improving community-based
rehabilitation for Aboriginal and Torres
project into other Aboriginal and Torres
Strait Islander communities.
Integrating individual parenting support
into the community rehabilitation and
Strait Islander Queenslanders with
Determinants of successful community
case management context: A pilot study
Acquired Brain Injury (Gauld S, Smith
transition for individuals with acquired
(Black G, Kendall M, Roser J, Smith S,
S, Kendall M). This is an ongoing
brain injury and their families (Fleming
Wright S, Morriss E). This project was
24
research - key to health
commenced as a pilot during 2008.
Awards & Prizes
Dr Melissa Kendall, E. Kendall, The study involved the development
Ms Susan Gauld, Ms Sharon Smith, H. Muenchberger
and evaluation of a psycho-educational
Dr Melissa Kendall
Annual Australian Society for the Study
support for parents with acquired Metro South Health Service District
of Brain Impairment Conference, brain injury and their partners. An
Engagement Competition – First Prize
Gold Coast
extension of the data collection Winner awarded by Queensland Health
process has continued.
for research investigating models
Self-directed support funding for people
with disabilities: A pilot evaluation
(Quinn R, Goddard K, Kendall M). This
of service delivery for brain injury
rehabilitation within Aboriginal and
Torres Strait Islander communities
Dr Melissa Kendall, Ray Quinn
Annual Australian Society for the Study
of Brain Impairment Conference, Gold Coast
Sharon Smith, Susan Gauld, project, funded by the Department of
Runner-up Queensland Healthcare
Communities, aims to implement and
Improvement Awards for research
evaluate self-directed funding support
investigating models of service delivery
models for 80 people with disabilities
for brain injury rehabilitation within
living in the community, with the aim of
Aboriginal and Torres Strait Islander
Sharon Smith, Susan Gauld
increasing client autonomy, perceived
communities
Creating Futures Conference, Cairns
Finalist- PA Week Poster Presentation
Areti Kennedy, Ben Turner
Awards for research investigating
Services for Australian Rural and
models of service delivery for brain
Remote Allied Health (SARRAH)
injury rehabilitation within Aboriginal and
Conference, Broome
control and self-determination. Internal
and external evaluations are key
components of the project.
Major Grants & Financial Support
Funding from other
sources:
$367,000
Dr Melissa Kendall
Joint World Conference on Social Work
and Social Development, Hong Kong
Torres Strait Islander communities
National & International Presentations
Susan Gauld, Sharon Smith, Mr Ray Quinn
National Disability Services Communities of Practice Conference,
Dr Melissa Kendall
8th World Congress on Brain Injury,
Brisbane
Washington
Centres for Health Research 2010 Annual Research Report
25
Alcohol and Drug Research
Based within the Division of Medicine, the service provides outpatient treatment for alcohol and other substance
use disorders. Investigating methods which improve assessment and treatment outcomes continued to be the
focus of clinical research. Patients referred from within the hospital and from the community continued to have
access to treatment programs. Disciplines represented within the unit include medicine, nursing, social work and
clinical psychology.
Dr Gerald Feeney
Medical Director
Research Activities
Clinical Trials
Other Research
This includes evaluation of clinical
Clinical Support Decision Making
Treatment Targeting Alcohol-Related
instruments applied in both
System for Alcohol Dependence
Issues in Young Adults (Feeney GFX,
assessment and treatment. A number
Treatment (Symons M, Connor J
Connor JP, Young R McD ). Patients
of psychometrically valid and reliable
P, Feeney G F X, Young R McD). A
under 30 years of age represent one
instruments are being developed in
computer based, clinical support
quarter of those treated at the unit.
the areas of alcohol, cannabis and
decision making system which scores
Existing Cognitive-Behavioural Therapy
amphetamine use.
and interprets clinical data, provides based programs effective in treating
a prognosis on likely treatment alcohol dependence have been modified
outcome and identifies key modifiable
to target the specific needs of this
treatment factors is being trialled. The
group. The efficacy of these approaches,
system is integrated with the existing
tailored to a younger population, is
clinical databases and employs non-
being assessed.
linear approaches to model outcomes
from 1400 patients previously treated at the service.
26
research - key to health
Alexithymia and Alcohol Dependence
Treatment (Thorberg FA, Young R
McD, Connor JP, Feeney GFX). This
personality trait characterised by
difficulties identifying and describing
feelings occurs frequently in alcohol
Development of Psychometric Tools for
dependence. Assessment and Substance Use Disorder Assessment
treatment approaches for this group (Connor JP, Feeney GFX, Young R McD).
are being developed.
Anaesthetic Department
Research in the Anaesthetic Department continued to gain momentum
with several new projects. Dr Pal Sivalingam continued as the
Department’s Director of Research and the Research Subcommittee (Drs
Moran, Burrow McKenzie, Fairweather, Wyssusek, Ferris and Davies)
entered its second year. A Hospital Private Practice Fund enabled the
employment of a full time Research Nurse in April.
Dr Peter Moran
Director
Pal Sivalingam
Dr Pal Sivalingam
Director of Research
Research Activities
Clinical Trials
IV Oxycodone: A comparison of
IV oxycodone and IV morphine
patient controlled analgesia in post
laparoscopic nephrectomy patient
(Solomos J, Sivalingam P, Breen C)
Gum Elastic Bougie vs. Frova intubating
Catheter when using the Glidescope
(Sivalingam P, Ariotti G).
Alcohol Rub vs. 3 minute surgical scrub
using 4% Chlorhexidine (Mckenzie B,
Faoagali J, Howard J)
Other Research
Perioperative anaesthetic management
Anaesthetic Research Group
of adult patients with diagnosed or
L-R (Front Row):Iain Salkield, Palvannan Sivalingam, Barton McKenzie, Peter Moran suspected Obstructive Sleep Apnoea
L-R (Back Row):Rebekah Ferris, Bruce Burrow and Catherine Jowett-the (Wyssusek K, Breen J)
department's research nurse.
Centres for Health Research 2010 Annual Research Report
27
Australian Prostate Cancer
Research Centre - Queensland
The Australian Prostate Cancer Research Centre – Queensland
(APCRC-Q) experienced several highlights during the year. The
Multidisciplinary Team for Advanced Prostate Cancer Clinical Trials Unit was officially launched and is making significant progress to
incorporate a multidisciplinary approach to management of these
patients. The annual Australian-Canadian Prostate Cancer Research
Alliance (ACPCRA) scientific meeting was held in conjunction with the
Prostate Cancer Foundation of Australia’s annual conference in June and the ACPCRA website was also officially launched in July (http://www.aus-canprostatealliance.org/).
Colleen Nelson
Judith Clements
Members of the Centre received a number of significant research funding
awards. Professor Judith Clements received a five-year NHMRC Principal
Research Fellowship of $690,000 (2011-2015), and led two successful NHMRC project grants ($1.16 million) for her
prostate cancer research awarded. Professors Judith Clements and Colleen Nelson were also awarded significant
funding from the PCFA for 2011-2013 ($1 million).
(For further information visit http://www.australianprostatecentre.org/)
Professor Colleen Nelson
Executive Director
Professor Judith Clements
Scientific Director
Research Activities
Clinical Trials
Other Research
The APCRC – Q’s Multidisciplinary Team
Targeted nanoparticles for imaging
Veridex CellSearch Circulating Tumour
for Advanced Prostate Cancer Clinical
prostate cancer (Russell PJ, Khatri A,
Cell (CTC) Test (Fung M, Jovanovic
Trials Unit is a key component of the
Cowin G, Thierry B, Power C). This study
L). Australasia’s first and only Veridex
Centre’s research. The unit integrates the
uses antibody-targeted ferromagnetic
CellSearch CTC automated system
expertise of urology, medical oncology,
nanoparticles to improve the sensitivity
arrived at the Princess Alexandra
radiation oncology, and endocrinology
of magnetic resonance imaging, in
Hospital in August. Two staff have been
for the treatment of prostate cancer. It is
order to detect microdeposits or
trained to use the system and several
a vital link between laboratory research
micrometastases of prostate cancer,
preoperative samples from prostate
and clinical trials and helps accelerate
including to lymph nodes. The ability to
cancer patients have been tested.
the discoveries that will ultimately
detect such deposits will allow imaging
With the PAH Cancer Collaborative
underpin improvements in clinical
of treatment effects in real time, and
Group, the study will also examine CTC
outcomes for prostate cancer patients
help in staging of prostate cancer to
numbers in high risk prostate cancer
across Australia.
assist clinical management decisions.
patients with localised disease.
28
research - key to health
Multifocal prostate cancer project
models to replicate the tumour
This project includes examining the
(Nelson C, Jovanovic L). The objectives
microenvironment that prostate cancer
stimulatory effects of insulin on intra-
of this study are to identify genes which
cells grow in. Providing these models
prostatic steroid (androgen) synthesis
are differentially expressed in multiple
in the laboratory setting should provide
and clinically based pilot studies
tumours, within a patient and across a
more meaningful molecular data when
assessing possible correlations between
cohort of patients. In collaboration with
investigating new drug targets. The
elevated insulin levels and time-to-
partners at PAH and Sullivan Nicolaides
analyses currently underway will provide
progression to castrate resistant
Pathology, archival tissue specimens
exciting data that may have a major
prostate cancer. These relationships
from ten patients have been examined.
impact on the way laboratory studies are
are also being examined in the LNCaP
To date, the majority of specimens
performed on tumour cell biology.
prostate tumour cell line treated have been processed in terms of
microdissection and RNA extraction,
and tissue sections have also been cut
for future DNA extraction. Expression
Systemic injection of Mesenchymal
Stem Cells to treat prostate cancer
(Hutmacher D, Clements J, Russell P,
with androgens or insulin. A whole
genome micro array analysis has been performed.
Soekmadji). This project explores the
Inter-relationships between castrate
use of new models for studying bony
resistant prostate cancer, radiation and
metastasis from prostate cancer and for
chemotherapy (Nelson C, Vasireddy
Insulin C-peptide as a biomarker for
delivering nanoparticles/therapy to the
R). This project will investigate the
androgen deprivation therapy-induced
metastatic sites. It will also investigate
biological significance and develop
Metabolic Syndrome (McKenzie I).
whether mesenchymal stem cells can
targeted therapeutics for GADD45g – a
This small pilot study confirms an
infiltrate tumours in the prostate or
key gene that promotes prostate cancer
increase in serum C-peptide levels in
those grown subcutaneously in cell survival. Dr Vasireddy, with Professor
men receiving androgen deprivation
bone scaffolds.
Nelson, identified that GADD45g acts
microarray experiments have been
successfully conducted.
therapy for advanced prostate cancers
and suggests the need for a formal
and larger prospective study assessing
the effects of hyperinsulinaemia on
progression to castrate resistance.
Delineating the role of progesterone
in castration-resistant prostate cancer
(Sadowski M, McPherson S, Nelson
C). This project focuses on cell cycle
as an upstream regulator of several
key molecules that control balance
between prostate cancer cell survival
and apoptosis.
regulated gene pathways. Several
Functional Analyses of Prostate Specific
Exosomes as a potential biomarker
candidate genes with critical roles
RNA in Prostate Cancer (Nelson C, Lai
for advanced prostate cancer (Russell
in the regulation of transcription,
J). In this project, Professor Nelson and
P, Soekmadji C). This study involves
proliferation and cell cycle progression
Dr Lai have mined RNA sequencing
isolating exosomes from human prostate
have been selected from the phase 2
libraries from the Illumina Tissue bank
cancer cell lines that have undergone
microarray data set of progesterone-
that was performed on 14 different
various treatment regimes and which
regulated genes. Quantitative RT-PCR
tissues. From this data RNA that are
reflect various stages of prostate cancer
has confirmed their up-regulation by
specifically expressed in the prostate
in order to analyse any differences in
progesterone. This project also aims have been mapped including ‘blocks’
their proteins and microRNA from those
to identify the role of progesterone of alternatively spliced, antisense,
isolated from untreated cells.
in regulating gene expression and
chimeric, and overlapping transcripts. At
activity that may control/promote
present, expression data indicates that
prostate cancer cell survival following
prostate specific blocks at the SLC45a3
androgen deprivation.
locus, a locus which forms chimeric
3D biomaterials to develop biomimetic
prostate cancer in vitro and in vivo
preclinical models (Hutmacher D,
Russell P, Nelson C, Clements J,
Relationship between Serum Insulin
Soekmadji C, Loessner D). This study
Levels and the Progression of Castrate
is developing 3D synthetic biomaterial
Resistant Prostate Cancer (Gunter J). RNA with the ELK4 transcription
factor downstream and is more highly
expressed in higher metastatic prostate
cancers, is androgen regulated. The
Centres for Health Research 2010 Annual Research Report
29
functional importance of this RNA block
(Stephenson S-A, Herington A, Mertens-
Proteolytic and non-proteolytic roles
is currently being assessed using a
Walker I, Rutkowski R, Lisle J, Gill P).
for PSA and related kallikrein serine
siRNA approach.
The group have made significant and
proteases in prostate cancer progression
novel evidence that EphB4 can localise
(Clements J, Nelson C, Russell P,
to the nucleus of prostate cancer cell
Hutmacher D, Gorman J, Harris J). PSA
lines and clinical tissue specimens and
is unregulated in prostate cancer and as
have found that it can bind directly to
such is used as a diagnostic biomarker.
DNA. To address the hypothesis that the
This study aims to clearly determine
nuclear presence and action of EphB4
the functional role of PSA and KLK4 in
provides new mechanisms of action for
prostate cancer progression, and will
this protein in tumour progression the
take a holistic approach to investigating
group are currently investigating the role
the role of Kallikreins in prostate cancer.
of nuclear localised EphB4 as a direct
Using novel proteomic techniques
modulator of gene expression.
a comprehensive analysis of KLK
Tyrosine kinases as therapeutic targets
for prostate cancer ( Ling P). Dr Patrick
Ling has performed a Lentiviral shorthairpin RNA library screening approach
to identify protein kinases associated
with chemotherapy drug (i.e. Docetaxel)
sensitivity and identified more than
10 candidate protein kinases which
appear to either increase or decrease
the response of prostate cancer cells
to Docetaxel treatment. These include
substrates and binding partners will BRAF and RAF-1, tyrosine kinases
Preclinical proof of principle of
known to be important in cancer
therapeutic targets (Ling P). In
progression as well as EphA4 and other
collaboration with Davos Life Science
Evaluation of the Therapeutic Potential
novel kinases. Further validation and
in Singapore, this study found that
of SFTI-FCQR, a Novel Kalikrein
characterization of these protein kinases
gamma-tocotrienol is a potent killer
4-Specific Protease Inhibitor (Harris
are in progress.
of prostate cancer stem cells. This
J, Clements J, Russell P). This project
small group of cells is responsible for
aims to complete a full pharmacokinetic
the initiation of prostate cancer and is
analysis of the KLK4 inhibitor compound
resistant to conventional chemotherapy
SFTI-FCQR. Preliminary studies will
drugs. It causes relapses in the cancer
determine factors such as toxicity and
by producing new chemo-resistant
bioavailability of SFTI-FCQR. Later
cancer cells. Gamma tocotrienol is a
studies will use sophisticated imaging
member of the Vitamin E family and techniques to monitor the metastatic
is derived naturally from palm oil.
potential of prostate tumours in the
Planning for an international clinical presence and absence of SFTI-FCQR.
trial is now underway.
At its completion, this study will have
Understanding the molecular pathways
of the EphB4 tyrosine kinase receptor in
controlling cellular function (Stephenson
S-A, Herington A, Mertens-Walker I,
Rutkowski R, Lisle J, Gill P). The EphB4
receptor tyrosine kinase is increased in
prostate cancer cells and contributes
to cancer cell survival and spread.
Intriguingly, EphB4 demonstrates
dual and opposing roles in a cell-
be undertaken.
extended proof of concept studies on
and environment context - tumour
The Role of Kallikrein Gene Variants in
suppression, when stimulated by its
Prostate Cancer Etiology, Detection and
cognate ligand, ephrin-B2, and tumour
Disease Progression (Clements J, Batra
promotion via proposed ligand-
J, Spurdle A, Lose F). This study aims
Applying a Novel Bone Tissue
independent mechanisms. The aim of
to investigate the role of kallikrein genes
Engineering Platform to Study Prostate
this project is to characterise ligand-
in prostate cancer development and
Cancer Metastasis to Bone (Hutmacher
dependent and ligand-independent
patient susceptibility. The detection of
DW, Clements J, Nelson C). This study
signalling pathways mediated by EphB4
gene variants associated with prostate
utilises novel bio-mimetic model
using cell models with both artificial and
cancer will provide the foundation for
systems to investigate the role of PSA
endogenous EphB4 over-expression.
development of sensitive and readily
and KLK4 in prostate cancer bone
applicable lab-based screening tools
metastasis. Tissue engineered bone
to be used clinically for diagnosis and
scaffolds can be used in vivo and in
monitoring of treatment and prognosis.
vitro to allow in depth analysis of the
Role of nuclear-localised EphB4 tyrosine
kinase receptor in prostate cancer
30
research - key to health
the inhibition of KLK4 by SFTI-FCQR to
the pre-commercialisation stage.
interaction between bone scaffolds
and prostate cancer cells. This work
will yield research results with greater
clinical relevance and aid in therapeutic
developments.
Awards & Prizes
Professor Pamela Russell
Outstanding Researcher, Prostate
Cancer Foundation of Australia
National & International Presentations
Professor Judith Clements
Advanced Prostate Cancer Seminar,
Brisbane
Gordon Research Conference Plasminogen Activation & Extracellular
Proteolysis, Ventura, USA
Winter School in Tiers - Proteinases and
Their Inhibitors - Recent Developments,
Germany
IMPACT & COGS meetings, Australian Prostate Cancer Centre Group
Professor Colleen Nelson
3rd Novartis Research & Development
Genitourinary Cancers Symposium, Symposium, Melbourne
San Diego, USA
11th International Symposium on the
NZ BIOtech, Auckland, NZ
Genetics of Industrial Microorganisms,
Melbourne
BIO, Chicago, USA
Australian-Canadian Prostate Cancer
Cambridge, UK
ENDO, San Diego, USA
PRACTICAL Consortium, SPORE Meeting, Toronto, Canada
Gold Coast
11th National Prostate Cancer
Genetics in Industrial Microorganisms
Symposium, Melbourne
International Meeting, Melbourne
Italy
Australian-Canadian Prostate Cancer
National Prostate Cancer Symposium,
Research Alliance Symposium, Melbourne
International Society for Biological and
Gold Coast
Cambridge, UK
Gordon Research Conference Proteolytic Enzymes & Their Inhibitors,
Environmental Repositories Conference,
Research Alliance Symposium, Prostate Cancer Foundation of Australia
The Netherlands
Endocrine Society of Australia, Sydney
Conference, Gold Coast
11th National Prostate Cancer
Cancer Conference, Sydney
TERMIS meeting, Sydney
Translational Research Excellence,
Australian Health & Medical Research
Brisbane
Congress, Melbourne
1st International Conference on
Major Grants & Financial Support
Translational Medicine, Canberra
Total NHMRC funding:
Professor Pamela Russell
Other competitive
funding: Symposium, Melbourne
Australian-Canadian Prostate Cancer
Research Alliance Symposium, Gold Coast
Hormones in Health & Disease: 50 years
of Endocrine Research at Prince Henry's
Institute, Melbourne
Lorne Cancer Conference, Victoria
$734,000
$3,894,000
Centres for Health Research 2010 Annual Research Report
31
Brain Injury Rehabilitation Unit
The Brain Injury Rehabilitation Unit accepts referrals for those in the
broad working age group with an acquired brain injury. Referrals from
Queensland and Northern New South Wales as well as other Australian
states and overseas are also accepted.
The Brain Injury Rehabilitation Unit is co-located with all allied health
professional services. The rehabilitation team is involved in collaborative
research in many areas of injury management. Research includes all
professional disciplines in the management of acquired brain injury.
Research highlights included: piloting and researching clinical programs
to improve the management of hypertonicity (spasticity); improved
management of recreation for those with acquired brain injury; and
utilising diffusion tensor imaging as a surrogate marker of recovery
following traumatic brain injury.
Ron Hazelton
Dr Ron A Hazelton
Medical Director
Research Activities
Clinical Trials
Management of the Painful Hemiplegic
the mechanism of this association
and function generally. Group and one
Shoulder (Kuipers K, Cave C,
and to develop clinical guidelines for
on one activities that are unstructured
Nascimento M, Hazelton R). Pain and
management.
and relevant to the patient can be
restricted active and passive movement
of the shoulder affects about 60%
of post stroke cases and results in
disability and prolongs hospital stay. The
development of a clinical pathway with
active management of the hemiplegic
shoulder has been developed and is
being trialled.
Abnormal Gait in association with the
hemiplegic upper limb (Nascimento M,
Trialling Models and Assessing Efficacy
of the Hypertonicity Service (Cave C,
Kuipers K, Nascimento M, Hazelton
R). A model for the service has been
developed and is being assessed for
efficacy in a prospective study.
Clinical research on recreational
opportunities for inpatients in BIRU (The BIRU Team).
Cave C, Kuipers K, Hazelton R). Gait
A common challenge following an
and balance are adversely affected by
acquired brain injury is to assist the
the hypertonic (spastic) upper limb. This
injured person to become aware of research aims to investigate how the injury has affected social skills 32
research - key to health
undertaken and are valuable in assisting
with recovery. Recreational activities
post discharge are identified whilst
awaiting further recovery to return to
usual lifestyle.
Other Research
A wide variety of collaborative studies
are listed in other areas of this report
under the appropriate allied health
professional grouping.
Major Grants & Financial Support
Total funding
received:
$65,000
Breast & Endocrine
Surgery Unit
The Breast and Endocrine Surgical Unit provides a comprehensive
world-class tertiary surgical service for the management of breast and
endocrine surgical conditions within a multi-disciplinary setting. Over 250 newly diagnosed breast cancers are treated within the unit each year. Breast cancer is managed in conjunction with the Medical Oncology and Radiation Oncology units. Surgeons meet on a weekly
basis with clinicians from the other disciplines in a combined breast
oncologic multi-disciplinary clinic to ensure that ‘state of the art’ breast cancer treatment is provided in keeping with nationally accepted best practice guidelines. A multidisciplinary Endocrine meeting is also conducted monthly between surgeons, endocrinologists
and radiologists to discuss and streamline management of patients with
endocrine disorders.
Ian Bennett
The respective surgeons work closely with the Breast Screen Queensland Brisbane South Service so that
surgical expertise is provided for screening, assessment and diagnosis of early stage breast cancer to facilitate
and integrate with definitive management. The unit is involved in collection of data for the RACS National Breast
Cancer Audit of all breast cancers treated at the Princess Alexandra Hospital.
Members of the unit have excellent collaborative working relationships with scientists from The University of
Queensland's Diamantina Institute for the conduct of clinically relevant research, particularly in the field of
breast cancer. The unit continues to play a role in both undergraduate and post-graduate teaching of breast and
endocrine surgical conditions.
Associate Professor Ian Bennett
Chairman
Research Activities
Clinical Trials
IBIS II DCIS Trial (Bennett I). An
IBIS II Prevention Trial (Bennett I).
Understanding the Heterogeneity of
International multicentre study of
An international multicentre study of
Invasive Ductal Breast Cancers – a
anastrozole versus tamoxifen in post-
anastrozole versus placebo in post-
proteomic approach for the discovery
menopausal women with hormone
menopausal women at increased risk
of biomarkers and novel therapeutic
sensitive Ductal-Carcinoma-in-Situ.
of breast cancer. Co-ordinated by
target (Chopin L, Simpson P, Lakhani
Co-ordinated by Australian New Zealand
Australian New Zealand Breast Cancer
S, Bennett I, Hill M). National Breast
Breast Cancer Trials Group.
Trials Group.
Cancer Centre Foundation Research
Grant. Pilot study award.
Centres for Health Research 2010 Annual Research Report
33
Morphological and Molecular Analysis
Breast and Ovarian Cancer Centre of
National & International Presentations
of a Breast Cancer Cluster at the ABC
Australia. (Members of the research
Associate Professor Ian Bennett
Studio in Toowong (Waddell N, Stein SR,
teams are from: Queensland Institute
79th Annual Scientific Congress Royal
Wagner SA, Bennett I, Holland J, Pogo
of Medical Research; The University
Australasian College of Surgeons Annual
Scientific Congress, Perth
B, Gonda T, Brown M, Leo P, Saunders
of Queensland’s Institute of Molecular
N, McMillan N, Cocciardi S, Lakhani
Biosciences, Diamantina Institute Centre
SR, Chenevix-Trench G, Newman B,
for Clinical Research and School of
Francis GD).
Chemistry and Molecular Biosciences;
This conjoint project received research
grant funding from the National
Pathology Queensland and Princess
Applied Ultrasound for Breast &
Endocrine Surgeons Workshop, GSA
Annual Scientific Meeting, Gold Coast
Alexandra Hospital)
L-R:Dr David Wilkinson, Dr Neil Wetzig, Associate Professor Ian Bennett, 34
research - key to health
Dr Petar Vujovic
Cardiology
The department has led the world with the investigator initiated Protect-Pace Study. Dr Gerald Kaye is the International Study Chair
and Professor Thomas Marwick is the Echocardiograph Core Lab Chair
for this study. The department has the highest number of participants
recruited worldwide.
Additional achievements have included the clinical investigation of:
echocardiographic optimisation of pacing cycle durations at rest and
on exercise in cardiac resynchronisation therapy; the effect of atrial
fibrillation, and ablation of atrial fibrillation, on cardiac neurohormonal
response and atrial remodelling, and correlation of electrical and
mechanical activity in the left ventricle using sophisticated mapping and
imaging techniques.
Paul Garrahy
The broad expertise the department offers has secured a large number of clinical trials from a variety of commercial
companies, the National Health and Medical Research Council, the National Institutes of Health and investigatordriven research over the past year. Also collaboration with The University of Queensland’s Cardiovascular Imaging
Research Centre has ensured an even broader range of cardiology modalities on offer to enhance research within
the department. Research areas cover coronary artery disease, cardiac arrhythmias, cardiac devices, acute/chronic
systolic/diastolic heart failure, coronary angiography and percutaneous transluminal coronary angioplasty, cardiac
echocardiography, cardiac magnetic resonance imaging and cardiac surgery.
Dr Paul Garrahy
Director
Research Activities
Clinical Trials
Alecardio Study (Garrahy P). New Atlas-2 Study (Garrahy P). Antiplatelet
dalHeart Study (Garrahy P).
study drug to reduce cardiovascular agent + ASA +/- Clopidogrel vs. Lipid medication vs. placebo on
risk in patients with a recent Acute
Placebo + ASA +/- Clopidogrel in Acute
cardiovascular risk in stable coronary
Coronary Syndrome event and Type 2
Coronary Syndrome.
disease patients with a documented
diabetes mellitus.
Averroes Study (Garrahy P). Antiplatelet
recent Acute Coronary Syndrome.
Alphee Study (Hill J). Anti-arrhythmic
agent vs. aspirin to prevent stroke in
Echo-CRT Study (Marwick T, Korczyk
study drug vs. amiodarone vs. placebo
atrial fibrillation patients who have
D). Heart failure subjects outside the
as a calibrator for the prevention of ICD
failed or are unsuitable for Vitamin K
standard ICD insertion guidelines
interventions or death.
antagonist treatment.
parameters.
Centres for Health Research 2010 Annual Research Report
35
Freedom Study (Garrahy P).
Other Research
Cindy Hall
Percutaneous transluminal coronary
BNP in metabolic syndrome (Korczyk
ARCs Scientific Congress, Sydney
angioplasty vs. coronary artery bypass
D, Gould P, Doneva S). Sub study of
grafting in diabetic subjects with multi-
Differential effect of right ventricular
vessel disease.
pacing sites on cardiac Neurohormone
Heart Failure Study (Korczyk D). Production
Study drug vs. Placebo in patients
Protect-Pace Study (Kaye G). The
with chronic heart failure at risk for
protection of left ventricular function
ventricular arrhythmia.
during right ventricular pacing.
Rhythm AF Study (Gould P).
Awards & Prizes
International Registry of atrial fibrillation.
Cindy Hall
ZoMaxx II Study (Garrahy P).
Comparison of new drug-eluting stent
Heart Failure and Palliative Care
Practitioners
4th Australasian Cardiovascular Nurses College (ACNC) National
Conference, Brisbane
Heart Foundation Queensland
Conference, Brisbane
Centre for Palliative Care Research Best Speaker National (Research
and Education Conference, Brisbane
Employment), ARCS Australia
Dr Sudhir Wahi
14th World Congress of
vs. TAXUS™ Express²™ Paclitaxel-
National & International Presentations
Eluting Coronary Stent System in de
Dr Dariusz Korczyk
Echocardiography and Vascular
novo coronary artery lesions.
4th Australasian Cardiovascular Ultrasound and Allied Techniques,
Nurses College (ACNC) National
Manila, Philippines
Conference, Brisbane
Heart Failure Association Heart Association of Malaysia, Kuala
Conference for the European Society Lumpur, Malaysia
of Cardiology, Berlin
36
research - key to health
14th Annual Scientific Meeting National
Cardiothoracic Surgery
The department was involved in nine research projects. This increased
activity allowed for the appointment of a new part-time research nurse
and greater opportunity for trials to be undertaken. The department
collaborated with Hamilton Health Sciences, McMaster University in
Canada in the international “Steroids in Cardiac Surgery Trial”. Highlights during the year included: Dr Shah’s investigator-initiated
prospective randomised controlled aortic valve study that is now also
conducted nationally with the inclusion of the Prince of Wales Hospital in
NSW, and Dr Shah’s commencement of a Doctor of Medicine at The University of Queensland.
Julie Mundy
The group had three publications in reputed journals with six other
papers under review. Six papers were presented at the National
Cardiothoracic meeting and Cardiac Society meeting, and three papers were accepted for the Tyco prize during the
Princess Alexandra Hospital Research Week. The eight registrars, two residents and one intern contributed to the
department’s research activity.
Associate Professor Julie Mundy
Director
Research Activities
Clinical Trials
Prospective randomised study to
and quality of life as compared to
There were three primary objectives
determine the clinical outcomes of
mechanical valves in the aortic position
to this phase of the study: 1). Analysis
tissue and mechanical aortic valve
in age group 55-70 yrs.
of the mRNA expression of perilipin
replacement in patients aged 55-70 yrs
(Shah, P). At present, every surgeon/
patient has their own valve preference,
but there is no evidence base to make a strong recommendation
regarding the optimal valve in 55-70
year-old patients undergoing aortic valve replacement (AVR).
(PLIN1), lipoprotein lipase (LPL),
The Expression of Genes in
Epicardial Adipose Tissue Involved
in Fat Mobilization: Comparison to
Subcutaneous Abdominal Fat (Shah P,
Kostner K). Epicardial adipose tissue
(EAT) mass correlates with Metabolic
Syndrome and coronary artery diseases
(CAD). In addition, the expression of
This is the first study of its kind in
inflammatory cytokines and of genes
literature and the hypothesis addressed
involved in oxidative stress in EAT
is that: tissue valves have fewer major
contribute significantly to the risk of
adverse postoperative events (MAPE:
CAD. Little is known however, about
reoperation, endocarditis, major
the expression of genes involved
bleeding or thromboembolism, valve
in triglyceride (TG) storage and
failure), better long term survival mobilization in EAT.
hormone sensitive lipase (HSL), adipose
triglyceride lipase (ATGL) and of
comparative gene identification-58 (CIG58) in EAT of patients who underwent
cardiac surgery; 2). Comparison of the
expression of these genes between EAT
and subcutaneous abdominal adipose
tissue (AAT); 3). Comparison of the
expression of these genes in adipose
tissues of patients with angiographically
proven CAD with non-CAD patients
undergoing primary cardiac surgery.
Samples taken are being analysed for
lipid specific genes and omega 3 fatty
Centres for Health Research 2010 Annual Research Report
37
(hepatic and renal). Comparison
of outcomes with a case matched
population of patients who did not have
prior transplant is also conducted.
Factors affecting return to work and
quality of life after primary coronary
artery bypass grafting in patients
operated at age less than 50 years
(Pinto N, Shah P). Important predictors
studied included: work status prior to
operation, effect of level of education,
type of occupation ( blue or white
collar), place of residence, ethnic origin,
effect of cardiac rehabilitation, effect of
recurrence of symptoms. Two-hundred
and fourteen patients were enrolled from
L-R: Rayleene Griffin, Julie Holliday
2000 to 2006. All patients were followed
acids in the Department of Molecular
Other Research
for a minimum of five years. The quality
Biology and Biochemistry, University of
Cardiac surgical outcomes in Jehovah
of life of patients who returned and
Graz, Austria
witness patients (Marshall L, Shah
those who did not return to work were
P). Minimising blood transfusion has
also compared using a questionnaire.
SIRS trial “Steroids in cardiac surgery”
(Shah P, Whitlock R). The objective of
this study is to determine whether highrisk patients undergoing cardiac surgery
requiring CPB derive benefit from
perioperative steroids
a number of medical and logistical
benefits in cardiac surgery and since the
introduction of the blood ban in 1945, is
particularly important for followers of the
Jehovah’s Witness (JW) faith. The shortterm outcomes in JW patients based on
This is a multicentre, international,
the institutional practice over the past
randomized, double-blind placebo-
decade are being examined.
controlled trial of high-risk adult patients
undergoing cardiopulmonary bypass.
Patients will be randomly allocated to
receive 500 mg of methylprednisolone
divided into two intravenous doses of
250 mg each, one during anaesthetic
induction and the other on CPB
initiation, or matching placebo
38
research - key to health
Cardiac surgical outcomes in patients
with solid organ transplants (Renal and
Hepatic): A case matched study (Sharma
R, Shah P). Involves the studying of
the long-term outcomes of patients
who have undergone cardiac surgery in
presence of prior solid organ transplant
Major Grants & Financial Support
Total competitive
funding:
$30,000
Funding from other
sources:
$25,000
Cardiovascular Imaging
Research Centre
The group provides clinical and research capability in cardiac imaging
and image processing, including multi-modality interests that are unique in Australia and the Asia-Pacific region. The group have expertise in new echocardiocardiographic imaging technologies such as tissue Doppler, strain and strain rate imaging, myocardial backscatter
and contrast echocardiography. This work is carried out in the research
echo/stress area in the main hospital and image processing area in the
Department of Medicine.
The group comprises researchers, physicians, PhD scholars, visiting
scholars, research study nurses, research assistants and students. The
members of the group generated over 130 publications in peer-reviewed
journals in the last five years, as well as presentations and invited lectures
at major international meetings in Asia, the USA and Europe.
Sudhir Wahi
The academic supervisor is Dr. Sudhir Wahi, senior lecturer with The University of Queensland and a consultant
cardiologist with Queensland Health. Dr. Brian Haluska holds a position as a research fellow and general manager
of the group. There is close collaboration with Adjunct Professor Tom Marwick, who founded the group in 1998 and
who is currently the Section Head of Cardiovascular Imaging at the Cleveland Clinic, Cleveland, Ohio, USA.
(For further information visit http://www.som.uq.edu.au/research/cig/default.asp)
Dr Sudhir Wahi
Academic Supervisor
Dr Brian Haluska
General Manager
Research Activities
The research work focuses on four
Detection of subclinical myocardial
to advanced cardiovascular disease.
themes to deal with the complex
disease. Using image processing
Early intervention and treatment in these
association of cardiovascular disease
techniques such as tissue Doppler
“at-risk” patients may prove beneficiary
with other diseases such as diabetes,
imaging, speckle tracking, strain and
in the long term.
hypertension and renal disease as well
strain rate image and myocardial torsion,
as to understand how cardiac imaging
the group are able to detect early
techniques can influence patient
changes in myocardial mechanics both
outcomes and cost-effectiveness of care.
at rest and with stress which may lead
Assessment of myocardial viability,
coronary artery disease and contractile
reserve. In patients at risk who have
Centres for Health Research 2010 Annual Research Report
39
symptoms, stress echocardiography
has been able to identify patients who
don’t need further treatment and can be
spared a coronary angiogram. The ability
to diagnose viable myocardial segments
in the heart after infarction without
having to use other expensive and
potentially dangerous tests is beneficial
to both the patients and surgeons
in decision making. In patients with
valvular disease assessing contractile
reserve with exercise is crucial in
deciding whether patients need surgery.
Nurse-led intervention in cardiovascular
disease management programs. In
patients with heart failure and peripheral
vascular disease as well as in patients
L-R (Back Row): Qurain Alshammari, Dr Arnold Ng, David Peiniger, Leah Wright, Dr Sudhir Wahi, Kassia Weston, Dr Matthew Cooke, Dr Brian Haluska, Erin Howden, Julian Sacre, Rodel Leano, Dr Christine Jellis, Leanne Jeffries
L-R (Front Row):Maureen Pollard, Deborah Gilroy, Julie Holliday, Sarah McLennan, Dr Carly Jenkins
Not pictured: Professor Thomas Marwick, Dr William Wang, Leanne Rigby
at risk of developing cardiovascular
disease, the ability to provide testing
large arteries to measure intima-media
Awards & Prizes
and manage the patient’s care without
thickness (IMT) which is a measure of
Dr Brian Haluska
having to spend time in hospital or travel
atherosclerotic burden. In patients with
Affiliate’s Abstract Prize winner, The
repeatedly to clinic appointments is
increased age-corrected increased
Cardiac Society of Australia and beneficial to both the patients and heath
IMT, early treatment and risk factor
New Zealand Scientific Sessions,
care system. A team of highly qualified
modification will probably decrease
Adelaide, SA
research nurses recruit patients, assist
future cardiovascular events. Work
in testing and then follow the patients’
done in the past has also shown that
progress and monitor their care. This
early detection of subclinical vascular
includes medication changes, referrals
dysfunction as evidenced by increased
to specialists, hospital admissions and
arterial stiffness and decreased arterial
Erin Howden
quality of life. It is the belief of the distensibility can not only be reversed
Best Paper Award Finalist, Exercise group that this is the future of managed
but when intervened on, but can also
and Sports Science Australia, care in Australia.
change patients’ risk of developing
Gold Coast Qld
High resolution vascular imaging,
assessment of central arterial pressure,
arterial distensibility and vascular
reactivity. There is a close association
between abnormal vascular function
and patients having coronary artery
disease, hypertension, renal failure and
heart failure. The group have been using
high resolution ultrasound imaging of
40
research - key to health
future disease. This is done using
Julian Sacre
Best Paper Award, Exercise and Sports
Science Australia, Gold Coast Qld
applanation tonometry which measures
Major Grants & Financial Support
arterial pressure non-invasively at either
Total NHMRC funding:
the brachial, carotid or femoral artery.
Funding from other
sources:
Using mathematical formulas the group
can derive central blood pressure
(pressure at the heart) and also how fast
the arterial pressure waves travel from
one site to the next which is a measure
of arterial stiffness.
$1,309,209
$20,000
Centre for Functioning
and Health Research
The Centre for Functioning and Health Research was founded mid-2010 within the Metro South Health Service
District of Queensland Health with partnership support from The University of Queensland, Griffith University
and the Queensland University of Technology. The research agenda of centre is underpinned by the International
Classification of Functioning, Disability and Health model. Team members include leading researchers across a
range of allied health disciplines. The centre’s main research objective is to conduct and facilitate high quality
research that will strengthen the delivery of health care to all people, at all time points along the health care
continuum. The centre leads a number of international level research projects as well as local clinical and service
research initiatives within Queensland Health. It has a strong focus on building the research workforce of the future
and assists in mentoring, training and supervising health practitioners to do research.
(For more information visit www.health.qld.gov.au/cfahr)
Professor Liz Ward
Head of Research Unit
Research Activities
Clinical Trials
Randomized controlled cross-over
(Peters C, Rogers A, Currin M, Tyson
The effect of Nintendo Wii-Fit on
Phase 3 trial comparing the new
S, Comans T, Healy S, Heathecote K,
outcomes in people with lower limb
indwelling Provox3 voice prosthesis with
McPhail S, Brauer S)
injuries (Kuys S, Tonks P, Toon M,
the currently used Blom-Singer Classic
Indwelling voice prosthesis for voice
Evidence of disagreement between
McPhail S).
patient-perceived change and
Does a multidisciplinary group education
conventional longitudinal evaluation of
program influence the outcome in
change in health-related quality of life
management of patients with non-
among older adults (McPhail S, Comans
specific chronic low back pain (Windred
T, Haines T)
T, Matthews L, McPhail S, Kuys S)
Patient Education to Prevent Falls
Other Research
Among Older Hospital Inpatients: A
Swallowing, nutrition and patient-rated
Randomized Controlled Trial (Haines T,
function in patients with oropharyngeal
Effectiveness of an enhanced
Hill A M, McPhail S, Hill K D, Oliver D,
SCC treated curatively with altered
multidisciplinary community based
Brauer S, Hoffmann T, Beer C)
fractionation radiotherapy with
rehabilitation after total laryngectomy
(Hancock, K, Ward E., Lawson, N, Van
As Brooks, C)
Evaluation of the use of group based
cognitive remediation therapy for people
with Psychosis (Hodgson A, Dark F,
McPhail S)
group program for Parkinson's disease
concomitant boost or chemoradiation
Centres for Health Research 2010 Annual Research Report
41
(Cartmill, B, Cornwell P, Ward E,
Clinical knowledge translation from
Clinical utility, reliability and validity of
Porceddu S)
specialist health practitioners to
the Self-Perceptions in Rehabilitation
generalist health practitioners -
Questionnaire (SPIRQ) in brain injury
evaluating a consultancy model of
rehabilitation (Ownsworth T, Fleming J,
service delivery (Amstrers D, Kendall M,
Ross J, Collier AM, Stewart E)
Can impaired swallow function
(dysphagia) be accurately assessed
online: A telehealth feasibility study
(Ward E, Sharma S, Burns C, Theodoros
Kuipers P, Lindeman M, Schuurs S)
Helping people with traumatic brain
An exploration of contextual factors
injury and their families adjust to driving
in completed suicides in the Northern
cessation (McKenna K, Fleming J, Liddle
Territory (Pridmore S, Kuipers P)
J, Turpin M, Weir N, Whitelaw P)
communication disorders of patients
Supporting Allied Health Professor
Rehabilitation of prospective memory
with head and neck cancer (Burns C,
essionals - evaluating a Peer Group
following traumatic brain injury (Fleming
J, Shum D, Strong J)
D, Russell T)
Examination of a telehealth service for
the management of swallowing and
Ward E, Bassett L, Malcolm K, DelRosso
Supervision model for Queensland (Hall
F, Kenny L, Greenup P)
K, Pager S, Kuipers P, Bell K).
Dysphagia following thermal burn injury:
Investigation of the transition from
experience of inpatients and their family
Clinical risk factors and prognostic
hospital to home for individuals with
caregivers (Fleming J, Sampson J,
indicators of recovery (Rumbach A,
acquired brain injury and their family
Cornwell P, Turner B, Knill J, Griffin J)
Ward E, Bassett L, Muller M)
caregivers (Fleming J, Nalder E, Turner
Factors affecting dysphagia
management in Malaysia (Mustaffa
Kamal R, Ward E, Cornwell P)
The evaluation of a tracheostomy
simulation training program for speech
pathologists (Bassett, L, Ward, E, Hyde
T, Baker S, Hancock K)
The effectiveness of intensive voice
therapy in the management of vocal
nodules (Fu S, Theodoros D, Ward E)
Food services in residential aged care:
financial, personnel and service delivery
factors (Wilson JE, Wright O, Hagney
DG, Ward EC)
Speech Pathology Service Provision in
Residential Aged Care Facilities (Bennett
M, Ward E, Scarinci N)
Evaluation of a dementia awareness
resource for use in remote Indigenous
communities (Lindeman M, Taylor K,
Kuipers P, Stothers K, Piper K)
42
research - key to health
B, Cornwell P, Worrall L, Ownsworth T,
Haines T, Kendall M, Chenoweth L)
Financing and management of lifetime
care for adults with acquired disabilities
and high care needs (Foster M, Henman
P, Fleming J, Tilse C)
Does individualised hand splinting
reduce spasticity after traumatic brain
injury (Copley J, Kuipers K, Fleming J,
Griffin J)
Brain injury rehabilitation: The lived
The effect of environmental barriers
on community integration following
traumatic brain injury (Fleming J, Nalder
E, Alves-Stein S)
The transition experiences of stroke
patients and their carers (Worrall L,
Fleming J, Grohn B, Nalder E, Hall A)
Early active motion of distal radius
fractures post open reduction internal
fixation improves patient outcomes
(Driessens S, Diserens-Chew T, Past and current leisure activities of
McPhail S + Logan Interdisciplinary
individuals in a brain injury rehabilitation
upper limb team)
unit (Braithwaite H, Fleming J,
Gustafsson L, Griffin J)
Comparison of Transitional Housing
Team data with the Transitional Housing
Investigations of care requirements of
Model of Service Delivery to identify a
people with brain tumour (Haines T,
strategic plan to respond to service gaps
Cornwell P, Fleming J, Olsen S, Omerod
and recognise resource implications
A, Dicks B)
(Gordon S, McPhail S)
Splinting to prevent forearm rotation –
Integrating remote access physical
to what degree? (Slaughter A, Miles L,
activity behaviour change programs into
Fleming J, McPhail S)
outpatient clinics: An investigation of
patient and staff perceptions (McPhail S)
Response shift, recall bias and their
effect on measuring change in healthrelated quality of life amongst older
hospital patients (McPhail S, Haines T)
Patient preference for falls prevention in
hospitals revealed through willingnessto-pay, contingent valuation survey
(Haines T, McPhail S).
Measuring falls events in acute
hospitals-a comparison of three
reporting methods to identify missing
data in the hospital reporting system
(Haines T, Hill AM, McPhail S, Hill KD,
L-R:Sue Pager, Dr Steven McPhail, Professor Liz Ward, Associate Professor Pim Kuipers, Associate Professor Jenny Fleming, Dr Emma Finch
Major Grants & Financial Support
Oliver D, Brauer S, Hoffmann T, Beer C)
Total competitive
funding:
Review of outcomes of people with
Funding from other
sources:
lower limb amputations (Batten H,
McPhail S, Kuys S, Varghese P)
$540,561
National & International Presentations
Associate Professor Jennifer Fleming
amongst therapists in physically
OT Australia NSW Cognitive
demanding roles: qualitative analysis of
Rehabilitation Workshop, Sydney
(Passier L, McPhail S)
Work related injuries amongst
occupational therapists: a preliminary
investigation (Passier L, McPhail S)
The effects of thrombolysis following
ischaemic stroke on communication and
swallowing outcomes (Finch E, Clark K,
Short K, Smith L, Antonio M, Aitken P)
Allied Health Research Capacity Survey:
Evaluation of the Centre for Functioning
and Health Research 2010-2014 (Pager S)
Evaluation of a settings-based approach
London
H&N Special Interest Group, London
$22,000
Work related musculoskeletal disorders
risk factors and strategies for prevention
Tracheostomy Special Interest Group,
Australian and New Zealand Head and
Neck Cancer Society: Pre-conference
workshop for Speech Pathologists in
H&N Cancer Management, Melbourne
Australia and New Zealand Head and
Neck Society, Melbourne
Dr Steven McPhail
Joint Relations, Brisbane
Australian and New Zealand Burn
Association, Darwin
Sue Pager
GP & Primary Health Care, Darwin
Professor Elizabeth Ward
Prosthetic voice rehabilitation: a
randomised control trial, Amsterdam
New issues in laryngectomy care, Horby
Sweden
MS Nurses Education Day, Brisbane
Dysphagia Research Society, San Diego USA
to research capacity building in primary
health care (Holden L, Pager S,
Golenko X)
Centres for Health Research 2010 Annual Research Report
43
Centre for Integrative Clinical
and Molecular Medicine
The Centre includes laboratory, clinical research and teaching,
specifically focused on the integration of Complementary and Alternative
Medicines within the conventional model. The aim of the centre is to
focus on evidence-based research on the mechanisms and actions
of nutraceuticals and natural compounds. The centre continued to
build research human capacity by supporting new MPhil and PhD
post graduate programs, fostering excellence and attracting increased
investment in research in integrative and complementary medicines.
The venomics research programme, partly funded by QRx Pharma Ltd/
Luis Vitetta
Venomics Ltd (with teams led by Professor. Martin Lavin in UQCCR and
Associate Professor Luke Guddat in SMMS) has continued the Australian
venom-derived drug development programme. QRx Pharma Ltd has
successfully entered into a joint venture in China with Nuokong Biopharmaceuticals, China; establishing a new
company in Hong Kong called Venomics, Hong Kong Ltd to bring to the China market the Textilinin and Haempatch products.
A new provisional patent entitled Serum Preparation was lodged at the APO on 20th September. Research towards
the Patent Cooperation Treaty document for this invention has also become a primary focus of the group’s research.
Several other patentable concepts led by Dr Kong-Nan Zhao are also in progress with invention disclosure
documents submitted to Uniquest for a patenting decision.
The centre endeavours to articulate national priorities in basic and translational research and promote national and
international collaborations to support beneficial connections with conventional medicine.
Associate Professor Luis Vitetta
Director
Research Activities
Clinical Trials
Does Tai Chi Regular Practice Improve
Males and Females 40 Years of Age or
Marine lipids, Leptin, Adiponectin levels
Depression and Metabolic Syndrome for
Older (Vitetta L, Coulson S, Vecchio P,
and inflammatory markers in obese
Depressed Adults at Risk of Developing
Masci P).
individuals (Vitetta L, Gray B)
Selected Micronutrients Absorption
Other Research
Studies (Vitetta L, Coulson S)
National Institute Complementary
Cardiovascular Disease (Xin L, Vitetta L,
Kostner K, Crompton D)
To Evaluate the Safety and Efficacy of
GlycOmega Green Shell Mussel
Powder on Osteoarthritis of the Knee in
44
research - key to health
B group vitamins and chemotherapy
induced peripheral neuropathy (Vitetta
L – CIA, Schloss J)
Medicine [NICM] Collaborative Centre
for Transitional Preclinical and Clinical
Research in Nutraceuticals and Herbal
Major Grants & Financial Support
Total NHMRC/ARC
funding:
$440,000
Other competitive
funding:
$320,405
Funding from
commercial studies:
$110,441
Funding from other
sources:
$182,500
National & International Presentations
Chenfeng Chen
16th International Holistic Health
L-R (Back Row): Belinda Gray, Samantha Coulson, Goce Demieski, Helen Gramotnev, Janet Schloss
L-R (Centre Row): Ellen van der Hall, Kong-Nan Zhao, Luis Vitetta, Paul Masci, Liu Xin
L-R (Front Row): Manu Trabi, Chenfeng Chen, Sharon Du
Not pictured: Ms Shoshannah Beck, AW Linnane, A Sali, D Colquhoun, M Whitehouse.
Conference, Sunshine Coast
Samantha Coulson
16th International Holistic Health
Conference, Sunshine Coast
Belinda Gray
19th Annual RBWH Health Care
Symposium, Brisbane
Medicines (Vitetta L, Komesaroff P,
strategy for “Serum preparation” IP
James D, Linnane AW, Roberts M, Day
commercialization strategy (Masci P,
Janet Schloss
R, Tiralongo E)
Dimeski G)
16th International Holistic Health
Ascorbate as a Treatment for Cancer
Uses of protease inhibitors to stimulate
(Vitetta L, Linnane AW, Chen CF)
wound healing (Zhao KN, Masci P)
Probiotic Supplementation as an
QRx Pharma Ltd/venomics Ltd./
Intervention against the Inflammatory
Nuekong Biopharmaceutical Ltd product
Effects of Gluten and Irritable Bowel
development for China (Masci P)
Syndrome (Vitetta L, Briskey D)
Platelet microparticle Fibrin diagnostic
development with Q Health (Masci P,
and in Liver Surgery ( Roberts M, Weiss
Bird R, Saal R)
Fletcher L)
Provisional patent entitled “Serum
Preparation” research to prepare
PCT document assist Uniquest in a
commercialization strategy (Masci P,
Dimeski G, de Jersey J, Lavin M)
Niikee Schoendorfer
Nutrition Society of Australia 34th
Pharmacodynamics in Liver Disease
M, McDonald G, Fawcett J, Vitetta L,
Conference, Sunshine Coast
Annual Scientific Meeting, Perth
Dr Manuela Trabi
2nd Australasian Symposium on
Metabolomics, Melbourne
Associate Professor Luis Vitetta
Development of novel oral-deliverable
anticoagulant with Dr Simone Osborne,
General Practitioner Conference and
Exhibition, Sydney
CSIRO St Lucia (Masci P)
Studies of Platelet-associated resistant
fibrin in Obese individuals using
Thromboelastography (Hickma I, Masci P)
Development of a venom-derived
prothrombin activator production
Centres for Health Research 2010 Annual Research Report
45
Centre for Kidney
Disease Research
The Centre for Kidney Disease Research (CKDR) is one of Australia’s
leading kidney disease research centres with an international reputation for
excellence in research. The centre consists of the Translational Research
Laboratories at Princess Alexandra Hospital (PAH) and the Royal Brisbane
and Women’s Hospital (RBWH), the PAH Nephrology Clinical Research
Group, the RBWH Clinical Research Group, and the Australasian Kidney
Trials Network. Researchers are working at the forefront of global trends in
research to understand the cellular and molecular basis of kidney disease
and to trial innovative new clinical treatments to improve the health and
well-being of people with kidney disease. Renowned for its studies in acute
and chronic kidney disease and kidney cancers, the centre has particular
expertise in translating results from laboratory and clinical sciences for
application to improve public health outcomes.
The centre continues to strengthen its international collaborations. These
help to enhance the profile of the School of Medicine and The University
of Queensland at an international level and help maintain the CKDR as a
leading research centre. International projects that were initiated during
the year include the Chronic Kidney Disease of unknown etiology (CKDu)
consortium with groups in Sri Lanka and Japan. The objective of the
consortium is to carry out investigations into the pathogenesis, etiology and
preventive measures of an epidemic of CKDu in a specific province of Sri
Lanka. Members of the consortium include: Ministry of Health and Nutrition
of Sri Lanka- General Hospital Kandy; University of Peradeniya, Sri Lanka;
Kyoto University, Japan; Kitano Hospital, Japan; Daiichi Pharmaceutical
University, Japan; and the CKDR and the Centre for Chronic Disease at The University of Queensland.
Glenda Gobe
David Johnson
One of the aims of the centre was to promote collaboration between
nephrology clinical research centres at RBWH and PAH. The success of CKD.
QLD a multidisciplinary research and practice network founded by Professors Hoy and Fassett has lead to an NHMRC
Centre of Research Excellence application for studying chronic kidney disease in Queensland. The application is lead by
Professor Robert Fassett and has included as CIs many of the members of the CKDR.
The year was extremely productive with major research highlights and achievements including: the publication of the
IDEAL trial (a randomised controlled trial of early versus late dialysis) in the New England Journal of Medicine; three
NHMRC project grants awarded for funding starting in 2011; a second five-year renewal of the Centre of Research
Excellence NHMRC Enabling Grant; and a Queensland Government Health Research Fellowship award to Professor
David Johnson.
Associate Professor Glenda Gobe
Administrative Co-Director
Professor David Johnson
Co-Director
Professor Robert Fassett
Co-Director
46
research - key to health
Research Activities
Clinical Trials
The CKDR clinical groups are involved
HERO Trial: This is a randomised,
Encapsulating peritoneal sclerosis in
in several multi-centre randomised
placebo-controlled trial of oxpentifylline
Australian and New Zealand Peritoneal
controlled trials (HONEYPOT, HERO,
on haemoglobin levels in patients with
Dialysis Patients – Incidence, predictors
FAVOURED, PEXIVAS, BLOCADE,
erythropoietin-resistant anaemia. The
and outcomes (Johnson DW, Cho Y).
IMPROVE-CKD, ACTIVE Dialysis, study aims to determine if oxpentifylline
IDEAL, SHARP, CORAL, balANZ).
administration will effectively treat
Outlined below are summaries of three
erythropoietin or darbepoietin-resistant
of the trials.
anaemia in chronic kidney disease
HONEYPOT Trial: This randomized,
controlled trial of exit site application
of Medihoney™ is designed for the
prevention of catheter-associated
infections in peritoneal dialysis patients. The study aims to determine
whether daily exit site application
of standardised antibacterial honey
(Medihoney™), effectively prevents
exit site infections, tunnel infections
and peritonitis in peritoneal dialysis
patients, compared with standard
topical mupirocin prophylaxis of nasal
staphylococcal carriers.
FAVOURED trial: (Fish oil and Aspirin
in Vascular access Outcomes in Renal
Disease) This study aims to determine
whether the use of the anti-platelet
agents aspirin and fish oil, either alone
or in combination, in a factorial design,
will effectively reduce the risk of early
thrombosis in de novo arterio-venous
fistulae (AVF). The study population
is patients with stage IV or V chronic
kidney disease who require or will
require haemodialysis, are scheduled to
undergo creation of an AVF and are not
patients. The study population is adult
patients with stage IV or V chronic
kidney disease (CKD) (including
patients on dialysis) with significant
anaemia (Hb =110 g/L) for at least 3
months that is unresponsive to large
doses of either erythropoietin (=200
The IMPENDIA trial – Multi-centre,
prospective, randomized trial to
demonstrate Improved Metabolic
Control of PPEN Vs DDDD in Diabetic
CAPD patients (Johnson DW, Coburn
A, Ranganathan D). A controlled clinical
trial evaluating the effects of sugar-free
dialysis on blood sugar control and
other metabolic parameters in diabetic
peritoneal dialysis patients.
IU/kg/week) or darbepoietin (=1μg/kg/
The impact of APD versus CAPD on
week) and for which there is no clear
survival of Australian and New Zealand
identifiable cause. The primary outcome
peritoneal dialysis patients (Johnson DW,
is haemoglobin level at four months after
Badve S).
randomisation. Other outcomes include
changes to the dosage of erythropoietic
Predictors of recovery (and time to
stimulatory proteins, changes to Key’s
recovery) of dialysis-independent
index, changes to blood transfusion
renal function in scleroderma renal
requirements and adverse events.
crisis patients commencing PD or
HD in Australia and New Zealand
Peritoneal Dialysis
(Johnson DW).
The balANZ trial - A multicentre
randomised controlled trial of Balance®
A systematic review of the effects
in Australian and New Zealand PD
of biocompatible peritoneal dialysis
patients (Johnson DW, Coburn A,
solutions on patient outcomes Ranganathan D). Aims to compare
(Johnson DW).
the effects of a novel, neutral pH, low
glucose-degradation product dialysis
fluids with conventional dialysis fluid on
remaining kidney function in peritoneal
dialysis patients.
Microbiology and outcomes of
peritonitis in Australian peritoneal
dialysis patients (Johnson DW).
ANZDATA Registry analysis of the
microbiological causes and outcomes of
currently taking anti-platelet agents. Predictors and outcomes of peritonitis
peritoneal dialysis-associated peritonitis
The primary outcome is patency
in the Australian and New Zealand PD
in Australia 2003 – 2006.
of the AVF at three months after
patient populations (Johnson DW).
randomisation. Other outcomes include
functional patency at six months,
primary patency time, secondary
(assisted) patency time, and adverse
events, particularly bleeding.
A randomised, controlled trial of exit site
The effect of dialysis modality on decline
application of Medihoney™ Wound Gel
of residual renal function (Hawley CM,
for the prevention of catheter-associated
Petrie J, Johnson DW).
infections in peritoneal dialysis patients
(HONEYPOT trial) (Johnson DW, Hawley
CM, Isbel NM, Clark C, Coburn A).
Centres for Health Research 2010 Annual Research Report
47
A randomised controlled trial of
Peritonitis-Related Mortality The impact of nocturnal home
oral HEMe iron polypeptide Against
(Johnson DW).
haemodialysis on patient outcomes (van
Treatment with Oral Controlled Release
Iron Tablets for the correction of
anaemia in peritoneal dialysis patients
(HEMATOCRIT trial) (Johnson DW,
Hawley CM).
Predictors of residual renal function
recovery in Australian and New Zealand
Effect of seasonal variation on peritonitis
incidence in Australia and New Zealand
(Cho Y, Johnson DW).
Effect of regional variation on peritonitis
incidence in Australia and New Zealand
(Cho Y, Johnson DW).
peritoneal dialysis patients (Johnson DW,
TUMMIE Trial (Ranganathan D).
McDonald S, Macdonald J).
Comparing the topical use of medihoney
Microbiology and outcomes of
peritonitis in Australian paediatric
peritoneal dialysis patients (Bordador E,
with mupiracin in the management of
PD exit site infection.
Timely PD trial (Ranganathan D).
Eps C, Hawley C, Isbel N, Campbell SB,
Johnson DW).
Effects of Alternate Night Nocturnal
Hemodialysis on Oxidative Stress
and Antioxidant Enzymes (Van Eps C,
Hawley C, Jeffries J).
SHARP trial: A randomized, placebocontrolled study to assess the effects
of Cholesterol-lowering therapy
with a combination of simvastatin
and Ezetimebe on the Risk of Major
Cardiovascular Complication Among
Individuals with Chronic Kidney disease
McTaggart S, Johnson DW).
GIPD Gentamicin in peritoneal
(Johnson DW, Sudak J).
Peritoneal dialysis outcomes after
dialysis Trial (Ranganathan D).
temporary haemodialysis transfer
Investigating the pharmacokinetics
The initiating dialysis early and late
for severe peritonitis (Badve S, and pharmacodynamics of gentamycin
(IDEAL) study (Johnson DW, Leary D,
Johnson DW).
administration in peritoneal dialysis.
Fassett RG, Healy H). An Australasian,
Predictors, treatments and outcomes
COMIVID Comparison of markers of
of relapsing versus recurrent peritonitis
of early versus late commencement
oxidative stress and inflammation and
(Burke M, Johnson DW).
of dialysis in end-stage kidney failure
myocardial and vascular structure and
patients.
Predictors, treatments and outcomes
of relapsing versus recurrent peritonitis
(Thirugnanasambathan T, Johnson DW).
Effect of aminoglycosides on residual
multi-centre, controlled clinical trial
function in incident peritoneal and
hemodialysis patients Trial (Fassett RG,
Evaluation of Cinacalcet HCl Therapy to
Coombes JS, Ranganathan D, Ratanjee
Lower Cardiovascular Events (EVOLVE)
S, Healy H).
(Hawley, C, Sudak, J, Kark A and
Fassett RG). A multi-centre, controlled
Harmodialysis
clinical trial of cinalcet versus placebo
Ethanol lock therapy for the prevention
in haemodialysis patients. The primary
of tunnelled catheter-related
outcome measure is a composite
Adherence to Guideline
bacteraemia in haemodialysis patients
cardiovascular end point.
Recommendations for Infection
(Broom J, Playford G, Johnson DW,
Prophylaxis in Peritoneal Dialysis
Hawley CM). Single centre, controlled
Quality of Life and alternate nightly
Patients (Badve S, Hawley CM, clinical trial examining the effect of
nocturnal home haemodialysis (van Eps
Johnson DW).
once-weekly alcohol lock treatment
CL, Jeffries J, Johnson DW, Campbell S,
versus conventional heparin locking
Isbel N, Mudge D, Hawley CM).
renal function decline in peritoneal
dialysis (Badve S, Johnson DW).
Elderly Peritoneal Dialysis Patients
Have Similar Peritonitis-Free Survival
and Lower Risk Of Technique Failure
on catheter-associated bloodstream
infection in haemodialysis patients.
C.E. DOSE trial: Effects of the dose of
erythropoiesis stimulating agents on
but Higher Risk Of Peritonitis-Related
The HERO trial: A randomised, placebo-
cardiovascular events, quality of life,
Mortality Compared With Younger
controlled trial of oxpentifylline on
and health-related costs in hemodialysis
Patients (Johnson DW).
haemoglobin levels in patients with
patients: the clinical evaluation of the
erythropoietin-resistant anaemia
dose of erythropoietins (Johnson DW,
(Johnson DW, Hawley CM, Fassett RG,
Strippoli GFM).
Remote Indigenous Peritoneal Dialysis
Patients Have Higher Risk Of Peritonitis,
Technique Failure, All-Cause and
48
research - key to health
Leary D).
The Impact of extended hours
home hemodialysis and buttonhole
canjnulation technique on hospitalization
rates for septic events related to dialysis
access (van Eps CL, Jones M, Ng T,
Johnson DW, Campbell SB, Isbel NM,
Mudge DW, Beller E, Hawley CM).
ACTIVE: A Clinical Trial of Intensive
Dialysis. A Multicentre, Unblinded,
Randomised, Controlled Trial to
assess Quality of Life, Clinical
Outcomes and Cost Utility for Extended
vs Standard Duration of Dialysis in
Patients with ESKD (Van Eps CL,
Johnson DW, Campbell S, Isbel N,
Centre for Kidney Disease Research
Mudge D, Hawley CM, Sudak J,
Ranganathan D). Investigating the
Intravenous versus oral iron
Transplant Recipients (Orazio L, Isbel
optimal dialysis duration.
supplementation for the correction of
NM, Johnson DW).
FAVOURED: A randomised, doubleblind, placebo-controlled, factorial
design trial to assess the effect of aspirin
post-transplant anaemia (Mudge DW,
Tan K, Haley CM, Campbell SB, Isbel
NM, Nicol DL, Johnson DW).
A partially blinded, prospective,
randomized multicentre study evaluating
efficacy, safety and tolerability of oral
and fish oil (omega 3 fatty acids) in the
The role of tumourectomised kidneys
sotrastaurin plus standard or reduced
prevention of early thrombosis in arterio-
as a potential source of allografts for
exposure tacrolimus vs myfortic® plus
venous fistulae in patients with Stage
renal transplantation (Brook N, Nicol
tacrolimus in de novo renal transplant
IV or V chronic kidney disease requiring
DL, Johnson DW, Campbell SB, Isbel N,
recipients (Campbell S, Isbel N, Johnson
haemodialysis (Hawley C, Mudge D,
Hawley C).
DW, Hawley CM, Mudge DW, Van Eps
Coburn A).
Polycystic kidneys as a potential source
CL, Bali V).
Time course and dose study of vitamin
of allografts for renal transplantation
Biomarkers in Transplantation External
E and oxidative stress in hemodialysis
(Nicol DL, Johnson DW, Campbell SB,
Qualification Phase (BiT2) (Isbel N,
patients (Fassett RG, Coombes JS).
Isbel N, Hawley C).
Campbell S, Johnson DW, Hawley CM,
DOPPS IV (Kark A and Ratanjee
Adiponectin in renal transplant recipients
S). Dialysis Outcomes and Practice
(Kaisar MO, Armstrong K, Prins J,
A prospective observational case-
Patterns Study
Johnson DW, Isbel N).
control study to assess predictors for
EXTEND study (Healy H).
Impact of aggressive intervention in
Transplantation
An investigation into the influence
of CYP3A5, CYP3A4 and MDR1 gene polymorphisms on
tacrolimus pharmacokinetics and
renal transplant recipients with impaired
glucose tolerance on insulin resistance
Mudge DW, Van Eps CL, Leary D).
BK viraemia in adult kidney transplant
recipients (Isbel N, Barraclough K, Leary D).
and atheroma burden (Kaisar MO,
Assessment of the Impact of
Armstrong K, Prins J, Johnson DW, nephrectomy on Cardiovascular Risk
Isbel N).
in Living Kidney Donors: Longitudinal
pharmacodynamics (Staatz C,
Higher Levels of Physical Activity
Barraclough K, Johnson DW, Isbel NM).
are Associated with a Lower Risk of
Abnormal Glucose Tolerance in Renal
follow-up. Focus on Endothelial
Dysfunction, Inflammation and oxidative
Stress (Isbel N, Kaisar MO, Leary D, Bali V).
Centres for Health Research 2010 Annual Research Report
49
ASCERTAIN Trial (Fassett RG). The
Outcomes of end-stage renal failure
Trial to Assess the Best Treatment for
assessment of Everolimusin addition
secondary to haemolytic-uraemic
Patients with High Blood Pressure and
to calcinurin inhibitors reduction in
syndrome in Australia and New
Renal Artery Stenosis: Stenting with
maintenance renal transplant recipients.
Zealand – a multi-centre registry study
Anti-Hypertensive Medical Therapy,
(Mahondas J, Johnson DW).
Compared to Medical Therapy alone.
Astaxanthin v placebo a randomised
Results of a national survey of Australian
An Open-label, Multicentre,
controlled trial in renal transplant
and New Zealand Renal nurses:
Randomised, 3-arm Study to Investigate
patients assessing oxidative stress
Opinions on the content and effects of
the Comparative Efficacy and Safety
inflammation and vascular structure clinical practice guidelines for chronic
of Intravenous Ferric Carboxymaltose
and function.
kidney disease (Johnson DW).
(Ferinject® High- and Low-dosage
Swine flu vaccination (John GT).
Rosuvastatin and cardiovascular events
Xanthin Trial (Fassett RG, Coombes JS).
Sirolimus proteinuria study (John G,
Healy H).
General Nephrology
Randomised and Multi-Center TwoGroup Clinical Trial to Assess the Best
Treatment for Patients with High Blood
Pressure and Renal Artery Stenosis:
Stenting with Anti-Hypertensive Medical
Therapy, Compared to Medical Therapy
alone (Mudge D, Martin A).
Treatment options for sexual dysfunction
in patients with chronic kidney disease:
A systematic review and meta-analysis
in patients undergoing hemodialysis
(Isbel NM, Johnson DW).
Regimens) versus Oral Iron for the
Treatment of Iron Deficiency Anaemia in
Subjects with Non-dialysis-dependent
Chronic Kidney Disease (Mudge DW, Van
The role of 25-hydroxyvitamin D
Eps CL, Johnson DW, Campbell S, Isbel
deficiency in promoting insulin
N, Hawley CM, Bali V).
resistance and inflammation in
patients with chronic kidney disease:
a randomised controlled trial (Petchey
WG, Hickman IJ, Duncan E, Prins JB,
Hawley CM, Johnson DW, Barraclough
K, Isbel NM).
LANDMARK 3: (Isbel N, Sonnenburg K,
Ditterich L). A randomised controlled
trial comparing the impact of aggressive
risk factor and lifestyle modification
utilising a nurse led coordinated
care with standard care to limit the
Interventions for erythropoietin-resistant
progression of cardiovascular disease in
anaemia in dialysis patients (Badve S,
patients with chronic kidney disease.
Hawley CM, Johnson DW).
PYR-210 (Isbel N, Pitkin M). A
of randomized controlled trials (Johnson
Consumer involvement in topic and
Randomized, Double-Blind, Placebo-
DW, Strippoli GFM).
outcome selection in the development
Controlled, Multi-Center, Phase 2b
of clinical practice guidelines Study to Evaluate the Safety and
(Johnson DW).
Efficacy of Pyridorin (pyridoxamine
Erythropoiesis-stimulating agents in
people with chronic kidney disease:
dihydrochloride) in Patients With
Systematic review and meta-analysis
Cardio respiratory fitness is
(Johnson DW, Strippoli GFM).
independently associated with
Angiotensin converting enzyme
inhibitors, angiotensin receptor blockers
and combined therapy in patients with
micro- and macroalbuminuria and other
Nephropathy Due to Type 2 Diabetes.
25-hydroxyvitamin D status in chronic
TEMPO (Johnson DW, Campbell S,
kidney disease (Petchey WG, Howden
Isbel N, Hawley CM, Mudge DW, Pitkin
EJ, Hawley CM, Johnson DW, Prins JB,
M). A Phase 3, Multi-center, Double-
Marwick T, Isbel NM).
blind, Placebo-controlled, Parallel-arm
Trial to Determine Long-term Safety
cardiovascular risk factors: a systematic
CORAL Cardiovascular Outcomes
and Efficacy of Oral Tolvaptan Tablet
review of randomized controlled trials
in Renal Atherosclerotic Lesions
Regimens in Adult Subjects with
(Johnson DW, Strippoli GF).
(Mudge DW, Sudak J). Randomised
Autosomal Dominant Polycystic and Multi-Center Two-Group Clinical
Kidney Disease.
50
research - key to health
DCVAS (Diagnostic Classification of
of unknown origin (Gobe G, Mott S,
Inflammation and oxidative stress –
Vasculitis) (Ranganathan D). ACR/
Hoy W, Paterson D, de Jonge M, CKDu
biomarkers for their detection (Fassett R,
EULAR endorsed study to develop
consortium).
Coombes J, Gobe G)
Does oxidative stress contribute to renal
CKD.QLD (Fassett R, Hoy W, Johnson D,
cell aging and chronic kidney disease
Healy H, Gobe G, Gardner G, Cooper M,
via dysfunctional mitochondria and can
Coombes J, Mitchell G, Palmer A)
classification and diagnostic criteria
for primary systemic vasculitis, in
collaboration with investigators from
University of Oxford.
this be modulated by using combined
POEMSUM study (Ranganathan D,
anti-oxidant therapy? (Gobe G, Small D,
Fassett RG). Mycophenolate study in
Coombes J, Fassett R, Roy S).
lupus nephritis .
Use of alternative therapies for chronic
CKD.QLD Site Profiling (Venuthurupalli
SK, Fassett R, Hoy W)
CKD.QLD CKD nurse practitioner study
(Gardner G, Hoy W, Fassett R, Healy H)
Acute Kidney Injury
kidney disease (Gobe G, Johnson D,
Arterial Stiffness in acute kidney injury
Fassett R, Coombes J, Wojcikowski K,
Bioactive botanical compounds as
(Fassett RG, Coombes JS).
Yamada M).
clinical intervention tools (Houghton C,
Other Research
Control of myofibroblast numbers
Enhancing erythropoietin therapy in
in chronic kidney disease (Gobe G,
ischaemia-reperfusion therapy in heart
Pathways to palliative care in renal
Hewitson T, Winterford C, Roy S).
disease (Fassett RG, Bull R, and kidney (Gobe G, Johnson D, West
M, Brown L, Vesey D, Bennett N, Diwan
V, Cowin G, Goligorsky M).
Mechanisms of cytoprotection by
erythropoietin in the hypoxia/ischaemiainjured neonatal brain (Yamada M, Gobe
G, Colditz P, Johnson D).
Anti-oxidant action of carvedilol in
protecting the kidney from cisplatininduced nephrotoxicity (Carvalho
Rodrigues MA, Gobe G, Cardoza dos
Santos A, Bennett N).
Cadmium toxicity to proximal tubular
epithelium of the kidney: roles of
inflammation and mitochondrial
dysfunction (Corbier M, Gobe G,
Bennett N, Vesey D, Whitbourne L, Roy S).
Elemental analysis of kidney biopsies
using x-ray fluorescence microscopy
at the Australian Synchrotron: a search
for causes of chronic kidney disease
Biomarkers for renal cell carcinoma
Coombes JS, Fassett RG)
Robertson IK)
(Rajandram R, Gobe G, Johnson D,
eKIDNNA electronic kidney disease
Oliver K).
national audit alliance (Fassett RG, Understanding the resistance of renal
cell carcinoma to therapies (Morais C,
Gobe G, Johnson D, Oliver K).
Protease-activated receptor-2 and
renal carcinogenesis (Vesey D, Gobe G,
Johnson D).
Endotoxins in dialysates and progression
of chronic kidney disease (Vesey D,
Wilkinson A, Isbel N).
Healy H)
Major Grants & Financial Support
Total NHMRC
funding:
$650,000
Other competitive
funding: $571,540
Funding from
commercial studies:
$84,637
Funding from other
sources:
$126,532
Androgen receptor and androgen self
sufficiency in prostate cancer (Bennett
N, Gobe G, Johnson D, Hooper J,
Gardiner R, Lambie D).
Using primary cultures of human
proximal tubular epithelial cells to
investigate pathophysiological and
biochemical pathways to renal diseases
(Wilkinson R, Healy H, Wang X)
Centres for Health Research 2010 Annual Research Report
51
Centre for Liver
Disease Research
The Centre for Liver Disease Research has an international reputation
in human liver disease research. The mission is to determine the
mechanisms by which obesity and fatty liver impair the response of the
liver to injury from multiple causes and to develop specific strategies
to improve the outcome of patients with liver disease. The vision is to
successfully integrate scientific and clinical research projects in order to
rapidly translate scientific outcomes into clinical practice to benefit the
health of the community affected by liver disease.
The Centre led a national and international collaboration that investigated
heterogeneity in fibrosis patterns in nonalcoholic steatohepatitis and
reported a previously unrecognised pattern of very fine, non-zonal
sinusoidal fibrosis that has implications for therapy and understanding
pathogenesis.
Elizabeth Powell Julie Jonsson
A further international collaboration demonstrated that IL-32 is a novel proinflammatory cytokine involved
in chronic hepatitis C-associated liver inflammation/fibrosis and that its expression is regulated by
proinflammatory stimuli.
PhD student, Dr Richard Skoien was awarded the Young Investigator Award - Basic Science by the
Gastroenterological Society of Queensland, Poster of Merit at Australian Gastroenterology Week and the
internationally prestigious Fellow Research Award by the American Association for the Study of Liver Diseases.
Ms Leigh Horsfall was awarded Young Investigator Award - Clinical Science by the Gastroenterological Society
of Queensland. Dr Michelle Melino was Young Investigator Award Finalist at the Coolum meeting of the
Gastroenterological Society of Queensland.
Associate Professor Elizabeth Powell
Co-Director
Associate Professor Julie Jonsson
Co-Director
Associate Professor Andrew Clouston
Associate Director
Research Activities
Clinical Trials
Non-invasive assessment of hepatic
(Powell E, Jonsson J, Clouston A, The pharmacogenetics of drug induced
steatosis by magnetic resonance
Horsfall L, Skoien R, Benson M, Cowin
liver injury (Martin J, Powell E, Horsfall L)
imaging (MRI) and spectroscopy (MRS)
G, Galloway G, Stuart K, Crawford D)
52
research - key to health
Other Research
Monocytes/macrophages in chronic liver
diseases (Powell E, Jonsson J, Clouston
A, Melino M, Gadd V, Walker G)
Characterising the portal inflammatory
response in NASH and its relationship to
fibrosis (Clouston A, Powell E, Jonsson
J, Skoien R, Gadd V)
Factors affecting the progression of
liver disease and response to treatment
(Powell EE, Jonsson JR, Clouston AD)
Effect of weight loss on liver protein
expression and response to antiviral
therapy in patients with chronic Hepatitis
C (Powell E, Jonsson J, Clouston A,
Horsfall L, Benson M, Cowin G)
Isolation of primary human liver cells
L-R (Back Row): Dr Richard Skoien, Ms Victoria Gadd, Associate Professor Elizabeth Powell
L-R (Front Row): Ms Leigh Horsfall, Dr Michelle Melino, Associate Professor Julie Jonsson
(Powell E, Jonsson J, Clouston A,
Fawcett J, Melino M)
Validation of selection criteria for liver
biopsy in patients with suspected fatty
AASLD Fellow Research Award,
Conjoint Australia New Zealand Upper
American Society for the Study of Liver
Gastrointestinal and Hepatic, Pancreatic
Diseases
and Biliary Association Meeting,
Queenstown, NZ
liver disease (Powell E, Skoien R, Rich G,
Poster of Merit, Australian
Horsfall L, Clouston A, Jonsson J)
Gastroenterology Week
Awards & Prizes
Major Grants & Financial Support
Leigh Horsfall
Dr Michelle Melino
Australian Gastroenterology Week, Gold Coast
Total NHMRC funding:
$242,312
Other competitive
funding:
$100,000
Queensland
Funding from other
sources:
$102,357
Dr Michelle Melino
National & International Presentations
Australian Gastroenterology Week, Young Investigator Award Finalist, Young
Associate Professor Andrew Clouston
Gold Coast
Investigator Award, Gastroenterological
Laennec Society for Hepatopathology
Society of Queensland
Summer Meeting, Seoul, Korea
The Liver Meeting of the American
Dr Richard Skoien
Challenges in Gastroenterology,
Diseases, Boston, USA
Young Investigator Award, Basic
Melbourne
Young Investigator Award, Clinical
Science Research Presentation,
Gastroenterological Society of
Associate Professor Elizabeth Powell
7th Australasian Viral Hepatitis
Conference, Melbourne
Dr Richard Skoien
Association for the Study of Liver
Science, Gastroenterological Society of Queensland
Centres for Health Research 2010 Annual Research Report
53
Centre for Research in
Geriatric Medicine
This was the first full year of operation as a School Centre, in the new
premises at Princess Alexandra Hospital. The centre’s activity was
dominated by extensive field work associated with grants secured in
2009. Data collection to support the studies involved over 20 sites in
three Australian states and seven countries, across Europe, Asia and
North America.
To support the work in developing quality indicators and systems for aged
care, the Research Collaborative for Quality Care of Older Persons has
been established which involves senior researcher collaborators from
Victoria and the USA, and which, to date, has engaged over 20 clinical
experts from around Australia.
Len Gray
The centre was successful in securing an NHMRC Project Grant to explore the efficacy, in an RCT format, of
personal accelerometers in promoting functional recovery in rehabilitation. A second major grant, awarded by the
Queensland Emergency Medicine Research Fund, will develop quality indicators for the care of older people in the
Emergency Department.
During the year, Professor Gray assumed the role of Director of the Centre for Online Health at UQ, thus cementing
the already strong collaboration between the centres.
The relationship with the interRAI international research collaborative (which builds assessment systems for aged
care) continues to flourish, with the Centre hosting a very successful international interRAI conference in Brisbane
during the year.
A Health Research Fellowship was awarded to support a new joint position with Princess Alexandra Hospital, which
will result in the appointment of a second full time academic geriatrician at CRGM in 2011.
Professor Len Gray
Director, Centre for Research in Geriatric Medicine
Director, Centre for Online Health UQ
Associate Professor Paul Varghese
Director, Geriatric and Rehabilitation Unit, PAH
Research Activities
Clinical Trial
Reliability of an “online” geriatric
is to test the reliability and safety of a
NHMRC Project Grant 2009-2011.
assessment procedure (Gray L, Counsell
comprehensive geriatric assessment
Patients in acute care referred for
S, Edwards H, Martin-Khan M, Wooton
performed ‘online’ in making geriatric
geriatric assessment are randomised
R, Darzins P). The aim of this project triage decisions. This project is a to either paired live and online
54
research - key to health
assessments or live/live assessments.
Are hospitals providing quality care
Clinical outcomes, staff and carer
Online assessments are completed by
for people with dementia? (Gray L,
perceptions of acute hospitalisation of
viewing the assessment ‘online’ in a web
Byrne G, Jones R, Martin-Khan M,
patients with dementia (Gray L, Byrne
based system. Each doctor designates
Morris J, Pachana N). The aim of this
G, Pachana N). This projects aims to
a triage decision and agreement is
project is to develop a suite of quality
provide a clear picture of the problem
compared between paired assessments.
indicators to measure the quality of
of dementia in hospital, including
Doctors and nurses have been trained care associated with patient outcomes
how often people with dementia are
in the assessment procedure and
for people with dementia in hospital.
admitted, what happens to them, how
research protocol at all three sites. The project is funded by the J.O. & J. R.
hospitals respond to their needs, and
Data collection is almost complete at
Wicking Trust. An initial set of QIs (both
how well carers perceive their needs
one site.
process and outcome) were developed
are met. The key objective is to provide
in consultation with an expert panel and
sufficient information to inform better
a review of relevant scientific literature.
design of hospital procedures for people
The focus was on common geriatric
with dementia.
Other Research
Development and Evaluation of Quality
Indicators in Post Acute Transition Care:
An Observational Study (Cameron
I, Crotty M, Gray L). This project is
part of an NHMRC Health Services
Program Grant 2006-2011 “Transition
Care: Innovation and Evidence”. The
project aims to develop and test a
suite of Quality Indicators (QIs) for
Transition Care Programs (TCPs) and
syndromes of significant relevance
to patients with dementia. Data was
Major Grants & Financial Support
$462,720
collected from 648 acute care patients
Total NHMRC funding:
in nine Australian hospitals. A final
Other competitive
funding:
$89,800
Funding from other
sources:
$90,668
expert panel was convened to review
the field study results and QI definitions.
The RAND-UCLA concensus approach
will be used to decide the final QI set.
National & International Presentations
Professor Len Gray
to examine the “whole of episode”
Development of quality indicators for
costs of persons moving from acute
the frail elderly in acute care (Gray L,
care through a transition care episode.
Brand C, Jones R, Morris J, Wright O,
An initial set of QIs (both process and
Martin-Khan M). This proposal aims
interRAI Asia Regional Conference,
outcome) was developed from literature
to develop outcome oriented QIs for
Brisbane, Queensland
and reviewed and refined by an expert
geriatric syndromes and functional
panel. Prevalence and incidence data
outcomes. An initial set of QIs (both
for the draft QIs collected from 351
process and outcome) were developed
TCP admissions in six community-
in consultation with an expert panel and
Gold Coast, Queensland
based TCPs will be provided to
a review of relevant scientific literature.
the expert panel in July 2011 and a
The focus was on common geriatric
Dr Prabha Lakhan
consensus approach will be adopted
syndromes, excluding cognition. Data
to develop a list of QIs for describing
was collected from 648 acute care
and benchmarking quality of care
patients in nine Australian hospitals.
Dr Melinda Martin-Khan
provided by TCPs. An economic analysis
A final expert panel was convened to
interRAI Asia Regional Conference,
will assess the clinical and resource
review the field study results and QI
Brisbane, Queensland
implications of the program and assess
definitions. The RAND-UCLA the cost effectiveness of different
concensus approach will be used to
models of transition care.
decide the final QI set.
Australian & New Zealand Society of
Geriatric Medicine, Coolum, Queensland
ACSA National Community Care
Conference & Trade Exhibition 2010,
interRAI Asia Regional Conference,
Brisbane, Queensland
Centres for Health Research 2010 Annual Research Report
55
Australian & New Zealand Society of
Geriatric Medicine, Coolum, Queensland
Aged Care Standards and Accreditation
Agency Ltd Better Practice, Glenelg,
Adelaide
Aged Care Standards and Accreditation
Agency Ltd Better Practice, Melbourne
Aged Care Standards and Accreditation
Agency Ltd Better Practice, Sydney
Aged Care Standards and Accreditation
Agency Ltd Better Practice, Brisbane
Australian Association of Gerontology
43rd National Conference, Hobart,
Tasmania
L-R (Back Row): Mark Rozario, Lawrence Lim, Sean Halloran, Elaine Fielding, Salih Salih, Linda Schnitker
L-R (Middle Row):Bonnie Pimm, Nancye Peel, Melinda Martin-Khan, Catherine Travers, Vivian Cheung, Lucy Dakin
L-R (Front Row): David Lie, Joanna Kho, Len Gray, Leigh Bradley
Dr Catherine Travers
4th National Dementia Forum, Surfers
Paradise, Queensland
interRAI Asia Regional Conference,
Brisbane, Queensland
Australian Association of Gerontology
43rd National Conference, Hobart,
Tasmania
56
research - key to health
Ms Linda Schnitker
Dr Nancye Peel
4th National Dementia Forum, Surfers
The Gerontological Society of Paradise, Queensland
America’s 63rd Annual Scientific
Emerging Researchers in Ageing
Conference – ERA Newcastle, NSW
Meeting, New Orleans, USA
interRAI Asia Regional Conference,
Brisbane, Queensland
Clinical Governance
The Unit continued to provide support and oversight to the safety and
quality systems across the Hospital. It consists of a number of sections:
the Quality Team, who manage accreditation, a range of clinical audits,
falls and the death review processes; the Clinical Services Evaluation
team, who manage the Senior Medical Performance Review, a range
of clinical audits, the Clinical review & Audit Register and the Clinical
Governance Scoreboard; the Patient Safety Officers, who manage the
Clinical Incident processes and provide HEAPS training. The unit includes
the hospital solicitor, who provides legal services and the Patient Liaison
team, who manage the complaints and compliments from patients.
Michael Daly
Dr Michael P Daly
Executive Director, Metro South
Research Activities
Senior Medical Officer Performance
Early Triage of senior clinician
National & International Presentations
Review: Establishing Reliability and
performance concerns- improving
Dr Michael Daly
Validity of Peer Review Assessment
outcomes for healthcare (Daly M,
ACHSM Symposium, Brisbane.
(Ashby R, Harris K, Winning M, Khatun
McCormack L, Dulhunty J, Seidl I). This
M). This is a performance appraisal
research is assessing the effects of a
and development tool that aims to
locally developed early Triage model, for
demonstrate and summarise clinician
the early management of senior clinician
performance and development
performance concerns.
activities. It is a quality activity that
allows examination, reflection and
potential improvement of an individual’s
medical practice. This provides a
combination of objective clinical and
administrative data and measured peer
review assessment.
This research is the first of its type in
Australia and will ultimately strengthen
the SMPR process and improve patient
A quality and safety scorecard for
hospitals: the missing element in clinical
governance. (with Dr Ian Scott)
National Forum on Safety and Quality in
Healthcare, Canberra.
Awards & Prizes
Dr Peter Lee
The Bundaberg Emergency Response
National Forum on Safety and Quality
Team. (with Ms Linda McCormack)
in Healthcare, Canberra, October.
First Prize, Poster presentation:
Health Care Complaints Management
Achieving culture-change in healthcare
Conference. Brisbane.
communication: Yes we can!
Triage of staff complaints about Senior Clinician Competency Concerns:
a case series.
safety and satisfaction.
Centres for Health Research 2010 Annual Research Report
57
Dr Peter Lee
National Forum on Safety and Quality in
Dr Michael Daly
Australian Aviation Psychology
Healthcare, Canberra. Achieving culture-
ACHSM Symposium, Brisbane. A quality
Association Symposium, Healthcare
change in healthcare communication:
and safety scorecard for hospitals: the
Human Factors Seminar, Sydney
Yes we can!
missing element in clinical governance
Communication for safety in healthcare
– can effective communication
be effectively taught? Concluding
workshop: Human Factors in Healthcare:
how far have we come? Where are we
now? Where to from here?
2nd Annual Emergency Department
Management Congress, Melbourne
Training for improved communication –
the good, the bad and the ugly.
Improving communication in your ED –
why does it seem so hard?
Clinical Governance Conference,
Australian Healthcare Week, Sydney.
National Forum on Safety and Quality in
Developing Better Communication Skills
Healthcare, Canberra. The Bundaberg
and Focusing on Team Building.
Emergency Response team (with Ms
IHI-BMJ International Forum on Quality
Health Care Complaints Management
The ‘Communication and Patient Safety’
Conference, Brisbane. Triage of staff
Program – a successful culture-change
complaints about Senior Clinician
initiative in Queensland Health, Australia
Competency Concerns: a case series.
Ms Kellie Allen
IHI 22nd Annual National Forum on
Quality Improvement in Healthcare,
Orlando Florida USA. Achieving culture-
and Quality in Healthcare, Perth.
change in healthcare communication:
Improving communication ‘on the floor’:
Yes we can!
58
research - key to health
Linda McCormack).
and Safety in Healthcare, Amsterdam.
8th Australasian Conference on Safety
What works? What doesn’t? And why?
(With Dr Ian Scott).
Clinical Pharmacology
The department has maintained an active research program, while
continuing to provide an expanded tacrolimus monitoring service for
transplant centres throughout the state. Apart from providing a state-wide
analytical service, the department has a long history of involvement in
the development and provision of drug assays for immunosuppressant
drugs and is a national and international reference centre. Collaborations
arising from this facility include research in the fields of transplantation,
haematology, renal medicine, gastroenterology, clinical toxicology,
endocrinology, hypertension, cardiology, pharmacy and industry.
Peter Pillans
A collaborative research agreement was undertaken with Waters
Corporation to investigate measurement of endogenous steroids utilising
the latest mass spectrometry technology. A highly accurate aldosterone
assay has been developed and clinical validation has taken place during the year. Collaborative studies have
been conducted on hepcidin, a novel iron biomarker, after the development of a new liquid chromatography–
mass spectrometry (LC-MS) method in the laboratory. An LC-MS assay has been developed for the tyrosine
kinase inhibitor, imatinib and monitoring of patients with chronic myelogenous leukaemia is envisaged to improve
outcomes and reduce toxicity. Numerous drug utilisation and pharmacovigilance studies have been performed in
collaboration with the hospital pharmacy department.
Associate Professor Peter Pillans
Director
Research Activities
Clinical Trials
Other Research
Androgen Replacement in Dialysis-
Optimising detection of curable
The role of hepcidin in iron regulation
dependent Men with Hypogonadism
hypertension by the development of a
(Hall S, Taylor PJ, Fletcher L, Bird R, Saal
(Iedema J, Pillans P, Taylor P, van Eps
highly accurate method for measuring
R, Mudge DW, Crawford D).
C, Russell T). The primary hypothesis
aldosterone concentrations in human
of this project is that replacement of
blood and urine (Taylor PJ, Stowasser
testosterone to physiological levels
M, Gordon RD).
in hypogonadal men is associated
with a reduction in the erythropoeitin
requirements to maintain haemoglobin
levels (assessed by the erythropoietin
resistance index).
chronic myelogenous leukaemia (Lee S,
Pillans P, Taylor P, Franklin M, Mills T).
Improved patient outcomes through
dosage individualisation of the newer
immunosuppressant drugs (Staatz CE,
Tett SE, Taylor PJ, Johnson DW, Lynch SV).
Pharmacokinetic variability of imatinib in
Development of LC-MS assays of clinical
significance and utility (collaboration
with Waters Corporation) (Taylor P,
Cooper D).
Centres for Health Research 2010 Annual Research Report
59
Evaluation of outcome in patients
aldosterone, Hong KongAsian Pacific
American Association of Clinical
with gram negative sepsis treated
Conference of Chromatography
Chemistry. The measurement of
with gentamicin (Pillans P, Newbery
and Mass Spectrometry. Liquid
immunosuppressant drugs – current
R, Whitehead V, Halliday C, Sheehy R,
chromatography-tandem mass
practice future directions, Anaheim, USA
Springford A, Patterson T, Iedema J).
spectrometry in the clinical laboratory:
Association of sub-trochanteric fractures
Now and into the future, Hong Kong
First IATDMCT Regional Meeting.
Current practice in the measurement of
with bisphosphonates (Iedema J, Pillans
Asian Pacific Conference of
immunosuppressant drugs in routine
P, Cooke C, Lynch G, Donnovan P).
Chromatography and Mass
clinical laboratories, Beijing, China
Major Grants & Financial Support
Total NHMRC funding:
$180,000
National & International Presentations
Mr Paul Taylor
Spectrometry. Therapeutic drug
monitoring of immunosuppressant
drugs by high-performance liquid
chromatography-tandem mass
spectrometry, Hong Kong
Asian Pacific Conference of
Australasian Association of Clinical
Chromatography and Mass
Biochemists Scientific Education
Spectrometry. A semi-automated
Seminar – Therapeutic Drug Monitoring.
liquid chromatography-tandem mass
Analytical issues in TDM – assay
spectrometry (LC-MS/MS) method
selection (immunosuppressant for the measurement of plasma
drugs), Brisbane
The 12th Asia-Pacific Congress on
Clinical Biochemistry. Application of LCMS/MS in therapeutic drug monitoring,
Seoul, Korea
Associate Professor Peter Pillans
Australasian Association of Clinical
Biochemists Scientific Education
Seminar – Therapeutic Drug Monitoring. Analytical issues in TDM –
assay selection (immunosuppressant
drugs), Brisbane
Society of Hospital Pharmacists of
Australia. Drugs: remember the risks, Brisbane
Australian Society of Clinical
Immunologists and Allergists.
Applications for Biologics, Gold Coast
Australasian Society of Clinical and
Experimental Pharmacology and
Toxicology (ASCEPT). Outcomes in
patients with gram negative sepsis
treated with gentamicin, Melbourne
L-R: Brenda Tai, Paul Taylor, Associate Professor Peter Pillans, Mike Franklin
60
research - key to health
Dermatology Research Centre
The University of Queensland’s Dermatology Research Centre (DRC)
confirmed its role within the skin cancer arena in South East Queensland
via the establishment of further key collaborations and the strengthening
of those already in place. Of significance, the centre has now been
awarded an NHMRC Project Grant commencing 2011, for research in
collaboration with the Institute of Molecular Biosciences (IMB) and
Queensland Institute of Medical Research (QIMR), which demonstrates
the national recognition of the quality of research capable within the group.
Peter Soyer
In June Professor H. Peter Soyer, chair of DRC, was appointed Adjunct
Professor within the Diamantina Institute. Formal collaborations have
been established with the Melanoma Cluster, lead by Associate Professor
Brian Gabrielli, and the SCC Cluster lead by Associate Professor Nick Saunders within the Diamantina Institute.
Professor Soyer is a senior member of the Skin Cancer Network initiative, launched in 2010. This network is a
collaborative effort of UQ School of Medicine, UQ DI as well as QIMR, and the IMB aimed at promoting and
expanding word class skin research currently undertaken in this region.
A long term plan in developing a new centre of excellence in dermatology in the PAH precinct, namely the
Queensland Centre of Dermatology, is now being presented as a business case and in avid discussion with key
stakeholders. Once established, the Centre aims to integrate provision of specialist clinical dermatology, education
and training, research and teledermatology and to foster expanded research and clinical trials, including within the
important area of melanoma.
Professor H. Peter Soyer
Director
Research Activities
Clinical Trials
Reflectance Confocal Microscopy careful management of potentially
Seborrheic Keratosis study (Wurm
(RCM) Studies
malignant lesions. Clinical, Dermoscopic
E). To describe RCM features of the
Histopathologic correlation study (DRC,
& RCM images are taken of all patients
three histopathological subtypes of
Lambie D). To increase knowledge of
with pigmented lesions prior to excision.
seborrheic keratoses. Although RCM features and correlate them to
These images are then viewed together
seborrheic keratoses are an important clinical, dermoscopic, histopathologic
with the histopathology slides together
differential diagnosis to malignant features of lesions that are excised. The
with the histopathologist. Ongoing
melanocytic and non-melanocytic skin
long term aim is for RCM to improve
longitudinal study in progress, with
lesions, a systematic review of RCM
management decisions, as RCM can
various oral and poster presentations
features is lacking.
add more confidence in the diagnosis completed.
of benign lesions and lead to a more Centres for Health Research 2010 Annual Research Report
61
Patients with seborrheic keratoses will
Smithers M). Aims: (1) To examine
Radiologists and Radiation Oncologists
be recruited from the Dermatology
the relationship between genes,
from private practises across Brisbane).
outpatient service. Images of 30
the dermoscopic characteristics of
Aims: 1) To identify outcomes relating
seborrheic keratoses (10 of each
melanocytic naevi and melanoma
to perineural invasion in BCC, SCC,
histological subtype) will be acquired
risk. (2) To characterise genes that
keratoacanthoma (KA) and melanoma.
using RMC. These images will be
influence the probability of an individual
2) Specifically, to quantify outcomes
evaluated for specific RCM features by
carrying particular naevus subclasses.
of local recurrence, distant metastasis
two confocal readers. Study and patient
Full body photography with individual
and disease specific death due to BCC,
recruitment is in progress.
dermoscopic naevus images recorded
SCC, KA and melanoma with PNI. 3) To
and morphology classified and
record treatment modalities for BCCs,
described. Digital photographs of hair
SCCs, KAs and melanomas with PNI.
and eyes to document pigmentary
4) To compare and contrast outcomes
phenotype, and skin pigmentation
(in terms of local recurrence, distant
measured with spectrophotometer.
metastasis and disease specific death)
Saliva samples collected for genotyping.
between treatment modalities. 5) To
Ongoing longitudinal study in progress.
define an evidence-based, risk adapted
Characterisation of striae distensae
with confocal microscopy (Gilmore S,
Rolfe H). To determine the confocal
microscopic features of established
striae distensae. In addition to this
characterisation, we aim to use the
confocal microscope to detect dermal
subclinical changes in early disease.
Perineural Invasion Registry (Conducted
Cohorts of healthy female subjects with
by the Queensland Perineural Invasion
established striae alba are investigated
Research Group which is a collaboration
using confocal microscopy. Eight
between Dermatologists, Plastic
subjects have been examined to date,
Surgeons, Pathologists, ENT specialists,
with a total of 30 planned treatment algorithm for skin cancer with
PNI, based on outcome and treatment
modality findings. 6) To evaluate
histopathological specimens of PNI from
a broad spectrum analysis including
mathematical modeling.
for recruitment.
Naevus Surveillance using total
body photography and dermoscopy
(DRC, Smithers M, Green A). To fully
characterise the elements and timing
of morphological changes associated
with the metamorphosis from naevus to
melanoma. Full body photography with
individual dermoscopic naevus images
recorded and morphology classified
and described. Follow patients up
twice a year for 5 years with re-imaging
of all naevi and documenting any
dermoscopic changes arising. Ongoing
longitudinal study in progress.
Pigmentation Genotypes (MC1R)
and Phenotypic Correlations with
dermoscopic naevus types and
distribution (DRC, Sturm R, Duffy D,
62
research - key to health
L-R (Back Row): Professor H. Peter Soyer, Professor Helmut Schaider, Dr Jose Neila Iglesias, Dr Nicky Douglas
L-R (Front Row): Dr Lissy Wurm, Ms Nicole Lin, Dr Cathy Xu
Patients diagnosed with perineural
Recent work has identified a micro
American Academy of Dermatology 68th
invasion are approached for inclusion
RNA that may be involved in the
Annual Meeting, Miami, USA
in the study and upon consenting have
regulation of gene expression in both
their relevant details input into the
keratinocytes and immunocytes. Work
secured web-based registry. The treating
of this kind has motivated us to seek
specialists generally follow up with their
possible regulatory elements that may
PNI patients every 6-12 months, and a
predispose to the psoriatic phenotype.
Australasian Dermatopathology Society
follow up proforma will be provided to
During the study we will examine, using
Annual Conference, Sydney
the registry coordinator at these visits.
conventional micro-array chips, or the
The registry will run for a minimum of
newer deep sequencing technology,
Joint Meeting of the Australasian
5 years looking to extend to 10 years.
normal-looking skin from psoriatic
College of Dermatologists and
The registry has been established and
subjects, and normal-looking skin from
Department of Dermatology, University
patient recruitment has begun. The
normal controls. All samples have been
of Rome Tor Vergata and University of
study is currently being run only collected; tissue and bioinformatic
L’Aquila, Rome, Italy
through private practise but will look to
analyses will begin in early 2011.
expand to Queensland Health facilities
in the near future.
Genome- wide investigation of the
phenotypic underpinnings of psoriasis
(Gilmore S, Saunders N). This study
aims to uncover regulatory elements,
perhaps micro RNAs or other noncoding RNAs, that play significant
roles in the inherited predisposition to
psoriasis. A large body of research has
shown that the phenotypic expression
Competitive funding:
$1,714
Funding from
commercial studies:
$11,378
$406,610
of Dermatology and Venereology and
Australasian College of Dermatologists,
Vienna, Austria
Melanoma Update for Primary Care
Clinicians, Sydney
Associate Professor Stephen Gilmore
6th World Congress for Hair Research, Cairns
Professor H. Peter Soyer
behaviour of keratinocytes, leading to
Raising Expectations in Dermatology
hyper-proliferation of the epidermis, and
Conference, Sydney
leading to dermal inflammation.
meeting, Brisbane
National & International Presentations
of psoriasis is due to the aberrant
the aberrant behaviour of immunocytes,
Medicine annual conference/scientific
Joint Meeting of the Austrian Society
Major Grants & Financial Support
Funding from other
sources:
Australasian College of Skin Cancer
AIDNID Conference, Rome, Italy
Centres for Health Research 2010 Annual Research Report
63
Diabetes &
Endocrinology
The Department continued to maintain a significant number of
collaborations broadly around translational research. The significant
workload in outpatients provides a fertile ground for recruitment of
patients for trials. Associate Professor Russell has established an
international collaboration with Professor Rayaz Malik (Manchester, UK)
and Professor Efron from QUT to investigate novel ophthalmic markers
of diabetic peripheral neuropathy. Associate Professor Russell is broadly
looking at novel ways to manage diabetes and continues to develop a
model of care for diabetes in the community with upskilled GPs. He is
also working with Professor Brian Oldenburg from Monash University,
Anthony Russell
Melbourne, utilising information technology to assist patients self manage
their disease and along with Dr O’Moore-Sullivan and Professor Eakin
looking at telephone counselling for maintenance of weight loss in
patients with diabetes. Professor Prins and Dr O’Moore-Sullivan maintain a role in a Clinical Research Excellence
grant looking at the effects of improved insulin sensitivity with lifestyle or drugs and vascular and cardiac function.
Professor McIntyre, is forging a international reputation in the area of Gestational Diabetes through his work
with the HAPO study. Close relationships continue to be maintained with the basic scientists through Associate
Professor Jon Whitehead and Professor Prins at the Mater Medical Research Institute assessing insulin signalling
and the role of adipose tissue in the development of insulin resistance.
Associate Professor Anthony Russell
Director
Research Activities
Clinical Trials
Using conversational computer
A longitudinal study of nerve
Ophthalmic markers in diabetic
technology to improve diabetes
morphology in diabetic neuropathy
neuropathy (Efron N, Boulton A, management (Oldenburg B, Courtney M,
using novel non-invasive ophthalmic
Malik R, Prins J. Russell A). A JDRF
Friedman R, Russell A). The aim of this
surrogate markers (Efron, N, Boulton, funded grant to longitudinally assess
NHMRC funded project is to assess a
novel ophthalmic markers of peripheral
novel self-management tool to assist A, Malik, R, Russell A). An NHMRC neuropathy in Type 1 diabetes.
in the management of patients with
funded study assessing corneal Recruitment complete. Cross-
Type 2 diabetes. Recruitment is now
nerves as markers of diabetic sectional data assessed with completed and 6 month data collection
peripheral neuropathy. Recruitment some publications.
nearly complete.
now completed.
64
research - key to health
Major Grants & Financial Support
Telephone Counselling For Maintenance
An Assessment of the Hypothalamic
Of Physical Activity, Weight Loss &
Pituitary Adrenal Axis at Day 5
Glycaemic Control In Type 2 Diabetes
post Pituitary Surgery Utilising the
(Eakin E, Marshall A, Dunstan D, Metyrapone Short Synacthen Test
Reeves M, Graves N, Russell A,
(Seedat S, Cuneo R, Duncan E, Russell
O’Moore-Sullivan T). NHMRC funded
A). This study is determining whether
trial looking at another assessment of
a test performed after pituitary surgery
a method to assist patients with Type 2
before discharge from hospital can
diabetes self manage their condition.
determine long term requirements.
Ongoing recruitment.
Recruitment continues for this trial.
Systematic diabetic retinopathy
The Mechanical Properties of the Human
screening and monitoring of early stage
Femur utilising Nanoindentation (Lin C,
disease in general practice (Jackson
Huang H, Cribb B, Russell A). This study
C, Askew D, Mitchell P, Russell A).
was a comparison of the mechanical
NHMRC funded grant assessing the
properties of bone in patients having hip
ability of general practice to screen
surgery with and without osteoporosis.
for early diabetic retinal disease. Sites
This study resulted in a publication
International Society for Obstetric
have been recruited and training of GPs
this year and the engineering student
Medicine, Melbourne
undertaken.
obtaining her Masters degree.
Vitamin C Improves Insulin Sensitivity
Pharmaceutical Company Trials
World Congress of Internal Medicine,
by Increasing High Molecular Weight
INSPIRE: International Study of
Melbourne
Adiponectin: A Pilot Study (Russell
Prediction of Intra-Abdominal A, Whitehead J, Prins J, O'Moore-
Adiposity and its Relationships Sullivan T, Macdonald G, Rose F). A
with Cardiometabolic Risk / Intra-
private practice funded study looking
Abdominal Adiposity
at whether Vitamin C supplementation
in patients with Type 2 diabetes will
improve insulin sensitivity by increasing
high molecular weight adiponectin.
IPSEN Protocol A-9B-52030-219 An
International Workshop Conference on
Gestational Diabetes, Pasadena
Queensland / NSW Chapter of Royal
Australasian College of Obstetrics and
Gynecology, Gold Coast
Australasian Diabetes in Pregnancy
Society, Sydney
Sydney
Association Conference, Melbourne
the long Term Safety and efficacy of
by patients or their partners(/”home
Mitchell G, Askew D, Scott I, Foster M,
injection group”) or administered by
Dart J, Hollingworth S, Davies P, Russell
health care professionals
upskilled GPs.
Professor David McIntyre
Non interventional Programme to assess
secondary level care (Jackson C,
Type 2 diabetes in the community with
Presentations
Observational, Multi Centre, Open label,
of Acromegaly when administered
model of care for the management of
National & International Invited
Australian Disease Management
the interface between primary and
by Dr Russell in developing a novel
$58,953
Directions in Diabetes Meeting – Lilly,
Somatuline Autogel in the treatment
this study will further assess the work
$72,000
Funding from
commercial studies:
Associate Professor Anthony Russell
Improving Quality and Safety at
A). An NHMRC funded grant. Part of
Competitive funding:
GSK GLP1: A Randomized, Open-Label,
Parallel Group, Multicenter Study to
Determine the Efficacy and Safety of
Albiglutide as Compared with Liraglutide
in Subjects with Type 2 Diabetes Mellitus
Centres for Health Research 2010 Annual Research Report
65
Diamantina Institute
The University of Queensland Diamantina Institute’s central mission is
to translate scientific discoveries into practical outcomes for patients.
This was another productive year in working to achieve this mission with
a number of exciting discoveries and achievements. Cancer vaccine
technology developed by Associate Professor Nigel McMillan’s team was
licensed to US-based developer of RNAi (ribonucleic acid interference)
therapeutics, Alnylam, and has the potential to be developed into new
vaccines for cancer and infectious disease. Professor Brown’s group
led an international consortium that discovered underlying genetic loci
associated with ankylosing spondylitis which may help target disease
susceptibility. These discoveries are important steps in the progression
of converting discoveries into real-life benefits. Trials of the application of
the Gardasil vaccine in the developing world have been occurring.
Ian Frazer
Efforts to engage with the next generation continue to be effective with the flagship program, Sparq-ed, seeing
high school students from around Queensland come into the research labs at UQDI to undertake week-long
research projects in the laboratory. The significance of the education benefits of this program was recently
recognized by the University of Queensland with the award of bonus rank status for students wishing to enter
tertiary education training.
Professor Ian Frazer was awarded the 2010 Ernst & Young Champion of Entrepreneurship, (Northern Region) Award in recognition of his discoveries that led to the development of the world’s first cervical cancer vaccine. With immunisation programs initiated across the world, this is a true indicator of bringing scientific discoveries to the patient.
Professor Ian Frazer
Director
Research Activities
Clinical Trials
A multicenter uncontrolled extension
A randomised, controlled double
Rheumavax) can safely modify (reduce
study evaluating the long term safety
blind study to evaluate the effects of
or desensitize) the body’s immune
and efficacy of sar153191 in patients
simvastatin in reducing atherosclerosis
response to a specific rheumatoid
with ankylosing spondylitis (Brown, MA).
in early rheumatoid arthritis (Thomas R,
arthritis antigen. The trial is taking place
White D, Pahua H).
at the Princess Alexandra Hospital
Multicenter study of the efficacy and
and is a co-operative effort between
safety of adalimumab in subjects with
Phase I Trial of Rheumavax to Induce
axial spondyloarthritis Brown, MA).
Antigen Specific Tolerance in Patients
This is a trial of the TNF-antagonist
with Rheumatoid Arthritis (Thomas
adalimumab in preradiographic
R, Vecchio P). This study aims to
ankylosing spondylitis, which
demonstrate that a vaccine made from a
A Randomised, Placebo Controlled,
commenced in late 2009.
patient’s own blood cells, (known as Double Blind Study to Evaluate the
66
research - key to health
clinicians and researchers at this hospital and at The University of Queensland.
Effects of Resveratrol Supplementation
Research Grant (Acute myeloid
Professor Matthew Brown
on Insulin Resistance, Hepatic and
leukaemia research, Cancer
International Bone and Mineral Society,
Abdominal Fat Deposition, Systemic
Collaborative Group, PAH
Switzerland
Travel Grant, HSANZ
Korean Rheumatology Association, Korea
Travel Grant, ALLG
Chinese Rheumatology Association,
Inflammation, Oxidative Stress,
Antioxiant Activity, Gene Expression and
Plasma Metabolic Markers in Patients
With Non-Alcoholic Fatty Liver Disease
China
(Chachay V, Prins J, Macdonald G,
Dr Michelle Hill
Hickman I, Whitehead J, Martin J,
Runner-up, Senior Category, Health and
Dr Katrina Campbell
Ferguson M, Kirkpatrick C, O'Moore
Medical Research Award, Australian
Improving Outcomes in Nephrology,
Sullivan T, Cowin G, Thomas G, Society for Medical Research QLD
Sydney, September
Finalist, Uniquest Trailblazer Competition
Pre-congress meeting: Australia New
Franklin M).
Awards & Prizes
Dr Antje Blumenthal
Award for Best Podium Presentation,
Australasian Society for Immunology
(40th Annual Meeting)
Zealand Society of Nephrology, Adelaide
Dr Elisabeth Isenring
Private Practice Grant ASMR Leadership
Dr Maree Ferguson
Seminar
Australasian Society for Parenteral and
Enteral Nutrition, Gold Coast
Diwakar Pattabiraman
Graduate School Travel Award,
Dr Brian Gabrielli
University of Queensland
SMR Melanoma Congress, Australia
AACR Travel Bursary, American
Novartis Oncology and Research
Association for Cancer Research
Symposium, Australia
Travel Grant: International Society of
American Association for Cancer
Professor Tom Gonda
Nutrition and Metabolism in Renal
Research, New Directions in Leukaemia
Lorne Genome Conference, Lorne, Vic
Disease, Private Practice, Princess
Research Conference
Professor Matthew Brown
Parr Prize in Rheumatology, Australian
Rheumatology Association 2010
Dr Katrina Campbell
Alexandra Hospital
Monash Institutes of Medical Research,
Jian Zhou travel award, UQDI
Melbourne, Vic
Travel Grant: Implementation of
Publication of the month, UQDI
Latrobe University, Melbourne, Vic
International Dietetic and Nutrition
Major Grants & Financial Support
Gordon Conference on Mammary Gland
Dr Maree Ferguson
Terminology, PA Society, Princess
Alexandra Hospital
Professor Ian Frazer
2010 Ernst & Young Champion of
Entrepreneurship, Northern Region,
Ernst & Young
Dr James Gray
Best poster award, New Directions in
Leukaemia Research Conference
Total NHMRC funding:
$5,122,940
Biology, Barga, Italy
Other competitive
funding:
$3,215,360
RNAi Australia, Melbourne, Vic
Funding from
commercial studies:
$5,278,168
Funding from other
sources:
$8,048,387
Queen Elizabeth Hospital, Adelaide, SA
Oz Bio 2010, Melbourne
Japanese Cancer Association Annual
National & International Presentations
Dr Antje Blumenthal
Australasian Society for Immunology
SERTF Research Grant (Acute myeloid
40th Annual Scientific Meeting, leukaemia research), Pathology
Perth, WA
Meeting, Osaka, Japan
Dr James Gray
Translational Research Excellence,
Brisbane, Qld
Queensland
Centres for Health Research 2010 Annual Research Report
67
Haematology Society of Australia and
New Zealand, Annual Conference,
Auckland
American Society of Haematology
Annual Meeting, Orlando, Florida,
December
New Directions in Leukaemia Research,
Sunshine Coast, Qld
Dr Ingrid Hickman
Australian Gastroenterology Week, Gold Coast
Professor Ian Frazer and laboratory research staff
International Conference on Obesity,
SanDiego, California
Endocrine Society of Australia, Australia
Dr Michelle Hill
12 Annual VVCRI Symposium, Australia
Lorne Proteomics Conference, Lorne
Australian Prostate Cancer Research
Centre, Queensland
PepCon 2010, Beijing
ASBMB WA Symposium "RNA Beyond
the Dogma", Australia
RNAi Asia, Singapore
Dr Raymond Steptoe
40th Annual Scientific Meeting,
Australasian Society for Immunology,
Perth WA
Dr Gethin Thomas
7th International Congress on
Spondyloarthropies, Gent, Belgium
Dr Ali Naderi
Prostate Cancer Foundation Australian
15th World Congress on Advances in
Translational Research Excellence
International Conference
Oncology, Greece
Conference, Brisbane
Bosch Institute Annual Scientific
13th International Symposium on
American College of Rheumatology
Symposium, Sydney
Molecular Medicine, Greece
Annual Scientific Meeting, Atlanta, USA
Dr Elisabeth Isenring
Mr Diwakar Pattabiraman
Dr Ranjeny Thomas
Australasian Society for Parenteral and
New Directions in Leukaemia Research,
Rheumatology 2010 Meeting
Enteral Nutrition, Gold Coast
Sunshine Coast, Qld
Clinical Oncological Society of Australia,
Mr Max Ranall
Melbourne
RNAi Australia, Melbourne, Vic
Dr Graham Leggatt
Dr Fiona Simpson
International Congress of Immunology,
17th Protein Kinase Meeting and FEBS
Kobe, Japan
Workshop on Spatiotemporal Dynamics
of CellSignalling, Oslo, Norway
Australasian Society for Immunology
National Meeting, Perth, Australia
Garvan Signalling Symposium, Sydney
Dr Nigel McMillan
Dr Duka Skalamera
Australian Health and Medical Research
Lorne Cancer Conference, Lorne, Vic
Conference, Australia
Tissue Engineering International
and Regenerative Medicine Society
(TERMIS), Australia
68
research - key to health
RNAi Australia, Melbourne, Vic
Asia Pacific League of Rheumatology,
China
Indian Pharmaceutical Society, India
Dr Ping Ye
New Directions in Leukaemia Research,
Sunshine Coast, Qld
Lowy Symposium, Sydney NSW
Dr Liang Zhao,
New Directions in Leukaemia Research,
Sunshine Coast, Qld
Ear Nose Throat
The department was very active in research and education during
the year. In July 2010 the annual Global Postlaryngectomy Cadaver
Demonstration Course was held at the Princess Alexandra and Prince
Charles Hospitals and the Head and Neck Cadaver Dissection Course.
Both courses were run by Professor Coman for the Princess Alexandra
Hospital and The University of Queensland and were highly successful.
In 2011 there will be three cadaver dissection courses – the Global
Postlaryngectomy Course, Head and Neck Course and FESS/Rhinoplasty
Course held at the Prince Charles and the University of Queensland and
a Thyroid Conference at Sheraton Noosa held in November. Professor
Coman will also run the annual Upover Downunder International ENT
Conference in Campitello, Italy.
William Corman
Professor William B Coman
Chairman and Director
Research Activities
There are a number of current research
With Professor Jake Najman, Centre
Professor Coman and Annika
activities with Associate Professor Chris
for Population Health, Medical School,
Anntonnson have been awarded an
Perry as outlined below.
The University of Queensland, looking
NHMRC grant in association with QIMR
at factors which may impact on the
for HPV on Squamous Cell Carcinomas
position of oral cavity cancer in of the Head and Neck’ for $218,129 for
smokers compared with non-smokers.
two years.
Hear to Learn’ Project. One of six
Chief Investigators under leadership
of Professor Allan Cripps, Griffith
University. This is a longitudinal study
on the prevalence, language and
educational effects, microbiology and
the impact of pneumococcal vaccine
on otitis media in children attending
Royal Children’s Hospital. $75,000 Royal
Children’s Hospital Foundation.
The group have already shown a
statistically significant difference in
the position of oral cavity cancer in
smokers compared to non-smokers.
Non-smoking cancers tend to occur
in the younger age, have an equal sex
distribution and be positioned at the
$1.6M NHMRC – Surgery for Otitis
Media in Indigenous populations.
Stephen O’Leary is Principle
Investigator. Other Chief Investigators
– Drs Chris Perry, Kelvin Kong, Harvey
Coates et al.
point of chronic rubbing irritation usually
$2.65M per year until 2014. Associate
Ataxic Telengiectasia study in
by teeth on the lateral tongue, but also
Professor Chris Perry. Founder association with Professor Martin Lavin
from dentures which are ill-fitting. This and Clinical Director for the Deadly of the QRI, and Allan Mackay-Sim,
is ongoing research.
Ears Program.
Griffith University to grow olfactory stem
cells for future drug therapy research.
Centres for Health Research 2010 Annual Research Report
69
Awards and Prizes
National & International Presentations
Head and Neck Surgery Congress
Associate Professor Chris Perry
32nd Annual Vanderbilt Otolaryngology
for the South African Society of
Founder and Clinical Director for the
Symposium, Vail, Colorado, February
Otorhinolaryngology, Drakensberg,
Deadly Ears Program. This program
received the Director General of Health’
Award, 2010, for the Program that best
ASOHNS 2010, Sydney
•
A prospective multi-centre
reflected Qld Health values; Closing
randomized trial comparing
the Gap’ Award for best Indigenous
transoral laser microsurgery and
Program in Qld Health, 2010; the
radiotherapy for early glottic cancer
Perioperative Nurses Association of – preliminary results
South Africa
•
From Laryngectomy to Laser
Microsurgery
•
•
Total NHMRC funding:
$109,065
•
•
Oropharyngeal Cancer – Then and Now
and now
•
Avoiding Laryngectomy
Steel, Laser or Radiotherapy –
•
Selective Neck Dissection V Radical
(OHNS Nurses Group)
research - key to health
•
Oropharyngeal Cancer – Then Treatment of Laryngeal Cancer
70
Laryngeal Cancer
The Scottish Influence on ENT in Australia
Major Grants & Financial Support
Laser Surgery versus Radiotherapy
for the Treatment of Early Qld’ Award for the best perioperative
team in Qld 2010.
The History of Laryngeal Surgery:
neck Dissection: When to do What
Emergency
The department is a designated Level 6 Trauma centre with over 45 000
attendance a year with an admission rate of over 34%. This is amongst
the highest in Australasia and demonstrates a high level of clinical
acuity. Research continued to be a focus and staff within the department
were successful in receiving funding from the Queensland Emergency
Research Fund.
Dr Phillip Kay
Director
Phillip Kay
Research Activities
Clinical Trials
Awards and Prizes
Dr Sean Lawrence
Randomised crossover evaluation of
Kim Nicholls
Australasian Association of Bioethics TSAC for peripheral vascular stasis
Princess Alexandra Hospital Excellence
& Health Law, Adelaide
(Powie D, Underwood M).
in Clinical Education
Other Research
Peter Thomas
Michigan, OSHA CET, East Developing a quality framework for the
Medal of the Order of Australia (OAM)
Lansing, USA
care of older patients in the Emergency
Australia Day Council
Department (Burket E).
Private Hospital Operating Theatre
National and International Invited
Major Grants & Financial Support
Total competitive
funding:
Dr Michael Sinnott
$296,139
Presentations
Organisation, Hong Kong
Dawn Bandiera
Association of Perioperative Nurses,
Discharge Planning, Brisbane
Denver USA
Centres for Health Research 2010 Annual Research Report
71
Endocrine Hypertension
Research Centre
It has been a particularly productive year for the Centre with a number of
major research highlights and achievements.
Collaboration with Professor Matt Brown’s group at the Diamantina
Institute searching for genetic causes of primary aldosteronism, the
commonest specifically treatable and potentially curable form of
hypertension has been strengthening. Extensive examination of a large
region of the genome found to be linked to a familial form of primary
aldosteronism (familial hyperaldosteronism type II, FH-II) and sequenced
through next-generation high throughput methods yielded a number of
candidate polymorphisms. In a further bid to find causative mutations,
the work has now moved to whole exomic sequencing using state-of-theart methodologies.
The establishment of a joint academic/clinical position (UQ Senior
Lecturer and Hypertension PHO) for Dr Eduardo Pimenta will facilitate
his ongoing work assessing the importance of salt in the development
of adverse cardiovascular and renal effects in patients with primary
aldosteronism. Dr Pimanta has continued to thrive in his current
environment, publishing this year, three book chapters and 16 peerreviewed full papers (nine as first author) in scientific journals. He was
also awarded the top paper published in Hypertension (Clinical Science
Category) by the American Heart Association, a Travel Award by the
Baker Institute to attend an international meeting, and the Early Career
Investigator Award by the High Blood Pressure Research Council of
Australia which includes funding to attend the British Hypertension
Society Meeting in 2011.
Michael Stowasser
Richard Gordon
Extensive progress has been made by Dr Ashraf Ahmed towards his PhD thesis examining physiological and
pharmacological factors affecting the aldosterone/renin ratio in screening for primary aldosteronism. This work
has included the demonstration of higher ratios among women (especially during the luteal phase of the menstrual
cycle and those taking a popular oral contraceptive preparation) than men, and in subjects taking beta-blockers,
and lower ratios in persons receiving antidepressants of the serotonin selective re-uptake inhibitor type, as well as
improvements in quality of life associated with the commencement of medications which antagonize aldosterone
in patients with primary aldosteronism. This work has already resulted in the publication of three full papers in the
prestigious Journal of Clinical Endocrinology and Metabolism, with a fourth in revision and a fifth newly submitted.
Professor Michael Stowasser
Co-Director
Emeritus Professor Richard Gordon
Co-Director
72
research - key to health
Research Activities
Elucidating genetic mechanisms
Definition of ambulatory blood pressure
Young Investigator of the Year Award
responsible for familial
targets for diagnosis and treatment
(Clinician), Princess Alexandra Hospital
hyperaldosteronism type II and other
of hypertension in relation to clinic
Week, Princess Alexandra Hospital
forms of primary aldosteronism
blood pressure (Head G, Mihailidou A,
(Stowasser M, Gordon R, Brown M,
Duggan K, Beilin L, Berry N, Brown M,
Duncan E, O’Shaughnessy K, Leo P,
Bune A, Cowley D, Chalmers J, Howe
Duffy D).
P, Hodgson J, Ludbrook J, Mangoni
Effects of dietary salt in determining the
severity of obstructive sleep apnoea
and cardiovascular and renal damage
in patients with hyperaldosteronism
(Pimenta E, Stowasser M, Gordon R).
Effects of physiological and
pharmacological factors on the
aldosterone/renin ratio, used to screen
for primary aldosteronism (Ahmed
A, Stowasser M, Gordon R, Taylor P,
Pimenta E).
Development of a semi-automated
liquid chromatography–tandem mass
spectrometry (LC–MS/MS) method for
A, McGrath B, Nelson M, Sharman
J, Stowasser M as members of the
Ambulatory Blood Pressure Working
of Essential Hypertension"), Vancouver,
Baker IDI Heart and Diabetes Institute,
Australia
Nominee to attend British Hypertension
Society Meeting 2011, High Blood
Pressure Research Council of Australia
Awards & Prizes
Dr Ashraf Ahmed
Major Grants & Financial Support
Travel Award to attend the Annual
Scientific Meeting of the High Blood
Pressure Research Council of Australia,
Melbourne, High Blood Pressure
Total NHMRC funding:
Funding from other
sources:
$628,425
$52,284
National & International Presentations
Research Council of Australia
Student Poster, Finalist, High Blood
Pressure Research Council of Australia
Dr Danielle Aspinall
Travel Award to attend the Annual
Cooper D).
Scientific Meeting of the High Blood
new, highly accurate mass spectrometric
Satellite Meeting ("The Pathogenesis
Research Council of Australia).
(Taylor P, Stowasser M, Gordon R,
of the postural stimulation test using a
International Society of Hypertension
Group of the High Blood Pressure
the measurement of plasma aldosterone
Reassessment of the predictive value
Travel Scholarship to attend an
Pressure Research Council of Australia,
Dr Ashraf Ahmed
53rd Annual Scientific Meeting of the
Endocrine Society of Australia, Sydney
23rd Scientific Meeting of the
International Society of Hypertension,
Vancouver Canada
Melbourne, High Blood Pressure
32nd Scientific Meeting of the High
Research Council of Australia
Blood Pressure Research Council of
Australia, Melbourne
approach for measuring aldosterone
Dr Eduardo Pimenta
(Aspinall D, Stowasser M, Gordon R,
Top paper published in "Hypertension"
Danielle Aspinall
Taylor P).
journal in 2009 - Category Clinical
32nd Scientific Meeting of the High
Science, American Heart Association
Blood Pressure Research Council of
The BP GUIDE study – assessing the
value of using central BP measurements
Early Career Investigator Award, to guide treatment of hypertension
High Blood Pressure Research Council
(Sharman J, Stowasser M).
of Australia
Australia, Melbourne
Centres for Health Research 2010 Annual Research Report
73
L-R (Back Row): Paul Taylor, Lorraine Suanders, Diane Cowley, Cynthia Kogovsek, Shengxin Xu
L-R (Front Row): Eduardo Pimenta, Michael Stowasser, Richard Gordon, Dianne Robson, Bartosz Kowalski, Ashraf Ahmed
Dr Eduardo Pimenta
to the 23rd Scientific Meeting of the
First Radboud Adrenal Symposium,
53rd Annual Scientific Meeting of the
International Society of Hypertension,
Nijmegen, Holland
Endocrine Society of Australia, Sydney
Whistler, Canada
23rd Scientific Meeting of the
32nd Scientific Meeting of the High
International Society of Hypertension,
Blood Pressure Research Council of
Vancouver Canada
Australia, Melbourne
The Pathogenesis of Essential
Professor Michael Stowasser
Chromatography and Mass
Hypertension: Focus on Salt, Stress and
14th International Congress of
Spectrometry, Hong Kong
Obesity; Whistler Satellite Symposium
Endocrinology, Kyoto, Japan
74
research - key to health
Festschrift for Judith Whitworth,
Melbourne
Paul Taylor
Asian Pacific Conference of
Gastroenterology & Hepatology
This year the department conducted clinical research examining the relationship between metabolic factors and
outcome in patients with liver disease including those with viral hepatitis, hepatic steatosis, cirrhosis and patients
following liver transplantation. Ongoing collaborative studies with other university centres, with both national and
international colleagues were a highlight of the year. Exciting developments in the management of viral hepatitis
with a number of new direct acting antiviral agents are in development for hepatitis C. The Clinical Trials Unit is a
major centre in Australia for phase 2 and 3 studies with these agents.
Dr Richard Skoien, PhD student, was awarded the Young Investigator Award - Basic Science by the
Gastroenterological Society of Queensland; a Poster of Merit at Australian Gastroenterology Week, and the
internationally prestigious Fellow Research Award by the American Association for the Study of Liver Diseases. Ms
Leigh Horsfall was awarded the Young Investigator Award - Clinical Science by the Gastroenterological Society of
Queensland.
Dr Bradley Kendall
Acting Director
Research Activities
Clinical Trials
CCRE in Cardiovascular and Metabolic
toxicity will allow us to move towards
AD, Jothimani D, Skoien R, Benson
Diseases (Marwick T, Prins J, Macdonald
targeted therapeutic interventions to
M, Cowin G, Galloway G, Stuart K,
GA, Isbel N, Hegney D, Stowasser
attenuate the fibrogenic process.
Crawford D).
The role of adiponectin multimers
The pharmacogenetics of drug induced
and receptors in fatty liver disease
liver injury (Martin J, Powell EE).
M). Collaborative study examining
predictors of cardiovascular disease in
a number of different disease states. In
relation to liver disease the focus is on
the prevalence of metabolic disturbance
and cardiovascular disease following
liver transplantation.
(Macdonald GA, Nguyen T, Fletcher
L, Murphy T, Lipka G, Whitehead J,
Hickman I). HMW adiponectin multimers
and adiponectin receptor expression
are thought to play significant roles in
Measurement of the iron regulatory
protein hepcidin in clinical samples
(Fletcher L, Hall SL, Franklin ME, Taylor
PJ, Saal R, Mudge D, Bird R).
The pathogenesis of co-toxic liver
the pathogenesis of liver disease. This
Hepatic Function and
disease (Fletcher L, Crawford D,
project aims to correlate adiponectin
Pharmacodynamics in Liver Disease
Tan, Murphy T, Jaskowski L). Excess
multimer ratios and receptor
and in Liver Transplantation (Roberts S,
alcohol consumption, iron overload
expression in liver disease with a view
Weiss, M, Macdonald GA, Fawcett J,
disease and obesity are major public
to characterising their role in disease
Vitetta L, Fletcher L).
health issues which often lead to liver
pathogenesis.
fibrosis and may progress to cirrhosis.
Coexistence of more than one toxin may
lead to accelerated disease. We aim
to understanding the interdependent
pathophysiological pathways in co-
Monocytes/macrophages in chronic
Non-invasive assessment of hepatic
liver diseases (Powell EE, Jonsson JR,
steatosis by magnetic resonance
Clouston AD).
imaging (MRI) and spectroscopy (MRS)
(Powell EE, Jonsson JR, Clouston Centres for Health Research 2010 Annual Research Report
75
Characterising the portal inflammatory
Boehringer Ingelheim 1220.5 Antiviral
response in NASH and its relationship to
effect, safety and pharmacokinetics of
fibrosis (Skoien R, Powell EE, Jonsson
once daily BI 201335 NA in hepatitis
JR, Clouston AD).
C virus genotype 1 infected treatment
Factors affecting the progression of
liver disease and response to treatment
(Powell EE, Jonsson JR, Clouston AD,
Macdonald GA, Crawford D, Skoien R).
Effect of weight loss on liver protein
expression and response to antiviral
therapy in patients with chronic Hepatitis
C (Powell EE, Jonsson JR, Clouston
AD, Jothimani D, Skoien R, Benson M,
Cowin G).
Isolation of primary human liver cells
(Powell EE, Jonsson JR, Clouston AD,
Fawcett J, Skoien R, Melino M, Walker G).
Industry sponsored trials
Gilead GS-US-174-0102 A randomised
double-blind controlled evaluation of
Tenofovir DF versus Adefovir Dipivoxil
for the treatment of presumed
pre-core mutant chronic Hepatitis B
(Macdonald GA).
naïve patients for 24 weeks as
combination therapy with pegylated
interferon alfa-2a and ribavirin
Major Grants & Financial Support
Total NHMRC funding:
$930,905
Other competitive
funding:
$79,857
Awards & Prizes
Dr Richard Skoien
(Macdonald GA).
Award for Best Research Abstract by
Roche NV 20536 A randomised double
Study of Liver Diseases
blind study of a polymerase inhibitor
prodrug (RO5024048) in combination
with chronic hepatitis C genotype 1 or 4
(Macdonald GA).
Tibotec Janssen Cilag TMC435-C205
A phase 2b, randomized, doubleblinded trial of TMC 435 as part of a
treatment regime including PegIFN
alfa 2a and Ribavirin in treatment naïve
genotype 1 Hepatitis C infected subjects
(Macdonald GA).
a Fellow, American Association for the
Young Investigator Award, Basic
Science Research Presentation,
Gastroenterological Society of
Queensland
Poster of Merit, Australian
Gastroenterology Week
Leigh Horsfall
Young Investigator Award, Clinical
Science Research Presentation,
Gastroenterological Society of
Tibotec Janssen Cilag TMC435-206 A
Queensland
phase 2b randomized, double-blinded
National & International Presentations
trial of TMC 435 as part of a treatment
regimen including PegIFN-2a and
ribavirin in HCV G1 infected subjects
who failed to respond or relapsed
Associate Professor Graeme Macdonald
Australian Gastroenterology Week, Gold Coast, October
Gilead GS-US-174-0103 A randomised
following at least 1 course of PegIFN
Associate Professor Elizabeth Powell
double-blind controlled evaluation of
and RBV therapy (Macdonald GA).
7th Australasian Viral Hepatitis
Tenofovir DF versus Adefovir Dipivoxil for
the treatment of HBeAg positive chronic
Hepatitis B (Macdonald GA).
Bristol Myers Squibb AI444-010 A phase
2B study of BMS-790052 in combination
with Peg-Interferon alfa-2a and ribavirin
Gilead AU-103-0163 A phase 4, open
in treatment naïve subjects with chronic
label, multi-centre, observational
hepatitis C genotype 1 and 4 infection.
extension study monitoring the long-
(Macdonald, GA).
term safety and efficacy of Adefovir
Dipivoxil 10mg daily on treatment
experienced patients with chronic
hepatitis B (Macdonald GA).
76
research - key to health
Conference, Melbourne, September
Haematology
The Haematology Department continues to expand the translational and
clinical trials programme in conjunction with its collaborating partners
including the Diamantina Institute, University of Queensland, QIMR,
Griffith University, Australasian Leukaemia Lymphoma Group (ALLG) and
others. The major focus of the research is to develop new treatments,
molecular diagnostic tests and monitoring of leukaemias, particularly
Acute Myeloid Leukaemia (AML) and Chronic Lymphoid Leukaemia
(CLL). Specific examples of this include the identification of new genetic
lesions in AML, the development of a new assay for AML patients and
the discovery of a new therapy for CLL patients. The collaboration
Devinder Gill
between Princess Alexandra Hospital, Diamantina Institute and Richard
D’Andrea from Adelaide has delivered a genome-wide analysis of genetic
alterations using parallel, high-throughput, paired-end DNA sequencing
and genotyping of an AML genome. Analysis is underway and new genetic lesions have been found. Amanuscript
for a molecular assay to predict relapse in a subset of AML patients is ready to be submitted for publication and
the findings will be incorporated into the next ALLG trial under the authorship of Dr Marlton, Dr Gray and Russell
Saal. Up-regulation of surface molecules in in-vitro cultures of primary in CLL cells has identified a novel target
for therapy and the provisional application of a patent through the efforts of Dr Gill, Dr McMillan, Dr Mollee and Dr
Burgess. This is in addition to the previously identified chemokines CCL2 and CXL2 in CLL.
Other Major Research Highlights:
•
•
•
•
•
•
•
•
The Australian Society of Medical Research Award: Clinician Researcher of the Year 2010 was awarded to Dr
Maher Gandhi.
Dr Tony Mills was elected to the ALLG Scientific Advisory Committee (SAC) and is Chair of Myeloproliferative
Diseases and Supportive Care Groups.
Dr Sally Mapp was appointed to a permanent full-time senior medical officer position and has submitted her
PhD thesis entitled “B cell biology and lymphomagenesis”.
The consolidation all our amyloidosis patients into a dedicated Multi-disciplinary Amyloid Clinic led by Dr Peter
Mollee has proved to be very successful, only 1 of 2 clinics in Australia.
The 3rd international meeting entitled “New Direction in Leukaemia Research” in April 2010 was oversubscribed
and highly successful with 6 eminent international speakers. The previous meetings were held in 2006 and
2008 and were initially founded, organised and chaired by Associate Professor Gill and Professor Gonda.
Clinical trial activity continues to prosper with trials in most blood diseases. The Cancer Services Research Unit
continues as one of the largest contributors in Australasia to ALLG co-operative trials. There are 58 trials open
with 40 trials actively recruiting patients.
The Stem Cell Transplant Program remains a strong component of the Unit activity. Some of the novel agents
are beginning to reduce the need for stem cell transplant. The development of cell therapy with donor EBV
specific cytotoxic T lymphocytes (CTLs) for the treatment of refractory lymphoma continues under the guidance
of Dr Maher Gandhi.
The National Leukaemia and Lymphoma Tissue Bank established and directed by Associate Professor Marlton
continues to grow resourcing many research projects around Australia and facilitating translational research in
association with clinical trials across the country. It is now in its 6th year of NHMRC funding and continues to
receive funding from the Leukaemia Foundation as well as in kind support from Queensland Health.
Associate Professor Devinder Gill
Director
Centres for Health Research 2010 Annual Research Report
77
Research Activities
Clinical trials
Trials activity continues to prosper with
ALLG CLL5 / OFOCIR An Australasian,
ALLG HD8 / RATHL A Randomised
trials in most blood diseases. The Unit
Phase II, Multicentre, Randomised, Dose
Phase III Trial to Assess Response
remains one of the largest contributors
Intensification Study Investigating Oral
Adapted Therapy Using FDG-PET
in Australasia to ALLG Co-operative
Fludarabine, Oral Cyclophosphamide
Imaging in Patients with Newly
trials. There are 58 trials open with 40
and IV Rituximab (poFCivR) Tolerance in
Diagnosed Advanced Hodgkin’s
trials actively recruiting patients.
Previously Untreated Elderly (≥ 65 years
Lymphoma (Gandhi M).
CC-5013-CLL-008 / ORIGIN A Phase 3,
Multicenter, Randomized, Open-Label,
old) Patients with Chronic Lymphocytic
Leukaemia (CLL) (OFOCIR) (Gill D).
CC-5013-DLC-001 A Phase 2/3
Multicenter, Randomized Open-Label
Parallel-Group Study of the Efficacy
ALLG AML M14 A Programme of
Study to Compare the Efficacy and
and Safety of Lenalidomide (Revlimid®)
Development for Older Patients with
Safety of Lenalidomide (Revlimid®)
versus Chlorambucil as First-Line
Acute Myeloid Leukaemia and High Risk
Versus Investigator’s Choice in Patients
Therapy for Previously Untreated
Myelodysplastic Syndrome (Marlton P).
with Relapsed or Refractory Diffuse
Elderly Patients with B-Cell Chronic
Lymphocytic Leukaemia (Gill D).
BO21000 / GAUDI An open-label,
Large B-Cell Lymphoma (Gill D).
multi-centre, non-randomised, dose-
PNH Registry The Paroxysmal Nocturnal
ALLG LS14 EBV Immune and viral
escalating phase Ib study to investigate
Hemoglobinuria (PNH) Patient Registry.
biomarkers as tools to assist clinical
the safety and tolerability of RO5072759
"PNH Registry". (Mills T).
outcomes in patients with EBV-
given in combination with CHOP or
associated lymphomas (Gandhi M).
FC chemotherapy in patients with
BO21004 / CLL-11 An Open-Label,
Multi-Center, Three Arm Randomized,
CD20+ B-cell follicular non-Hodgkin’s
lymphoma (Marlton P).
EBV CTL Autologous EBV-specific T cells
as therapy for relapsed / refractory EBVpositive lymphomas (Gandhi M).
PTLD 1 Treatment of Patients with
Phase III Study to Compare the
ALLG NHL21 Early Treatment
Efficacy and Safety of RO5072759
Intensification with R-ICE Chemotherapy
+ Chlorambucil (GClb), Rituximab +
Followed by Autologous Stem Cell
Chlorambucil (RClb) or Chlorambucil
Transplantation Using Z-BEAM for
(Clb) Alone in Previously Untreated CLL
Patients with Poor Prognosis Diffuse
Patients Not Eligible for Fludarabine-
Large B-Cell Lymphoma as Identified
Based Chemoimmunotherapy by Interim PET/CT Scan Performed
ALLG CML8 / TWISTER A Phase II
(Marlton P).
After Four Cycles of R-CHOP-14
Study of Withdrawal of Imatinib Therapy
Chemotherapy (Gill D).
in Adult Patients with Chronic Phase
C18083 / BRIGHT An Open-Label,
Post-Transplant Lymphoproliferative
Disorder (PTLD) with a Sequential
Treatment Consisting of Anti-CD20
Antibody Rituximab and CHOP + GCSF
Chemotherapy (Mollee P).
Chronic Myeloid Leukaemia in Stable
Randomized, Multi-Center Trial of
ALLG MM11 A Phase 3, Multicentre,
Bendamustine HCL and Rituximab
Randomized, Controlled Study to
(BR) Compared to Rituximab,
Determine the Efficacy and Safety of
Cyclophosphamide, Vincristine and
AMP Tissue Bank The AMP Leukaemia
Cyclophosphamide, Lenalidomide and
Prednisone (R-CVP) or Rituximab,
and Lymphoma Tissue Bank: A Joint
Dexamethasone (CRD) versus Melphalan
Cyclophosphamide, Doxorubicin,
Research Initiative of the ALLG and the
(200mg/m2) Followed by Stem Cell
Vincristine and Prednisone (R-CHOP)
Leukaemia Foundation (Marlton P).
Transplant in Newly Diagnosed Multiple
Chemotherapy in First Line Treatment of
Myeloma Subjects (Mollee P).
Complete Molecular Remission (Mills T).
Griffith Lymphoma: The Griffith
Subjects with Indolent Non-Hodgkin’s
University Genomics Research Centre
Lymphoma (NHL) (Wood P).
Lymphoma Project (Marlton P).
78
research - key to health
ALLG AML M13 High Dose Cytarabine
and Flurarabine without Anthracycline for
Patients with Core Binding Factor Acute
Myeloid Leukaemia (Marlton P).
ALLG AML M12 A Randomised
Trial of Idarubicin Dose Escalation
in Consolidation Therapy Following
Intensive Chemotherapy incorporating
High Dose Cytarabine in Patients
with Untreated Adult Acute Myeloid
Leukaemia (Marlton P).
CC-5013-MM-015 A Phase III, Multicentre, Randomised, Double-Blind,
Haematology Group
Placebo-Controlled, 3-Arm Parallel
Group Study to Determine the Efficacy
CLBH589D2308 / PANORAMA A
for Remission Induction, and (ii) Adding
and Safety of Lenalidomide (Revlimid)
randomized, double-blind, phase III
Arsenic Trioxide to All Trans Retinoic Acid
in Combination with Melphalan and
study of the efficacy and safety of oral
as Consolidation (Bird R).
Prednisone Versus Placebo Plus
panobinostat vs placebo in combination
with bortezomib and dexamethasone, in
patients requiring therapy for relapsed or
refractory multiple myeloma (Mapp S).
MUC1 MUC1 as a Marker of Bleomycin
Lung Toxicity (Keane C).
CSTI571BAU12 / INDY A Phase II Study
of Imatinib Mesylate in Patients with
Neoplastic Diseases Involving Activated
Tyrosine Kinases (Marlton P).
152CL201 / LUCID A Randomized,
Open-Label, Multicenter, Phase 2 Study
Melphalan and Prednisone in Subjects
with Newly Diagnosed Multiple Myeloma
Who are 65 Years of Age or Older
(Mollee P).
CLBH589B2206 A Phase Ib, Multicenter, Open-label, Dose-escalation
Study of Oral LBH589 when
CAMN107A2405 / ENESTcmr An Open
to Evaluate the Safety and Efficacy
Label, Randomized Study of Nilotinib
of Lumiliximab in Combination With
Versus Standard Imatinib (400/600
Fludarabine, Cyclophosphamide,
mg QD) Comparing the Kinetics of
and Rituximab Versus Fludarabine,
Complete Molecular Response for CML-
Cyclophosphamide, and Rituximab
CP Patients With Evidence of Persistent
Alone in Subjects with Relapsed Chronic
CSTI1572301 / TOPS A Randomized
Leukaemia by RQ-PCR (ENESTcmr)
Lymphocytic Leukaemia (152CL201)
Open-Label Study of 400mg versus
(NCT00760877) (Mills T).
(Marlton P).
800mg of Gleevec/Glivec (Imatinib
ALLG CLL2 International Phase III Trial
BO20603 / MAIN A Multi-center,
of Primary Therapy for B-Cell Chronic
Randomised, Double-blind, Placebo-
Lymphocytic Leukaemia (Gill D).
controlled Phase III Trial Comparing the
ALLG APML4 Phase II Trial in Patients
with Previously Untreated Acute
Promyelocytic Leukaemia to Evaluate
the Effects of (i) Adding Arsenic Trioxide
to All Trans Retinoic Acid and Idarubicin
Administered in Combination with Oral
Lenalidomide & Dexamethasone in
Adult Patients with Multiple Myeloma
(CLBH589B2206) (Marlton P).
Mesylate) in Patients with Newly
Efficacy of Bevacizumab in Combination
with Rituximab and CHOP (RA CHOP)
Diagnosed, Previously Untreated
Chronic Myeloid Leukaemia in Chronic
Phase (CML-CP) Using Molecular
Endpoints (Mills T).
versus Rituximab and CHOP (R CHOP)
ALLG CML9 / TIDEL2 A Phase II Study
in Previously Untreated Patients with
in Adult Patients with Newly Diagnosed
CD20 Positive Diffuse Large B Cell
Chronic-Phase Chronic Myeloid
Lymphoma (DLBCL) (Marlton P).
Leukaemia of Initial Intensified Imatinib
Centres for Health Research 2010 Annual Research Report
79
Therapy and Sequential Dose Escalation
INCB 18424-351 / COMFORT1 A
Chemokines in chronic lymphocytic
Followed by Treatment with Nilotinib in
Randomized, Double-blind, Placebo-
leukaemia cells (CLL) (Gill D, McMillan
Suboptimal Responders to Determine
controlled Study of the JAK Inhibitor
N, Mollee P). Research into defining
the Rate and Duration of Major
INCB018424 Tablets Administered Orally
the biological significance of CCL2 and
Molecular Response. (Mills, T).
to Subjects with Primary Myelofibrosis
CXCL2 chemokines in CLL.
ML20948 / R-ITP 1000 A multi centre,
single arm, open label study to evaluate
the efficacy and safety of 1000mg fixed
dose of rituximab (MabThera) on day
(PMF), Post-Polycythemia VeraMyelofibrosis (PPV-MF) or Essential
Thrombocythemia Myelofibrosis (PETMF). (COMFORT1) (Perkins A).
Genome wide sequencing in Acute
Myeloid Leukaemia. (Gray J, Marlton
P, Gonda T, Brown M, D’Andrea).
Commenced in collaboration with
one and fifteen among patients with
ALLG MDS3 A Phase I/II Trial of
Diamantina Institute. The results of this
refractory, relapsing or chronic idiopathic
Combination Therapy with 5-Azacytidine
cutting edge research is being analysed
thrombocytopenic purpura (Marltn P).
(Vidaza) and Thalidomide in Patients
and the preliminary results have already
with Myelodysplastic Syndromes (MDS) identified new genetic lesions.
H6Q-MC-JCBJ / PRELUDE A
Randomised, Double-Blind, Phase
(Mills T).
Identification of a novel target in chronic
III Study of Oral Enzastaurin Versus
Other Research
lymphocytic leukaemia cells (CLL)
Placebo as Maintenance Therapy
Identification of new genetic lesions
(Gill D, McMillan N, Mollee P, Burgess
Immediately Following First-Line
in Acute Myeloid Leukaemia (AML).
M). Research has identified a surface
Treatment for Patients with High-Risk
The genome-wide analysis of genetic
molecule which looks promising for
Diffuse Large B-Cell Lymphoma alterations using parallel, high-
therapy of CLL .
(Marlton P).
throughput, paired-end DNA sequencing
CC-5013-MM-020 / FIRST A Phase III,
Randomized, Open-Label, 3-Arm Study
to Determine the Efficacy and Safety of
Lenalidomide (REVLIMID) Plus LowDose Dexamethasone When Given Until
Progressive Disease or for 18 Four-
and genotyping of an AML genome has
been completed. This is a collaboration
between PA Hospital, Diamantina
Institute and Richard D’Andrea,
Adelaide. Analysis is underway and new
genetic lesions have been found.
The Stem Cell Transplant Program
remains a strong component of the Unit
activity. Some of the novel agents are
beginning to reduce the need for stem
cell transplant. Development of Cell
therapy with donor EBV specific CTLs
for treatment of Refractory Lymphoma
Week Cycles Versus the Combination of
Manuscript for a molecular assay to
Melphalan, Prednisone, and Thalidomide
predict relapse in a subset of AML
Given for 12 Six-Week Cycles in Patients
patients is ready to be submitted for
With Previously Untreated Multiple
publication (Marlton P, Gray J, Saal R).
Total NHMRC funding:
$300,000
Myeloma Who Are Either 65 Years of
The findings will be incorporated into
Age or Older or Not Candidates for
the next ALLG trial.
Other competitive
funding:
$100,000
Up-regulation of surface molecules in
Funding from
commercial studies:
$396,724
Stem Cell Transplantation.(MM-020)
(NCT00689936) (Mollee P).
in-vitro cultures of primary in chronic
ALLG LY03 A Randomised Trial of
lymphocytic leukaemia cells has
Chlorambucil versus Fludarabine
identified a novel target for therapy –
as Initial Therapy of Waldenström’s
provisional application of a patent. (Gill
Macroglobulinaemia and Splenic
D, McMillan N, Mollee P, Burgess). This
Lymphoma with Villous Lymphocytes
is in addition to the previously identified
(Marlton P).
chemokines CCL2 and CXL2 in CLL.
80
research - key to health
continues (Gandhi M).
Major Grants & Financial Support
Awards & Prizes
Dr Maher Gandi
Australian Society of Medical Research
Award: Clinician Researcher of the Year 2010
Infection Management
Services
The department continued to provide clinical infectious diseases
programmes, sexual health services, alternate site infusion services and
infection control programmes at Princess Alexandra, Logan, Ipswich, QEII and Redland Hospitals. Undergraduate and post-graduate teaching
was provided in all areas of infectious diseases and infection control, as
well as some microbiology to medical, pharmacy and science students at The University of Queensland.
Associate Professor Michael Whitby
Director
Michael Whitby
Research Activities
Clinical Trials
of Patients with Invasive Fungal Disease
A phase lll, double-blind, randomised
caused by Rare Moulds, Yeasts or
study to evaluate the safety and efficacy
Dimorphic Fungi.
of BAL8557 versus a Caspofungin
followed by Voriconazole regimen in the
treatment of candidaemia and other
invasive Candida infections.
A phase lll, double-blind, randomised
study to evaluate the safety and efficacy
of BAL8557 versus Voriconazole for
primary treatment of invasive fungal
Ethanol lock therapy for the prevention
$80,000
National & International Presentations
Dr Elliott G Playford
controlled trial.
50th Interscience Conference on
Prospective Surveillance of Invasive
Antimicrobial Agents and Chemotherapy
Fungal Infections in Australian Intensive
11th Annual Scientific Meeting of the
Care Units.
Australian Society for Antimicrobials
A Phase 3, Open Label, Randomized
Study of the Antiviral Activity, Safety and
Aspergillosis and Renal Impairment or
Other competitive
funding:
$271,400
associated bacteraemias: a randomised
or other filamentous fungi.
In the Treatment of Patients with
Total NHMRC funding:
of tunnelled intravenous catheter-
disease caused by aspergillus species
Open Label Study of Isavuconazole
Major Grants & Financial Support
Tolerability of Intravenous Peramivir in
Hospitalized Subjects with Confirmed or
Suspected Influenza Infection.
Centres for Health Research 2010 Annual Research Report
81
Intensive Care Unit
The Intensive Care Unit has demonstrated another successful year in
the development of a successful critical care research program. This is
evidenced by the award of two prestigious NHMRC grants, an increase
in the number of collaborations, and a consistent track record of
publications and presentations. Highlights of the year included:
•
•
•
The “ESCAPE Trial” $3.27 million NHMRC funding for a bi-national
multi-centre study (ANZ) ‘A Randomised Controlled trial of the effect
of hydrocortisone on mortality in critically ill patients with septic
shock’ to be led by Professor Bala Venkatesh from PAH ICU, It is the
largest funding for a sepsis trial from the NHMRC.
$2.5 million NHMRC funding for a Centre of Research Excellence
(CRE) in Nursing Interventions for Hospitalised Patients, being led by
Griffith University with Professor Leanne Aitken as a chief investigator
and PAH as a partner organisation. It is the largest funding by
NHMRC for a CRE in Nursing in recent history.
Establishment of a collaborative intensive care research centre
between the intensive care units at Princess Alexandra Hospital,
the Royal Brisbane and Women’s Hospital and The Prince Charles
Hospital with the University of Queensland.
The unit continued to actively participate in a number of national and
international clinical trials, particularly with the Australian and New
Zealand Intensive Care Society (ANZICS) Clinical Trials Group (CTG), as
well as encouraging investigator-initiated studies and projects for those in
training including registrars and doctoral students.
Bala Venkatesh
Chris Joyce
Strengths of the research program include the multi-disciplinary nature
of the team, with involvement from medical, nursing, social work, physiotherapy, nutrition and dietetics and
pharmacy; as well as the broad reach of research questions across the entire continuum of critical illness.
This level of productivity and success is only possible because of the enthusiasm and dedication of the medical,
nursing and allied health staff of the unit. The group is looking forward to another productive year.
Professor Bala Venkatesh
Director of Research
Professor Leanne Aitken
Chair in Critical Care Nursing
Associate Professor Chris Joyce
Director of Intensive Care
82
research - key to health
Major Grants & Financial Support
Total NHMRC funding:
Other competitive
funding:
$1,070,546
$406,824
National & International Presentations
Professor Leanne Aitken
Dr Marion Mitchell
International Congress of Intensive Care
The 4th Australasian Cardiovascular
and Emergency Medicine, Brussels
Nursing College Annual Conference:
Belgium
Cardiovascular nursing, prevent,
Acid base and biochemistry in critical
educate, treatment, Brisbane
illness; Acute Care Medicine Course,
Simulation and Beyond: Creative
RCN International Nursing Research
teaching approaches for improving
Conference, Newcastle upon Tyne
patient safety, Hunter Valley
England
ANZICS/ACCCN Australian and New
ACCCN Institute of Continuing
Zealand Annual Scientific Meeting on
Education (ICE). 11th Annual Meeting,
Intensive Care, Melbourne
Sydney
Associate Professor Peter Kruger
British Association of Critical Care
8th World Congress on Trauma, Shock,
Conference - Taking Pride in Practice,
Inflammation and Sepsis, Munich
Southport England
ANZICS- Clinical Trials Group Winter
ANZICS/ACCCN Australian and New
Research Forum
Zealand Annual Scientific Meeting on
ANZICS- Spring Research Forum,
Melbourne
ANZICS/ACCCN Australian and New
Zealand Annual Scientific Meeting on
Intensive Care, Melbourne
Training in Australia - Christian Medical
College, Vellore, India
Passing the ICU Fellowship examination
- Registrar Course, Wellington New
Zealand
ECG interpretation in Critical
Care practice - Seminar on Data
Interpretation in Acute Medicine, Kuala
Intensive Care, Melbourne
Lumpur, Malaysia
Anti-fungal agents – Indo Australian
Critical Care Program, Calcutta, India
Professor Bala Venkatesh
The interstitium: The platform of the
future for diagnosis and therapy; Round
Table conference: "Thinking outside the
box", Brussels Belgium
Melbourne
ECG interpretation in Critical
Care practice - Seminar on Data
Interpretation in Acute Medicine,
Calcutta, India
Centres for Health Research 2010 Annual Research Report
83
Internal Medicine &
Clinical Epidemiology
The department's profile in health services research continued to grow
with its participation as co-investigators in a successful application
for a major NHMRC grant of $2 million to fund a Centre of Research
Excellence in Primary-Secondary Care Interface for Complex Medical
Illness. A 5-year program of research will evaluate the effects of a
primary care amplified management (PCAM) model of integrated primarysecondary care on the quality of care and clinical outcomes of patients
with complicated diabetes, chronic heart failure or terminal conditions
requiring palliative care. It will also assess whether the PCAM model
produces higher levels of professional skills and satisfaction, GPspecialist liaison, multidisciplinary teamwork, efficient use of services and
resources, and deployment of information technology.
Ian Scott
The department was also awarded a PAH Private Practice Foundation grant worth $75,000 to be used in
developing a prescribing technology for older patients aimed at minimising inappropriate use of medications and
reducing iatrogenic burden of polypharmacy.
The department has continued its collaboration with colleagues at Monash University and the Centre for Research
Excellence in Patient Safety in researching tools for screening for adverse events in hospitalised patients,
assessing the validity and reliability of standardised hospital mortality ratios as an indicator of hospital quality, and
evaluating methods for assessing clinical performance of individual physicians.
The department has been involved in research into the pharmacokinetics of oncologic drugs in diabetes,
metabolic syndrome and obesity and has also completed an extensive retrospective review of the incidence and
management of iron deficiency anaemia in a tertiary hospital setting.
Associate Professor Ian Scott
Director
Research Activities
To what extent is suboptimal in-
Ongoing retrospective audit of
CA, Phelps G, Barker A, Cameron PA).
patient care responsible for unplanned
management of patients presenting to
Systematic review of the literature on readmissions to hospital? (Scott IA,
emergency department with syncope.
the validity, reliability and impact of Khadem G). Retrospective review of
unplanned readmissions to a general
medicine service aiming to identify
patient and system of care factors that
account for most readmissions and
to discern prevalence of suboptimal
in-patient care and peri-discharge
processes.
Management of syncope in a tertiary
hospital (Susarla M, Scott IA, Jones M). 84
research - key to health
Incidence and management of iron
deficiency in a tertiary hospital (Khadem
G, Scott IA). Retrospective review of
the hospital standardised mortality ratio as an indicator of the quality of
hospital care.
the incidence and management of iron
Clinical practice guidelines: the
deficiency anaemia in a large cohort of
need for greater transparency in
patients admitted to a tertiary hospital.
developing care recommendations
Using hospital standardised mortality
ratios to assess quality of care – proceed
with extreme caution (Scott IA, Brand
(Scott IA, Guyatt GH). Analysis of
the processes of formulating clinical
practice guideline recommendations
in regards to the rating of the quality of
evidence and grading the strength of
genotyping of cases and matched
recommendations.
controls that develop DILI on commonly
Adverse events in people admitted
used medications.
Major Grants & Financial Support
Total NHMRC funding:
$679,000
Other competitive
funding:
$75,000
Funding from other
sources:
$50,000
to hospital for management of
Centre of Research Excellence in Dose
chronic heart failure and pneumonia:
individualisation: Integrating clinical
Development of the medical adverse
pharmacology with pharmaco-genetics,
events screening Tool (MAST) (Brand
–metrics and -economics to deliver
CA, Tropea J, Gorelick A, Jolley D,
optimal patient care ( Martin J, Norris
Scott IA, Sundararajan V). Development
R, Charles B, Duley J, Coory M, Barras
of a screening tool (MAST) based
M, Valery P). A national Centre for
on administrative data for detecting
integration of pharmacogenetics and
Australian Society of Clinical
adverse events in people admitted to
pharmacokinetics to understand toxicity
Biochemists. Therapeutic Drug
hospital for management of chronic
and improve efficacy in medications
Monitoring SES, Brisbane
heart failure and pneumonia.
National & International Presentations
Associate Professor Jenny Martin
World Congress of Internal Medicine,
Melbourne
Effects of diabetes and obesity on breast
Australian Pharmacogenetics Summit
Minimising inappropriate medication
cancer outcomes in women with node
Sydney
use in older populations (Scott IA, Scott
positive breast cancer (Martin J, Coory
IA, Martin JH, Gray LA, Mitchell CA).
M, Fay M, Walpole E, Green M, Saleem
3rd International Conference on Fixed
Development of a drug minimisation
M, Wilcken N). Does underdosing in
Combination, Brisbane
guide aimed at reducing inappropriate
obesity lead to worse health outcomes:
use of medications in older patients
Measuring chemotherapy exposure in
at risk of adverse events from
obese and lean women with First National Roundtable on Indigenous
polypharmacy.
breast cancer.
Health, Brisbane
Assessing individual clinical
Obesity and underdosing of antibiotics
Associate Professor Ian Scott
performance (Scott IA, Phelps G, Brand
(Martin J, Looke). Retrospective review
World Congress of Internal Medicine,
CA). Systematic review of the literature
of the dose and plasma concentration of
Melbourne, March
on the performance and feasibility of
commonly used antibiotics in an obese
tools for assessing individual physician
and lean cohort of patients admitted to
performance.
a tertiary hospital.
Improving the interface between primary
Incidence, prevalence and
and secondary care in managing
pathophysiology of metabolic syndrome
patients with complex medical problems
post allogeneic hematopoietic
(Jackson C, Mitchell G, Davies P,
progenitor cell transplantation (HPCT)
Hollingsworth S, Ashkew D, Dart
(Martin J, Kennedy, O’Moore-Sullivan T,
J). Major research project aimed at
Prins J).
evaluating the effects of a primary care
amplified management (PCAM) model
of integrated primary-secondary care on
quality of care and outcomes of patients
with complicated diabetes or chronic
heart failure or requiring palliative care.
Drug Induced Liver Injury (DILI) –
understanding the pharmacogenetic
mechanisms International Collaboration
SEAC (Daly A). Retrospective
ASCEPT, Melbourne
Victorian Department of Health and
Human Services Conference, Melbourne
CRE Patient Safety Conference on Inhospital Mortality, Melbourne
Readmissions Conference, Melbourne
2010 ACHSM Conference, Brisbane
AHHA/AIHPS 2010 Congress, Adelaide
Resveratrol pharmacokinetics: effect
of obesity. (Chachay V, Kirkpatrick C,
Taylor, Hickman I, Fergusson M, Franklin,
Martin J).
RACP Measurement for Improvement
Seminar, Gold Coast
IMSANZ-RACP Annual Scientific
An Evaluation of Gentamicin Monitoring
Meeting, Gold Coast
Practises at a Tertiary Hospital (Ah Yui,
2010 General Practitioners Congress,
Kirkpatrick, Barras, Kubler, Norris,
Cairns
Martin).
Healthcare Complaints Conference,
Brisbane
Centres for Health Research 2010 Annual Research Report
85
Medical Oncology
The department is a tertiary-referral centre for cancer. Most clinics
operate in a multi-disciplinary format with radiation oncology, surgical
and allied health services. The department has an active clinical trials
program primarily in breast cancer, melanoma, gastroesophageal cancer,
colorectal cancer, head and neck cancer, pancreatic cancer, lung cancer
and germ cell tumours. Participation in clinical trials conducted under
the auspices of national and international study groups such as the
Australasian Gastro-Intestinal Trials Group, the Australian New Zealand
Germ Cell Trials Group (now a section of the Australian New Zealand
Urogenital and Prostate Cancer Trials Group), the Australian New Zealand
Damien Thomson
Breast Cancer Trials Group, Australian Sarcoma Study Group, Eastern
Cooperative Oncology Group, National Surgical Adjuvant Breast and
Bowel Group, European Organisation for Research and Treatment of
Cancer, has enabled the department access to and experience with the latest developments in treatment
regimens for cancer patients. The unit has a significant history in the conduct of industry-initiated research
trials allowing the hospital, and ultimately the patient, access to potential cutting-edge developments in cancer
therapy. The department has a considerable infrastructure of clinical trial research staff and shares research
nurses and data managers with the Haematology and the Radiation Oncology departments.
Associate Professor Damien Thomson
Director
Research Activities
Clinical Trials
20062004 / Denosumab (Joubert
(Ipilimumab) versus Placebo after
AG0507GS / REGISTER (Walpole E).
W). An Open-Label, Multi-Center,
Complete Resection of High-Risk
A Multicentre Phase II Study of Risk
Phase 2 Safety and Efficacy Study of
Stage III Melanoma: A Randomized,
Evaluation in GIST with Selective
Denosumab (AMG 162) in Patients with
Double-blind Phase 3 Trial of the EORTC
Therapy Escalation for Response.
Recurrent or Unresectable Giant Cell
Melanoma Group.
Tumour (GCT) of Bone
SCOT: Short Course Oncology Therapy
ANZGCTG 0106 / ChemoCog (Thomson
(Joubert W). An International, Open-
D). Germ Cell CogState. Cognitive
label Randomised, Two-arm Phase
Randomized, Double Blind, Placebo
Function and Treatment for Testicular
III Non-inferiority Trial Investigating
Controlled, Multicenter Phase III Trial
Cancer: Chemo and Cognition.
a Shortened Duration of Treatment
BO21990 / AVAGLIO (Atkinson V). A
of Bevacizumab, Temozolomide and
Radiotherapy, Followed by Bevacizumab
plus Temozolomide versus Placebo,
Temozolomide and Radiotherapy
followed by Placebo and Temozolomide
ANZUP 0901 / EVERSUN (McCaffrey
E). A Phase 2 Study of Everolimus
STX 0206 (Walpole E). Randomised
with Advanced Renal Cell Carcinoma.
Comparative Study of FOLFOX6m plus
EORTC 40054 / PETACC-6 (Walpole
Glioblastoma.
E, Jennifer H). Preoperative
D). Adjuvant Immunotherapy with AntiCTLA-4 Monoclonal Antibody 86
research - key to health
Colorectal Cancer.
Alternating with Sunitinib in Patients
in Patients with Newly Diagnosed
EORTC 18071 / CA184-029 (Thomson
for Patients with High-risk Stage II/III
Chemoradiotherapy and Postoperative
Chemotherapy with Capecitabine and
SIR-Spheres® versus FOLFOX6m Alone
as First Line Treatment in Patients with
Non-resectable Liver Metastases from
Primary Colorectal Carcinoma.
Oxaliplatin vs. Capecitabine Alone in
EMR 62 202-505 / APEC (Walpole
Locally Advanced Rectal Cancer.
E). An Asia Pacific Non-randomized,
Open-label Phase II Study Evaluating
blind, Placebo-controlled Study to
Treatment in Patients with Metastatic
the Safety and Efficacy of FOLFIRI plus
Evaluate the Efficacy and Safety of
Melanoma
Cetuximab (Erbitux) or FOLFOX plus
AVE5026 in the Prevention of Venous
Cetuximab in Patients with Wild-type
Thromboembolism (VTE) in Cancer
KRAS Status as First-line Therapy in
Patients at High Risk for VTE and who
Subjects with Metastatic Colorectal
are undergoing Chemotherapy.
Cancer (APEC-Study).
IBCSG 24-02 / SOFT (Woodward N).
NO25026 / BRIM-3 (Atkinson, V). A
A Phase III Trial Evaluating the Role
Multicenter, Randomized, Double-
of Ovarian Function Suppression and
blinded, Controlled, Phase III Study
the Role of Exemestane as Adjuvant
in Previously Untreated Patients With
Therapies for Premenopausal Women
Unresectable Stage IIIc or Stage IV
with Endocrine Responsive Breast
Melanoma with V600E-Positive BRAF
Cancer (IBCSG 24-02 / BIG 2-02).
Mutation Receiving RO5185426 or
Dacarbazine
QUASAR2 (Walpole E). Multicentre
International Study of Capecitabine +/-
ANZ 0702 / BIG 2-06 / ALTTO
Bevacizumab as Adjuvant Treatment of
(Woodward N). A Randomised, Multi-
Colon Cancer.
centre, Open-label, Phase III Study
of Adjuvant Lapatinib, Trastuzumab,
their Sequence and their Combination
in Patients with HER2/ErbB2 Positive
Primary Breast Cancer (BIG 2-06).
TCSS (Thomson D). Understanding the
Psychosocial Sequelae of Surviving
Testicular Cancer.
BAY73-4506/1437 / CORRECT (Joubert
W). A Randomized, Double-blind,
Placebo-controlled Phase III Study of
Regorafenib plus Best Supportive Care
in Patients with Metastatic Colorectal
Cancer (CRC) who have Progressed
after Standard Therapy.
EORTC 62072 / PALETTE (Thomson
D). A Randomized Double-blind Phase
III trial of Pazopanib versus Placebo
in Patients with Soft Tissue Sarcoma
whose Disease has Progressed during
M10-440 / PARP (Thomson D). A
or following Prior Therapy. PAzopanib
Randomized, Double-Blind, Placebo-
ExpLorEd in SofT-Tissue Sarcoma - A
Controlled, Phase 2 Study Evaluating
phase III study.
the Efficacy of ABT-888 in Combination
with Temozolomide Versus Temozolomide
Major Grants & Financial Support
AGITG CO20 (Joubert W). A Phase III
Alone in Subjects with Metastatic
Competitive funding:
$112,860
Randomized Study of Brivanib Alaninate
Melanoma.
Funding from
commercial studies:
$377,229
H8K-MC-JZAO / SUMMIT-1 (Atkinson
Funding from other
sources:
$77,031
(BMS-582664) in Combination with
Cetuximab (Erbitux®) versus Placebo
in Combination with Cetuximab
(Erbitux®) in Patients Previously Treated
with Combination Chemotherapy for
Metastatic Colorectal Carcinoma.
V). A Randomized Phase 3 Study
of Tasisulam Administered as an
Intravenous Infusion on Day 1 of a 28Day Cycle vs. Paclitaxel as Second-Line
ANZGCTG 0206 / Accelerated BEP
(Thomson D). A Feasibility Study
of Accelerated BEP as First Line
Chemotherapy for Advanced Germ Cell
Tumours.
ANZGCTG 0801 / Aprepitant Study
(Thomson D). A Phase II Multi-centre
Trial of a Seven Day Aprepitant Schedule
for the Prevention of Chemotherapy
Induced Nausea and Vomiting in Patients
receiving Five Day Cisplatin-based
Chemotherapy for Germ Cell Tumours.
EFC6521 / SAVE-ONCO (Atkinson V).
A Multinational, Randomized, Double
Medical Oncology Team
Centres for Health Research 2010 Annual Research Report
87
Mental Health
This was a significant year for research at the Metro South Health
District Mental Health Service. The central focus was the development
of infrastructure and support which aimed at further strengthening
the quality and outcome of research activities within the service. The
year also witnessed a gathering of momentum of the staff’s desire to
participate in clinical research and utilisation of clinical data to improve
practice and using evidence to achieve better consumer outcomes.
The journey to increase Metro South Mental Health Service’s contribution
to research commenced with the appointment of Professor Steve
David Crompton
Kisely. Professor Kisely is trained in psychiatry, addiction medicine and
public health medicine in both the U.K and Australia. His research and
clinical interests are in health services research (HSR) and physical and
psychiatric co-morbidity. He was the winner of the Special Judges Award in the category of Best Use of IT in
Clinical Care in Great Britain as part of the 1998 National Health care IT Effectiveness Award and the Canadian
Psychiatric Association 2008 RO Jones Award. As part of the process of cultivating research, a monthly Metro
South Mental Health Service Clinical Research Forum was also implemented. Video conference technology
has enabled the forum to link clinical researchers to share their findings with peers and colleagues across the
district both at the hospital setting and all the community sites. There are positive indicators that clinicians are
becoming adept at using research to enhance consumer recovery and embrace systematic searches for clinical
evidence to bridge the gaps that may interfere with positive clinical and consumer outcomes.
Professor David Crompton
Executive Clinical Director
Research Activities
Evaluation of Supported
be broken, and the journey to recovery
S, Broome A, McCallum E and Lie
Accommodation for People with Severe
restarted (3). Programs that avert
D). Electroconvulsive therapy (ECT)
and Persistent Mental Illness at Metro
hospital bed days have the potential
guidelines, across various regulatory
South Division of Mental Health (Siskind
to be cost saving for the public mental
bodies, lack consensus as to the
D, Whiteford H, Pirkis J). Mental Health
health system.
optimal frequency of treatment for
Consumers in crisis often become
stuck in a revolving door of hospital
admissions, discharge to an inadequate
support networks and re-admission (1).
Homelessness is common in patients
with psychosis and is linked to poorer
engagement with mental health services
(2). If the social framework of consumers
can be stabilized with accommodation,
Using administrative data sets for
program participants and matched
controls at neighbouring districts
without supported accommodation
services, we are evaluating the effect
of these programs on hospitalisations,
illness acuity, ED presentations and
contact with community services.
individual patients. Some authors
postulate that twice weekly ECT may
have a similar efficacy to thrice weekly,
and may have a lower risk of adverse
cognitive outcomes. Systematic review
and a meta-analysis to assess the
strength of associations between ECT
frequency and depression scores,
duration of treatment, number of ECTs,
engagement with mental health
ECT efficacy and treatment course:
and remission rates was undertaken by
services, re-connection to community,
A systematic review and meta-
the group. The group concluded that
living skills and strengthening of
analysis of twice vs thrice weekly
twice weekly ECT is associated with
personal relationships, this cycle can
schedules (Charlton F, Siskind D, Doi
similar efficacy to thrice weekly ECT,
88
research - key to health
may require fewer treatments and resource allocation decisions regarding
Feedback received from mental health
may be associated with longer healthcare. The aim is to undertake a
staff highlighted the importance of
treatment duration when compared to
cost-effectiveness analysis of treatments
the partnership and its role in meeting
thrice weekly.
for depression contextualised to Chile.
the oral health needs of patients.
Using data from studies in Chile, we
Generally patients were satisfied with
developed a computer-based Markov
the treatment they received and valued
cohort model of depression among
the dental service. Results highlighted
Chilean women to evaluate the cost-
an ongoing problem of poor dietary and
effectiveness of usual care or improved
lifestyle choices. Dental staff felt that
stepped care.
patients were less likely to take care
These epidemiological observations
support the routine use of twice weekly
ECT in acute courses, though choice
of frequency should take into account
individual patient factors. These
observations have implications for
resource utilisation e.g. costs of duration
The incremental cost-effectiveness ratio
of admission vs cost of provision of ECT,
of usual care was I$113 per quality-
as well as issues of access to inpatient
adjusted life-year (QALY) gained, versus
beds and anaesthetist time.
no treatment, whereas stepped care had
Evaluation of outcomes of Twice and
Thrice Weekly ECT at a Metropolitan
Australian Mental Health Service
(Siskind, D, Charlton F, Lie, D). Using
retrospective administrative datasets
the group are examining the outcomes
for consumers receiving ECT twice
weekly vs thrice weekly in a naturalistic
study before and after a policy change
suggesting consultants review ECT
prescribing. Outcomes will include
length of stay, readmission rates,
a ratio of I$468 per QALY versus usual
care. This compared favourably with
sustainable way to ensure improved
to cost of treatment, and insensitive
dental health outcomes for patients of
to changes in health-state utility of
mental health services. This partnership
depression and rate of recurrence.
has led to increased access to dental
The results suggest that treatments for
services and consequently greater
depression in low- and middle-income
follow-up. Significantly, forming
countries may be more cost-effective
partnerships with other health services
than previously estimated.
is worthwhile despite barriers, as it
(Wieland B, Lau G, Seifert D, Siskind
hypnotics, anti-psychotics and
stimulants. Sub-analysis of prescribing
trends in the elderly and very old.
a recommended course of treatment.
episode coverage, marginally sensitive
and diagnosis.
of PBS prescribing data for anxiolytics/
appointments or following through with
local Dental Hospital has created a
Mental Health and Dental Services
L, Scott J, Byrne G, Lie D). Evaluation
with a mental illness not attending
Overall, the partnership with the
ECTs. Data will be stratified by Age Siskind D, Whiteford H, Hall W, Nissen
acknowledged frustration with patients
most sensitive to variation in recurrent
The Partnership Evaluation: Public
medications in Australia (Hollingworth S,
cancel appointments. Dental staff also
Chile’s per-capita GDP. Results were
duration of ECT course and number of
Prescribing Trends for psychotropic
of their teeth and were more likely to
D). The aim of the present study was to
evaluate the partnership between the
greatly benefits patients.
Major Grants & Financial Support
Competitive funding:
$10,000
Funding from other
sources:
$25,000
Mobile Intensive Treatment Team and
the South Brisbane Dental Hospital
in providing patients with a mental
illness with timely and efficient access
to dentistry and the factors that
contributed to the sustainability of the
partnership itself. The outcomes of
Cost-effectiveness of improved primary
the partnership were appraised using
care treatment of depression in women
a survey based evaluation with 20
in Chile (Siskind D, Araya R, Kim J).
patients, 43 community mental Low- and middle-income countries
health staff and 14 dental staff, and
lack information on contextualised
focus groups with mental health and
mental health interventions to aid
dental staff.
Centres for Health Research 2010 Annual Research Report
89
Microbiology
Research activities within the department have continued to utilise partnerships with students from the QUT and
Griffith University. Projects undertaken included a search for optimal methods to demonstrate extended betalactamase production in AmpC producing E. coli and Klebsiella species; and a study into the effects of colloidal
silver solutions on multi-drug resistant organisms and human cells.
An investigation of endoscopic sinus surgery on bacterial biofilms in chronic rhinosinusitis was a collaborative
effort between the Microbiology Department, the PAH’s ENT department and UQ. Biofilm coefficients were
assessed from bacteria isolated from patient’s nares before and after endoscopic sinus surgery. The study
demonstrated that endoscopic sinus surgery reduced but did not eliminate bacterial biofilms. The project outcomes
were significant and were published in Otolaryngology Head Neck Surgery in March.
The department also takes part in the collection and data storage for a number of studies that investigate the
epidemiology and antimicrobial resistance patterns of bacterial pathogens. These studies were co-ordinated by the
Australian Group of Antimicrobial Resistance, the International Health Management Associates Inc., the AMAZES
trial and the Australia New Zealand Cooperative on Outcomes in Staphylococcal Sepsis. The collaboration of
our laboratory with other Australian microbiology laboratories enhances the knowledge and understanding of
the epidemiology and the mechanisms of resistance in bacteria and identifies trends in resistance that ultimately
benefits patient outcomes.
Dr Joan Faoagali
Deputy Director of Microbiology, Pathology Queensland, Clinical and State-wide Services
Research Activities
Clinical Trials
Offenders’ MRSA Health Surveillance
Assessment of bacterial biofilms on
A Comparison of Chromogenic, Non-
(Faoagali J, Campbell, V).
chronic rhinosinusitis patients post
chromogenic and Broth Media for the
endoscopic surgery (Hai P, Lidstone C,
Detection of Vancomycin Resistant
Wallwork, B).
Enterococci in a Tertiary Referral Hospital
AMAZES trial to evaluate benefits of
azithromycin prophylaxis on chronic
obstructive airway disease – assessment
Tigecycline Evaluation Surveillance Trial
of clinical microbiology specimens
2010 (Nessen S, Faoagali J).
from patients in tria. (Faoagali J,
Kleinschmidt, S in collaboration with
Towers M, Gibson P).
Methodology for in-house identification
of ESBLs and AmpC beta lactamase
production in E. coli and Klebsiella
species (Coleman L, Faoagali J).
Effect of colloidal silver solutions on
multi-drug resistant organisms and
human cells. (Castillo L, Faoagali J).
Collection of significant gram negative
organisms and data causing urinary
tract infections in outpatients (Australian
Group of Antimicrobial Resistance).
Collection of Staphylococcus aureus
isolates and data from outpatients
(Australian Group of Antimicrobial
Resistance).
Collection of clinically significant
isolates of Enterococci and associated
(Greening K, Lingard S and Faoagali, J).
Blood and urine culture paired isolates
of Escherichia coli (Faoagali J, Looke D,
Schembri M).
Major Grants & Financial Support
Funding from
commercial studies:
$7,878
Funding from other
sources:
$5,917
National & International Presentations
Dr Joan Faoagali
Pathology Update, Melbourne
Other Research
antimicrobial and identification data
Marjoree Sehu
Identification and collection of yeasts
(Australian Group of Antimicrobial
Pathology Update, Melbourne
from ICU patients (Playford G, Faoagali, J).
Resistance).
90
research - key to health
Neurosurgery
The Department of Neurosurgery has made significant research gains
this year. An arrangement has been formalised with the Diamantina
Institute for a neurosurgery registrar to complete a masters or PhD in
brain tumour research. The Brain Tumour Clinic continues to run several
trials in collaboration with the national trial groups COGNO and TROG. A
registrar has been funded fulltime for a second year undertaking research
in minimally invasive spine surgery. In addition, funding has been attained
for a speech therapist to study language and cognitive function via
functional magnetic resonance imaging and tractography in patients with
brain tumours. Two studies are currently being completed.
Bruce Hall
The unit is participating in national and international trials into
subarachnoid haemorrhage and brain trauma.
Dr Bruce Hall
Chair
Research Activities
Clinical Trials
Health Economics and Clinical
Glioblastoma multiforme; Whole brain
of stress-inducing drugs and identify
Outcomes of Minimally Invasive Lumbar
radiation for melanoma; EORTC grade
synergistic and additive combinations.
Spine Fusion (Tsahtsarlis A, wood M).
II astrocytoma trial; Cabaret trial Avastin
(Rumal Jayalath, Sarah Olson, Bruce
and carboplatinum in high grade
Hall, Angus Harding, Brian Gabrielli)
Safety and Efficacy of intradural
extramedullary spinal tumour removal
using a minimally invasive approach
(Mannion R, Nowitzke A, Efendy J,
Wood M).
Anthropomorphic study of C2 pars
dimensions (Laherty R, Grainger A).
Preparation of aneurysm and
subarachnoid haemorrhage database
(Laherty R, Grainger A).
gliomas on progression; Language and
cognitive function in brain tumours;
Basic science research in Brain
tumours; Investigation of chromosomal
Instability in glioblastoma cell lines
Synergistic chemotherapy treatment in
Glioblastoma
Glioblastoma Multiforme: Treatment and
outcomes in South East Queensland,
Patients between 2004 and 2009
(Olsson G, Olson S, Harding A, Gabrielli B).
PI3 Kinase, ERK, PKC, JNK and SRC
cellular signalling pathways drive
Aims of these studies are to: Confirm
glioblastoma multiforme survival and
that GBM tumours contain a range
growth (Olsson G, Olson S, Harding A,
of adaptor phenotypes; Confirm
Gabrielli B).
Conscious 3 Trial. Clazosantan.
GBM polyploid cells are a reservoir
Endothelial receptor antagonist
of adaptive therapy resistant cells
in prevention of vasospasm in
in GBM tumours; Classification of
Competitive funding:
$30,000
subarachnoid haemorrhage (Webster J,
GBM tumoursphere lines based on
Funding from
commercial studies:
$85,000
Lee J).
aggression; Classification of GBM
Funding from other
sources:
$10,000
tumoursphere lines based on the level
Trials running through the Brain Clinic
of aneuploidy; Classification of GBM
Tumour (Smith L, Whiting E, Olson S,
tumoursphere lines based on CIN gene McCullum W, de Zubicary G, Copland D)
expression profile; Formally characterise
include:Avaglio study: Avastin in the drug interactions of different classes Major Grants & Financial Support
Centres for Health Research 2010 Annual Research Report
91
Nursing Practice
Development Unit
The Nursing Practice Development Unit aims to increase the visibility,
capability, and quality of nurse-led research at the hospital. The unit has
continued to strive to develop the culture of enquiry within the hospital.
This year, the unit has implemented tailored research and evidence-based
programs, hosting seminars presented by specialists in the area of health
promotion research, formalising links with the Joanna Briggs Institute,
establishing and supporting positive links with the tertiary sector, and
providing ongoing support to nurses engaging in research practice, both
in their endeavours in the clinical unit and post graduate study.
These strategies have been particularly effective. There has been an
increase in the number of nurses initiating and participating in research
projects, with outcomes resulting in changes to practice. The number of
nurses enrolling in post graduate study with a research dissertation has also increased.
Kerri Holzhauser
Nurse scholars and research fellows jointly appointed have continued to collaboratively engage in research
projects with outcomes that have influenced care on a local, national, and international scale. Additionally, our
nurse researchers have continued to disseminate their findings in national and international arenas through
strategic conferences and professional journals.
Funding attained for nurse-led research has once again exceeded that of the previous years. This is a sound
record of achievement upon which the group will continue to build.
Kerri Holzhauser
Director
Research Activities
The Patient Assessment Project.
factors affecting patient assessment by
is currently taught at the undergraduate
This study is an evidence-based
nurses include: (1) nursing expertise, (2)
level, and can ensure consistency for
quality improvement project designed
workload, (3) value, (4) communication
nurses in daily practice.
to improve patient assessment,
and handover, and (5) documentation
documentation, and outcomes at the
and risk assessment forms. From this
Princess Alexandra Hospital being
evidence, the steering committee
coordinated through the NPDU.
decided to focus on more than ‘just the
Through an extensive literature review
and site visits to many Australian
hospitals plus focus groups with PAH
form,’ and address the organisational
culture and processes that impact upon change.
ward nurses and mapping exercises
The systems assessment approach has
of the tools and processes in use at
been chosen as the preferred patient
the PAH, it was found that the major
assessment model because this model
92
research - key to health
A 3-month trial, including
documentation audits, vignette study,
and focus groups, will be conducted
from November 2010 till January 2011
to measure the effectiveness of the
new process and forms. This project is
expected to be completed in June 2011.
Discpline Scholar: NPDU Education are
currently completing studies examining
how learning situated in the clinical
Gillian Ray-Barruel
Dr Marion Mitchell
context directly impacts on the ability Best Oral Abstract Paper, Queensland
The 4th Australasian Cardiovascular
of the student to subsequently deliver
Health
Nursing College Annual Conference,
care. The studies are using pre and
post test designs with control and
Major Grants & Financial Support
intervention groups. The studies evaluate
Total NHMRC funding:
strategies that could be incorporated
Other competitive
funding:
within a clinical education role to foster
learning in acute care teams. The effect
of a unit based intervention on staff
$510,431
$1,416,545
Funding from other
sources:
$285,000
Brisbane
Australian College of Critical Care
Nurses Institute of Continuing Education
11th Annual Meeting, Sydney
Royal College of Nursing International
Nursing Research Conference,
perception of support (SINTR) and the
National & International Presentations
clinical learning organisational culture
Professor Leanne Aitken
(CLOCS) are measured. The studies
Royal Brisbane and Women's Hospital
are nearing completion and will be
Research Symposium, Brisbane
Conference, Southport, England, UK
Simulation and Beyond: Creative
Australian and New Zealand Scientific
published in 2011.
In collaboration with the clinical units
Teaching Approaches for Improving
we are also involved with clinical studies
Patient Safety, University of Newcastle,
such as the randomised controlled trial
Australian Learning and Teaching
of early versus normal discharge for
Grants, and University of Western
patients with negative pressure wound
Sydney, Hunter Valley NSW
therapy for skin grafts. This study has
begun recruitment and is hoped to be
completed by the end of 2011.
Mary Boyde
Australasian Cardiovascular Nursing
College Conference, Brisbane
European Society of Cardiology
Academic Excellence (Semester 1 & 2),
Conference, Stockholm, Sweden
Melbourne
Gillian Ray-Barruel
National Australian Conference on
Ramon Shaban
Renal Society of Australia Annual
Australasian Bioethics Association of
Bioethics and Health Law Conference,
Adelaide
Vanessa Brunelli
16th Biannual Conference of the
Registered Nurse Scholarship,
International Society of Nurses in
Queensland Nurses Union
Cancer Care, Atlanta, Georgia, USA
Professor Amanda Henderson
37th Annual Scientific Meeting Clinical
Discipline Scholar, Australian Learning
Oncology Society Australia, Melbourne,
and Teaching Council
November
Nicola Melton
Professor Amanda Henderson
General Nursing Scholarship, Office of
Nurse Education Today (NET) and Nurse
the Chief Nurse Officer
Education in Practice (NEP): NETNAP,
Sydney
Meeting on Intensive Care Medicine,
Conference, Cairns
Professor Vanessa Brunelli
(Faculty of Health)
British Association of Critical Care
Evidence-Based Healthcare, Adelaide
Awards and Prizes
Queensland University of Technology
Newcastle upon Tyne, England, UK
8th International Conference for
Emergency Nurses, Canberra
Nurses at the Helm: Steering Health
Across the Pacific, 15th South Pacific
Nurses Forum, Auckland, New Zealand
27th Annual Scientific Meeting
Australasian College of Emergency
Medicine Scientific Committee Meeting,
Canberra
Dr Marion Mitchell
Research Scholarship, Queensland
Nursing Council
Centres for Health Research 2010 Annual Research Report
93
Nutrition & Dietetics
In recognition of the active culture in dietetic research and practice at
the hospital, three new research positions have been funded until 2015.
Dr Liz Isenring, Clinical Academic Fellow, was jointly appointed with The
University of Queensland (UQ) (School of Human Movement Studies) and
Office of Health and Medical Research. Dr Katrina Campbell received a
Lions Senior Medical Research Fellowship and was appointed as a Health
Research Fellow, funded by the Office of Health and Medical Research.
Dr Ingrid Hickman, Principal Research Fellow, is funded conjointly by
Queensland Health and UQ Diamantina Institute through the Health
Practitioner awards.
Maree Ferguson
Dietetics presented five oral abstracts, eight posters, and led one
workshop at the national association’s conference. Dr Ferguson
received a PAH Society travel scholarship contributing to the International Nutrition and Dietetics Terminology
implementation. Based on identified needs, a Research Competency Framework was developed and
implemented to enhance staff capacity and skill.
Other staff achievements include the appointments of: Dr Ferguson as QUT and Griffith University Adjunct
Associate Professor and UQ adjunct Senior Lecturer; Dr Vivanti as UQ Senior Lecturer and Griffith University
Adjunct Lecture; Dr Campbell as UQ Adjunct Lecturer, and Dr Hickman as honorary Research Fellow with
the Mater Medical Research Institute and Program Director for Metabolic Research at the UQ Liver Research
Centre.
In 2010, dietetics received over $500,000 in grants for research incorporating oncology, lifestyle diseases and
service models and partnered with Griffith University and UQ to provide student research placements and three
summer scholarships.
Dr Maree Ferguson
Director
Research Activities
Clinical Trials
Comparison of pre- and perioperative
complications and length of stay. Data ( Hickman I). NHMRC Project Grant
immunonutrition in patients undergoing
collection commenced at the PAH last
(2008-2011). This study investigates the surgical resection of oesophageal
year. PAH has been a leading site in
role of diet and exercise as treatment
cancer (Jamieson G, Watson D,
this multistate NHMRC funded trial and
options for obesity-related liver disease.
Smithers M, Isenring E, Ferguson M).
assisting other sites in effective data
The randomised controlled trial
NHMRC Project Grant (2010). This
collection procedures. Data collection
investigates the effect of weight loss
project aims to investigate whether a
will continue for two years.
or exercise on insulin resistance, body
specialist nutrition supplement is better
than a traditional supplement in patients
with oesophageal cancer undergoing
surgical resection in terms of minimising 94
research - key to health
Obesity-related inflammation and insulin
resistance in chronic liver disease:
Exercise and Diet as treatment options
composition and liver histology and
aims to identify mechanisms whereby
lifestyle intervention may benefit chronic
liver disease.
The role of resveratrol in the
Other Research
Assessing Nutritional Status and
management of non-alcoholic fatty
Nutrition as medication for geriatric
intakes in heart failure patients
liver disease (NAFLD) (Chachay V,
hospitalised patients with malnutrition
(Gillen L, Mudge A, Vivanti A, Davies
Hickman I, Ferguson M, Martin J,
(Ferguson M, Vivanti A, Varghese P, Amin
P, Mullins R, Adsett J, Porteous H,
Prins J, Macdonald G, Whitehead J,
H, Dickson P, Capra S). This study aims
Mayrseidl J). This observational study
O’Moore-Sullivan T, Cowin, G, Franklin
to assess the more effective delivery
aims to describe nutritional status in
M, Kirkpatrick C). This study investigates
system of nutrition support, "Med Pass"
heart failure (HF) patients at different
the effect of resveratrol, a plant derived
in comparison to traditional supplement
stages of presentation and to inform
antioxidant, on factors associated with
practices. Long-term feasibility will
evidence based nutrition outcome
severity of fatty liver disease such as
be evaluated to determine the most
measures for HF patients to assist in the
insulin resistance, visceral adiposity
effective delivery systems based on
multidisciplinary management of this
and hepatic steatosis. This randomised
nutritional intakes, cost and clinical
patient group and provide valuable pilot
placebo controlled trial will assess the
outcomes, staff and patient satisfaction
data for intervention studies.
Innovation in clinical education in
Vitamin D & carnitine deficiencies in
dietetics – developing evidence for
medical oncology patients receiving
best practice (Vivanti A, Ferguson M,
chemotherapy (Ferguson M, Walpole
The effect of sodium intake on blood
Capra S, Wright O). The study assesses
E, Davidson W, Isenring E). Preliminary
pressure and cardiovascular risk in
the impact of a novel, evidence
results show that approximately two
patients with chronic kidney disease: a
based, dietetics programme (includes
thirds of oncology patients receiving
blinded randomised crossover trial and
accelerated learning through the use
chemotherapy have low levels of vitamin
six month follow up. (Hall E, Campbell
of peer teams with support and clinical
D. These results will be presented at
K, Bauer J, Stowasser M, Pimenta E,
placements throughout the year,
the Multinational Society for Supportive
Isbel N, Hawley C).This project will aim
primarily at one site as opposed to the
Care in Cancer in Greece in 2010.
to investigate the effect of a high versus
traditional shorter placement blocks
Further analysis will demonstrate if
low sodium diet on blood pressure (BP),
across different facilities) upon patient
vitamin D levels continue to deteriorate
cardiovascular risk factors, risk factors
services, staff time and perceptions.
during chemotherapy and help to
effectiveness of daily supplements as a
treatment option for patients with fatty
liver disease.
for kidney function decline and salt taste
preference in participants with moderate
Randomised controlled trial assessing
identify contributing factors.
outcomes of two service models
Prevalence of malnutrition and nutrition
providing nutritional support to older
impact symptoms in chemotherapy
The effect of sodium intake on blood
people presenting to Emergency
patients (Davidson W, Ferguson
pressure and cardiovascular risk in
Department (Vivanti A, Ferguson
M, McCarthy A, Vick J, Isenring E,
patients with chronic kidney disease: a
M, Powrie D, O’Neill M, Isenring E).
Campbell V). This observational study
blinded randomised crossover trial and
This study investigates the benefit
identified the prevalence of malnutrition
six month follow up (Hall E, Campbell
of incorporating frequent, individual
and nutrition impact symptoms in
K, Bauer J, Stowasser M, Pimenta E,
nutrition support by a dietitian,
chemotherapy patients.
Isbel N, Hawley C). This project will aim
compared with providing current
to investigate the effect of a high versus
services to community-dwelling low sodium diet on blood pressure (BP),
older adults identified as at risk of
cardiovascular risk factors, risk factors
malnutrition upon nutritional status
for kidney function decline and salt taste
and other outcomes including frail
preference in participants with moderate
mechanical falls, hospital admission kidney disease.
and quality of life.
kidney disease.
Establishing best practice for
the identification and treatment
of malnutrition, nationally and
internationally (Burton K, Vivanti A,
Wright O, Gray L, Ferguson M, Lakhan
P). This study aims to compare
Centres for Health Research 2010 Annual Research Report
95
J, Orazio L, Murray E, Douglas B).
Co-ordinated care clinics utilising
a case management approach and
a multidisciplinary team have been
demonstrated to optimise CKD care.
This study is aims to investigate the
impact of aggressive risk factor and
lifestyle modification utilising nurse led
co-ordinated care with standard care to limit the progression of cardiovascular
disease in patients with chronic kidney disease.
Nutrition Algorithm for Patients with
Chronic Kidney Disease (CKD):
Feasibility Study (Steiber A, Campbell
L-R (Back Row): Azmat Ali, Elisabeth Isenring, Angela Vivanti, Ingrid Hickman, Helen Porteous
L-R (Front Row): Katrina Campbell, Maree Ferguson, Wendy Davidson
KL, Rossi M). This is a pilot study to test
a nutrition algorithm in chronic kidney
disease (CKD) patients for clinical
feasibility, logical progression, ability to
nutritional and comprehensive geriatric
for ascertaining dehydration, the
collect data needed for tracking nutrition
assessments amongst patients >70
degree of daily weight fluctuation within
diagnoses, etiologies, interventions and
years to ensure older adults requiring
stable, well hydrated populations is not
outcomes, and finally effectiveness to
nutrition support are identified quickly
known. As not previously documented,
improve nutrition-related outcomes.
upon hospital admission. Streamlined
the descriptive study will quantify the
nutrition assessment procedures for
extent and contributors to daily weight
older adults and an efficient integration
fluctuations amongst medically stable
of dietetic and medical expertise are
older hospitalised adults >60 years.
anticipated outcomes.
Evaluation of the implementation of
an information technology system for
capturing the nutrition care process
on patient outcomes (Ferguson M,
LM3 (LandMark 3): A Randomised
Campbell KL, Rossi M, Capra S,
Short-term body weight fluctuations
Controlled Trial Comparing The Impact
Hulcombe J, Lees M, Johnson DW). amongst well-hydrated older
Of Aggressive Risk Factor And Lifestyle
The aim of this study is to compare
people admitted to a Geriatric and
Modification To Limit The Progression
use of an innovative electronic vs
Rehabilitation Unit (Vivanti A, Palmer
Of Cardiovascular Disease In Patients
current manual system for capturing
M, Dakan L, Varghese P, Yu L, Amin H,
With CKD (Chronic Kidney Disease)
the nutrition care process (ie nutrition
Webb L). Although short-term weight
(Isbel N, Petchy W, Howden E, Strand
screening, assessment, intervention,
change is considered the gold standard
H, Sonnenburg K, Marwick T, Coombs
monitoring and evaluation) on 96
research - key to health
patient outcomes such as weight,
by Renal Dietitians (Campbell KL, Hall
Dr Elisabeth Isenring
nutritional status, dietary intake,
E). This research project aims to identify
Private Practice, Princess Alexandra
nutrition impact symptoms, quality of the barriers (or enablers) which exist for
Hospital, ASMR Leadership Seminar
life and treatment compliance.
dietitians to integrate evidence based
Obesity and clinical outcome in patients
with Chronic Kidney Disease (Campbell
KL, Isbel I, Hurst K). This research will
investigate measures of obesity (BMI
and waist circumference) for patients on
practice (EBP) with their clinical practice
and facilitate planning and support
Total NHMRC funding:
$161, 357
in the implementation of EBP in the
nutritional management of Other competitive
funding: $340, 880
kidney disease.
National & International Presentations
referral to our Nephrology service and
Pre-Liver Transplant Nutrition Status
compare this to clinical outcome. The
And Impact On Post-Liver Transplant
hypothesis is that obesity upon referral
Outcomes (Murray E, Ali A, Bowser N,
for CKD treatment (that is BMI > 30kg/
MacDonald G, Khatoon M).
m2) result in different clinical outcome
compared to non-obese patients.
Clinical outcome is measured as
mortality or commencement of dialysis.
Guidelines for Nutrition in Kidney
Transplant Recipients: are they
translating to quality care and improved
clinical outcomes? (Murray E, Orazio
Major Grants & Financial Support
Dr Katrina Campbell
Improving Outcomes in Nephrology,
Sydney
Pre-congress meeting: Australia New
Measurement of physical activity levels
in people with stroke using sensewear
armbands (Kuys S, Vivanti A, Morris N).
Zealand Society of Nephrology, Adelaide
Dr Maree Ferguson
Australasian Society for Parenteral and
Enteral Nutrition, Gold Coast
Swallowing management and
radiotherapy trial (Riddle B, Cornwell
P, Porceddu S, Ward E, Stuckey S,
Davidson W).
Dr Ingrid Hickman
Australian Gastroenterology Week, Gold
Coast
L, Campbell KL). The aim of this study
Awards & Prizes
is to evaluate the new dietetics clinic
Dr Katrina Campbell
and implementation of key service
Private Practice, Princess Alexandra
recommendations from new Evidence
Hospital, Travel Grant: International
Dr Elisabeth Isenring
Based Practice (EBP) Guidelines
Society of Nutrition and Metabolism in
Australasian Society for Parenteral and
for Nutrition in Kidney Transplant
Renal Disease
Enteral Nutrition, Gold Coast
Dr Maree Ferguson
Clinical Oncological Society of Australia,
PA Society, Princess Alexandra
Melbourne
Recipients, whilst characterising
transplant patients determinates of
lifestyle behaviours and changes International Conference on Obesity,
post transplant.
Hospital, Travel Grant: Implementation
Mind the gap: Implementation of
Terminology
SanDiego, California, USA
of International Dietetic and Nutrition
Evidence-based Nutrition Assessment
Centres for Health Research 2010 Annual Research Report
97
Occupational Therapy
The hospital occupational therapists are health professionals who
work in partnership with adults to overcome factors which limit their
ability to function in their chosen ‘occupational roles’ and impact on
their quality of life. Injury or illness, environmental, psychological or
emotional difficulties, or the effects of aging can cause these limiting
factors. Through developing research capacity and strength in a variety
of clinical areas, the occupational therapists are major contributor to the
Occupational Therapy clinical knowledge base, creating a strong research
profile nationally and internationally, and enhancing evidenced based
clinical decision making locally.
Mary Whitehead Ruth Cox
Research activity concentrated in the areas of brain injury acute care
and rehabilitation, cancer services, spinal cord injury research, aged
care assessment and management, and hand and upper limb rehabilitation. The department is involved in two
ARC Linkage grants for multidisciplinary research projects in the field of acquired disability. Staff disseminated
their research outcomes through publication in peer-reviewed journals and books and by presentation at many
national conferences throughout the year. The department currently supports 12 postgraduate research students conducting research in the fields of brain injury, aged care, cancer, and hand therapy.
Mrs Mary Whitehead Director
Dr Amanda Purcell
Acting Director
Mrs Ruth Cox Acting Director
Dr Jennifer Fleming
Associate Professor
Research Activities
Clinical Trials
Community based rehabilitation after
(Purcell A, Fleming J, Haines T,
Skill mix in an aged care rehabilitation
traumatic brain injury: a comparison of
Burmeister, B.) This trial recruited 110
setting: Trial of an advanced scope
home and hospital based outpatient
participants to investigate whether
of practice Occupational Therapy
intervention (Doig E, Fleming J, Kuipers
group-based education sessions
Assistant role at the Princess Alexandra
P, Cornwell, P). This PhD research
were effective in reducing cancer-
Hospital, Demonstration Project (Cox R,
project used within-subjects repeated
related fatigue and to identify the most
Wood A, Wiemers A, Mills V, Clements
measures cross-over design to
effective timing of these sessions. The
L, Fleming J.). This project aims to
compare two contexts for the delivery
trial found that whilst fatigue levels
establish and test a more appropriate
of occupational therapy to patients
did not significantly improve, pre-
staff mix resulting in more optimal use
with brain injury. Completion of the PhD
radiotherapy education was associated
of resources and enhanced service
resulted in three journal publications.
with increased activity levels without a
productivity within the Occupational
Therapy Aged Care Team at the Princess
Alexandra Hospital. Results will be
used to guide the workforce in the
implementation of similar roles in the future.
98
research - key to health
A randomised control trial investigating
corresponding increase in fatigue.
the effects of group education and
Other Research
support in reducing cancer-related
Investigation of the transition from
fatigue and improving quality of life
hospital to home for individuals with
in patients undergoing radiotherapy.
acquired brain injury and their family
caregivers. (Fleming J, Nalder E, Turner
newly developed telephone screening
Investigations of care requirements of
B, Cornwell P, Worrall L, Ownsworth
tool. The confirmation of this research
people with brain tumour (Haines T,
T, Haines T, Kendall M, Chenoweth
would allow confident and effective
Cornwell P, Fleming J, Olsen S, Omerod
L). This ARC Linkage project aims
assessment of patients with mild head
A, Dicks B). This qualitative study used
to understand the determinants of
injury in emergency departments at PAH
in depth semi-structured interviews
successful transitions from hospital to
and across the state.
to gather data on the experiences of
home following acquired brain injury
using a mixed methodology approach
with longitudinal follow-up for the first
6 months after discharge. The project
resulted in four journal publications.
Financing and management of lifetime
care for adults with acquired disabilities
and high care needs (Foster M, Henman
patients with brain tumours and their
family care-givers over the first 3 months
following hospital discharge.
P, Fleming J, Tilse C, Harrington R). This
Improving MDT care for Post-coma
ARC Linkage project aims to investigate
Unresponsive and Minimally Responsive
Facilitation of self management of the
the lifetime care and support needs of
State patients in the acute care setting
upper limb following a stroke (Bower
young people with high care needs due
(Seeto T, Griffin E, Budden C). This
K, Hoffmann T, Gustafsson L). This
to trauma or neurological disease, and
project aims to determine the feasibility
program of research aims to develop
to understand the complex financing
and potential effect of a twice-weekly
and evaluate resources for occupational
and service systems which address
multi-disciplinary early intervention
therapists and physiotherapists to
these needs.
group for patients in a minimally
use in subacute stroke rehabilitation.
The resources will aim to foster selfmanagement skills for the ongoing
recovery of the stroke-affected upper
limb. A descriptive study of current
practice was completed and resource
development commenced.
Does individualised hand splinting
reduce spasticity after traumatic brain
injury (Copley J, Kuipers K, Fleming
J, Griffin J). This randomised single
case series study examines the use of
individualised hand splinting to reduce
hypertonicity and improve passive range
responsive state. The project objectives
are to determine the feasibility and
effect of a multi-disciplinary early
intervention group on patients in a
minimally responsive state, and to
investigate the clinical changes in group participants.
Determining PTA and cognitive status in
of motion in rehabilitation clients with
Splinting to prevent forearm rotation
patients with mild-moderate traumatic
brain impairment.
– to what degree? (Slaughter A, Miles
brain injury: A study of discharge
readiness (Brennan K, Wright S, Ross J,
Fleming J, McKafferty K, Worley L, Knill
J). This project examined the use of the
Westmead PTA Scale for determining
emergence from post-traumatic amnesia
after mild-moderate brain injury.
L, Fleming J, McPhail S). This study
Goal setting and attainment by
evaluated the effectiveness of five
individuals in spinal cord injury
rehabilitation using the Canadian
Occupational Performance Measure.
(Mitchell G, Gustafsson L, Fleming
J, Price G.) This honours student
project aimed to determine the clinical
different splint designs on the prevention
of forearm pronation and supination
to determine which provided the best
form of immobilisation while maintaining
patient comfort. Results were published
in the Journal of Hand Therapy.
Evaluation of a telephone screening tool
utility of the Canadian Occupational
for the presence of post-concussive
Performance Measure in the spinal cord
Comparison of two methods of
symptoms (Wright S, Prescott C,
injury inpatient rehabilitation setting.
measuring for compression armsleeves
Fleming J). The multidisciplinary team
at PAH have developed a pragmatic
telephone assessment screening
tool, that aims to assist in identifying
post concussive symptoms and
reviewing return to functional activity
post mild traumatic brain injury. The
aim of this research is to evaluate the
appropriateness and accuracy of this
Past and current leisure activities of
individuals in a brain injury rehabilitation
unit (Braithwaite H, Fleming J,
Gustafsson L, Griffin J). The aim of this
study was to describe the participation
in leisure activities by adults undergoing
brain injury rehabilitation and to identify
barriers to leisure participation.
for lymphoedema (Nixon J, Purcell A).
This project aims to establish the most
accurate method of measuring for
custom-made compression sleeves for
patients with upper limb lymphoedema
to improve both fit and comfort. The
trial has ethical approval and is due to
commence recruitment in 2011.
Centres for Health Research 2010 Annual Research Report
99
Clinical utility, reliability and validity of
the Self-Perceptions in Rehabilitation
Questionnaire (SPIRQ) in brain injury
rehabilitation (Ownsworth T, Fleming
J, Ross J, Collier AM, Stewart E). The
SPIRQ is a newly developed self-report
questionnaire designed to measure selfperceptions of progress in rehabilitation.
This study examines its psychometric
properties with patients from the Brain
Injury Rehabilitation Unit.
Helping people with traumatic brain
injury and their families adjust to driving
cessation (McKenna K, Fleming J, Liddle
J, Turpin M, Weir N, Whitelaw P). Using a
qualitative research approach, this study
aimed to understand the experience of
driving cessation from the perspective
of individuals with brain injury, their
family members and involved health
professionals.
Rehabilitation of prospective memory
following traumatic brain injury (Fleming
J, Shum D, Strong J). This NHMRC
funded randomised controlled trial
investigated the effectiveness of a
compensatory approach to prospective
memory rehabilitation. Final results were
accepted for journal publication.
Brain injury rehabilitation: The lived
experience of inpatients and their
family caregivers (Fleming, J, Sampson
J, Cornwell P, Turner B, Knill J, Griffin
J). This honours student project
used a qualitative research approach
to investigate the experiences of
individuals and their family members
during admission to the Brain Injury
Rehabilitation Unit.
The effect of environmental barriers
on community integration following
traumatic brain injury (Fleming J, Nalder
100
research - key to health
L-R: Susanne Wright, Emily Nalder, Ruth Cox, Elizabeth Caldwell, Associate Professor Jenny Fleming
E, Alves-Stein S). This honours student
Associate Professor Jennifer Fleming
project was commenced in 2010
OT Australia Qld Cognitive Rehabilitation
examining the effect of environmental
Workshop, Brisbane
factors on the level of community
integration at 6 months post-discharge
for patients with traumatic brain injury.
The transition experiences of stroke
patients and their carers (Worrall L,
Fleming J, Grohn B, Nalder E, Hall
OT Australia NSW Cognitive
Rehabilitation Workshop, Sydney
Lauran Fulop
Oncology Nursing and Allied Health
Conference, Gold Coast
A). This honours student project
Lyndal Gray
commenced in 2010, and uses in-depth
Oncology Nursing and Allied Health
qualitative interviews to examine the
Conference, Gold Coast
experiences of stroke patients and their
family caregivers during the first six-
Erin Griffin
months of transition from hospital Radio National, Radio interview
to home.
Janelle Griffin
Awards & Prizes
Best of Both Worlds Rehabilitation
Kylie Bower
Conference, Melbourne
Peer support program "Stroke
Connect", Selection as trial site,
National Stroke Foundation
$402,489
National & International Presentations
Margo Coffey
Australian Hand Therapy Association
Conference, Perth
Oncology Nursing and Allied Health
Conference
Major Grants & Financial Support
Competitive funding:
Jodie Nixon
Patterson, Freyr
Public Health Association of Australia
National Conference, Adelaide,
September
Older Persons Mental Health
The service continues to enjoy a close relationship with the Centre
for Research in Geriatric Medicine and the Dementia Collaborative
Research Centres (QUT, ANU, UNSW). The group had collaborations with
colleagues from the Queensland Centre for Mental Health Research and
UQDRIVE.
Emily McCallum (Medical Student, UQ SOM) was the inaugural Research
Intern. Her work led to a paper recently being accepted by the Journal of
Affective Disorders. The group have been successful in receiving a grant
for work towards a future national Dementia strategy and funding from
Queensland Health to support research into Electroconvulsive Therapy.
David Lie
Congratulations to Dr Natasha Squelch, Clinical Psychologist and
Neuropsychologist on her PhD completion.
Dr David Lie
Clinical Director
Research Activities
Grevillea B12 and Folate Study (Abbott
intervention options for the next national
National & International Presentations
W, Hokin B, Schilling K, Dark F, Lie D).
dementia strategy in collaboration
Dr David Lie
Aims to discover nutritional biomarker
with Alzheimers Australia Victoria,
Annual Scientific Meeting, RANZCP
profiles of patients admitted to an
Mental Health Alcohol and Other Drugs
Faculty of Psychatry of Old Age, Hobart
Older Persons Mental Health ward and
Directorate
examine the relationship with diagnostic
and other variables. Findings will inform
statewide practice. Supported from the PAH Psychogeriatric Research Trust Fund.
Annual Scientific Meeting, Aust NZ Soc
ECT Quality Initiative Study – Frequency
(EQuIS-F) (Siskind D, Charlson F, Doi
S, McCullum E, Broome A, Lie D).
The Service is examining the best
evidence for current ECT practice
Dementia and Population Health: a
at PAH following a recent review of
Needs Evaluation (DAPHNE) (Lie D,
clinical practice. Qld Health funded a
Travers C, Martin-Khan M, Halliday L).
systematic review and meta-analysis.
This DoHa funded literature review and
consensus development study examines
prevention, promotion and early
Geriatric Medicine, Coolum, QLD
RACP Annual Geriatric Medicine
Advanced Trainee Workshop: Nambour
Hospital
Major Grants & Financial Support
Competitive funding:
$5,500
Centres for Health Research 2010 Annual Research Report
101
Ophthalmology
Dr Madden has been assisting in the reorganisation of the organ, eye
and tissue banks into a single entity. Recent changes have resulted in
a decrease in research activity. A productive group has been recently
formed investigating the use of silk fibroin as a substratum for ocular
tissue. The group have been able to demonstrate corneal endothelial
growth on a transparent fibroin membrane. This has the potential to
improve corneal transplantation and reduce reliance on corneas from
deceased donors.
Peter W Madden
Scientific Director
Queensland Eye Bank
Peter Madden
Research Activities
Current PAH work involves analysis of
Eye Bank data, particularly the utility of
the Australian Organ Donor Register and
the impact and future value of automatic
notification of death.
102
research - key to health
Major Grants & Financial Support
Funding from other
sources:
$4,000
Pathology Queensland
Based at the Princess Alexandra Hospital, the Molecular and Clinical
Pathology Research Laboratory (MaCH R) is a unique research facility
dedicated to providing downstream research and development to enable
translation of basic biomedical research from existing research facilities
into effective clinical treatments to improve cancer patient outcomes.
This year MaCH R laboratory equipment that was purchased has been
installed and staff have been allocated and trained. The ability to perform
service work has been developed and this has been gradually increased
over the financial year. A specific internet website (www.health.qld.
gov.au/qhcss/research/machr/default.asp) has been constructed to
increase awareness of the facility and we have had agreement that we
officially open the facility. This is due to take place this year. The MaCH
R purchased two pieces of new equipment. The SOLiD E Z Bead system
and the Dell Computer storage system (mirrored server array). The purchasing of these pieces of equipment was facilitated through Queensland Health.
Glenn Francis
Dr Glenn Francis has been interviewed for various media pieces related to the ABC Breast Cancer Cluster for
both print and radio outlets.
The MaCH R laboratory has developed the methodology for Cytogenetic Microarray Analysis (CGH) and
successfully managed to transfer the existing work for CGH from an external provider to the MaCH R laboratory.
Dr Glenn Francis
Director
Research Activities
Phenotypic/genotypic profiling and
Prospective assessment of patient
Professor Zee Upton, Institute of Health
outcome in breast cancer: Identification
response to treatment with the drug
and Biomedical Innovation, Queensland
of biomarkers to determine outcome
Trastuzumab: To determine biomarkers
University of Technology, Professor
in breast cancer patients (Francis G,
to predict response of HER2 positive
David Leavesly, Institute of Health and
Stein S, Wagner S). Collaborators/
patients to targeted therapy (Francis G,
Biomedical Innovation, Queensland
Partnerships Dr Geoff Beadle,
Stein S, Wagner S)
University of Technology
High-through-put tissue analysis of novel
E-Health extraction of pathology
Queensland Institute of Medical
Research
candidate biomarkers of breast cancer
data from text reports: To extract data
Prediction of lymph node status in
progression: To determine biomarkers
from pathology reports into synoptic
breast cancer patients: Prediction of
to predict breast cancer progression in
format (Francis G, Stein S, Wagner
lymph node status from characteristics
lymph node positive patients (Francis
S). Collaborators/Partnerships David
of the primary tumour (Francis G, Stein
G, Stein S, Wagner S). Students Helen
Hansen, Commonwealth Scientific
S, Wagner S). Scientist Collaborators/
McCosker, Queensland University of
and Industrial Research Organisation,
Partnerships (Wetzig N)
Technology, Collaborators/Partnerships
Anthony Nygun, Commonwealth
Centres for Health Research 2010 Annual Research Report
103
Novel Strategies for Prediction
and Control of Advanced Breast
Cancer via Nanoscaled EpigeneticBased Biosensors: Identification
of DNA methylation profiles using
nanotechnology that enables prediction
advanced breast cancer (Francis G,
Stein S, Wagner S). Yvette Emmanuel,
Scientist (University of Queensland)
Collaborators/Partnerships Professor
Matt Trau, Associate Professor Melissa
Brown, University of Queensland,
Professor Alex Dobrovic, Peter
MacCallum Cancer Centre, Professor
Sue Clark, Garvan Institute, Professor
Pathology Team
John Forbes, Australian New Zealand
Scientific and Industrial Research
To identify non-coding RNAs that
Organisation
contribute to advanced breast cancer
Utilization of biomarkers to determine
(Francis G, Stein S, Wagner S)
outcome in HER2 positive breast cancer
Collaborators/Partnerships Associate
patients: To determine biomarkers to
Professor Melissa Brown, University of
predict response of HER2 positive
Queensland, Dr Juliet French, University
patients to therapy (Francis G, Stein S,
of Queensland
Wagner S).
An analysis of the Pathological
Collaborators/Partnerships Associate
Characteristics of a Proven
Professor Camile Farah, University of
Epidemiological Cluster of
Queensland,
Breast Cancers
Gene expression analysis of breast
To review the pathology of the
cancer cell populations and correlation
tumours form the breast cancer
with metastatic clones using immuno-
patient cluster (Francis G, Stein S,
laser capture microdissection: To identify
Wagner S). Collaborators/Partnerships
gene expression profiles of breast
Professor Sunil Lakhani & Associate
cancer cell populations and correlation
Professor Melissa Brown, University
with metastatic clones (Francis G,
of Queensland, Professor Tom Gonda,
Stein S, Wagner S). Collaborators/
Associate Professor Nigel McMillan and
Partnerships Associate Professor Camile
Dr Nick Saunders, Diamantina Institute
Farah, University of Queensland
for Cancer Immunology and Metabolic
Identification and analysis of non-coding
RNAs that contribute to advanced
breast cancer
Medicine, University of Queensland, Dr
Ian Bennett, PAH, Dr Georgia ChenevixTrench, Queensland Institute of Medical
Research, Beth Newman, Queensland
University of Technology
104
research - key to health
Breast Cancer Trials Group, Professor
Rodney Scott, Newcastle University
Novel nanoparticle-based biosensor
technology for multiplexed detection
of methylation profiles in breast cancer
metastases: To identify methylation prof
iles in breast cancer (Francis G, Stein S,
Wagner S).
Collaborators/Partnerships: Professor
Matt Trau, Associate Professor Melissa
Brown, Dr Kate Peters, University of
Queensland
Translational pilot study of combined
Androgen Receptor and ErbB2 inhibition
in Molecular Apocrine subtype of
Breast Cancer: To identify androgen
receptor status in apocrine type breast
cancer (Francis G, Stein S, Wagner
S). Collaborators/Partnerships: Dr Ali
Naderi, University of Queensland
Major Grants & Financial Support
Competitive funding:
$100,000
Pharmacy
The department improved its research output significantly this year,
particularly in cancer services where the department had a significant
increase in research and publications. A particular focus has been
on local audit and clinical practice improvement/development. In
collaboration with medical specialities the group have completed a
program of twelve internal Drug Use Evaluations during the year, which
have all influenced local guidelines/practice.
The department had a specialist pharmacist working in over 100 clinical
trials, as well as an infectious diseases specialist pharmacist involved in
multiple clinical trials and an oncology pharmacist involved in close to
100 clinical trials.
Lynette Loy
Lynette Loy
Director
Research Activities
Clinical Trials
Improving adherence to medication in
Prescribing and safety issues of oral
Compliance with chemotherapy safety
ACS patients using the repertory grid
molecular therapies and chemotherapies
guidelines (Sandhu G, Carrington C).
technique: a randomised interventional
in Australian haematology oncology
controlled trial (Gujral G, Winckel K,
practice (Carrington C). The aim
Cottrell N).
of the study was to determine the
Other Research
The Role of the Pharmacist in the
prescribing practices of oncologists and
haematologists regarding oral molecular
An electronic prescription for safer
chemotherapy: an audit of pharmacist
interventions (McKavanagh D,
Carrington C).
and chemotherapy medications across
Relationship of obesity and breast
various practice settings in Australia
cancer outcomes (Carrington C).
Cancer in Day Care. Research for Doctor
Does closed system compounding
of Clinical Pharmacy (Carrington C).
Standardisation of the documentation
reduce levels of contamination in
The aim of this study is to investigate
to support the prescribing, dispensing
pharmacy preparation areas? (Bates J,
what effect the pharmacist has on the
and administration of anticancer therapy
Semmler J). This trial is in recognition
medication management for patients
(Sandhu G, Carrington C).
of new developments that may help
who are receiving chemotherapy for
to achieve a reduction in occupational
Antibiotic stability for the application in
breast cancer in the oncology day
exposure to cytotoxic drugs
home intravenous therapy (McDougall D,
Medication Management of Patients
Receiving Chemotherapy for Breast
care unit. It also aims to develop novel
methodology using a modified repertory
grid method to measure patient
McWhinney B).
Patients access to cancer medications
across Australia (Carrington C).
understanding of medications.
Centres for Health Research 2010 Annual Research Report
105
Investigating a relationship between the
usage of extended spectrum antibiotics
and the incidence of clostridium difficile
associated diarrhoea (McDougall D,
Morton A).
Evaluation of a collaborative doctor/
pharmacist prescribing model in elective
surgery patients (Hale A).
Evaluation of a collaborative doctor/
pharmacist prescribing model in HIV
patients at a sexual health clinic (Hale A).
Major Grants and Financial Support
Competitive funding:
$75,000
Pharmacy Department
National & International Presentations
Christine Carrington
Australasian Pharmaceutical Science
International Society of Oncology
Advancing Key Initiatives in Cancer
Association, Brisbane
Pharmacy Practitioners International
Care, Brisbane
Cancer Council Oncology Nurses,
Sydney
J. La
SHPA Annual Conference, Melbourne
T. Le
Symposium, Prague
33rd Annual Oncology Nurses Group
Conference, Gold Coast
33rd Annual Oncology Nurses Group
International Society of Oncology
2nd National Conference for Young
Conference, Gold Coast
Pharmacy Practitioners International
Women affected by Breast Cancer,
Symposium, Prague
Cancer Council Queensland, Gold Coast
Daniel McKavanagh
Statewide Adolescent and Young Adult
COSA Clinical Skills Course, Brisbane
Cancer Conference, Brisbane
Advancing Key Initiatives in Cancer
COSA Annual Scientific Meeting,
Care, Brisbane
Melbourne
SHPA Annual Conference, Melbourne
SHPA CPD, Brisbane,
Sally Taylor
G. Gujral
COSA Annual Scientific Meeting,
National Medicines Symposium,
Melbourne
COSA Annual Scientific Meeting,
Melbourne
Tina Chang
SHPA Annual Conference, Melbourne
J. Grant
Melbourne
Andrew Hale
National Medicines Symposium,
Melbourne
Australasian Professional Society on
Alcohol and other Drugs (APSAD),
Canberra
SHPA Annual Conference, Melbourne
106
research - key to health
Tina Patterson
ASCEPT, Melbourne
Sally Porter
SHPA Annual Conference, Melbourne
Geetpal Sandhu
Advancing Key Initiatives in Cancer
Care, Brisbane
SHPA Annual Conference, Melbourne
J. Weir
International Society of Oncology
Pharmacy Practitioners International
Symposium, Prague
K. Winckel
National Medicines Symposium,
Melbourne
Physiotherapy
The Physiotherapy Department had a successful year with five publications in peer reviewed journals and a large
number of projects underway across the department. The group received $50,000 in grant funding. Two research
higher degree students continued to make substantial progress in their studies. During the year the department
farewelled Steve McPhail and Dr Suzanne Kuys. Steve McPhail who played a lead role in research joined the Centre
for Allied Health Research in February. Dr Suzanne Kuys who resigned on 30 June 2010 has made a significant
contribution to research and facilitated and assisted physiotherapists in turning clinical questions into research
projects. Their support and contribution was greatly appreciated by the group. The energy and enthusiasm of both
will be greatly missed.
Kathy Grudzinskas
Director
Research Activities
Clinical Trials
Review of outcomes of people with
Management of respiratory dysfunction
Measurement of physical activity levels
lower limb amputations (Batten H,
after acute SCI- ICU to SIU (Wadsworth
in people with stroke using Sensewear
McPhail S, Kuys S, Varghese P).
B, Clements L, Illif E, Hackett C, Tooth A,
Armbands (Kuys S, Mitchell J, Vivanti D,
Cassar T, Simmons J).
Morris N).
Brain Injury Physiotherapy Assessment
Evaluating the effectiveness of a
Functional outcomes following stroke:
(Gesch J, Low Choy N, Steele M, multidisciplinary hypertonicity service
a multicentre trial (Kuys S, Brauer S,
Novak K).
for the acquired brain injury population
Morrison G, Bew P, Moroney T).
Validation and reliability of the Acute
The effect of Nintendo Wii-Fit on
outcomes in people with lower limb
(Cave C, Nascimento M, Kuys S,
Kuipers K, Doherty D, Weir N).
incontinence in patients with heart
injuries (Kuys S, Tonks P, McPhail, Preparation for discharge from a
Toon M).
rehabilitation unit: patient perceptions
The effect of Nintendo Wii-Fit on
endurance, balance and rehabilitation
engagement following a traumatic brain
failure (Hwand R, Chuan F, Kuys S).
and functional outcomes (Mitchell J,
Morrison G, Satake E, Low Choy N,
White S).
Prevalence of falls and musculoskeletal
conditions in elderly individuals with
chronic heart failure: an observational
study (Adsett J, Hwang R, Hogden A,
injury (Gesch J, Griffin J, Fleming J,
The efficacy of a novel, non-robotic
Kuys S).
intervention to train reaching post stroke
The use of spaced retrieval, errorless
Incidence and prevalence of
(Brauer S, Barker R, Hayward K).
Kuys S, Mandrusiak A, Peters R).
Aquatic versus Land Based Exercise
for Patients with Chronic Heart Failure
learning and vanishing cues in retraining
Does a multidisciplinary group education
(Adsett J, Hwang R, Mullins R, Kuys
sit to stand in patients with dementia
program influence the outcome in
S, Mandrusiak A, Mudge A, Korczyk,
during hospitalisation (Dolecka U, management of patients with non-
Paratz J).
Kuys S).
specific chronic low back pain (Windred
T, Matthews L, McPhail S, Kuys S).
Centres for Health Research 2010 Annual Research Report
107
Effectiveness of education on urinary
incontinence in people with heart failure:
an observational study (Chuan F, Hwang
R, Kuys S, Marsh C, Peters R).
Gait pattern following femoral to distal
artery bypass graft (Lehtonen N, Kuys S).
Activity levels of elderly patients
admitted to the Internal Medicine Unit
(Kuys S, Dolecka U, Lehtonen N, L-R:Tony Windred, Leanne Passier, Emma Pettet, Miranda Toon, Cherie Hearn, Susan Bathersby
Guard A).
Functional level of elderly patients on
discharge form Internal Medicine Unit
(Dolecka U, Kuys S).
Physiotherapy enhancement of Internal
Medicine Unit (Kuys S, Dolecka U,
O’Gorman P).
Prevalence of dizziness, balance
disorders and falls in head and neck
cancer patients undergoing treatment
Lymphoedema in patients following
breast surgery (Manning S, Kuys S,
Pinkham L).
Major Grants & Financial Support
Competitive funding:
$24,000
Funding from other
sources:
$22,000
National & International Presentations
Heather Batten
Queensland Rehabilitation
Physiotherapy Network Bond University,
Queensland Rehabilitation
Physiotherapy Network Griffith
University, Gold Coast
108
research - key to health
Suzanne Kuys
Physiotherapy Network, Brisbane
Queensland Rehabilitation
S Chatterton
Physiotherapy Network, Brisbane
Cardiac Rehabilitation Workshop,
Society of Hospital Pharmacists of
Brisbane
Australia Conference, Melbourne
Workshop for Respiratory Nurses,
Greg Morrison
Brisbane
Occupational Therapy Australia,
Leah Clements
(Pinkham L).
Brisbane
Queensland Rehabilitation
Occupational Therapy Australia,
Queensland Conference, Sunshine Coast
Queensland Conference, Queensland Rehabilitation
Sunshine Coast
Physiotherapy Network, Brisbane
Workforce Innovation Conference
Micky Nasciemento
Urszula Dolecka
Bariatric Conference, Brisbane
Annual Gerontology Update Weekend,
Brisbane
Queensland Rehabilitation
Physiotherapy Network, Brisbane
Cherie Hearn
National Allied Health Benchmarking
Consortium National Meeting, Sydney
Inviting Innovation Forum, Brisbane
Serial Casting for Upper and Lower
Limbs, Caloundra, Nambour
Serial Casting for Lower Limb, Brisbane
Assessment and Management of
Hypertonicity, Brisbane
Brooke Wadsworth
If you can't breathe, you can't function,
Brisbane
Plastics & Burns
The Plastic and Reconstructive Surgery Unit has had ongoing involvement in both clinical and laboratory research
throughout the year. Dr Michael Wagels has completed his PhD research under the supervision of Dr David Theile
Jnr. The department had a number of studies investigating reconstructive procedures and techniques relating to
head and neck cancer reconstruction, orthopaedic reconstruction and the influence of angiogenesis on muscle flap
revascularisation.
Dr David Theile (Jnr)
Chair
Research Activities
Mathematical modelling of the tibia for
Free jejunal interposition reconstruction
Review of long term outcomes for
the design of a periosteal reconstruction
post pharyngolaryngectomy: 368
compound tibial fractures at the PAH
in trauma (Allison S, Wagels M,
consecutive cases (Perez-Smith
(Jardim C and Wagels M). The aims of
Senewiratne S, Rowe, D, Theile, DR).
D, Wagels, M, Sharp DA, Cook
this study are to elucidate the long term
The ability of a formal periosteal
R and Theile DR). Free jejunum
outcomes for patients with compound
reconstruction to prevent non-union has
has been the preferred method of
tibial fractures and determine whether or
never been investigated. The aim of this
pharyngolaryngectomy reconstruction
not these are significantly different from
study is to accurately estimate the area
at the Princess Alexandra Hospital for
outcomes prior to the year 2000.
of periosteum required to reconstruct
33 years. The Department of Plastic
periosteum in lower limb trauma.
and Reconstructive Surgery review
Harmonic scalpel in muscle flaps: a
non-randomised animal study (Gu J,
their experience with the technique and
analyse temporal changes in outcomes.
Pre-Treatment Diagnosis of NonMelanomatous Skin Cancer: to shave
or punch, that is the question (te Kloot
M, Perez-Smith D, Lewis J, Wagels M
Wagels M, Senewiratne S, Rowe D,
Re-raising muscle flaps: a randomised
and Kane A). This study aims to make a
Theile DR). This study aims to compare
controlled animal study (Wagels M,
recommendation regarding the optimal
wound complications and angiogenesis
Senewiratne S, Rowe D, Theile DR).
type of biopsy to accompany a referral
in electrosurgery and harmonic scalpel
30-70% of reconstructed compound
to the Department of Plastic and
using a rat muscle flap model.
lower limb injuries will need to be re-
Reconstructive Surgery for the treatment
exposed. 25% will need revision after
of non-melanomatous skin cancers.
The Relative Contributions of the Inset
and the Wound Bed on Full Thickness
Graft Take: A non-randomised controlled
animal study (Chan KG, Wagels M,
Senewiratne S, Rowe D, Theile DR). This
study aims to determine the contribution
of the inset to graft by controlling for
contact with the wound bed.
the re-exposure if muscle is used. Reexposure is achievable by re-raising the
Major Grants & Financial Support
inset to protect the pedicle (marginal)
Total NHMRC funding:
$35,750
or by splitting the flap to protect the
Other competitive
funding:
$18,150
inset (split). The aim of this study was
to determine which approach results in
less necrosis.
Centres for Health Research 2010 Annual Research Report
109
Queensland Clinical Trials
& Biostatistics Centre
The centre was established by The University of Queensland in
September 2009, within the School of Population Health, with the
goal of promoting and running high quality clinical and biostatistical
methodological studies, both nationally and internationally. Since its
establishment, four scientific staff members including a senior statistician,
clinical data manager, and project manager have been recruited, with
negotiations ongoing for two additional fulltime statisticians. A statistician
PhD student has recently joined to work on an international collaborative
project in the field of biostatistics and clinical epidemiology.
Sanjoy Paul
While still a relatively new centre, it has been successful in securing
research funding from both commonwealth government and commercial
sources. The centre is currently involved in eight research projects and
thirteen collaborations, covering broad areas of basic science, clinical biostatistics and clinical epidemiology.
It has recently obtained a competitive grant from the Australian government to participate in the development
of a network of discovery studies and clinical trials. New collaborative research programs were initiated with
the University of Oxford, Imperial College London, University of Leicester, Peking University, Baker IDI; and
pharmaceutical companies including Amylin Pharmaceuticals Inc. and Medtronic USA.
The centre is currently involved in the design, conduct and analysis of funded clinical studies with several internal
collaborators including Diamantina Institute, Centre for Research in Geriatric Medicine, Cancer Services PA
Hospital, Diabetes & Endocrinology Department of PA Hospital and Griffith University. The centre is responsive to
the needs of both academically led and industry initiated research studies, as well as service providers such as
Queensland Health.
(For further information visit http://www.sph.uq.edu.au/staff-767-124656
http://www.health.qld.gov.au/pahospital/research/biostatistics.asp)
Associate Professor Sanjoy K. Paul
Director
Research Activities
Clinical Trials
Promoting activity for frail aged in post-
Rheumatoid Arthritis (Paul S). In
melphalan dosing in acute leukaemia.
acute hospital settings: a randomised
collaboration with Diamantina Institute;
In partnership with Cancer Services, PA
controlled trial of accelerometry. In
a phase I clinical trial led by R Thomas,
Hospital: an ALLG-sponsored trial led by
partnership with Centre for Research in
Principal Investigator.
P Mollee, Principal Investigator. Study
Geriatric Medicine: an NHHMC-funded
clinical trial led by L Gray, Principal
Investigator.
110
research - key to health
ALLG MM8 Trial: A phase II study of a
risk-adapted strategy to intravenous
closed to follow up and data analysis in
progress.
Clinical & Biostatistical Research
Projects
Exploring the dynamics of interrelationships between clinical &
biochemical parameters in type 2
diabetes patients (Paul S). The aim
of this study is to understand the
pathophysiology of certain risk factors
and biomarkers in type 2 diabetes
patients; funded by a research program
grant from Amylin Pharmaceuticals Inc.,
USA. Manuscript submitted to BMJ.
L-R: Gijo Thomas, Kere Klein, Margaret Haughton, Sanjoy Paul, Namitha Bobby
Dynamics of weight change and
glycaemic control in type 2 diabetes
Comparison of diabetic cardiovascular
sterol concentrations and cholesterol
patients treated with exenatide or insulin
risk factors between the Caucasian
synthesis in 800 patients with Type 2
(Paul S). The aim of this pioneering study
and South-Asian populations (Paul S).
diabetes. In collaboration with University
is to understand the benefits of GLP-
This study addresses the long-standing
of Oxford. Published (Atherosclerosis
1 Agonist in diabetes and metabolic
issue of the possible differences
2010).
diseases; led by QCTBC in collaboration
between Caucasian and South-Asian
with Amylin Pharmaceuticals Inc., USA.
populations in the behaviour and
Manuscript submitted to Circulation.
association of anthropometric, clinical,
Competitive funding:
and biochemical risk factors defining
Funding from other
sources:
Prediction of incipient hypoglycaemia
using continuous blood glucose
monitoring system (Paul, S).
A program of study initiated by QCTBC
to use data collected using the
Continuous Blood Glucose Monitoring
System (CGMS) to develop real-time
models that can reliably forecast the
likelihood of incipient hypoglycaemia.
Manuscript submitted to IEEE
Transactions in Biomedical Engineering.
Initiation of insulin in type 2 diabetes
patients using CGMS based glycaemic
assessment (Paul S). This pilot study
aims to explore the ability of CGMS to
provide a means of characterizing a
patient’s glycaemic patterns in order
that the most appropriate method
the likelihood of Type 2 diabetes.
In collaboration with University of
Leicester, UK. Manuscript submitted to
Diabetes Care.
Major Grants & Financial Support
$147,721
$77,282
National & International Presentations
Associate Professor Sanjoy Paul
China International Medical Foundation
Forum, Beijing, China
Statistical analysis of disease
progression in type 2 diabetes patients
(Paul S). Research study in the fields of
clinical epidemiology and biostatistics,
using the 20-year longitudinal UK-GPRD
American Diabetes Association 70th Scientific Sessions, Orlando, Florida USA
study data. In collaboration with Imperial
ARCS Scientific Congress 2010, College London, and University of
Sydney, NSW
Leicester, UK. Manuscripts submitted to
Lancet and BMJ.
New Zealand Clinical Research
Conference 2010, Auckland, WT1 Expression: A biomarker study. In collaboration with Cancer Services PA Hospital, led by Principal Investigator
J Gray.
New Zealand
PA Hospital Week, Brisbane, QLD
ADS & ADEA Annual Scientific Meeting,
Sydney, NSW
of insulin administration can be
Plant sterols in type 2 diabetes (Paul
selected for each individual patient. In
S). This study aims at determining
2010 Translational Research Excellence
collaboration with J Shaw, Baker IDI,
the effect of statin treatment and
(TRX10) Conference, Brisbane, QLD
and supported by Medtronic USA.
omega-3 polyunsaturated fatty acid
supplementation on plasma plant
Centres for Health Research 2010 Annual Research Report
111
Queensland Melanoma Project
The Queensland Melanoma Project focuses on clinical research into
all aspects of cutaneous melanoma from diagnosis to surgery to
immunotherapy for metastatic melanoma. It is involved in local, national
and international clinical trials. This year the unit became the fourth
highest recruiter in a phase III international immunotherapy vaccine trial.
The Queensland Melanoma Project has developed over the years to
include a multi-disciplinary meeting and clinic that involves General
Surgeons (Surgical Oncology), Plastic and Reconstructive Surgeons,
Medical Oncology, Radiation Oncology and Allied Health. This is the only
specialist melanoma clinic in Queensland and offers patient care and
advice to clinicians in Queensland and Northern New South Wales.
Mark Smithers
The project continues to collect prospective data on all patients undergoing nodal surgery and isolated limb
therapy. This clinical data is being used in collaboration with scientists at the University of Queensland to try to
identify molecular markers of sentinel node invasion.
Associate Professor B Mark Smithers
General Surgeon, Associate Professor, The University of Queensland Department of Surgery,
Chairman Queensland Melanoma Project Princess Alexandra Hospital
Director, Upper GI and Soft Tissue Unit Princess Alexandra Hospital
Research Activities
Clinical Trials
Multicenter Selective Lymphadenectomy
melanoma subjects with evidence of
III melanoma (Smithers BM, Barbour
for Melanoma Trial II: A Phase III
SN metastases by histopathologic or
A, Burmeister B, Walpole W, Bayley
Multicenter Randomized Trial of Sentinel
molecular evaluation will lead to longer
G, Allan C). The objectives of this
Lymphadenectomy and Complete
melanoma-specific survival than study are to assess the efficacy in
Lymph Node Dissection versus
that observed after LM/SL alone and
terms of Disease-Free Survival of the
Sentinel Lymphadenectomy Alone in
postoperative observation with serial
recMAGE-A3 + AS15 ASCI in the overall
Cutaneous Melanoma Patients with
nodal ultrasound.
population of patients and to evaluate
Molecular or Histopathological Evidence
of Metastases in the Sentinel Node.
(Smithers BM, Bayley G, Barbour A,
Jones S, Allan C). The objective of this
study is to determine whether LM/SL
and CLND in cutaneous 112
research - key to health
A Double blind, randomised, placebocontrolled Phase III study to assess the
efficacy of recMAGE-A3 + AS15 ASCI
as adjuvant therapy in patients with
MAGE-A3 positive resected stage
other indicators of efficacy and safety of recMAGE-A3 + AS15 ASCI such as
overall survival, distant metastasis free survival, 1-year, 2-year and 3-year
DFS rates and the immune response to
the ASCI.
A Phase II, open-label, non-comparative
conducted with the University of
Other Research
study on intralesional PV-10 followed
Queensland using the existing database
Melanoma Database – Sentinel Node
by Radiotherapy in the treatment
being managed through the QMP and Nodal Dissection Established
of metastatic melanoma. (Smithers
office. The objective of the study is to
in 2004 data has been collected on
BM, Barbour A, Burmeister B, Foote
look at different markers in the tumour
all patients undergoing a sentinel
M, Bayley G, Allan C). The primary
to see if they could predict the invasion
lymph node dissection or complete
objective of this study is to investigate
of the sentinel node and the severity of
lymph node dissection for metastatic
the effectiveness of intralesional (IL)
the melanoma.
melanoma. Retrospective data has been
PV-10 followed by hypofractionated
radiotherapy for the locoregional
treatment of metastatic melanoma.
Phase I clinical trial of interferon
modified B7 positive melanoma call
vaccine in patients with Stage IV
malignant melanoma. (Smithers BM,
Barbour A, Burmeister B, Walpole E,
Bayley G, Allan C). The objectives of
this study are to test the safety of the
vaccine, Genvax, at different dose levels
and to see the effect the vaccine has on
melanoma cancer.
Prospective evaluation of prognostic
factors in patients with medium risk
melanoma (Green A, Smithers BM).
invasion in melanoma. (Khosrotehrani
1468 patients. (Smithers BM, Jones S,
Barbour A, Bayley G, Allan C).
Melanoma - Isolated Limb Infusion
Follow-up Study of randomised
double-blind phase II trial of NY-ESO-1
Iscomatrix vaccine and Iscomatrix
adjuvant alone in patients with resected
stage IIc, II or IV malignant melanoma.
(Multicentred trial) (Smithers BM,
Barbour A, Burmeister B, Walpole E,
Bayley G).
Database Data has been collected on
all patients who have undergone an
isolated limb infusion at the Princess
Alexandra Hospital since 1997. The
majority of these procedures have been
for metastatic melanoma. There are
currently 132 patients. (Smithers BM,
Jones S, Barbour A, Bayley G, Allan C).
The natural history of patients who were
Molecular markers of sentinel node
collected since 1997. There are currently
entered into the MRPQ0161A study.
(Smithers BM, O’Rourke M, Schmidt C).
Major Grants & Financial Support
Funding from
commercial studies:
$176,924
K, Smithers BM). This study is being
Queensland Melanoma Group
Centres for Health Research 2010 Annual Research Report
113
Queensland Spinal Cord
Injuries Services
The Queensland Spinal Cord Injuries Service (QSCIS) consists of the Spinal Injuries Unit (SIU), the Transitional
Rehabilitation Program (TRP) and the Spinal Outreach Team (SPOT). All three services have active research
programs.
Spinal Injuries Unit (SIU)
The Queensland Spinal Cord Injuries Service (QSCIS) multidisciplinary
team is involved in two international clinical trials. One is comparing
the addition of an intensive task specific motor training program to
standard rehabilitation in people with recent tetraplegia. The second
trial will determine the effect of nocturnal nasal continuous positive
airway pressure (CPAP) for the treatment of obstructive sleep apnoea on
neuropsychological function, quality of life, autonomic dysfunction and
breathing in people with acute quadriplegia. The Department did also
conduct research into managing respiratory dysfunction after SCI-ICU.
The education package developed may provide for future collaborations
with the Austin Hospital in Melbourne.
Sridhar Atresh
Dr Sridhar Atresh
Director
Research Activities
Clinical Trials
program and standard rehabilitation
Investigator); Tsai P, Deuce, B (Co-
SCIPA (Spinal Cord Injury and Physical
compared with standard rehabilitation
investigators); Jones R (Research
Activity) Hands-On: Early Intensive Hand
alone for improving hand function Nurse); Lewis J (Blinded Assessor)). An
Rehabilitation After Spinal Cord Injury
and clinical outcomes in people with
international, multi-site, randomised
(Chief Investigators: Harvey L, Galea
recent tetraplegia. SCIPA Hands-
controlled trial to determine the effect
M, Dunlop S, QSCIS Staff: Geraghty
On is funded through The Victorian
of nocturnal nasal continuous positive
T, (Principal Investigator); Tsai P (Co-
Neurotrauma Initiative.
airway pressure (CPAP) treatment
investigator); Jones R (Research Nurse);
Cullen C (Intervention Therapist); Wallace M (Blinded Assessor)). Multisite, randomised controlled trial to
determine the relative effectiveness of
an intensive task-specific motor training
114
research - key to health
COSAQ: A prospective, randomised
controlled trial for auto-titrating
Continuos positive airway pressure
for Obstructive Sleep Apnoea after
Acute Quadriplegia (Chief Investigator:
Berlowitz D, Staff: Geraghty T, (Principal
for obstructive sleep apnoea (OSA)
on neuropsychological function,
quality of life, autonomic dysfunction
and breathing in people with acute
quadriplegia. COSAQ is funded by The
Institute for Breathing and Sleep.
Sleep-disordered breathing in spinal
Management of Respiratory dysfunction
be utilised within QHealth and future
cord injured patients: A short term
after acute SCI- ICU to SIU. This project
collaborative research options with
longitudinal study (Tran K, Huckins C,
involves a retrospective chart review
Austin Hospital in Melbourne).
Geraghty T, Eckert B, Fraser L).
of 30+charts (education package to
Spinal Outreach Team (SPOT)
The Spinal Outreach Team continues to focus its research endeavours on service enhancement projects. The
Clinical Knowledge Translation Through Consultancy project has implications well beyond spinal cord injury
practice. A novice grant received from the Queensland Health Nursing and Midwifery Research Grants Program
means that this research will be extended to examine clinicians’ motivations for seeking consultancy.
Kiley Pershouse
Manager
Research Activities
Long term outcomes after spinal cord
Functioning and Health Research and
in collaboration with the Rehabilitation
injury in Queensland (Amsters D,
the Centre for Remote Health (NT).
Engineering Centre at RBWH, Metro
Pershouse K, Schuurs S, Kendall M,
Barker R, Kuipers P). The aim of this
study is to track changes in quality of
life and function for people with spinal
cord injury (SCI) along the lifespan. Data
analysis has continued throughout 2010.
The findings to date have highlighted
the importance of prevention and
intervention for secondary conditions
following a SCI.
A study of outcomes for spinal cord
injured clients after interventions for
complex seating problems (Amsters D,
Schuurs S). This project aims to examine
Bettina Power
of a wound care consultant, when
ANZCoS Annual Meeting, Adelaide,
faced with a spinal cord injured client
September
with skin breakdown. An online survey
design will be used to gather data from
commencing in 2011.
by the Spinal Outreach Team is
investigating the nature of consultancy
amongst health professionals and its
efficacy as a model for translation of
research evidence to practice. It is
in collaboration with the Transitional
Rehabilitation Program, Acquired Brain
Injury Outreach Service, Centre for
$8,800
nurses’ decisions to seek the assistance
Factors influencing consultancy seeking
This broad study being undertaken
Competitive funding:
National & International Presentations
community nurses across Queensland,
(Ladhams J, Schuurs S, Amsters D).
Major Grants & Financial Support
factors which influence community
When do community nurses seek help?
for wound care in spinal cord injury?
North Health Service District.
Clinical knowledge translation from
specialist health practitioners to
Carey Bayliss
ISCoS Annual Meeting, New Delhi, India,
October
Julie Ladhams
National Continence Foundation
Australia, Brisbane
generalist health practitioners –
evaluating a consultancy model of
service delivery (Amsters D, Kuipers P,
Kendall M, Lindeman M). This project
aims to evaluate the outcomes and
ANZCoS Annual Meeting, Adelaide
Bettina Power
ANZCoS Annual Meeting, Adelaide
impact of a custom seating service for
people with complex wheelchair seating
problems after spinal cord injury. It is
Centres for Health Research 2010 Annual Research Report
115
Transitional Rehabilitation Program
The Transitional Rehabilitation Program provides post-primary rehabilitation services for people with spinal cord
injuries who have undergone inpatient rehabilitation in the Queensland Spinal Injuries Unit.
Research highlights during the year have included the completion of research into staff training on client sexuality
with the publication of two year follow-up findings. Work continued on collaborative research being undertaken with
the Spinal Outreach Team, the Acquired Brain Injury Outreach Service, Centre for Functioning and Health Research
and the Centre for Remote Health (NT) investigating the efficacy of consultancy as a model for translating clinical
evidence in rehabilitation and aged care settings. Significant quality improvement work has occurred in the area of
goal setting and attainment and this body of work is expected to be published within the coming year. Work has
also continued on finalising research into professional boundaries while collaboration has continued with the Spinal
Outreach Team in preparing publications from research into long term outcomes following spinal cord injury. New
research, in collaboration with the Acquired Brain Injury Outreach Service, the Spinal Outreach Team and Griffith
University has been explored in the area of psychosocial models of care, in particular identity reconstruction.
Greg Ungerer
Manager
Research Activities
Clinical knowledge translation from
attitudes and ethical decision making
National & International Presentations
specialist health practitioners to general
(Fronek P, Kendall M, Ungerer G, Malt
Emilie Gollan
health practitioners- evaluating a
J, Eugarde E, Geraghty T). This project
Joint 49th International Spinal Cord
consultancy model of service delivery
evaluated an intervention to address
Society (ISCoS), 9th Asian Spinal Cord
(Amsters D, Kuipers P, Kendall M,
Professional boundaries in practitioner/
Network (ASCoN) and 10th Spinal Cord
Lindeman M).
client relationships. Data analysis has
Society (SCS) Meeting, New Delhi, India
This project, which commenced in
continued throughout 2010.
Kirsten Hinchy
2009, has continued with significant
Goal setting and attainment in the
Annual Scientific Meeting of the
data collection occurring during 2010.
community setting: An evaluation of
Australian and New Zealand Spinal Cord
The project aims to explore the efficacy
goal content, processes and outcomes
Society, Adelaide
of consultancy as a means of health
(Kendall M, Ungerer G). Developed
service delivery and clinical capacity
as a quality improvement initiative,
building in rehabilitation and aged this project has involved the analysis
care settings.
of clinically generated goal content,
Professional boundaries: development
and evaluation of an intervention to
address staff knowledge, comfort,
116
research - key to health
processes and outcomes prior to and
following the implementation of a group
goal setting process.
Radiation Oncology (PAH)
The Princess Alexandra Hospital Radiation Oncology Department has
maintained a high level of clinical trial activity throughout the year. The
department administered more than 1500 courses of radiation therapy
during the year and was able to expand the consultant staff with the
appointment of Dr Matthew Foote who returned from Canada, having
completed a fellowship at Princess Margaret Hospital in Toronto. Matthew
has a strong focus in research and will be pioneering several projects in
melanoma, brain tumours and stereotactic radiation therapy.
The department had the privilege of being able to host their first radiation
Bryan Burmeister
oncology fellow, David Pryor who has already excelled himself with
some prestigious awards as a registrar. David has focussed his efforts
in projects involving head and neck and oesophageal cancer and has
submitted some important manuscripts for publication. Another highlight of 2010 was an oral presentation on
the predictive value of PET scanning in head and neck cancer by Associate Professor Sandro Porceddu at the
American Society of Therapeutic Radiation Oncology (ASTRO) meeting in San Diego. Sandro has since had some
initial outcomes of his work published. Contributions to research from radiation therapists and medical physicists
continue to increase with several projects close to completion.
Work has commenced on the radiation oncology expansion which will not only increase the numbers of patients
being treated but also the capacity to conduct research within the department. The clinics will be much closer to
the treatment facility which should lead to increased collaboration among all researchers. The new clinical areas
will commence in July 2011 and the new linear accelerator in November 2011.
Professor Bryan Burmeister
Director
Research Activities
Clinical Trials
TROG 08.03 / RAVES (Lehman M). A
Cetuximab as Palliation for Locally Inoperable Early Stage I Non-Small Cell
Phase III Multi-Centre Randomised
Advanced Head and Neck Squamous
Lung Cancer (CHISEL)
Trial Comparing Adjuvant Radiotherapy
Cell Carcinoma – A Phase II Study
(RT) With Early Salvage RT in Patients
With Positive Margins or ExtraProstatic Disease Following Radical
Prostatectomy.
TROG 07.01 / DCIS (Harvey J). A Phase
TROG 09.02 / CHISEL (Mai T). A
III Study of Radiation Dose Escalation
Randomised Phase III Trial of Highly
and Fractionation in Women with Non-
Conformal Hypofractionated Image
Low Risk Ductal Carcinoma In Situ
Guided (“Stereotactic”) Radiotherapy
(DCIS) of the Breast
Hypo Cetux / 62202-828 (Porceddu S).
(HypoRT) versus Conventionally
Hypofractionated Radiotherapy with Fractionated Radiotherapy (ConRT) for Centres for Health Research 2010 Annual Research Report
117
Pmab / CSCCS (Porceddu S). Open-
TROG 08.05 / WBRT (Burmeister B).
Treated with Radiotherapy versus
Label, Uncontrolled, Phase II Study to
Whole Brain Radiotherapy following
Chemoradiotherapy
Evaluate the Efficacy and Toxicity of
Local Treatment of Intracranial
Single-Agent Panitumumab in Patients
Metastases of Melanoma
with Incurable Cutaneous Squamous
TROG 06.01 / LGG (Lehman M) Primary
Chemotherapy with Temozolomide
TROG 08.09 / RTN2 (Foote M). A
vs. Radiotherapy in Patients with Low
Randomised Trial of Post-Operative
Grade Gliomas after Stratification for
TROG 05.01 / POST (Porceddu
Radiation Therapy following Wide
Genetic 1p Loss: A Phase III Study
S). Post-Operative Concurrent
Excision of Neurotropic Melanoma of
Chemoradiotherapy versus Post
the Head and Neck
Cell Carcinoma
Operative Radiotherapy in High-Risk
Other Research
CT PET (Porceddu S). Prospective
TROG 07.04 / LOUD (Porceddu S).
Database Collection of Neck Node
A Phase II Study of Cetuximab,
Positive Head and Neck Cancer
Carboplatin and Concomitant Boost
Patients Undergoing CT-PET
TROG 08.01 / PROFIT (Lehman M) A
Radiotherapy for Locally Advanced
Guided Management of the Neck
Randomised Trial of Shorter Radiation
Head and Neck Squamous Cell
Policy following Definitive (Chemo)
Fractionation Schedule for the Treatment
Carcinoma
Radiotherapy
TROG 08.02 / Elderly GBM (Foote
Major Grants & Financial Support
Cutaneous Squamous Cell Carcinoma
of the Head and Neck
of Localised Prostate Cancer (PROFIT:
Prostate Fractionated Irradiation Trial)
M). A Randomised Phase III Study
TROG 07.02 / QUARTZ (Burmeister B).
of Temozolomide and Short-course
A Phase III Multi-Centre Randomised
Radiation versus Short-course Radiation
Controlled Trial to Assess Whether
Alone in the Treatment of Newly
Optimal Supportive Care Alone
Diagnosed Glioblastoma Multiforme in
(Including Dexamethasone) is as
Elderly Patients
Effective as Optimal Supporting Care
(Including Dexamethasone) plus Whole Brain Radiotherapy in the
Treatment of Patients with Inoperable
Brain Metastases from Non-Small Cell
Lung Cancer.
TROG 07.03 / RadioHum (Porceddu S).
Radiotherapy with Humidification in
Head and Neck Cancer (RadioHum): A Randomised Phase III Trial of the Trans Tasman Radiation Oncology Group in Collaboration with Fisher and Paykel Healthcare.
118
research - key to health
STARS Pilot (Harvey J) Pilot for a
Randomised Comparison of Anastrozole
Commenced Before and Continued
During Adjuvant Radiotherapy for
Breast Cancer versus Anastrozole and
Subsequent Anti-Oestrogen Therapy
Delayed Until After Radiotherapy
TROG 03.01 / Palliative Oesophageal
(Harvey J). A Randomised Phase III
Study in Advanced Oesophageal
Cancer to Compare Quality of Life
and Palliation of Dysphagia in Patients
Competitive funding:
$214,634
Radiation Oncology (Mater)
This year has been a productive year for the Mater research team. The
delivery of radiation oncology services resulted in 33,757 treatment
attendances and 113,882 treatment fields. The past 12 months has been
a year of consolidation with the gradual expansion of the Image Guided
Radiotherapy and the Intensity Modulated Radiotherapy programs. This
has included the implementation of stereotactic spinal treatments using
Intensity Modulated Radiation Therapy (IMRT) under the supervision of
Dr Matthew Foote as well as the development of an IMRT protocol for
gynaecological malignancy with Dr Bryant and Dr Peres. The expertise of
the IMRT team under the guidance of Robyn Guidi, Tammy Barry, Penny
Michael Poulsen
Knapp and Adrian Gibbs has been appreciated. The staff continue to
accrue to clinical trials. There were 63 patients entered onto clinical trials
in the last financial year. The site remains a principle site for a number of
TROG trials and the research staff have worked tirelessly to achieve high quality data collection.
The group was enormously proud to see Pauline Rose graduate with her PhD. This is an outstanding achievement
for radiation oncology nursing. There has been continued expansion of radiation therapy research on the campus
and the appointment of Dr Owen as Radiation Research fellow will further assist in fostering research. Dr Poulson
successfully completed his MD and graduated this year. A state-wide cross sectional survey on burnout and work
engagement in cancer workers has also been completed and submitted for publication.
Associate Professor Michael Poulsen
Director
Research Activities
State-wide survey of cancer workers in
Queensland (Poulsen MG, Poulsen A).
This is a cross sectional study which
aims to identify the factors associated
with burnout and worker engagement
in all professional streams involved with
cancer care.
Investigation of Image guidance
methods for improved localisation
in external beam radiotherapy of the
prostate (Deegan T). This project will
allow the more accurate delivery of
radiotherapy for cancers of the prostate.
Improving head and neck stabilisation:
a comparative study of the Civco and
Posifix immobilisation systems (Cronin
B). This project will improve on the
stabilisation of the head for head and
neck radiotherapy.
Exploration of Lung Imaging in External
Beam Radiotherapy (Schloman T). This
project will improve target definition for
lung cancer treatment.
Intra-fractional respiratory motion
and its impact on breast radiotherapy
(Jones RFS). To document the effect
of respiratory movement of breast
radiotherapy.
Methods for automated 3D analysis of
volume variation for tumours, healthy
tissues and planned dose in patients
undergoing RT (Project Manager:
Hargrave C, Moore M PhD student
at QUT). This will allow us to develop
method for 3-D change in treatment
volumes during radiotherapy.
A dosimetric comparison of 3DCRT
with IMRT for treatment of anal canal
cancer (Barry T). A technique to reduce
morbidity of radiotherapy.
Inter-observer variability of MRI and
CT in prostate radiation therapy (Parfitt
M). To study the variability of MRI and
CT contouring.
Measuring dose delivered by CBCT and
kV setup images during radiation therapy
treatment to the head and neck (Cronin
B). To evaluate radiation dose from on
line imaging.
An evaluation of reflective tutorial
sessions and their outcomes (Abrahams
K). An educational project.
Circumventing the infrastructure drain:
A comparative study of e-learning as
a clinical training method in radiation
therapy (Brady C). To study the impact of
e-learning.
A prone technique for treatment of
the breast, supraclavicular and axillary
nodes (Mason N, MacFarlane D).
Centres for Health Research 2010 Annual Research Report
119
Radiology
Escalating service commitment and the introduction of new Accident
and Emergency CT facilities, and arrangements to introduce PET/CT
scanning, together with difficulties in radiologist recruitment has hindered
our research endeavours this year.
However, the group still participate in international trials and have had
papers published as well as posters and presentations at conferences
and scientific meetings during the year.
With new teaching positions appointed, radiographic and nuclear
medicine staff had increased presentations at national and international
scientific meetings.
Mark Benson
With a change in the training rules for radiology registrars, they are now
expected to produce at least two major projects, this is expected to stimulate a greater amount of research in the
department, especially related to the new Emergency Department CT and PET/CT equipment.
Dr Mark Benson
Acting Director
Research Activities
Clinical Trials
Other Research
CORAL Study Cardiovascular Outcomes
PERI Study (Benson M, Macdonald G,
Radiologic Patterns in H1N1 Admissions
with Renal Atherosclerotic Lesions
Soyer P). Prospective non-randomised
(Saad N, Greenslade S, McEniery J).
(Redmond K, Mudge D). Randomised
(pharmacoepidemiologic) cohort
and multi-center two-group Clinical Trial
(open-label, multicentre) to assess the
to assess the best treatment for patients
magnitude of potential risk with the
with high blood pressure and Renal
administration of Primovist/Eovist in
Artery Stenosis: Stenting with anti-
patients with moderate to severe renal
Diffusion-weighted imaging of liver
hypertensive medical therapy, compared
impairment for the development of
lesions: A retrospective Study
to medical therapy alone.
nephrogenic systemic fibrosis (NSF)
(Saad N, Moghaddam A).
SIRFLOX Study (Leggett D, Walpole
based on diagnostically specific clinical
Superior Ophthalmic vein size as
predictor of increased intracranial
pressure (Saad N, Dehdari A).
and histopathologic information.
Awards & Prizes
of FOLFOX6m Plus SIR-Spheres VS
RETRIEVE 4 Study (Harper J, Redmond
Annual Teaching Award, RANZCR
FOLFOX6m alone as first line treatment
K, Leggett D, McCann A). Investigational
Training Scheme Adelaide
in patients with non-resectable liver
plan for CRUX Biomedical Evaluation metastases from colorectal cancer.
of the Crux Inferior Vena Cava E). Randomised Comparative Study
Filter System.
120
research - key to health
Dr Nivene Saad
National & International Presentations
Sally Bell
16th International Society of
Radiographers & Radiological
Technologists World Congress, Gold Coast
Dr Mark Benson
RANZCR ASM - Early experience in
contrast-enhanced ultrasound, Brisbane
Richard Boytar
16th International Society of
Radiographers & Radiological
Technologists World Congress, Gold Coast
L-R (Back Row): Sally Ball, Dr Sue Jeavons, Dr Stanley Ngai, Dr Jennifer Chang, Dr Nivene Saad
L-R (Front Row): Tom Steffans, Tim Way, Dr Mark Benson, Gary Smith, Dr John Coucher
Associate Professor John Earwaker
RANZCR ASM - The Nobel Prize and
Susan Rattray
Gary Smith
Radiation Sciences, Brisbane
16th International Society of
16th International Society of
Radiographers & Radiological
Radiographers & Radiological
Dr Mitesh Gandhi
Technologists World Congress, Technologists World Congress, Radiological Society of North America
Gold Coast
Gold Coast
(RSNA), Chicago USA
Dr Kendal Redmond
Thomas Steffens
Madeleine Neels
RANZCR ASM - MR Abdominal
16th International Society of
16th International Society of
apoplexy: when good blood vessels go
Radiographers & Radiological
Radiographers & Radiological
bad, Brisbane
Technologists World Congress, Technologists World Congress, Gold Coast
Gold Coast
Dr Nivene Saas
Intensive Care Medicine Clinical
Andrew Whiteman
Dr Ben Ong
Refresher Course - Data Interpretation
16th International Society of
RANZCR ASM - MR Perfusion in Brain
2010, Brisbane, September
Radiographers & Radiological
Tumors, Brisbane
Hepatology Group Meeting - Advances
Jit Pratrap
in MRI, Brisbane, September
Technologists World Congress, Gold Coast
RADAIM 2010, Gold Coast
Centres for Health Research 2010 Annual Research Report
121
Respiratory and
Sleep Medicine
The Department of Respiratory Medicine and the Lung & Allergy Research Centre (UQ School of Medicine) have an active research
program focussing on (a) the role of viral infections and allergy in patients with asthma and chronic obstructive pulmonary disease, (b) improving influenza vaccination and (c) finding better ways to diagnose sleep apnoea.
This past year has seen further growth in staff numbers and expertise,
and has been highly productive for all concerned with success in
attracting research funding, 21 publications in peer-reviewed journals and
book chapters, and a successful patent application.
John Upham
Key achievements included:
•
•
•
Investigating the importance of antigen presenting dendritic cells (DC) in the pathogenesis of human allergic
disease, confirming the importance of DC in both established asthma in adults, and in the development of the
disease in young children.
New approaches to inhibiting allergen specific Th2 cytokine production using bacterial lipopeptides that alter
antigen presenting cell function.
Describing the key determinants of host defence against viral infections in chronic respiratory disease, with
particular emphasis on the function of plasmacytoid dendritic cells and innate interferon production.
During the year major conference presentations included a State of the Art Lecture at the major international
allergy conference in the USA, and the prestigious oration at the Australasian Society of Clinical Allergy and
Immunology.
Professor John Upham
Head of Research
Dr Craig Hukins
Head of Respiratory and Sleep Medicine
Research Activities
Clinical Trials
Other Research
Randomised trial of azithromycin in
with anti-inflammatory properties,
Developmental aspects of respiratory
asthma: efficacy and safety study
will help people with severe asthma.
inflammation, allergy & asthma (NHMRC
(NHMRC funded) (Gibson P, Simpson
Over four hundred people from several
Program Grant) (Sly P, Holt P, LeSouef
J, Upham J, Reynolds P, Yang I, James
Australian cities will take part in this
P, Thomas W, Stick S, Upham J). The
A). This project is studying whether low
randomised controlled trial. Recruitment
investigators are studying how delays
dose azithromycin, an antibiotic is continuing with final results expected
in immune system development predict
in 2013.
the onset of asthma and allergies in
122
research - key to health
children. In particular, it has been found
Protracted bacterial bronchitis (Chang A,
that a particular type of white blood
Yerkovich S, Upham J). Recurrent chest
cell known as a plasmacytoid dendritic
infections are a common and distressing
cell plays a key role in protecting
problem in young children. This study
against virus infections of the lungs and
aims to discover why these infections
protecting against asthma.
develop in some children, and whether
Major Grants & Financial Support
Total NHMRC funding:
$302,815
Other competitive
funding:
$377,100
National & International Presentations
this has any long term health effects.
Professor John Upham
patients with allergic rhinitis and asthma
Using components of bacteria to treat
& Immunology (State of the art Lecture),
in subtropical regions of Australia
asthma and allergy (State Government,
New Orleans, USA
(Asthma Foundation of Qld) (Davies J,
Office of Health & Medical Research)
Upham J). Grass pollens often make
(Upham J). This study aims to find new
asthma and hay fever worse. However
treatments for asthma and allergies. A
much previous research has ignored
component of the cell wall of common
the pollens found in subtropical areas.
bacteria can re-program the immune
It appears that allergy to paspalum
system and reverse the allergic response
grass pollen is much more common in
in the test tube. Recent findings have
Brisbane than in Melbourne. This has
uncovered some of the important
important implications for the design of
mechanisms involved. This is an initial
allergy vaccines used in desensitisation.
step to developing a new treatment.
Allergic sensitization to grass pollens in
American Academy of Allergy, Asthma
Australasian Society of Clinical Allergy
and Immunology; Basten Oration, Gold Coast
Respiratory and Sleep Medicine Group
Centres for Health Research 2010 Annual Research Report
123
Speech Pathology
The Speech Pathology Department continued to advance the evidence
base for clinical practice in the areas of communication and swallowing.
As in previous years, head and neck cancer and acquired brain injury
remained strong research themes. Additionally, staff continued to be
actively involved in a number of multidisciplinary research projects
spanning across the hospital.
The department's research profile continued to develop with a large
number of staff presenting the results of projects and clinical trials at
national and international conferences throughout the year. In August, Dr
Wendy McCallum
Emma Finch was appointed in the conjoint research fellow position (PAH
and the University of Queensland), replacing Dr Petrea Cornwell who
resigned in 2009. Dr Finch’s research interests are based primarily around
communication and swallowing disorders in neurological conditions. On her commencement Emma became a
member of the newly formed Centre for Functioning and Health Research which has already begun to provide
an exciting range of collaborative research opportunities.
Wendy McCallum
Director
Research Activities
Clinical Trials
Other Research
Randomized controlled cross-over
Long-term swallowing outcomes in head
of an intervention based on the ICF
Phase 3 trial comparing the new
and neck cancer patients: comparing
“environment” dimension for enhancing
indwelling Provox Vega voice prosthesis
non-surgical treatment regimens (Riddle
the well being and psychosocial
with the currently used Blom-Singer
B, Cornwell P, Porceddu S, Stuckey S,
outcomes of adults in day hospital
Classic Indwelling voice prosthesis
Ward, E, Davidson W). Patients who
brain injury rehabilitation. The program
for voice rehabilitation after total
have undergone altered fractionation
was developed as part of a research
laryngectomy (Hancock K, Ward E,
radiotherapy with concomitant boost
project with the short term treatment
Lawson N). The long term component
and radiotherapy have now been
effects evaluated and published. Further
of this Provox Vega voice prosthesis
assessed along the continuum of care
evidence of the long term effects of the
trial was completed in 2010 with the
from pre-treatment to 2 years post
program are now being investigated.
collation of objective data from 24
treatment. In 2010, data analysis for the
laryngectomy patients. The data that
prospective study, comparative study
was collected related to device life and
and acute study have been completed.
complications including the reasons for
One paper has been published and
voice prosthesis change. By the end of
the research has been presented at
2010, key data had been analysed and
statewide and national conferences.
presented at national and international
forums. One paper had been accepted
for publication.
124
research - key to health
Communication partner training
(Lethlean J, McGovern D). The Training
Communication Partners project aims to
investigate the impact of implementing
a communication partner training
program on people with aphasia, health
Personal Environment Enhancing
practitioners and health practitioner
Rehabilitation Program Quality
students. It is hoped that this research
Improvement project (Addis P, Watter K,
will assist people with aphasia to
Freebairn C, Fleming J, Finch E). The overcome the barriers aphasia creates
project evaluates the implementation and facilitate re-engagement in health
care decisions and everyday life. To date a pilot training program has
been conducted with positive outcomes reported.
The effects of thrombolysis following
ischaemic stroke on communication
and swallowing outcomes (Finch E,
Clark K, Short K, Smith L, Antonio
M, Aitken P). Evidence suggests that
thrombolysis shortly after ischaemic
stroke may reduce some of the
subsequent neurological damage. The
L-R (Back Row): Kate Robinson, Leanne Smith, Michaela Antonio, Kerrin Watter, Cassandra Budden
L-R (Front Row): Nadine Lawson, Bena Cartmill, Emma Finch, Kathy Clark
current study is investigating the effects
of thrombolysis on communication
Neurocognitive substrates of naming
and swallowing recovery after stroke.
facilitation in aphasia (Copland D,
Increasing knowledge in this area will
Heath S). (Sponsor is K. Clark). There is
assist in the development of effective
evidence to support the effectiveness
patient rehabilitation programs to
of certain naming treatments, however
maximise quality of life post stroke.
the mechanism for the positive
Kelli Hancock, Nadine Lawson
outcomes remains unclear. This
Global Postlaryngectomy Rehabilitation
project will compare the effectiveness
Cadaver Demonstration Course, Brisbane
ASSIST Swallowing screening tool trial
(Robinson K, Lawson N). This project
initially evaluated the outcomes of
the use of a nursing administered
of three naming therapy techniques
at a cognitive and neural level using
ATOS Medical Meeting, Horby, Sweden
Voice Prosthesis Workshop, Brisbane
ANZHNC, Sydney
Speech Pathology Australia, Melbourne
functional MRI.
ANZHNC Pre-meeting workshop, Sydney
stroke population to detect patients
Awards & Prizes
Annie Johnson
who were able to proceed directly to
Jenni Boxall
ANZHNC, Sydney
their premorbid diet and those who
ANZHNC Poster Prize, Head and Neck
required specialist speech pathology
Cancer, ANZHNC
Nadine Lawson
Major Grants & Financial Support
Queensland, Brisbane
dysphagia screening tool with the
intervention. Modifications will be
made to the current tool and will then
be implemented in all neurological
Competitive funding:
populations. It is expected that at the
Funding from other
sources:
completion of the project, a single
nursing dysphagia screening tool will be used effectively in the
neurosciences ward.
Understanding what helps people
live successfully with aphasia (Grohn
B, Worrall L, Simmons-Mackie N).
ANZHNC, Sydney
Speech Pathology Australia, Melbourne
ANZHNC, Sydney
and how speech pathology assisted in
achieving some of those goals.
Pathology Interest Group, Melbourne
FEES Clinical Education and Training
Queensland, Brisbane
Provox vega voice prosthesis workshop,
Brisbane
Nadine Lawson, Kelli Hancock, Annie
Johnson
ANZHNC Pre-meeting workshop,
Kelli Hancock
Sydney
Annual German ENT Conference,
Weisbaden Germany
Victorian Head and Neck Speech
Nadine Lawson, Kelli Hancock
Cass Budden, Michaela Antonio,
to investigate what people with aphasia
with aphasia want from aphasia services
$26,000
Jenni Boxall
Bena Cartmill
investigates what the families of those
$7,000
National & International Presentations
(Sponsor is K. Clark). The study aims is
want from aphasia services. It also
FEES Clinical Education and Training
Kerrin Water, Carly Freebairn
ASSBI, Gold Coast
Centres for Health Research 2010 Annual Research Report
125
Therapeutics Research Centre
Under the directorship of Professor Mike Roberts, the Therapeutics
Research Centre studied basic and clinical therapeutics, ranging from
theoretical mathematical modelling of drug disposition, to practical
aspects such as drug trials. A major highlight was the renewal of
Professor Roberts’ NHMRC fellowship, ensuring his strong leadership in
the centre for 2011 – 2016, while mentoring young scientists to become
independent researchers.
Another highlight came with the success of Postdoctoral Fellow, Dr
Tarl Prow in achieving several research grants, including his first
NHMRC project grant with Professor Roberts and a UQ Early Career
Research Award, studying targeted delivery using microdevices such as
microneedles and microfibers.
Mike Roberts
New NHMRC funding for 2011-2013 was also achieved in collaboration with Professor Nick Buckley, studying
renal toxicity.
Targeted topical delivery, focussing mainly on imaging in skin, microneedles for vaccines and nanoparticle
delivery continued to be a major interest, with 14 papers and 3 chapters published and several conference
presentations. The liver / pharmacokinetics and the clinical research areas were also productive, with 13
publications and a number of conference presentations.
The NHMRC-funded STATiNS trial with Dr Peter Kruger was completed and the centre has commenced the
analysis of the huge numbers of samples generated. The results of the trial are expected to have a major impact
on the management of patients with severe sepsis.
Professor Vania Leite, visiting from Brazil, provided expertise in topical formulation and gave invaluable help to
students and staff.
Professor Mike Roberts
Director
Research Activities
Clinical Trials
Other Research
A phase II randomised controlled trial
Toxicology of Nanomaterials (Minchin
Pharmacodynamics in Liver Disease
of atorvastatin therapy in intensive care
RF, Roberts MS, Martin DJ, Smith
and in Liver Surgery (Roberts MS, Weiss
patients with severe sepsis (Roberts
SV, Monteiro MJ, Gahan). This
M, Macdonald G, Fawcett J, Vitetta L,
MS, Kruger P, Venkatesh B, Bellomo R,
multidisciplinary study progressed
Fletcher L). Commencing in 2010, work
Kostner K, Cooper D). The project was
well, with the TRC contributing
concentrated on multiphoton imaging of
completed in 2010 and final sample
studies showing no penetration of
the disposition of fluorescent solutes in
analyses are due for completion in
various inorganic nanoparticles, or of
rat liver in vivo. Other studies examined
early 2011. Dr Kruger has been invited
radiolabelled zinc ions across excised
the disposition of clinically important
to delivered several presentations on
human skin. Eight publications were
drugs in diseased liver models. Seven
the results of this trial, as soon as they
achieved by the team in 2010.
publications were achieved.
become available.
126
research - key to health
Antibiotic dosing in the "at risk" critically
Dr Tarl Prow
Pre conference course for 12th
ill patient (Roberts MS, Lipman J,
Highly Commended – Open category,
Perspectives in Percutaneous
Paterson D, Kirkpatrick C, Kruger P,
Uniquest Trailblazer Original, Early-
Penetration International Conference,
Roberts J). Clinical data collection with
stage Research and Entrepreneurial
Skin structure and function, La Grande
patients recently admitted and those
Ideas Competition, The University of
Motte, France
under stable management (hepatic,
Queensland, UniQuest
renal and cardiac function and body
fluid distribution) is nearing completion.
The team had 16 articles published or in
press in 2010.
Targeted delivery by topical application
(Roberts MS). Work carried out in
Australian Pesticides and Veterinary
Dr Kanchana Ranasinghe
Medicines Authority (APVMA)
Nominee, clinical coach award,
nanotechnology workshop, APVMA,
Contribution to advanced training, UQ
Pharmacokinetics of nanomaterials,
School of Medicine
Canberra
Major Grants and Financial Support
5th Workshop on Advanced Multiphoton
$1,251,661
2010 included studies of nanoparticle
Total NHMRC funding:
penetration with flexing and massage
Competitive funding:
$564,000
and in diseased skin, the stratum
Funding from
commercial studies:
$12,000
corneum reservoir, molecular structureskin penetration relationships and
follicular targeting. Thirteen articles,
reviews and chapters were published or
accepted in 2010.
A world-wide comparison of
nanoparticle properties and safety,
sponsored by the OECD (Roberts MS,
Sanchez WH, Grice JE, Prow TW). TRC
researchers presented data at a CSIROsponsored OECD workshop showing no
zinc oxide nanoparticle penetration in
Australian Office of Chemical Safety &
United States of America Defense Threat
Environmental Health, Dermal Exposure,
Reduction Agency Meeting, Dermal
Canberra
Kinetics, Florida
Australian Office of Chemical Safety &
Royal Australian Chemical Institute
Environmental Health, Pharmacokinetic/
(RACI) Pharmaceutical Workshop
toxicokinetic principles, Canberra
Preparing a New Dosage Form for
Clinical Trial, Preparing a New Dosage
Form for Clinical Trial, Adelaide
vivo were commenced and are due for
delivery - chemical structure, product,
completion in 2011.
skin and pharmacokinetic relationships,
Basel, Switzerland
Professor Michael Roberts
8th International Conference and
Knight of Order of Saint John of
Workshop on Biological Barriers –
Jerusalem (KSJ), Services to the
in vitro Tools, Nanotoxicology, and
Community, Knights Hospitaller
Nanomedicine, Fluorescence Lifetime
acceptance and mentoring of Pharmacy elective students, School
Imaging (FLIM) and Its Application On
Skin, Saarland University, Saarbrücken,
Germany
Australia’s National Industrial Chemicals
Notification and Assessment Scheme –
NICNAS, Dermal Absorption, Sydney
Modelling & Simulation, Topical drug
Preceptor of the Year, For microscopy and FLIM imaging, Saarland
Professor MS Roberts
Novartis Pharma AG: Development,
Dr Jeffrey Grice
in skin and liver in vivo using multiphoton
University, Saarbrücken, Germany
zinc oxide penetration in human skin in
Professor Michael Roberts, FLIM 2010, Studies on dynamic changes
National & International Presentations
intact excised skin. Further studies on
Awards & Prizes
and Fluorescence Lifetime Techniques:
Australian Health and Medical Research
Congress, Unraveling drug disposition in
organs using 4D imaging and impulseresponse modelling, Melbourne
Dr Peter Kruger
8th world congress on Trauma, Shock,
Inflammation and Sepsis, Statins
in sepsis: the first clinical results.
(International invited speaker) Munich,
Germany
Heinrich Heine University, Statins in
sepsis. (International invited guest)
Dusseldorf, Germany
of Pharmacy, University of Manitoba,
Winnipeg, Canada
Centres for Health Research 2010 Annual Research Report
127
12th International Conference
on Perspectives in Percutaneous
Penetration, Chemical enhancer-induced
changes in the endogenous fluorophore,
NAD(P)H within keratinocytes, La Grande Motte, France
Dr Xin Liu
23rd Annual Meeting of the EuropeanSociety-of-Intensive-Care-Medicine,
Clearance of antibiotics by high and low
intensity continuous renal replacement
therapy in critically ill patients,
Therapeutics Research Centre Group
Barcelona
Australasian Pharmaceutical Science
Physiotherapy Association Education
lesion or non-lesion sites in the skin of
meeting, Acute management of
volunteers with psoriasis or dermatitis,
Tetraplegia - - pitfalls, case studies &
La Grande Motte, France
of cyclosporine A on hepatic disposition
OECD Nanomaterials Testing Workshop,
imaging, (oral presentation) Brisbane
respiratory failure, Brisbane
Association Annual Conference, Effect
of rhodamine 123 in rat by in vivo
ANZICS clinical trials group, winter
Zinc Oxide Nanoparticle Sunsceens and
research forum, (i) STATInS in sepsis
Compromised Volunteer Skin, Sydney,
RCT– an update, (ii) Pandemic
October
8th International Conference and
Hosts, pathogens and their interactions
Synthetic Hectorite Nanoparticles do
at the mucosal barrier: evolution,
not Penetrate Excised Human Skin,
ANZICS / ACCCN National Scientific
epidemiology, mechanisms &
Saarbrücken, Germany
Meeting, Statins in Sepsis – clinical
interventions Symposium, Microfibre
results, (National invited speaker),
delivery for therapeutic, prophylactic and
Melbourne
diagnostic purposes (Invited Speaker),
influenza – Shovel ready RCT’s.,
Creswick, Victoria
ANZICS clinical trials group Spring
research forum, STATInS in sepsis RCT–
an update, Melbourne
Dr Tarl Prow
8th International Conference and
Workshop on Biological Barriers, Zinc
oxide nanoparticles from sunscreens do
Sansom Institute for Health Research,
Nanoparticle Penetration and NAD(P)
H Effects in the Skin of Volunteers,
Brisbane, December
8th International Conference and
Workshop on Biological Barriers,
128
research - key to health
Society for Burn Injuries, Antibiotic
acute thermal injury, Istanbul, Turkey
Association (APSA) conference, Silver
dermatitis Saarbrücken, Germany
from sunscreens do not penetrate
15th Congress of the International
2010 Australian Pharmaceutical Science
SKIN of volunteers with psoriasis or
Penetration, Zinc oxide nanoparticles
Dr Kanchana Ranasinghe
transport into Keratinocytes with
Dr Jeff Grice
on Perspectives in Percutaneous
Workshop on Biological Barriers, Topical
University of South Australia, Adelaide
not penetrate lesionAL or non-lesionAL
12th International Conference
Ms Michelle Wu
Chemical enhancer-induced changes in the endogenous fluorophore, NAD(P)H within keratinocytes,
Saarbrücken, Germany
administered resuscitation fluids in
Trauma Service
The Trauma Service Department expanded clinical service delivery,
education and research throughout the year. The department’s goal was
to provide evidence based practice that achieves optimum care for multiinjured patients by engaging all hospitals throughout the Metro South
Health Service District in education that best achieves that goal as well as
influencing Statewide delivery of acute care to multi-trauma patients.
The department restructured the existing team and model of care to
enhance patient care. The realignment of existing staff within the Trauma
Service as well as the establishment of new roles to meet the needs of
the Trauma Service in moving forward has been developed, ensuring that
the key objectives of the Queensland Health Strategic Plan 2007-2012 are
met in improving patient care, safety and patient outcomes, and better
meeting peoples’ needs across the health continuum, and in aligning with Royal Australasian College of Surgeons recommendations to achieve these aims.
Michael Schuetz
The basic research components remain focussed on fracture healing and the influence of severe soft tissue
injuries, carried out at QUT’s Institute of Health and Biomedical Innovation (IHBI). In 2011 the Trauma Service’s
goal is to establish a stronger clinical aspect of trauma research.
This year governance meetings between the Royal Darwin Hospital (RDH) and Princess Alexandra Hospital
(PAH) continued along with successful nurse rotations to Darwin. Through the National Critical Care and Trauma
Response Centre agreement a first round of research grants was offered to RDH and PAH for collaborative
research projects in the field of trauma/disaster management.
Professor Michael Schuetz
Director
Dr Tom O’Rourke
Deputy Director
Research Activities
Clinical Trials
plate versus the gold standard in an in
Role of mechanical stability in
Determinants of internal fixation
vivo model of fracture healing.
metaphyseal fracture healing in mice
stability and healing outcome (Epari
DW, Schuetz MA). The aims of this
project are to: (i) Determine the in vitro
stiffness characteristics of an internal
fixator configured according to best
clinical practise and compare with
previously determined optimal values.
(ii) Investigate the influence of modifying
the internal fixator configuration on the
stiffness characteristics to optimise the
fixation stability and (iii) Evaluate the
performance of an optimally configured
Establishing a non-invasive method for
assessing the musculoskeletal loading
of the lower limb during the golf swing
(Epari DW, Cole M, Kerr G). The primary
aim of this study is to establish a
non-invasive method to determine the
musculoskeletal loading of the lower
(Steck R, Histing T, Gregory L). This
project aims to characterise the
physiological mechanical environment
of the intact distal femur of the mouse
from evaluation of high resolution
dynamic radiographs, as well as using
FE analyses and mechanical testing.
limb (hip and knee contact forces)
3D reconstruction of the orbita from 3T
during the golf swing addressing the
MRI as an alternative to CT (Schmutz
influence of club head speed, type of
B, Lynham A, Coulthard A, Rahmel B,
club and position (stance).
Schuetz M). The objective of this study
Centres for Health Research 2010 Annual Research Report
129
is to design MRI acquisition protocols
Proteins (BMPs) are currently under
Development of Integrated Trauma
for imaging the orbita that reproduce
clinical evaluation; however the costs
Management System for Head Injury
the 3D bone geometry obtained from
associated with high doses required
(Chattopadhyay G, Mishra S, Rashford
CT images. It will further quantify and
to stimulate healing are likely to
S, Schuetz M, Kemsley J, Halder S,
compare the accuracy that can be
be unsustainable to overburdened
Toft Y). The project aim to develop a
achieved by using MRI data instead of
healthcare systems. The applicants
risk and cost assessment model and
CT data for the virtual 3D reconstruction
propose that by greater understanding
Decision Support System (DSS) based
of the orbita. Looking to quantify the
of tissue regeneration using BMP on real time patient condition, resource,
increase in the relative amount of
loaded scaffolds the clinical dose and
logistics and environmental conditions
manual segmentation time of MR-based
hence cost of using BMPs may be
for head injury trauma cases and to
images compared to CT based images.
reduced, consequently making the
provide timely and relevant information
system more feasible.
and help in decision making with ‘what
Establishment of an experimental small
if’ scenarios for better coordination and
animal model that enables research for
An innovative system for accurate
improving the prevention, assessment
bending of fracture fixation plates in
and treatment of traumatic soft tissue
orthopaedic surgery (Yarlagadda PK,
injuries (Steck R). The aim of this project
Schmutz B, Gu Y, Schuetz MA). The
is to develop a soft tissue impaction
novel system developed in this project
device and to develop methods for the
will not only shorten surgical procedures
non-invasive in vivo monitoring of the
but also result in anatomically better
progression of the soft tissue injury. It
fitting plates which will improve the
Business Process Management Analysis
will also look at establishing techniques
functional outcome and reduce the
of Trauma Patients in an Emergency
for the post mortem histological
need for surgical implant removal. It will
Department (Clements S, Schuetz M,
assessment of experimental soft tissue
further lessen degenerative changes in
Rosemann M, Sinnott M, Hofstede A).
injuries and perform a baseline in vivo
adjacent joints as a result of incorrect
The project aims to use established
animal experiment to characterise
fracture alignment. It can be expected
process modelling techniques and
the recovery of rat hind limbs after
that these improvements in surgical
tools to design an intuitive end-to-
soft tissue injury by applying methods
techniques will translate into reduced
end process model that facilitates the
developed above.
healthcare expenditure and ensure
re-design of current trauma practices.
patients quality of life.
The objective is to understand and
Other Research
planning for optimal management under
competing risk conditions based on real
time information. This will be achieved
by developing a prototype for an
Integrated Trauma Management System
for multi injured patients.
comprehensively improve the processes
Development and characterization
Understanding the biomechanical
of a technology platform to study
effects of fixation strategies to improve
the mechanisms of scaffold/BMP
the technology of fracture management
augmented large segmental bone
(Chen G, Mishra S, Schuetz M, Perren
healing (Hutmacher DW, Schuetz MA,
S M). This project will study the
Epari DR, Saifzadeh S, Knackstedt MA,
regulation of fracture healing by fixation
Duda G). Large bone defects remain
devices, using finite element analysis to
a challenging situation in orthopaedic
characterise their biomechanical effects.
trauma and tumour management. The
While the mechanical environment is
Reducing the incidence of screw
field of tissue engineering has already
critical to the healing process, neither
jamming in locked compression plates
demonstrated its enormous potential
the optimal conditions nor those created
(Lutton C, Perren S, Schuetz M).
with the successful transplantation in
by each fixation strategy have been
human. The field is a multidisciplinary
defined. Hence, the innovative, validated
one relying heavily on biomaterials and
models created will be a major step
cellular processes. Tissue engineering of
towards practical applications of the
bone is one of the favoured topics in the
technology, enabling refinements in
research community. Bone Morphogenic
fixation methods and device design.
130
research - key to health
involved with multi-trauma patients,
and the main outcome will be a highly
intuitive reference model encapsulating
guidance for the re-design of the current
processes leading to measurable
improvements for all involved
stakeholders.
Major Grants & Financial Support
Competitive funding:
$543,150
Upper Gastrointestinal
& Soft Tissue
The department treats patients with oesophagogastric disease, including
oesophageal and gastric cancer, and benign conditions such as gastrooesophageal reflux, Barrett’s oesophagus and achalasia. It is the largest
referral unit for oesophagogastric cancer in Australia, all of which is
documented and maintained in a prospective database.
A large proportion of patients seen have a malignant cancer. The
department conducts multi-disciplinary meetings and clinics for these
patients in conjunction with General Surgeons, Medical Oncologists,
Radiation Oncologists and Allied Health. All data on these patients
Mark Smithers
are collected in a prospective database. The department is involved in
local, national and international clinical trials. A phase II clinical trial in
oesophageal cancer that was initiated by one of our clinician’s in 2009
was successful in obtaining NHMRC funding in 2010. This funding will enable the group to conduct this study in a
number of facilities throughout Australia in 2011.
The department is also experienced in advanced Upper Gastrointestinal laparoscopic surgery all of which is
documented (including progressive quality of life assessment) and maintained in a prospective database.
Associate Professor B Mark Smithers
Director
Upper GI and Soft Tissue Unit
Chairman, Queensland Melanoma Project
Research Activities
Clinical Trials
Intermediate and high risk localized,
A randomised Phase II trial of pre-
after surgery and give them a more
completely resected, gastro-intestinal
operative Cisplatin, 5 Fluorouracil and
intense course of therapy trying to
stromal tumours (GIST) expressing KIT
Docetaxel or Cisplatin, 5 Fluorouracil,
improve the survival from the disease.
receptor: a controlled randomised trial
Docetaxel plus radiotherapy based
on adjuvant Imatinib mesylate (Glivec)
on poor early response to standard
versus no further therapy after complete
Chemotherapy for resectable
surgery. Intergroup study (EORTC
adenocarcinoma of the oesophagus
62024) (Smithers BM, Gotley D, and/or OG Junction (Barbour A, Walpole
Barbour A, Walpole E, Thomson D,
E, Mai T, Smithers BM, Gotley D, Martin
Woodward N, Joubert W, Atkinson V).
I, Thomson D, Woodward N, Joubert
Assesses whether the use of the drug
W, Atkinson V, Burmeister B, Harvey
Glivec in patients who have had Gastro-
J). Using a PET scan after standard
Intestinal Stromal Tumours completely
chemotherapy, we aim to select patients
removed surgically.
who are likely to have a worse prognosis A randomised phase II/III trial of
preoperative chemoradiotherapy
versus preoperative chemotherapy for
resectable gastric cancer (Smithers
BM, Walpole E, Burmeister B, Barbour
A, Gotley D, Martin I, Thomson D,
Woodward N, Joubert W, Atkinson V,
Harvey J). The study aims to assess
whether the outcome from resectable
gastric cancer can be improved by
Centres for Health Research 2010 Annual Research Report
131
giving patients preoperative radiation as
(Smithers BM, Gotley D, Martin I,
who have undergone a redo hiatus
well as the standard chemotherapy.
Barbour A).
hernia repair. The database currently has
Comparison of pre and peri-operative
Gastric Cancer Database: Established
immunonutrition to standard formula in
in 2006 data has been collected both
patients undergoing surgical resection
retrospectively and prospectively since
for oesophageal cancer (Smithers
2000. The database currently has 450
BM, Gotley DC, Barbour AP, Martin
patients who have been diagnosed with
I). NHMRC sponsored trial assessing
gastric cancer. (Barbour A, Smithers
whether the peri-operative use of a
BM, Gotley D, Martin I).
form of immune-nutrition will decrease
the infective complications after
oesophagectomy for cancer. Presently
accruing patients.
Gastro-intestinal Stromal Tumour
550 patients with quality of life in over
85% of patients. (Gotley D, Smithers
BM, Martin I, Barbour A).
Major Grants & Financial Support
$1,800
Total NHMRC funding:
Competitive funding:
$83,500
Funding from other
sources:
$24,850
Database: Established in 2006 data has
National & International Presentations
been collected both retrospectively and
Associate Professor Andrew Barbour
prospectively since 2000. The database
AGITG Annual Scientific Meeting
Basic Research Projects
currently has 110 patients diagnosed
Whether inhibition of the shh pathway
with GISTs. (Smithers BM, Gotley D,
represents a potential therapeutic target
Martin I, Barbour A).
Oesophageal Surgeons Association
High Grade Dysplasia Database:
New Zealand
in gastric cancer (Barbour A, Gotley
D, Woodhall E). A Cancer Council
Queensland funded project that aims
to perform genome wide studies of
oesophageal cancer primary tumours
using microarray technology. We have
performed high resolution DNA copy
number analyses to date with mRNA
expression and DNA methylation studies
to be done in 2011. Biomarker discovery
is ongoing.
The identification and characterisation of
cancer stem cells in oesophagogastric
cancer cell lines (Barbour A, Gotley
D, Woodhall E). We have isolated
subpopulations of cancer cells with
stem cell-like behaviour: slower growing
and resistant to standard doses of
chemotherapy. DNA copy number
analyses have been undertaken.
Other Research
Oesophageal Cancer Database and
Quality of Life: Established in 1997 the
database currently has 1862 patients
who have been diagnosed with cancer
of the oesophagus or OG Junction.
Quality of Life has been conducted on
all curative intent patients at baseline,
3, 6, 9, 12, 18, 24, 36, 48 & 60 months.
132
research - key to health
Established in 2006 data has been
collected both retrospectively and
prospectively since 2000. The database
currently has 95 patients diagnosed with
HGD. (Smithers BM, Gotley D, Martin I,
Barbour A).
Laparoscopic Fundoplication
Database: Established in 1991 data
has been collected prospectively on all
patients undergoing a Laparoscopic
Fundoplication. The database currently
has 4400 patients with quality of life on
approximately 88% of patients. (Gotley
D, Smithers BM, Martin I, Barbour A).
Para-oesophageal Hernia Repair
Database: Established in 1991 data
Australian and New Zealand GastroAnnual Scientific Meeting, Queenstown,
Professor David Gotley
Adelaide Surgical Seminars, Adelaide,
Australia
Associate Professor Bernard Mark
Smithers
Annual Scientific Congress, Royal
Australiasian College of Surgeons,
Perth, Australia
Australian and New Zealand GastroOesophageal Surgeons Association
Annual Scientific Meeting, Queenstown,
New Zealand
International Society for the Diseases of
the Esophagus, Kagoshima, Japan
has been collected prospectively on all
3rd Asia Pacific Gastro-esophageal
patients who have undergone a repair
Cancer Congress, Kuala Lumpur,
of a para-oesophageal hernia. The
Malaysia
database currently has 730 patients with
quality of life in over 88% of patients.
(Gotley D, Smithers BM, Martin I,
Barbour A).
Redo Hiatal Surgery Database:
Established in 1991 data has been
collected prospectively on all patients
The 3rd MATTU Oesophago-Gastric
Cancer Symposium, Guilford, England
Vascular Medicine
The Vascular Medicine Department provides clinical and diagnostic services for patients with disorders of
the arterial, venous and lymphatic circulations. Research activities include participation in clinical trials and
investigation of vascular diagnostic techniques.
Departmental staff published one article and six abstracts in peer reviewed journals and were invited to speak at a
number of local and international meetings
Dr Andrew McCann
Director
Research Activities
Clinical Trials
ADOPT: Apixaban Dosing to Optimize
Protection from Thrombosis. A phase
III Randomized, Double-blind, Parallelgroup, Multi-centre Study of the Safety
and Efficacy of Apixaban for Prophylaxis
of Venous Thromboembolism in Acutely
Ill Medical Subjects During and
Following Hospitalization.
EINSTEIN VTE Study 11702. A multicentre, randomised, open-label,
assessor-blind, non-inferiority program
for efficacy 3, 6 or 12 month treatment
for acute symptomatic DVT or PE,
comparing the safety and efficacy of
Rivaroxaban compared to standard
treatment of warfarin/Enoxaparin.
AMPLIFY. A multicentre, randomised,
double-blind safety and efficacy trial
evaluating the use of Apixaban in the
treatment of symptomatic deep vein
thrombosis and pulmonary embolism.
REMEDY. A phase III, randomised,
multicenter, double-blind, parallel-group,
active controlled study to evaluate the
efficacy and safety of oral dabigatran
etexilate (150 mg bid) compared to
warfarin (INR 2.0-3.0) for the secondary
prevention of venous thromboembolism
AMPLIFY EXTENSION. A multicentre,
randomised, double-blind, placebocontrolled study evaluating the safety
and efficacy of the use of Apixaban for
the extended treatment of deep vein
thrombosis and pulmonary embolism.
ASPIRE - NHMRC: (ASPIrin to prevent
REcurrent venous thromboembolism).
A multi-centre, randomised, doubleblind, placebo-controlled clinical trial
examining the efficacy and safety
of low-dose aspirin after initial oral
anticoagulation to prevent recurrent
venous thromboembolism.
Tra2P TIMI 50: A Multicenter,
Randomized, Double-blind, Placebo
controlled Study to Evaluate the
Safety and Efficacy of Care in Subjects
with a History of Atherosclerotic
Disease: Thrombin Receptor
Antagonist in Secondary Prevention of
Atherothrombotic Ischaemic Events.
National & International Presentations
R Collins
VTE Champions Weekend: Invited
Speaker and Scholarship committee
member
2nd EFORT Orthopaedic Asia
Symposium, Invited Speaker, Taiwan
Dr Andrew McCann
International Medical Society of
Australia and New Zealand –Royal
Australasian College of Physicians
Queensland: Venous thromboembolism
Update
Vascular Medicine Group
Major Grants & Financial Support
Total NHMRC funding:
Funding from other
sources:
$2,000
$120,565
CRUX biomedical evaluation of the Crux
Inferior Vena Cava Filter System.
Centres for Health Research 2010 Annual Research Report
133
Publications, Major Grants
& People
T4 – Translation to population health:
Moving scientific discoveries into the community. Researchers study factors and interventions that
influence the health of populations, ultimately leading to improved global health.
T4
T1
Discovery
to Application
Application
to Evidence
Evidence
to Health
Practice
T2
T3
Journal Articles

Abeyratne UR, Swarnkar V, Hukins C, Duce

Altamura D, Menzies SW, Argenziano
B. Interhemispheric asynchrony correlates
G, Zalaudek I, Soyer HP, Sera F, et al.
with severity of respiratory disturbance index
Dermatoscopy of basal cell carcinoma:
in patients with sleep apnea. IEEE Trans
Morphologic variability of global and local
Biomed Eng. 2010 Dec;57(12):2947-55.
features and accuracy of diagnosis. J Am
Acad Dermatol. 2010 Jan;62(1):67-75.

Acelajado MC, Pimenta E, Calhoun DA. Salt
and aldosterone: a concert of bad effects.
Hypertension. 2010 Nov;56(5):804-5.

Andrieu C, Taieb D, Baylot V, Ettinger S,
Soubeyran P, De-Thonel A, et al. Heat
shock protein 27 confers resistance to

Agar JWM, Hawley CM, George CRP,
androgen ablation and chemotherapy
Mathew TH, McDonald SP, Kerr PG. Home
in prostate cancer cells through eIF4E.
haemodialysis in Australia - is the wheel
Oncogene. 2010 Apr 1;29(13):1883-96.
Ian Frazer
turning full circle? Med J Aust. 2010
Apr;192(7):403-6.

Antalis TM, Buzza MS, Hodge KM,

Aung CS, Hill MM, Bastiani M, Parton
Hooper JD, Netzel-Arnett S. The
cutting edge: membrane-anchored serine
RG, Parat MO. PTRF-cavin-1 expression
Pimenta E, Stowasser M. Effect of atenolol
protease activities in the pericellular
decreases the migration of PC3
on aldosterone/renin ratio calculated by
microenvironment. Biochem J. 2010 Jun
prostate cancer cells: role of matrix
both plasma Renin activity and direct Renin
15;428(3):325-46.
metalloprotease 9. Eur J Cell Biol. 2010 Feb-

Ahmed AH, Gordon RD, Taylor P, Ward G,
Mar;90(2-3):136-42.
concentration in healthy male volunteers. J
Clin Endocrinol Metab. 2010 Jul;95(7):3201-6.

Askew DA, Jackson CL, Ware RS, Russell
A. Protocol and baseline data from The

Avent ML, Pattullo C, Dines A, Martin J,
Inala Chronic Disease Management
Kubler P. Drug Use Evaluation Services
Stowasser M. Is the phase of the menstrual
Service evaluation study: a health services
in Australia and New Zealand: A
cycle important when screening for primary
intervention study for diabetes care. BMC
Neglected Area of Research? . Journal of
aldosteronism (PAL) in women, and does
Health Serv Res. 2010;10:134.
Pharmacy Practice and Research. 2010

Ahmed AH, Gordon RD, Taylor P, Ward G,
March;40(1):15-8.
renin assay method matter? Hypertension.
2010 June;55(6):1494 (007).

Askew DA, Jackson CL, Ware RS, Russell
A. Study protocol Protocol and baseline

Baade PD, Green AC, Smithers BM,
data from The Inala Chronic Disease
Aitken JF. Trends in melanoma incidence
impact of nursing rounds on nurses'
Management Service evaluation study:
among children: possible influence of sun-
perceptions of the practice environment.
a health services intervention study for
protection programs. Expert Rev Anticancer
ACC. 2010;23(1):33.
diabetes care. BMC Health Serv Res. 2010
Ther. 2010 May;11(5):661-4.

Aitken L, Burmeister E, Clayton S. The
May;10:9.

Baade PD, Herrero Hernandez E, Freedman

Aitken LM. Improving long-term patient
outcomes following intensive care. Nurs Crit

Assimes T, Holm H, Kathiresan S, Reilly
DM, Smithers BM, Fritschi L. No role for
M, Thorleifsson G, Voight B, et al. Lack
melanoma treatment in the association
of association between the Trp719Arg
between melanoma and amyotrophic
polymorphism in kinesin-like protein-6 and
lateral sclerosis or Parkinson's disease.
W, Richmond TS. Characteristics and
coronary artery disease in 19 case-control
Neuroepidemiology. 2010;35(4):303-4.
Outcomes of Injured Older Adults After
studies. J Am Coll Cardiol. 2010 Nov
Hospital Admission. J Am Geriatr Soc. 2010
2;56(19):1552-63.
Care. 2010 Mar-Apr;15(2):47-8.

Aitken LM, Burmeister E, Lang J, Chaboyer

Badve SV, Beller E, Cass A, Francis
DP, Hawley C, Macdougall IC, et al.
Mar;58(3):442-9.

Astuti P, Boutros R, Ducommun B, Gabrielli
Interventions for erythropoietin-resistant
BG. Mitotic phosphorylation of Cdc25B
anaemia in dialysis patients (Protocol).
S. Critical care nurses' decision making:
Ser321 disrupts 14-3-3 binding to the high
Cochrane Database of Systematic Reviews.
sedation assessment and management
affinity Ser323 site. J Biol Chem. 2010 Nov
2010(1):Art. No.: CD006861.
in intensive care. J Clin Nurs. 2010
5;285(45):34364-70.

Aitken LM, Marshall AP, Elliott R, McKinley
Jan;18(1):36-45.
Centres for Health Research 2010 Annual Research Report
135

Bahlo M, Stankovich J, Danoy P, Hickey PF,

Baumgartner L, Vivanti A, Smithers M.

Bird D, Oldenburg B, Cassimatis M, Russell
Taylor BV, Browning SR, et al. Saliva-derived
Improved energy intake of patients post
A, Ash S, Courtney MD, et al. Randomised
DNA performs well in large-scale, high-
oesophagectomy and gastrectomy receiving
controlled trial of an automated, interactive
density single-nucleotide polymorphism
high energy jejunal feeds. Complete
telephone intervention to improve type 2
microarray studies. Cancer Epidemiol
Nutrition. 2010;5(2):29.
diabetes self-management (TelephoneLinked Care Diabetes Project): study
Biomarkers Prev. 2010 Mar;19(3):794-8.

Baxi S, Deb S, Weedon D, Baumann K,

Bandara Gawarammana I, Roberts DM,
protocol. BMC Public Health. 2010;10:599.
Poulsen M. Microcystic adnexal carcinoma

Blumenthal A, Trujillo C, Ehrt S,
Mohamed F, Roberts MS, Medley G,
of the skin: the role of adjuvant radiotherapy.
Jayamanne S, et al. Acute human self-
J Med Imaging Radiat Oncol. 2010
Schnappinger D. Simultaneous analysis
poisoning with bispyribac-containing
Oct;54(5):477-82.
of multiple Mycobacterium tuberculosis
knockdown mutants in vitro and in vivo.
herbicide Nominee: a prospective
observational study. Clin Toxicol (Phila). 2010
Mar;48(3):198-202.

Bennett IC. Outcomes of multimodality
risk of familial breast cancer: Reply to Letter.

Barbour AP, Jones M, Brown I, Gotley DC,
World J Surg. 2010;34(11):2788-9.

Bennett IC, Muller J, Cockburn L, Joshua
analysis of lymphatic spread and
H, Thorley G, Baker C, et al. Outcomes of
prognostic factors. Ann Surg Oncol. 2010
multimodality breast screening for women
Sep;17(9):2494-502.
at increased risk of familial breast cancer.
World J Surg. 2010 May;34(5):979-86.
Evans S, Pilcher DV, Scott I, et al. Data
potential problems. BMC Health Serv Res.
2010;10:346.

Bordador EB, Johnson DW, Henning P,
Kennedy SE, McDonald SP, Burke JR, et al.
Epidemiology and outcomes of peritonitis in

Barraclough K, Hawley CM, McDonald
SP, Brown FG, Rosman JB, Wiggins KJ, et

Bohensky MA, Jolley D, Sundararajan V,
linkage: a powerful research tool with
Martin I, Thomas J, et al. Risk stratification
for early esophageal adenocarcinoma:
PLoS One. 2010;5(12):e15667.
breast screening for women at increased

Bennett NC, Gardiner RA, Hooper JD,
al. Polymicrobial Peritonitis in Peritoneal
Johnson DW, Gobe GC. Molecular cell
Dialysis Patients in Australia: Predictors,
biology of androgen receptor signalling.
Treatment, and Outcomes. Am J Kidney Dis.
International Journal of Biochemistry & Cell
2010 Jan;55(1):121-31.
Biology. 2010 Jun;42(6):813-27.
children on peritoneal dialysis in Australasia.
Pediatr Nephrol. 2010 Sep;25(9):1739-45.

Brennan S, Corry J, Kleid S, Porceddu S,
Yuen K, Rischin D, et al. Prospective trial to
evaluate staged neck dissection or elective

Barraclough KA, Isbel NM, Franklin ME,

Bennett S, Purcell A, Meredith P, Beller
Lee KJ, Taylor PJ, Campbell SB, et al.
E, Haines T, Fleming J. Educational
staged T1-2 N0 squamous cell carcinoma
Evaluation of Limited Sampling Strategies
interventions for the management of
of the oral tongue. Head Neck. 2010
for Mycophenolic Acid After Mycophenolate
cancer-related fatigue in adults (Protocol).
Feb;32(2):191-8.
Mofetil Intake in Adult Kidney Transplant
Cochrane Database of Systematic Reviews.
Recipients. Ther Drug Monit. 2010
2010(4):CD008144.
neck radiotherapy in patients with CT-

Brook NR, Gibbons N, Johnson DW, Nicol
DL. Outcomes of transplants from patients
Dec;32(6):723-33.

Bertin-Maghit S, Pang D, O'Sullivan B, Best
with small renal tumours, live unrelated
S, Duggan E, Paul S, et al. Interleukin-1beta
donors and dialysis wait-listed patients.
Evaluation of the Mycophenolic Acid
produced in response to islet autoantigen
Transpl Int. 2010 May;23(5):476-83.
Exposure Estimation Methods Used in the
presentation differentiates T-helper
APOMYGERE, FDCC, and Opticept Trials.
17 cells at the expense of regulatory
Transplantation. 2010 Jul;90(1):44-51.
T-cells: Implications for the timing of
TJ, Leggatt GR, Frazer IH. Antigen-specific
tolerizing immunotherapy. Diabetes. 2010
CD4 cells assist CD8 T-effector cells in
Jan;60(1):248-57.
eliminating keratinocytes. J Invest Dermatol.

Barraclough KA, Isbel NM, Staatz CE.

Barraclough KA, Playford EG. Hepatitis B
2010 Jun;130(6):1581-9.
virus infection in hemodialysis populations:
progress toward prevention. Kidney Int.
2010 Feb;77(3):177-80.

Broom JK, Lew AM, Azukizawa H, Kenna

Bianco-Miotto T, Chiam K, Buchanan G,
Jindal S, Day TK, Thomas M, et al. Global

Brown CY, Sadlon T, Gargett T, Melville E,
levels of specific histone modifications
Zhang R, Drabsch Y, et al. Robust, reversible
and an epigenetic gene signature
gene knockdown using a single lentiviral
McTaggart SJ. Pharmacodynamic
predict prostate cancer progression and
short hairpin RNA vector. Hum Gene Ther.
monitoring of immunosuppression in
development. Cancer Epidemiol Biomarkers
2010 Aug;21(8):1005-17.
kidney transplantation. Nephrology. 2010
Prev. 2010 Oct;19(10):2611-22.

Barraclough KA, Staatz CE, Isbel NM,
Aug;15(5):522-32.

Brown E. Evaluation of a Sinmed Shoulder
Support Cushion for Head and Neck
Immobilisation. Radiographer. 2010
2010;57(3):12-6.
136
research - key to health

Brown MA. Genetics of ankylosing

Casey SJ, de Alwis WD. Review article:

Campbell KL, MacLaughlin HL.
Emergency department assessment and
spondylitis: Review. Curr Opin Rheumatol.
Unintentional Weight Loss Is an
2010 Mar;22(2):126-32.
Independent Predictor of Mortality in a
management of stab wounds to the neck.
Hemodialysis Population. Journal of Renal
Emerg Med Australas. 2010 Jun;22(3):201-10.

Brown NW, Franklin ME, Einarsdottir
Nutrition. 2010;20(6):414-8.

Charlton HK, Webster J, Kruger S, Simpson
EN, Gonde CE, Pires M, Taylor PJ, et al.
An investigation into the bias between

Campbell LA, Kisely S. Prescribing preferred
F, Richards AA, Whitehead JP. ERp46
liquid chromatography-tandem mass
medications improves adherence in people
binds to AdipoR1, but not AdipoR2,
spectrometry and an enzyme multiplied
with severe mental illness. Evid Based Ment
and modulates adiponectin signalling.
immunoassay technique for the
Health. 2010 Nov;13(4):108.
Biochem Biophys Res Commun. 2010 Feb
5;392(2):234-9.
measurement of mycophenolic acid. Ther
Drug Monit. 2010 Aug;32(4):420-6.

Campbell S, Hawley C, Irish A, Hutchison B,
Walker R, Butcher BE, et al. Pre-transplant

Chen G, Schmutz B, Epari D, Rathnayaka
pharmacokinetic profiling and tacrolimus
K, Ibrahim S, Schuetz MA, et al. A new
Harden HE, Colquist SP, Cossio DL, et al.
requirements post-transplant. Nephrology.
approach for assigning bone material
Lung cancer patients in Queensland suffer
2010 Oct;15(7):714-9.
properties from CT images into finite

Burmeister BH, Zarate DD, Burmeister EA,
element models. J Biomech. 2010
delays in receiving radiation therapy--but
not as a result of distance. Intern Med J.
2010 Feb;40(2):126-32.

Campbell-Lloyd AJ, Mundy J, Pinto N, Wood
Mar;43(5):1011-5.
A, Beller E, Strahan S, et al. Contemporary
results following surgical repair of acute

Chen SCA, Playford EG, Sorrell
type a aortic dissection (AAAD): a single
TC. Antifungal therapy in invasive
complications of giant cell arteritis: a
centre experience. Heart Lung Circ. 2010
fungal infections. Current Opinion in
diagnostic and management dilemma. J
Nov;19(11):665-72.
Pharmacology. 2010 Oct;10(5):522-30.

Butler N, Mundy J, Shah P. Aortic
Card Surg. 2010 Sep;25(5):572-81.

Carrington C, Stone L, Koczwara B, Searle

Chen X, Kask AS, Crichton ML, McNeilly
C. Development of guidelines for the safe
C, Yukiko S, Dong L, et al. Improved DNA
Sturtevant J. Off-label use of rituximab in a
prescribing, dispensing and administration
vaccination by skin-targeted delivery using
tertiary Queensland hospital. Intern Med J.
of cancer chemotherapy. Asia Pac J Clin
dry-coated densely-packed microprojection
2010 Jun;40(6):443-52.
Oncol. 2010 Sep;6(3):213-9.
arrays. J Control Release. 2010 Dec

Butterly SJ, Pillans P, Horn B, Miles R,
20;148(3):327-33.

Callaway LK, Colditz PB, Byrne NM,

Carrington C, Stone L, Koczwara B, Searle

Chia K, Beamish H, Jafferi K, Gabrielli
Lingwood BE, Rowlands IJ, Foxcroft K, et al.
C, Siderov J, Stevenson B, et al. The
Prevention of gestational diabetes: feasibility
Clinical Oncological Society of Australia
B. The histone deacetylase inhibitor
issues for an exercise intervention in obese
(COSA) guidelines for the safe prescribing,
MGCD0103 has both deacetylase and
pregnant women. Diabetes Care. 2010
dispensing and administration of cancer
microtubule inhibitory activity. Mol
Jul;33(7):1457-9.
chemotherapy. Asia Pac J Clin Oncol. 2010
Pharmacol. 2010 Sep;78(3):436-43.
Sep;6(3):220-37.

Chirila TV, Madden PW, Hirst LW.

Calleja P, Aitken LM, Cooke ML. Information
transfer for multi-trauma patients on

Carrington C, Weir J, Do C. Study to
Replacement of the corneal endothelium
discharge from the emergency department:
support the standardization of the
and the conceptual framework for an
mixed-method narrative review. Journal of
prescribing, dispensing and labelling of
artificial substitute. J Biomim Biomater
Advanced Nursing. 2010;67(1):4-18.
etoposide formulations in Australia. Asia Pac
Tissue Eng. 2010;5:13-29.
J Clin Oncol. 2010 Sep;6(3):173-86.

Cho Y, Mills K, Sturtevant JM, Pillans PI,

Cameron ID, Crotty M, Gray L, Kurrle SE,
Peel NM, Monaghan N, et al. Whither

Carroll ML, Yerkovich ST, Pritchard AL,
Mudge DW. Dabigatran may not be an
transition care. Australas J Ageing. 2010
Davies JM, Upham JW. Adaptive immunity
effective anticoagulant for haemodialysis.
Dec;29(4):147-9.
to rhinoviruses: sex and age matter. Respir
Nephrology (Carlton). 2010 Aug;15(5):594-5.
Res. 2010;11:184.

Chong BH, Gan E, Bird R, Pidcock M, Lloyd

Cameron SR, Dahler AL, Endo-Munoz LB,
Jabbar I, Thomas GP, Leo PJ, et al. Tumor-

Carty ML, Wixey JA, Kesby J, Reinebrant
J, Tay L, et al. An open-label, multicenter
initiating activity and tumour morphology
HE, Colditz PB, Gobe G, et al. Long-term
study evaluating the efficacy and safety of a
of HNSCC is modulated by interactions
losses of amygdala corticotropin-releasing
new 10% liquid intravenous immunoglobulin
between clonal variants within the tumor.
factor neurons are associated with
in patients with primary immune
Lab Invest. 2010 Nov;90(11):1594-603.
behavioural outcomes following neonatal
thrombocytopenia (ITP). Asia Pac J Oncol
hypoxia-ischemia. Behav Brain Res. 2010
Hematol. 2010 August;2(2):7-12.
Apr 2;208(2):609-18.
Centres for Health Research 2010 Annual Research Report
137

Choong K, Walker NJ, Apel AJG, Whitby

Connor JP, Feeney GF, Jack A, Young RM.

Craig JC, Hawley C. Clinical research
M. Aciclovir-resistant herpes keratitis. Clin
The obsessive compulsive drinking scale
for nephrologists: a practical series.
Experiment Ophthalmol. 2010 Apr;38(3):
is a valid measure of alcohol craving in
Nephrology. 2010 Feb;15(1):7.
309-13.
young adults. Alcohol Clin Exp Res. 2010
Dec;34(12):2155-61.
X, Ling MT, et al. Differential expression of

Crawford DHG, Fletcher LM, Stuart KA.
Reply: Ferritin and Liver Allocation? Impact

Chua CW, Chiu YT, Yuen HF, Chan KW, Wang

Constantinescu G, Theodoros D, Russell
on Mortality Not Only on the Waiting List But
MSX2 in nodular hyperplasia, high-grade
T, Ward E, Wilson S, Wootton R. Assessing
Also After Orthotopic Liver Transplantation
prostatic intraepithelial neoplasia and
disordered speech and voice in Parkinson's
Should Be Considered. Hepatology.
prostate adenocarcinoma. APMIS. 2010
disease: a telerehabilitation application. Int 2010;52(1):393.
Dec;118(12):918-26.
J Lang Commun Disord. 2010 Nov;45(6):
630-44.

Crichton ML, Ansaldo A, Chen X, Prow TW,
Fernando GJ, Kendall MA. The effect of

Churchman A, O'Leary MA, Buckley NA,

Constantinescu GA, Theodoros DG, Russell
strain rate on the precision of penetration of
Clinical effects of red-bellied black snake
TG, Ward EC, Wilson SJ, Wootton R. Home-
short densely-packed microprojection array
(Pseudechis porphyriacus) envenoming
based speech treatment for Parkinson's
patches coated with vaccine. Biomaterials.
and correlation with venom concentrations:
disease delivered remotely: a case report. J
2010 Jun;31(16):4562-72.
Australian Snakebite Project (ASP-11). Med
Telemed Telecare. 2010;16(2):100-4.
Page CB, Tankel A, Gavaghan C, et al.

Crompton D, Groves A, McGrath J.
J Aust. 2010 Dec 6-20;193(11-12):696-700.

Cooke M, Mitchell M, Moyle W, Henderson
What can we do to reduce the burden of
A, Murfield J. Application and student
avoidable deaths in those with serious
tacrolimus toxicity from tibolone co-
evaluation of a Clinical Progression Portfolio:
mental illness? Epidemiol Psichiatr Soc.
administration in a woman: a case report. J
A pilot. Nurse Educ Pract 2010;10(4):227-32.
2010 Jan-Mar;19(1):4-7.

Clark CJ, Hawley CM, Mudge DW. Probable
Med Case Reports. 2010;4(1):276.

Coombes I, Avent M, Cardiff L, Bettenay K,

Dahiya A, Vollbon W, Jellis C, Prior D,
Coombes J, Whitfield K, et al. Improvement
Wahi S, Marwick T. Echocardiographic
PS, Kaiser M, Beveridge AJ, et al. Common
in Pharmacist's Performance Facilitated by
assessment of raised pulmonary vascular
variants near TERC are associated with
an Adapted Competency-Based General
resistance: application to diagnosis and
mean telomere length. Nat Genet. 2010
Level Framework. J Pharm Pract. 2010
follow-up of pulmonary hypertension. Heart.
Mar;42(3):197-9.
June;118(40 No. 2):111-8.
2010 Dec;96(24):2005-9.

Codd V, Mangino M, van der Harst P, Braund

Cohen J, Venkatesh B. Relative adrenal

Cooper BA, Branley P, Bulfone L, Collins

Dakin L, Gray L, Peel N, Salih S, Cheung V.
insufficiency in the intensive care
JF, Craig JC, Fraenkel MB, et al. A
Promoting walking amongst older patients
population; background and critical
Randomised, Controlled Trial of Early versus
in rehabilitation: Are accelerometers the
appraisal of the evidence. Anaesth Intensive
Late Initiation of Dialysis. N Engl J Med.
answer? J Nutr Health Aging. 2010:1-3.
Care. 2010 May;38(3):425-36.
2010 Aug;363(7):609-19.

Dakin L, Peel N. Effect of accelerometry on

Cohen J, Venkatesh B. When an effect

Corbett HJ, Fernando GJ, Chen X, Frazer
the functional mobility of older rehabilitation
is unclear, questioning its proposed
IH, Kendall MA. Skin vaccination against
inpatients as measured by functional
mechanism is appropriate. Crit Care
cervical cancer associated human
independence measure — Locomotion
Resusc. 2010 Mar;12(1):68.
papillomavirus with a novel micro-projection
(FIM) gain: A retrospective matched cohort
array in a mouse model. PLoS One.
study. The Journal of Nutrition, Health &
2010;5(10):e13460.
Aging. 2010:1-5.

Coles AJ. A Patient Presenting with an
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asthma: The next therapeutic frontier?
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soluble receptor for advanced glycation end
products in chronic obstructive pulmonary
disease. Eur Respir J 2010.

Varghese D, Scott J, Welham J, Bor
W, Najman JM, O'Callaghan M, et al.
Psychotic-like experiences in major

Thorberg FA, Young RM, Sullivan KA, Lyvers
depression and anxiety disorders: a
M, Connor JP, Feeney GF. Alexithymia,
population-based survey in young adults.
craving and attachment in a heavy drinking
Schizophr Bull 2010.
population. Addict Behav 2010.

Walker R, Cooke M, Henderson A, Creedy

Thorberg FA, Young RM, Sullivan KA, Lyvers
DK. Characteristics of leadership that
M, Hurst CP, Connor JP, et al. Alexithymia
influence clinical learning: A narrative review.
in alcohol dependent patients is partially
Nurse Educ Today 2010.
mediated by alcohol expectancy. Drug
Alcohol Depend 2010.

Waller A, Girgis A, Johnson C, Mitchell G,
Yates P, Kristjanson L, et al. Facilitating

Tong A, Lopez-Vargas P, Howell M, Phoon
needs based cancer care for people
R, Johnson D, Campbell D, et al. Consumer
with a chronic disease: Evaluation of an
involvement in topic and outcome selection
intervention using a multi-centre interrupted
in the development of clinical practice
time series design. BMC Palliat Care 2010.
guidelines. Healthy Expectations 2010.
166
Abuse Treat 2010.
Cancer-related symptom clusters for
research - key to health
Oncol 2010.
Summary of Publications
and Postgraduate Students
Departments (A to H)
Publications
Journal
Articles
Acquired Brain Injury
Student #
Departments (I to Z)
Publications
Journal
Articles
Student #
Abstracts
Articles
in press
Books/
Chapters
Postgraduate
Students
Articles in Books/
Abstracts
press
Chapters
Postgraduate
Students
3
0
6
1
1
Infection Management
19
2
1
8
0
Alcohol and Drug Research
7
0
1
1
3
Intensive Care
20
4
1
1
2
Anaesthetic Department
0
0
1
0
0
21
12
9
0
6
Australian Prostate
Cancer Research Centre Queensland
Internal Medicine &
Clinical Epidemiology
35
0
1
0
9
Medical Oncology
9
2
0
0
0
Mental Health
51
9
0
0
29
Brain Injury Rehabilitation
0
0
0
0
0
Microbiology
2
0
0
0
2
Breast and Endocrine
4
2
0
0
0
Neurosurgery
5
0
0
0
3
Cardiology
6
1
0
1
3
Nursing Practice Development
38
6
4
3
10
Cardiothoracic Surgery
5
1
0
0
1
Nutrition & Dietetics
11
14
4
0
6
Cardiovascular Imaging
Research Centre
43
40
0
0
12
Occupational Therapy
13
5
9
2
12
Centre for Functioning
& Health Research
Older Persons Mental Health
1
0
1
0
1
24
8
13
3
14
Ophthalmology
1
1
2
0
0
Centre for Integrative Clinical
and Molecular Medicine
7
7
1
2
8
Pathology Queensland
4
0
0
0
3
Pharmacy
9
3
0
0
8
Centre for Kidney Disease
Research
46
3
9
4
17
Physiotherapy
5
0
9
0
3
Centre for Liver Disease
Research
3
4
1
0
3
Centre for Research in
Geriatric Medicine
11
7
6
6
6
Clinical Governance
0
0
1
0
0
Clinical Pharmacology
10
6
3
0
0
Dermatology Research Centre
15
2
0
0
5
Diabetes and Endocrinology
36
1
1
0
6
Diamantina Institute for
Cancer, Immunology and
Metabolic Disorders
104
0
0
1
55
Ear Nose Throat
8
0
0
0
0
Emergency
12
0
0
0
4
Endocrine Hypertension
Research Centre
25
3
0
3
3
Gastroenterology &
Hepatology
8
0
2
0
Haematology
16
5
0
0
Plastics & Burns
0
4
0
0
1
Queensland Clinical Trials
& Biostatics Centre (QC TBC)
2
6
1
0
2
Queensland Melanoma
Project
2
3
0
0
1
Queensland Spinal Cord
Injuries Service
0
0
0
0
0
Radiation Oncology (Mater)
19
0
2
0
4
Radiation Oncology (PAH)
2
14
0
1
0
Radiology
3
0
0
0
0
Respiratory and Sleep
Medicine
20
19
0
1
3
Speech Pathology
1
0
0
0
1
Therapeutics Research Centre
28
10
0
3
13
Trauma Service
13
1
0
0
12
9
Upper Gastrointestinal &
Soft Tissue
7
0
4
0
2
1
Vascular Medicine
1
6
0
0
0
# Students supervised at the Princess Alexandra Hospital
Centres for Health Research 2010 Annual Research Report
167
Major Grants
Selected funds received in 2010 over $50,000 per grant
ARC/ARC Discovery
$270,000
Improving immune response to vaccines
(Kendall MA, Frazer IH, Roberts MS, Ambrosi DC)
$130,900
Food services in residential aged care:
financial, personnel and service delivery factors
(Wilson JE, Wright O, Hagney DG, Ward EC)
$124,970
The MYB gene as a model for global
transcriptional regulation: stopping, starting
and looping (Gonda T, Ramsay R, Brown M)
$124,325
Determinants of successful community
transition for individuals with ABI (Fleming J,
Worrall L, Cornwell P, Haines T, Kendall M,
$499,856
$288,497
Nursing interventions for hospitalised patients
Predicting the risk of invasive candidiasis
(Chaboyer W, Rickard C, Aitken L, Wallis M,
in critically ill patients (Sorrell TC, Lipman J,
Webster J, Cooke M, Thalib L, Scuffham P,
Playford EG, Jones M, Iredell JR, Paterson D,
Doran D, Cullum N)
Marriott D)
$471,000
$288,392
Toxicology of Nanomaterials (Minchin RF,
Telephone Counselling For Maintenance of
Roberts MS, Martin DJ, Smith SV, Monteiro
Physical Activity, Weight Loss & Glycaemic
MJ, Gahan L)
Control In Type 2 Diabetes (Eakin E, Marshall A,
Dunstan D, Reeves M, Graves N)
$424,920
Early origins, progression and aetiology of
$278,949
obesity, metabolic syndrome and diabetes: a
Pharmacodynamics in Liver Disease and in
30 years follow-up study (Mamun A)
Liver Surgery (Roberts M, Weiss M, Macdonald
GA, Fawcett J, Vitetta L, Fletcher L)
$400,000
Enabling grant for Australian Prostate Cancer
$212,162
Collaboration Bio-Resource (Clements J,
Clinical outcomes-hospitalisation of patients
Risbridger G, Tilley W, Sutherland R)
with dementia (Gray L, Byrne G, Pachana N)
$400,000
$211,724
Clinical Centre of Research Excellence
Obesity-related inflammation and insulin
in Cardiovascular Disease and Metabolic
resistance in chronic liver disease: Exercise
Disorders (Marwick T, Prins J, Macdonald G,
and Diet as treatment options (Hickman I)
Ownsworth T, Chenoweth L)
$113,656
Future Fellowship (Thomas R)
$110,000
Preclinical evaluation of snake venom proteins
with therapeutic potential (Lavin M, de Jersey
J, Masci P, Guddatt L, Trabi M)
$104,612
Financing and management of lifetime care
(Foster M, Henman P, Fleming J, Tilse C)
Isbel N, Hegney D, Stowasser M)
$202,600
$379,493
Immunological therapies for cancer, chronic
PET/CT (positron emission tomography-
infection and autoimmunity (Thomas R, Hill G,
computed tomography) (Thomas R, Frazer I,
Frazer IH, Brown MA, Degli-Esposti M)
Brown M, Saunders N, Gonda T, McMillan N)
$186,985
$338,750
RNA interference and the Immune System
Retroviral Expression Cloning using an Arrayed
(McMillan N, Preiss T, Steptoe R)
Full-Length cDNA Gene Set (ARVEC) (Gonda T,
National Health and Medical Research
Council (NHMRC)
$913,770
Integration of risk evaluation in cardiovascular
disease management programs (Marwick, T
Stewart, S Scuffham, P Inglis, S Kostner, K
Abhayaratna, W Gould, P Carrington, M)
Gabrielli B, Grimmond S, Barry S)
$183,500
Targeted delivery by topical application
$300,000
(Roberts MS)
Australasian Leukaemia Lymphoma Group
(ALLG) National Leukaemia and Lymphoma
Tissue Bank (NLLTB) (Marlton P)
$180,025
Role of obesity in impaired treatment response
in chronic hepatitis C: mechanisms and
therapeutic strategies (Powell EE, Jonsson JR,
Clouston AD)
168
research - key to health
$180,000
$128,975
$96,040
Improved patient outcomes through
A longitudinal study of nerve morphology in
Molecular mechanisms underlying the positive
dosage individualisation of the newer
diabetic neuropathy using novel non-invasive
associations between male gender & leptin
immunosuppressant drugs (Staatz CE, Tett SE,
ophthalmic surrogate markers (Efron N,
with Barrett's oesophagus CDA (Biomedical)
Taylor PJ, Johnson DW, Lynch SV)
Boulton A, Malik R)
Fellowship (Hill M)
$174,757
$126,250
$93,592
A novel tumour suppressor function of E2F7 Elucidating genetic mechanisms responsible
Australian genome-wide study of osteoporosis
in squamous cell carcinoma formation
for familial hyperaldosteronism type II
(Brown M, Eisman J, Evand D, Jones G,
(Saunders N)
(Stowasser M, Leo P, Duffy D, Gordon R)
Nicholson G, Prince R, Uitterlinded-Erasmus A)
$173,750
$123,169
$85,340
IL-17 in bone marrow transplantation (Hill GR,
Improving Quality and Safety at the interface
Systematic diabetic retinopathy screening and
Clouston AD, Negrin RS)
between primary and secondary level care
monitoring of early stage disease in general
(Jackson C, Mitchell G, Askew D, Scott I,
practice (Jackson C, Askew D, Mitchell P)
$173,000
Foster M, Dart J, Hollingworth S, Davies P)
$85,060
Antibiotic dosing in critical illness (Roberts MS,
Lipman J, Paterson D, Kirkpatrick C, Kruger P,
$118,000
Reliability of an Online Geriatric Assessment
Roberts J)
Collaborative Oncological Gene-environment
Procedure (Gray L, Counsell S, Edwards H,
Study (EU-COGS) (Giles, Clements, English,
Martin-Khan M, Wootton R, Parzins P)
$171,500
A novel Receptor Activated Pathway
Hayes, Hopper, Kedda, Nelson, Pedersen,
Severi, Southey, Spurdle)
$69,026
(Subramaniam N, Wallace D, Lopez-Otin C,
Hooper J)
The AMAZES Study: Asthma and Macrolides:
$114,128
the AZithromycin Efficacy and Safety study
Uncoupled Research Fellowship (Gabrielli B)
(Gibson P, Simpson L, Upham J, Reynolds N,
Yang I, Hodge J, James A)
$170,477
A comprehensive analysis of Myb target
$107,249
genes involved in myelopoiesis and myeloid
Centrosome overduplication contributes to
$65,948
transformation (Gonda T)
tumorigenesis (Gabrielli B, Boutros R)
Major Histocompatibility Complex (MHC)
Genetics of Ankylosing Spondylitis (Brown MA,
Xu H, Evans D)
$156,161
$106,408
Continuing Research Fellowship (Roberts MS)
Value of central Blood Pressure for Guiding
management of hypertension (BP GUIDE
$62,287
Study) (Sharman J, Stowasser M)
NHMRC Practitioner Fellowship (Powell EE)
improve diabetes management (Oldenburg B,
$106,007
$50,000
Courtney M, Friedman R)
Squamous cell carcinomas of the head
NHMRC-European Union Health Collaborative
and neck: Exploring the role of human
Grant (Brown MA, Eisman J, Jones G,
papillomavirus Infection (Antonsson A, Coman
Nicholson G, Prince R, Seeman E)
$151,116
Using conversational computer technology to
$134,723
Development of Quality Indicators for the frail
W, et. al.)
elderly in acute care (Gray L, Brand C, Morris
J, Jones R, Wright O)
$102,893
Cancer Council Queensland
Practitioner Fellowship (Upham J)
$130,825
A behavioural intervention for managing
$130,896
menopausal symptoms in women with breast
Developmental Aspects of Respiratory
$96,040
Inflammation Allergy & Asthma (Sly P, Holt P,
Endosomal tubule formation in health and
LeSoeuf P, Thomas W, Stick S, Upham J)
disease CDA Fellowship (biomedical) cancer (Anderson D, Yates P, McCarthy N,
Hargraves M, White K.)
(Simpson F)
Centres for Health Research 2010 Annual Research Report
169
$100,000
$250,000
Synthetic lethality screen targeting a defective
Effective immunotherapy for chronic infection
checkpoint in melanoma (Gabrielli B,
and cancer - Innovation Skills Fund Smart
Waterhouse N.)
State Premier's Fellowship (Frazer I)
$100,000
$250,000
Understanding a potential mediator of
Development of New Therapeutic Approaches
metastasis (Hooper J, Quigley J, Waterhouse N.)
for Prostate Cancer Progression - Dissecting
the Efforts of Diabetes and Obesity in Cancer
$100,000
The role of osteoclasts in the development
Progression - Queensland Smart Futures
Premier's Fellowships (Nelson C)
of osteosarcoma metastases (Saunders N,
Thomas D, Evdokiou A.)
$110,000
Development of cancer survivorship self
$98,250
Understanding the functional role of KLK4 in
prostate cancer progression: an integrated
management plans - Department of Health
and Ageing (Yates P, McCarthy A, Anderson D,
Walpole E, Salkield G)
systems biology approach (Clements J,
Hutmacher D, Nelson C, Russell PJ.)
$100,000
Using components of bacteria to treat
$93,750
S-allylmercaptocysteine as an adjuvant therapy
asthma and allergies – Qld Clinical Research
Fellowship (Upham J)
in the treatment of prostate cancer
(Ling P, Nelson C.)
$94,300
To establish a Speech Pathology Telehealth
$83,500
service (Bassett L, Burns C, Ward E)
Genome-wide analysis of oesophageal cancer:
Other Grants & Funding
$1,500,000
Australian Government- Department of Health
& Ageing (Nelson C, Clements J, Nicol D)
$692,287
Ophthalmic markers in diabetic neuropathy –
JDRF (Efron N, Boulton A, Malik R, Prins J)
$338,333
Epiderm Scientific Research Grant - Australian
Dermatology Research and Education
Foundation Limited (Epiderm), UQ & PAH
Research Foundation (Soyer, H.P.)
$330,000
NICM Collaborative Centre for Transitional
Preclinical and Clinical Research in
Nutraceuticals and Herbal Medicines. (Vitetta
L, Komesaroff P, James D, Linnane AW,
Roberts M, Day R, Tiralongo E)
$272,405
Does Tai Chi regular practice improve
depression and metabolic syndrome for
depressed adults at risk of developing
cardiovascular disease – Heart Foundation
towards biomakers or response and outcomes
$80,000
& Beyond Blue (Liu X, Vitetta L, Kostner K,
of therapy (Barbour A.)
Queensland Health Smart Health Grant
Cromptonn D)
(Hawley C, Johnson DW, Beller E, De Zoysa,
$82,000
Playford EG, Cass A)
RNA and Immunity (McMillan N, Tindle R.)
Genetics and ankylosing spondylitis (AS)
$75,000
$66,847.83
MYB regulation of differentiation and apoptosis
$231,982
pathogenesis – NIH (Reveille JD, Brown MA)
Senior Clinical Academic Fellowship – OHMR
(Ferguson M, Capra S)
in breast cancer: Targets and Targeting (Gonda
$220,000
Harmonising higher education and professional
$65,000
quality assurance processes for the
Queensland Health Cancer Care Research
assessment of learning outcomes in health
Fellowship (Carrington C)
(O’Keefe, Henderson A)
$50,000
$212,000
The Road Ambulance Matters to Patients
An implementation framework for OSCE;
experiencing delayed off-loading (RAMPing)
Queensland Government best practice guidelines designed to improve
study (Ting J, Holzhauser K, Crilly J, Odwyer J,
nurse preparedness for practice (Mitchell M,
and Queensland Health
Scuffham P, Burmeister E)
Henderson A, Jeffrey C, Nulty D)
Australian-Canadian Prostate Cancer Research
$50,000
$207,318
Alliance - Queensland State Government
Combined Androgen Receptor and MEK
Genome wide Association Study of Ankylosing
National and International Research Alliance
inhibition in Breast Cancer - University of
Spondylitis Susceptibility (National Institute of
Program (Nelson C, Clements J, Nicol D,
Queensland and Queensland Department of
Arthritis and Musculoskeletal Skin Diseases
Gleave M,)
Employment, Economic Development and
(USA ) and Uni Texas) Reveille JD, Brown MA)
T, Ramsay R.)
$45,625
Suppressor NKT cell trafficking to epithelial
precancer (Leggatt G, Saunders N.)
$660,000
Innovation (Naderi A)
170
research - key to health
$196,500
$119,436
$69,507
Mechanisms of abiraterone resistance in
Workforce Innovation and Reform: Caring for
Automated Flow Cytometry (Thomas R, Frazer
prostate cancer – Prostate Cancer Foundation
older people project funding - Health Workforce
I, Brown M, Saunders N, Gonda T, McMillan N)
of Australia (Turner J, Kelly B, Clarke D, Yates P,
Australia (Cox R, Mills V, Wiemers A, Wood A,
Aranda S, Jolley D, Chambers S, Hargraves M,
Clements L)
$65,391
McFadyen L)
The Genetic Determination of Rheumatoid
$100,000
Arthritis in the Chinese Population (Danoy P)
$190,000
The role of Wnt proteins in inflammation –
Analytical instrumentation enabling rapid
Balzan Fellowship (Blumenthal A)
$57,465
compound separation and chemical structure
analysis via mass fingerprinting (Shaw PN,
Roberts MS, Gidley MJ, Coombes AGA,
Fuerst JA, Cabot PJ, Duley JA, McGeary
RP, Steadman KJ, Parekh HS, Ross BP,
Hewavitharana AK, Staatz CE)
nPOD Research Projects- Pathological
$100,000
changes associated with chronic RelB
Long-term paediatric liver allograft function:
activation in T1D - Juvenile Diabetes Research
role of obesity and metabolic factors and
Foundation Int (Thomas R, Irvine K)
investigation of a new model for fibrosis - Royal
Children's Hospital Foundation (Sasakawa
Memorial Fund) (Jonsson J)
Pick Your Partners-High Throughput
$181,000
Inactivation of the Inhibitor of Differentiation
(Id-1) as a Therapy for the Treatment of
Advanced Prostate Cancer - Vice-Chancellor’s
Fellowship, QUT (Ling P)
$180,000
Targeting autoreactive memory T cells in type 1
diabetes – JDRF (Steptoe R)
$150,000
Characterization of miRNA in prostate cancer
progression - Cancer Australia/ Prostate
Cancer Foundation of Australia (Nelson C, Tilley
W, Risbridger G)
$125,000
Targeted nanoparticles for treating prostate
cancer - Prostate Cancer Foundation of
Australia (Russell PJ, Khatri A, Cowin G, Thierry
B, Power C)
$124,912
Agilent Bravo Automated Liquid Handler Prostate Cancer Foundation of Australia (Quinn
R, Nelson C, Camp D)
$124,261
A systems biology approach to eluciadte the
molecular mechanisms of caveolin-1 and
$50,000
identification of calcium transporter targets for
$100,000
breast cancer (Gonda T, Monteith G, Roberts-
Leukaemia Foundation (Keane C)
Thompson S)
$100,000
$50,000
Obesity-related chronic liver disease - Lions
Obesity-related inflammation and insulin
Medical Research Foundation (Hickman I)
resistance in chronic liver disease: Exercise
and diet as treatment options - Lions Medical
Research Foundation (Hickman I)
$100,000
Understanding the Heterogeneity of Invasive
Ductal Breast Cancers – a proteomic approach
$50,000
for the discovery of biomarkers and novel
Dietary factors influencing cardiovascular
therapeutic targets - National Breast Cancer
disease progression in chronic kidney disease -
Centre Foundation (Chopin L, Simpson P,
Lions Medical Research Foundation Lakhani S, Bennett I, Hill M)
(Campbell, K)
$86,825
$50,000
Induction of tolerance in memory diabetogenic
Inhibition of sex hormone binding globulin
T cells - Juvenile Diabetes Research
proteolysis by kallikrein-related protease 4; a
Foundation Int. (Steptoe R)
potential target for prostate cancer therapy Prostate Cancer Foundation of Australia (Harris
J,Clements J)
$76,100
Asthma Foundation Qld (Davies J, Upham, J)
$50,000
The role of the transcription factors PITX2
$75,000
(paired-like homeodomain) and YB-1 (Y-box
Identifying the molecular basis for
osteosarcoma metastasis - Wesley Research
Institute Ltd (Saunders N, Endo-Munoz L,
Sommerville S)
binding protein 1) in metastatic prostate
cancer and possible therapeutic implications Australasian Urological Foundation (Nelson C,
Pokorny, M)
statins in prostate cancer progression and
metastasis - Prostate Cancer Foundation of
Australia (Hill M, Pareton R, Chopin L)
Centres for Health Research 2010 Annual Research Report
171
Committees
Human Research Ethics Committee -
Health Practitioner Research
Metro South Health Service District
Collaborative - Metro South Health
The Committee is constituted in accordance
Service District
with the National Statement on Ethical

Dr Jennifer Lethlean, Chair Health
Conduct in Human Research (2007), section
5.1.29-5, 1.33

Dr Jennifer Fleming, Chair (to July 2010)

Associate Professor Carl Kirkpatrick, Acting Chair (to September 2010)

Dr. Eleanor Milligan, Acting Chair (from September 2010)

Ms Beverley Gaye Kurkowski, Lay Person Female

Mr Col Sutcliffe, Lay Person Male

Mr Denzil Scrivens, Lay Person Male

Dr Karam Kostner, Physician and
Researcher

Associate Professor Richard Roylance,
Paediatrician

Dr John North, Surgeon Orthopaedic
Practitioner Research Collaborative)

Ms Delena Amsters, Spinal Outreach Team

Associate Professor Damien Thomson, Director, Medical Oncology

Dr Alexandra McCarthy, Senior Research
Fellow, SAHSCCN; Senior Lecturer, QUT

Dr Peter Mollee, Haematologist

Dr Maree Ferguson, Director, Nutrition & Dietetics

Ms Annette Broome, Psychology

Dr Katrina Campbell, Research Fellow, Nutrition and Dietetics

Ms Julie Connell, Executive Director, Clinical Support Services
PA Research Foundation
Board of Directors

Mr Robert Bowen, Chairman

Mr William Deutrom OAM, Deputy

Ms Judith Coombes, Pharmacy
Chairman, Chair, Marketing Committee,

Ms Sue Cumming, Director, Social Work
Company Director

Dr Maree Ferguson, Director, Nutrition 
Mr Richard Bowly, Queensland Hotels
Association
and Dietetics

Dr Emma Finch, Conjoint Research Fellow 
Dr Richard Ashby, AO, Executive Director of Medical Services, PAH
in Speech Pathology PAH/UQ

Associate Professor Jenny Fleming, 
Professor Ian Frazer, Director, Diamantina
Conjoint Research Fellow in Occupational
InstituteMr Andrew Griffiths, Company,
Therapy PAH/UQ
Director

Dr Robert Zubeshaw, Medical Practitioner

Dr Pim Kuipers, CFaHR

Mr Michael T Wille OAM, Company Director

Michael Jerome-Smith, Professional Care

Mr Steve McPhail, CFaHR

Mr Bob Vines

Dr Sean Hatherill, Professional Care -

Dr Melissa Kendall, Transitional

Mr Cameron Buchanan
Psychiatrist Child Youth Mental Health
Rehabilitation Program & Acquired, Service
Brain Injury Outreach Service

Dr Adam La Caze, Pharmacist

Rev.Father Bernard Thomas, Minister of Religion

Mr John Bennett, Lawyer

Dr Dan Siskind, Psychiatrist

Ms Sue Pager, Allied Health Project Officer, Metro South

Dr Angela Vivanti, Research & Development Dietitian
PAH Cancer Collaborative Group

Associate Professor Maher Gandhi,

Associate Professor Devinder Gill, Chair,

Dr Peter Mollee, Haematologist Physician and Researcher

Mr Russell Saal, Scientific Director Laboratory Haematology
Director, Clinical Haematology

Areti Gavrilidis, Director, Research

Ms Heather Tyrrell, Company Secretary,
Manager, Governance, PAH

Mr Michael Back, (Honorary Solicitor)

Mr Phillip Sciacca, (Honorary Accountant)
Research Committee

Professor Mark Smithers, Chairman

Professor Leanne Aitken

Professor John Upham
Health Research

Professor Len Gray

Associate Professor Nicholas Saunders,
& Metabolic Medicine

Associate Professor Mark Smithers
research - key to health

Mr Les Watson, District Health Council
Development & Ethics, Centres for Diamantina Institute for Cancer, Immunology
172
CEO, Metro South Health Service District

Professor Elizabeth Ward, CFaHR

Dr Scott Campbell, Renal Physician
Haematologist Physician and Researcher

Professor David Theile (Snr) AO, District

Dr Maree Ferguson

Emeritus Professor Robert Tindle
Research Staff
Acquired Brain Injury

Ray Quinn, Manager

Areti Kennedy, Program Manager, STEPS

Dr Melissa Kendall, Research & Development Officer

Susan Gauld, Rehabilitation Coordinator

Karen Goddard, Rehabilitation Coordinator

Marie Hollingworth, Rehabilitation
Coordinator

Ann Lancaster, Rehabilitation Coordinator

Alison Liley, Rehabilitation Coordinator

Clair Morgan, Rehabilitation Coordinator

Elissa Morriss, Rehabilitation Coordinator

Judith Nance, Rehabilitation Coordinator

Judy Roser, Rehabilitation Coordinator

Sharon Smith, Rehabilitation Coordinator

Benjamin Turner, STEPS Coordinator

Suzanne Wright, Rehabilitation Coordinator

Vicky Beh, Acting NUM

Professor Judith Clements, Scientific Director

Simone Cahill, Senior Social Worker

Professor Pamela Russell, Research Leader
Breast and Endocrine

Professor Adrian Herington, 
Associate Professor Ian Bennett, Chairman
Research Leader

Dr Petar Vujovic, Breast & Endocrine

Dr Lisa Chopin, Research Leader
Surgeon

Dr Jon Harris, Research Leader

Dr Sally-Anne Stephenson, Research

Dr Neil Wetzig, Consultant Surgeon

Dr David Wilkinson, Consultant Surgeon
Leader

Ms Maggie Fung, Clinical Coordinator

Dr Patrick Ling, Vice Chancellor Fellow

Dr Magdalene Biggar, Breast and Endocrine Fellow

Amanda Smith, Breast Care Nurse

Dr Jiyuan An, Postdoctoral Fellow

Dr Jyotsna Batra, Postdoctoral Fellow

Dr Jennifer Gunter, Postdoctoral Fellow

Karen Miles, Breast Care Nurse

Cathy Daunt, NUM 4D

Dr Varinder Jeet, Postdoctoral Fellow
Cardiology

Dr Lidija Jovanovic, Postdoctoral Fellow

Dr Paul Garrahy, Director

Dr John Lai, Postdoctoral Fellow

Dr John Hill, Director of Cardiac Pacing 
Dr Max Mariasegaram, Postdoctoral Fellow
& Electrophysiology

Dr Stephen McPherson, Postdoctoral Fellow

Dr Paul Gould, Consultant Cardiologist

Dr Melanie Murrell, Postdoctoral Fellow

Dr Gerald Kaye, Consultant Cardiologist

Dr Anya Rockstroh, Postdoctoral Fellow

Dr Dariusz Korczyk, Consultant Cardiologist

Dr Martin Sadowski, Postdoctoral Fellow

Dr Richard Lim, Consultant Cardiologist

Dr Carolina Soekmadji, Postdoctoral Fellow

Dr Sudhir Wahi, Consultant Cardiologist
Anaesthetic

Dr Sonika Tyagi, Postdoctoral Fellow

Dr William Wang, Consultant Cardiologist

Dr Peter Moran, Director

Dr Raj Vasireddy, Postdoctoral Fellow

Cindy Hall, Manager Cardiology 
Dr Pal Sivalingam, Director of Research

Jiyuan Liu, Research Assistant

Dr Bruce Burrow, Deputy Director

Vandhana Bharti, Research Assistant
Alcohol and Drug

Dr Gerald Feeny, Medical Director

Associate Professor Jason Connor, Visiting Senior Clinical Psychologist
Research Department

Ruth Calvert, Clinical Trials

Dr Bart McKenzie, Deputy Director

Dr Nicole Fairweather, Anaesthetist

Dr Rebekah Ferris, Consultant Anaesthetist

Dr Kerstin Wyssusek, Anaesthetist SMO

Dr Paul Davies, Consultant Anaesthetist
Australian Prostate Cancer Research
Centre

Professor Colleen Nelson, Executive Director

Charmaine Sieg, Clinical Trials
Brain Injury Rehabilitation
Cardiothoracic Surgery

Dr Ron Hazelton, Medical Director

Associate Professor Julie Mundy

Dr Wilbur Chan, Senior Specialist

Dr Dale Fogarty, Neuropsychologist

Dr Pallav Shah

Erin Griffin, Senior Occupational Therapist
Cardiovascular Imaging Group

Janelle Griffin, Senior Occupational

Professor Thomas H Marwick, Academic
Therapist

Associate Professor Karam Kostner,

Paula Addis, Senior Speech Pathologist
Academic

Janelle Gesh, Senior Physiotherapist
Centres for Health Research 2010 Annual Research Report
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
Associate Professor William Wang,
Academic
Institute of Integrative Medicine in
Centre for Research in Melbourne
Geriatric Medicine

Associate Professor Paul Gould, Academic

Dr Rick Abraham, Affiliated Oncologist

Professor Len Gray, Director Research

Associate Professor Gerald Kaye, Academic

Dr Maree Colosimo, Affiliated Oncologist

Associate Professor Paul Varghese, Director

Dr Sudhir Wahi, Academic

Associate Professor Karam Kostner, 
Dr Glenise Berry, Senior Lecturer

Dr Brian Haluska, Research Academic
Affiliated Cardiologist

Dr Charles Lie, Senior Lecturer

Dr Carly Jenkins, Research Academic
Centre for Kidney Disease Research

Dr Salih Salih, Senior Lecturer

Dr Matthew Cooke, Research Academic

Professor David Johnson, Director

Dr Catherine Yelland, Senior Lecturer

Dr Eduardo Pimento, Medical Registrar

Associate Professor Glenda Gobe,

Dr Lucy Dakin, Lecturer

Rodel Leano, Research Academic
Administrative Director, Centre for Kidney
Disease Research
Centre for Functioning 
Associate Professor Carmel, Hawley,

Dr Prabha Lakhan, Research Fellow

Dr Melinda Martin–Khan, Research Fellow
& Health Research
Assistant Director of Haemodialysis, Chair

Dr Nancye Peel, Research Fellow

Dr Elizabeth ward, Conjoint Professor
of AKTN Operations Secretariat

Dr Catherine Travers, Research Fellow

Dr Jennifer Fleming, Conjoint Associate Professor

Dr Pim Kuipers, Principal Research Fellow

Dr Steven McPhail, Senior Research Fellow

Dr Emma Finch, Conjoint Research Fellow

Susan Pager, Research Workforce Development Officer

Associate Professor Nikky Isbel, Assistant
Director of Ambulatory Renal Services

Associate Professor David Mudge, Assistant
Director of Redlands Renal Service

Dr Nigel Bennett

Dr Ashley Wilkinson

David Small

Dr Will Petchey
Centre for Integrative Clinical & Molecular Medicine

Associate Professor Luis Vitetta, Director

Dr Paul Masci, Principal Professional Officer

Assoc Professor David Colquhoun, Honorary Professor

Professor Anthony Linnane, Honorary
Professor

Dr Carolyn van Eps

Dr Magid Fahim

Dr Carolyn Clark

Ms Miko Yamada

Dr Jun Li

Dr David Vesey

Dr Liu Xin, Senior Research Fellow

Dr Ellen Van der Hall, Senior Research Assistant

Dr Michael Whitehouse, Honorary Research Consultant

Ms Shoshannah Beck, Admin & Research Assistant

Helen Gramotnev, Statistician

Professor Robert Allen, Affiliated General
Practitioner / Academic from the National
174
research - key to health

Mark Rozaria, Research Assistant

Rochelle Vincent, Research Assistant

Catherine Beverely, Research Nurse

Bonnie Pimm, Research Nurse

Leigh Bradley, Nurse Assessor

Dr Michael Daly

Dr David Small

Dr Manuela Trabi, Research Associate

Lisa Mackenzie, Research Assistant
Clinical Governance

Associate Professor David Colquhoun,

Dr Nathan Reiden, Research Associate

Joanna Kho, Research Assistant

Dr Modh Kaisar

Dr Sunil Badve

Dr Kong-Nan Zhao, Senior Research Fellow

Sean Halloran, Research Assistant

Dr Katherine Barraclough

Professor Avni Sali, Honorary Professor
Honorary Associate Professor [Cardiologist]

Dr Elaine Fielding, Data Manager
Centre for Liver Disease

Associate Professor Elizabeth Powell, NHMRC Practitioner Fellow, Co-Director

Associate Professor Julie Jonsson, Principal Research Fellow, Co-Director

Associate Professor Andrew Clouston, Deputy Director

Dr Melino Michelle, Postdoctoral Research Fellow

Ms Leigh Horsfall, Clinical Research
Coordinator

Ms Victoria Gadd, Research Assistant

Ms Millicent Williams, Technical Assistant
Clinical Pharmacology

Associate Professor Peter Pillans, Director

Paul Taylor, Senior Scientist

Michael Franklin, Senior Scientist

Dr Joel Iedema, Registrar

Dr Christine Staatz, Senior Lecturer

Chun-hai Tai, Scientist
Dermatology Research Centre

Professor H. Peter Soyer, Professor of
Dermatology

Associate Professor Stephen Gilmore,
Dermatology

Prof Helmut Schaider, Visiting Professor

Dr Jose Neila Iglesias, Visiting Scholar

Dr Cathy Xu, Senior Research Fellow

Dr Shobhan Manoharan, Senior Lecturer

Dr Jim Muir, Senior Lecturer

Dr Greg Siller, Senior Lecturer

Dr Jason Wu, Senior Lecturer

Dr Laura Baillie, Research Assistant

Theodore Borgovan, Research Assistant

Dr Zachary Boyce, Research Assistant

Terri Campbell, Research Assistant

Dr Claudia Curchin, Research Assistant

Dr Nicola Douglas, Research Assistant

Associate Professor Chris Perry, Visiting
Medical Officer

Dr Brad Kendall, Acting Director

Dr Benedict Panizza, Visiting Medical Officer

Dr Ben Wallwork, Visiting Medical Officer

Dr Christian Betz, German Fellow

Geraldine Lipka, Clinical Research

Associate Professor Anthony Russell,

Dr David Hogan, Registrar Logan

Associate Professor Devinder Gill, Director
Emergency

Professor John Prins

Dr Phillip Kay, Director

Professor David McIntyre

Dr Ellen Burkett, Co-director of Research

Jody Sawyer, Study Coordinator

Dr Michael Sinnott, Co-Director of Research
Deputy Director Academic, Group Leader
Epithelial Cancer Division

Professor Melissa Brown, Deputy Director Research;
Coordinator
Haematology

Dr Trisha O’Moore-Sullivan

Associate Professor Nigel McMillan, 
Sid Siddle, Clinical Trials Coordinator
Coordinator

Dr Kristy Fraser-Kirk, Registrar PAH/Logan
Leader Immunotherapy Group

Fiona Giddons, Clinical Trials Coordinator
Surgery - Logan
Diabetes and Endocrinology

Professor Ian Frazer, Director, Research 
Professor Graeme Macdonald, Senior Staff

Leigh Horsfall, Clinical Research
Otolaryngology, Head and Neck 
Dr David Hall, Registrar PAH
Immunology & metabolic Medicine
Director Centre for Liver Disease Research

Dr Linda Fletcher, Senior Scientist
Surgery - PAH

Dr Herman Basson, South African Fellow
Diamantina Institute of Cancer,
Research Fellow, Hepatologist and Co
Gastroenterologist
Otolaryngology, Head and Neck 
Dr Melissa Hickey, Research Assistant
Director
NHMRC Practitioner Fellow, QLD Health

Dr Bernard Whitfield, Senior Staff Specialist

Dr Parag Patel, UK Fellow Skull Base

Dr Elisabeth Wurm, Research Assistant

Associate Professor Elizabeth Powell,

Dr Scott Coman, Visiting Medical Officer

Dr Daniel Gaffney, Research Assistant

Christopher Torpy, Research Assistant
Gastroenterology & Hepatology
Clinical Haematology

Cathy Davis, Acting Nurse Researcher
(Southern Districts Emergency Department

Dr Robert Bird, Director, Haematology

Associate Professor Paula Marlton

Dr Anthony Mills

Dr Peter Mollee

Associate Professor Peter Wood
Clinical Network)

Dr Sally Mapp, Specialist

Eleanor Hammond, Acting Nurse
Researcher (Southern Districts Emergency
Department Clinical Network)

Dr Iain McNeil, Co-director of Research

Nicola Melton, Research Officer

Ramon Shaban, Visiting Senior Research
Fellow

Associate Professor Maher Gandhi

Professor Andrew Perkins

Dr Helen Wordsworth

Dr Matt Hourigan

Dr Catherine Cheung, PD Research
Scientist

Professor Ranjeny Thomas, Research
Leader Dendritic Cell Biology Group

Professor Tom Gonda, Research Leader Cancer Biology

Associate Professor Brian Gabrielle,
Research Leader Cell Cycle Group

Associate Professor Nick Saunders,
Research Leader Epithelial Pathobiology
Group

Professor Matthew Brown, Research Leader
Musculoskeletal Genetics Group

Professor Mark Kendall, Research Leader
Delivery of Drugs and Genes Group
Endocrine Hypertension 
Dr James Gray, Haematology Fellow
Research Centre

Dr Lyle McMillan, Translational Research
Scientist

Professor Michael Stowasser, Co-Director

Professor Richard Gordon, Co-Director

Melinda Burgess, Research Scientist

Dr Eduardo Pimenta, Clinical Research

Lynn Chambers, Research Scientist
Fellow
Tissue bank

Dr Ashraf Ahmed, PhD Student

Jana Augsten, Sample Coordinator

Paul Taylor, PhD Student

Bartosz Kowalski, Research Assistant

Diane Cowley, Clinical Nurse Consultant

Dianne Robson, Hypertension Nurse

Megan Ellis, TB Manager

Andrea Shaw, Sample Coordinator

Josie Thomas, Laboratory Technician
Ear Nose Throat

Cynthia Kogovsek, Hypertension Nurse
Infection Management

Professor William B Coman, Chairman 
Danielle Aspinall, Honours Student

Associate Professor Michael Whitby,
and Director

Lorraine Saunders, Administration Officer
Director
Centres for Health Research 2010 Annual Research Report
175

Dr Geoffrey Playford, Consultant

Dr David Looke, Consultant

Professor Wendy Chaboyer, Griffith
University, Visiting Scholar
Mental Health

Professor David Crompton, Executive Clinical Director

Dr Naomi Runnegar, Consultant
Internal Medicine and 
Dr Wendy Munckhof, Consultant
Clinical Epidemiology

Dr Brian Dwyer, Consultant

Associate Professor Ian Scott, Director

Dr David Jardine, SMO

Dr Golam Khadem, Staff Physician
Microbiology Pathology

Dr Cheryn Palmer, SMO

Associate Professor Jennifer Martin, 
Dr Joan Faoagali, Head of Research

Dr Mekala Srirajalingam, SMO
Staff Physician

Dr Daniel Varghese, Consultant Psychiatrist

Dr Dan Siskind, Consultant Psychiatrist
Department

Dr Tony Morton, Consultant Statistician
Medical Oncology

Dr Nicola Townell, Advanced Trainee
Neurosurgery

Associate Professor Damien Thomson,

Dr Bruce Hall, Director

Dr Trent Yarwood, Advanced Trainee

Dr Rohan Bopage, Advanced Trainee
Director

Associate Professor Euan Walpole, Senior
Medical Oncologist, Director of Cancer
Intensive Care

Professor Bala Venkatesh, Director of
Research

Associate Professor Chris Joyce, Director

Associate Professor Peter Kruger, Deputy Director

Professor Leanne Aitken, Chair of Critical Care Nursing

Dr David Cooke, Senior Staff Specialist

Dr David Fraenkel, Senior Staff Specialist

Dr Anand Krishnan, Staff Specialist

Dr Roslyn Purcell, Staff Specialist

Dr Leo Nunnink, Staff Specialist

Dr James Walsham, Staff Specialist

Dr Gordon Laurie, Staff Specialist

Dr Wayne Kelly, Visiting Specialist

Nicola West, Nurse Unit Manager

Jennifer Robertson, Nurse Unit Manager

Kellie Beard, Nurse Unit Manager

Michael Abbey, Clinical Nurse Consultant

Sharon Wetsig, Clinical Nurse Consultant

Danielle Griffiths, Clinical Nurse Consultant

Leanne Jack, Clinical Nurse

Meg Harward, Research Coordinator

Georgina Sexton, Research Coordinator

Kelly Perkins, Research Coordinator

Kelly Hayes, CN Research

Anne-Marie Kelly, CN Research

Elizabeth Burmeister, Research Assistant

Jennie Abbey, Research Assistant
176
research - key to health
Services and Metro South Cancer Services
and Cancer Care leadership Group

Dr Natasha Woodward, Senior Staff Medical
Oncologist (PT)

Dr Elizabeth McCaffrey, Staff Medical
Oncologist

Dr Warren Joubert, Staff Medical Oncologist

Dr Victoria Atkinson, Staff Medical
Oncologist

Dr Margaret McGrath, Staff Medical Oncologist (PT)

Dr Keith Horwood, Senior Medical
Oncologist

Dr Maree Colosimo, Senior Medical
Oncologist
Nursing Practice Development Unit

Kerri Holzhauser, Nursing Director, Research

Professor Leanne Aitken, Chair, Critical Care Nursing

Professor Amanda Henderson, Nursing
Director, Education

Dr Marion Mitchell, Senior Research
Fellow

Dr Lyndall Spencer, Clinical Nurse
Researcher

Nicola Melton, Clinical Nurse Researcher

Mary Boyde, Nurse Researcher

Vanessa Brunelli, Nurse Researcher

Liz Burmeister, Nurse Researcher

Christine Ossenberg, Research Officer

Gillian Ray-Barruel, Research Officer

Dr Alexandra McCarthy, Senior Research
Fellow, Southern Area Cancer Network
Nutrition and Dietetics

Adam Stoneley, Research Unit Coordinator

Dr Maree Ferguson, Director

Susan Arnold, Research Nurse

Dr Ingrid Hickman, Principle Research

Mary Ashmead, Research Nurse

Paul Baxter, Research Nurse

Sharon Cox, Data Manager

Nicky Gill, Data Manager

Tanya Graham, Research Nurse

Steven Ivanhoe, Data Manager

Louise Knop, Data Manager

Josephine Logan, Data Manager

Janelle Meakin, Data Manager

Leah Peut, Research Nurse

Jenny Suffolk, Research Nurse

Kim Wright, Data Manager
Fellow

Dr Katrina Campbell, Senior Research
Fellow

Dr Angela Vivanti, Research & Development Dietitian

Eryn Murray, Research Dietician
Occupational Therapy

Mary Whitehead, Director

Ruth Cox, Acting Director

Dr Amanda Purcell, Acting Director

Associate Professor Jennifer Fleming, Conjoint Research Fellow
Older Persons Mental Health
Queensland Melanoma Project

Hannah Moore, Clinical Trial Coordinator

Dr David Lie, Clinical Director

Associate Professor B. Mark Smithers,

Adrienne See, Clinical Trial Coordinator

Dr Melinda Martin-Khan, Research Assistant

Dr Catherine Travers, Chief Researcher

Emily McCullum, Research Intern
Director

Dr Peter Madden, Scientific Director

Janine Thomas, Trials Coordinator

Sandra Stein, Research Scientist

Sarah Wagner, Research Assistant
Pharmacy

Lynette Loy, Director

Christine Carrington, Principal Project
Officer

Judith Coombes, Senior Pharmacists
Radiation Oncology (PAH)

Dr Gerard Bayley, Investigator

Dr Christopher Allan, Investigator

Dr Glenn Francis, Director MaCH R
Coordinator – QA
Investigator
Ophthalmology
Pathology

Narelle Wallace, Clinical Trial 
Associate Professor Andrew Barbour,

Professor Bryan Burmeister, Director

Associate Professor Sandro Porceddu,
Consultant Radiation Oncology

Sharan Burton, Research Nurse

Dr Jennifer Harvey, Radiation Oncologist

Jennifer Addison, Research Nurse

Dr Margot Lehman, Radiation Oncologist

Nicole Wayte, Research Officer

Dr Andrew Pullar, Radiation Oncologist
Queensland Spinal Cord 
Susan Arnold, Research Nurse
Injuries Service

Mary Ashmead, Research Nurse

Dr Sridhar Atresh, Director

Sharon Rowe, Research Coordinator

Dr Timothy Geraghty, Principal Investigator

Josephine Logan, Research Database
Manager

Dr Melissa Kendall, Research & Development Officer

Janelle Meakin, Research Coordinator

Greg Ungerer, Program Manager

Adam Stoneley, Research Unit Coordinator

Kiley Pershouse, Program Manager

Jennifer Suffolk, Research Nurse

Robyn Peters, Clinical Trails Pharmacist

Julianne Malt, Clinical Nurse

Deborah Urquhart, Research Admin Officer

Tina Patterson, DUE pharmacist

Kirsten Hinchy, Social Worker

Kim Wright, Research Coordinator

Janet Weir, Senior Pharmacist Oncology /

Delena Amsters, Research Officer
Education, Conjoint Lecturer School of
Pharmacy
Haematology

Karl Winckel, Senior Pharmacists Education,
Conjoint Lecturer School of Pharmacy,
Radiology

Sarita Schuurs, Research Officer

Dr Mark Benson, Acting Director Radiology

Polly Tsai, Investigator

Dr John Harper, Acting Director Radiology

Brett Duce, Investigator

Dr Sue Jeavons, Acting Director Radiology
Physiotherapy

Christine Cullen, Intervention Therapist

Kathy Grudzinskas, Director

Melissa Wallace, Occupational Therapist

Cherie Hearn, Assistant Director

Rachel Jones, Research Nurse

Dr Suzanne Kuys, Research Fellow

Joanne Lewis, Research Nurse
Plastic & Burns
Radiation Oncology (Mater)

Dr John Coucher, Radiologist

Dr David Theile Jnr., Director

Associate Professor Michael Poulsen,

Dr Laetitia deVilliers, Radiologist

Dr Michael Wagels, Registrar

Sally Ball, Senior Radiographer

Richard Boytar, Nuclear Medicine
Technologist

Dr Jennifer Chang, Radiologist
Director

Tara Devonport, Senior Radiographer

Dr Shiren Senewiratne, Consultant

Dr Guy Bryant

Dr Mitesh Gandhi, VMO

Dr Daniel Rowe, Consultant

Dr Brigid Hickey

Dr David Leggett, Radiologist

Dr Tanya Holt

Madeleine Neels, Radiographer

Dr Kumar Gogna

Dr Stanley Ngai, Radiologist

Dr Andrew Pullar

Dr Ben Ong, Radiologist

Dr Jonathan Ramsay

Jit Pratap, Radiographer

Dr Jennifer Harvey

Susan Rattray, Nuclear Medicine
Queensland Clinical Trials Centre Biostatistics

Associate Professor Paul Sanjoy, Director

Dr Margaret Haughton, Project Manager

Dr Kere Klein, Senior Biostatistian

Namitha Bobby, Data Manager & Programmer

Gijo Thomas, Research Assistant
Technologist

Kacy Baumann, Clinical Trial Unit Supervisor

Dr Kendal Redmond, Radiologist

Wendy Hansford, Clinical Trial Coordinator

Dr Nivene Saad, Radiologist
Centres for Health Research 2010 Annual Research Report
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
Dr Eric Sclavos, Radiologist
Therapeutics Research Centre

Gary Smith, Radiographer

Professor Michael Roberts, Director

Thomas Steffens, Radiographer

Dr Jeff Grice, Academic Manager

Tim Way, radiographer

Dr Tarl Prow, Postdoctoral Fellow

Andrew Whiteman, Radiographer

Dr Xin Liu, Postdoctoral Fellow
Respiratory and Sleep Medicine

Dr Craig Hukins, Director

Professor John Upham, Research Director

Dr Janet Davies, Senior Research Fellow

Dr Sebastien Bertin-Maghit, Research Officer

Dr Antonia Pritchard, Research Officer

Dr John Armstrong, Clinical Trials

Dr Washington Sanchez Sr., Postdoctoral
Fellow

Dr Yuri Dancik, Postdoctoral Fellow

Dr Gregory Medley, Postdoctoral Fellow
Assistant

Ms Camilla Thompson, PhD student, general casual staff

Hongzhuo Li, Technician

Sukhpreet Kaur, Affiliate, PhD student,

Dr Emma Finch, Conjoint Research Fellow

Dr Jennifer Lethlean, Advanced Speech
Pathologist

Kelli Hancock, Advanced Speech Pathology
Team leader acute

Nadine Lawson, Advanced Speech
Pathology Team leader Acute

Bena Cartmill, Advanced Speech
Pathologist

Paula Addis, Advanced Speech Pathology
Team leader - BIRU

Kathy Clark, Advanced Speech Pathology

Lin Li, Occupational Trainee

Julia Fiorino, Occupational Trainee (Canada)

Jovanka Bodirogo, Occupational Trainee
(Canada)

Terri Jarema, Occupational Trainee (Canada)

Professor Michael Schuetz, Director

Dr Simon Gunn, Affiliate, UniSA

Wendy McCallum, Director
(France)

Dr Washington Sanchez Jr., Research

Julie Burel, Research Assistant
Speech Pathology

Eleonor Rehnstrom, Occupational Trainee
Trauma Service

Dr Tom Robertson, Affiliate, UniSA

Melissa Green, Research Nurse
(Sweden)

Jenny Ordonez, Laboratory Manager

Melanie Carroll, Research Assistant

Michelle Towers, Research Nurse

Gaelle Tachon, Occupational Trainee
UniSA

Qian Zhang, Affiliate, PhD student, UniSA

Dr Gongfa Chen, Senior Research Fellow

Dr Devakara Epari, Senior Research Fellow

Dr Beat Schmutz, Senior Research Fellow

Dr Roland Steck, Senior Research Fellow
Upper Gastrointestinal & Soft Tissue

Associate Professor B. Mark Smithers,
Chairman

Peng Li, Affiliate, PhD student, UniSA

Professor David Gotley, Investigator

Professor Michael Whitehouse, Honorary

Dr Andrew Barbour, Principal Investigator
Research Consultant

Professor Michael Weiss, Honorary
Research Consultant

Dr Sheree Cross, Honorary Research
Consultant

Dr Yuri Anissimov, Honorary Research
Consultant

Dr Owen Jepps, Honorary Research
Consultant

Dr Ken Newton, Honorary Research
Consultant

Prof Frank Burczynski, Visitor, Research
Consultant

Dr Yuk Man Kan, Senior Fellow

Dr Andrew MacDonald, Research Fellow

Jennifer Addison, Research Nurse

Sharan Burton, Research Nurse

Janine Thomas, Trials Coordinator

Nicole Wyatt, Research Assistant
Vascular Medicine Research

Dr Andrew McCann, Director

Rebecca Hetherington, Senior Vascular
Scientist

Susan Gibb, Senior Vascular Scientist

Dr Chong-Jin Loy, Research Consultant

Jenny Bocock, Senior Vascular Scientist

Leanne Smith, Speech Pathologist Senior

Prof Chris Anderson, Research Consultant

Carissa Ceccato, Vascular Scientist

Kerrin Watter, Speech Pathologist Senior

Dr Kanchana Ranasinghe, PhD student

Amanada Lane, Vascular Scientist

Kate Robinson, Speech Pathologist Senior

Adnan Mahmoud, PhD student

Damon Judges, Vascular Scientist

Carly Freebairn, Speech Pathologist Senior

David Liu, PhD student

Leah Blacker, Vascular Scientist

Annie Johnson, Speech Pathologist Senior

Klintean Wunnapuk, PhD student

Rachel Morrison, Vascular Scientist

Jenni Boxall, Speech Pathologist Senior

Gayathri Krishnan, Visiting PhD student

Renea Collins, Clinical Nurse Consultant
Team Leader GARU

Cassandra Budden, Speech Pathologist

Michaela Antonio, Speech Pathologist

Danielle McGovern, Speech Pathologist
(Curtin Uni)

Ahmed Mostafa, Occupational Trainee
(Egypt)

Emeline Kirassian, Occupational Trainee
(France)
178
research - key to health

Ursula Sanderson, Clinical Trials Coordinator

Julie Kirby, Clinical Trials Coordinator
Postgraduate Students
PhD Completions

Bennett, Dr Nigel

Doig, Emmah

Madawi, T

Mapp, Sally

Purcell, Amanda

Ranasinghe, Dr
Kanchanamala

Rose, Pauline

Squelch, Natasha

Statham, Dr Dixie

Stephenson, Mathew

Thorberg, Dr Fred

Wagels, Michael

Wilkinson, Dr Ashley
PhD
Commencements

Badve, Dr Sunil

Benham, Dr Helen

Chia, Kee

Choi, April

Coleman, Miranda

Cortes, Adrian

Fatehi, Farhad

Frankel, Adam

Hall, E

Hermann, Arndt

Hunter, Michelle

Lim, Lawrence

Luttrell, Dr Matthew

McCaskill, Jana

Momeny, Majid

Moon, Sunny

Pimenta, Dr Eduardo

Saleem, M.

Sandhu, Geetpal

Schnitker, Linda

Small, David

Thomas, Gijo

Wunnapuk, Klintean

Wurzel, Danielle
PhD In Progress

Abd Warif, Nor

Agarwal, E

Ahmed, Dr Ashraf

Al Shamaly, Hanan

Kaisar, Dr Mohd

Sieh, Shirly

Astuti, Puji

Kaur, Sukhpreet

Singhania, Richa

Barraclough, 
Khairuddin, Norliana

Siskind, Dan

Kim, Yu

Skoien, Dr Richard

Bennett, Michelle

Lie, Dr Jun

Smith, Louise

Bokhair, Fawzi

Li, Peng

Sobbe, Amy

Bower, Kylie

Lim, S

Stolic, Snezana

Briskey, David

Liu, David

Sturgess, Dr David

Brooks, Kelly

Long, Debbie

Sweet, Alison

Broom, Jennifer

Lubik, Amy

Symons, Martyn

Broome, Keiran

Luetterforst, Robert

Tan, Dr Terrance

Cajella, Pauline

Mahmood, Adnan

Taylor, Paul

Cameron, Sarina

Massey, Debbie

Thomas, Elaine

Capra, Carina

McIntyre, Deborah

Thompson, Camilla

Carrington, Christine

McNally, Alice

Turner, Ben

Cartmill, Bena

McPhail, Steven

Turner, Benjamin

Cato, Kathleen

Mitchell, Deborah

van Eps, Dr Carolyn

Chachay, Veronique

Mostafa, Ahmed

Varghese, Dr Daniel

Chan, Dora

Nalder, Emily

Warrener, Robyn

Chenfeng Chen

Nguyen, Thien

Wigan, Matthew

Cheung, Vivian

Nisbet, Janelle

Wu, Sherry

Chong, A

O'Moore-Sullivan, 
Wu, Ya Ting
Dr Katherine

Clark, Dr Carolyn

Constantinescu,
Gabrielle
Dr Trish

Yamada, Miko

Ong, Dr Cynthia

Zhang, Qian

Pang, Dimeng

Zhe, Yang

Coulson, Samantha

Pasieczny, Nathan

Croci, Ilaria

Pattabiraman, Diwakar

Crompton, Dr David

Petchey, Dr William
Masters Completions

Davidson, Stuart

Phillips, Dr Liza

Chih-Ling, Lin

Dimeski, Goce

Pike, Tanya

Izzard, Leanne

Doneva, S

Pizzutto, Susan

Madson, Kathy

Drabsch, Yvette

Pokorny, Dr Morgan

Morrison, Thomas

Du, Sharon

Poth, Kim

Poulsen, Dr Michael

Dziopa, Fiona

Pritchard, Nicola

Salih, Dr Salih

Fahim, Dr Magid

Protani, M.

Stokes, Phillip

Fiorenza, Salvatore

Pyne, Dr John

Fuhrman-Luck, Ruth

Rahayu, Mustaffa

Gannon, Orla
Kamal
Masters
Commencements

Gill, Hannah

Rahimpour, Azad

Glasgow, Celeste

Riddle, Bena
Hassan Alsalihi

Gordon, Cassandra

Rollo, Megan

Gaffney, Dr Daniel

Gosmann, Christina

Rose, Felicity

Gray, Belinda

Hale, Andrew

Rosendahl, Dr Clifford

Hughes, Ritchie

Harrington, Rosumund

Rumbach, Anna

Jon, Clair

Harrison, Matthew

Ruscher, Roland

Nicholls, Kim

Hesami, Parisa

Sankar, Sujaya

Schloss, Janet

Holzhauser, Kerri

Schmidt, Julia

Turner, Dr Liam

Irving, Aaron

Schoendorffer, Niikee

Walker, Gene

Jack, Leanne

Shar, Neha

Wang, Jie

Jellis, Dr Christine

Sharma, Shobha

Abdalrahman F.
Masters In Progress

Angok, Chol

Brosnan, Jessica

Brown, James

Bryson Swan

Castillo, L

Chang, Tina

Chen, Yueh

Choolun, Praline

Coleman, L

Delaforce, Caroline

Eugarde, Ellen

Flack, Tarsha

Fu, Sherry

Green, Vicki

Harvey, Simone

Hawksworth, Wendy

Hendren, Amanda

Hulse, Belinda

Inoue, Masue

Japar, Salimah

Kirassian, Emeline

Mabiza, Clement

McDougall, David

McKenzie, Dr Ian

Melton, Nicola

Ojala, Sonya

Olsson, Gemma

Parker, Rebecca

Peters, Nimali

Readett, Jacqueline

Rehnstrom, Eleonor

Salama, Rosemary

Samuel, Cynthia

Shah, Pallav

Sim, Lucy

Suleman, Farah

Tachon, Gaelle

Unwin, Sean

Wadsworth

Wirges, Sally

Young, Debra

Zhu, Cathy Wei
Centres for Health Research 2010 Annual Research Report
179
T1 – Translation to first in humans (refer to inside cover)
T2 – Translation to patients (refer page 17)
T3 – Translation to clinical practice (refer page 23)
T4 – Translation to population health (refer page 134)
References:
Westfall JM et al. Practice-Based Research—“Blue Highways” on the NIH Roadmap. JAMA, Jan 24/31, 2007—Vol 297, No. 4, 403-406
Woolf SH. The Meaning of Translation Research and why it Matters. JAMA, Jan 9/16, 2008—Vol 299, No. 2, 211-213
Khoury JM et al. The continuum of translation research in genomic medicine: Gen in Med, Oct 2007, Vol. 9, No. 10, 665-674
Contact
Mailing Address
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Centres for Health Research
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Phone
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Fax
+61 7 3176 7667
Email
[email protected]
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