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Curriculum Vitae PERSONAL Name: Nicola Bottoni Address: Via De Ruggero n° 4, 42100 REGGIO EMILIA ITALY Date of Birth: 5th March, 1962 Telephone Nbr: 039 / 0522 / 284803 Fax: 039 / 0522 / 296288 E-mail: [email protected] [email protected] EDUCATION 1976-1981: Educated at Grammar School in Reggio Emilia (Liceo Classico L. Ariosto), Italy. 1981-1987: Studied Medicine and Surgery at the Faculty of the University of Parma, Italy. Graduated cum laude in Medicine and Surgery at the same University in 1987, presenting a thesis on “Effects of different nitrates on vascular smooth muscle cells. Experimental study”. 1987-1991: Attended the course of specialisation in Cardiology, University of Parma. Presented thesis of specialisation on “Carotid Sinus Syndrome”. Registered as a specialist in Cardiology in 1991. TRAINING 1986-1987: Intern scholar at the Institute of Internal Medicine, Parma University. 1988-1989: Obtained a scholarship for the multicentric study GISSI-2 at the 1st Cardiology Unit and Intensive Care, Arcispedale S. Maria Nuova, Reggio Emilia. - Attended the Laboratory of Electrophysiology directed by professor J.A. Salerno-Uriarte in the following periods: from 13/11/1995 to 27/12/1995 (Division of Cardiology, Policlinico S.Matteo, Pavia, Italy), from 12/11/1996 to 28/12/1996 (Casa di cura Città di Pavia, Pavia, Italy), from 15/10/1997 al 25/4/1998 and from 12/3/2000 to 12/4/2000 (Casa di cura Mater Domini, Insubria University, Castellanza, Italy). 1 - Attended the Laboratory of Electrophysiology of the Hopital Cardiologique du Haut-Leveque, Bordeaux-Pessac (France), directed by professor M. Haissaguerre in the following period: from 19/11/2001 to 01/12/2001; from 02/11/2003 to 15/11/2003; from 12/11/2007 to 25/11/2007. - Attended the Laboratory of Electrophysiology of the II. Med. Abteilung, Allgemeines Krankenhaus St Georg, Hamburg, Germany, directed by professor Karl-Heinz Kuck in the following period: from 15/11/2004 to 27/11/2004. - Attended the Laboratory of Electrophysiology of the S. Raffaele Hospital, Milan, Italy, directed by professor Carlo Pappone in the following period: from 21/11/2005 to 26/11/2005. - Attended the Section of Cardiac Electrophysiology at the Cleveland Clinic Heart Center, Cleveland, Ohio, directed by doctor Andrea Natale from November 20th through December 2nd 2006. EXPERIENCE From December 1990 up to the current time: Senior Registrar at the Department of Cardiology and Arrhythmologic Center, Santa Maria Nuova Hospital, Reggio Emilia, Italy, routinely performing electrophysiologic studies, RF catheter ablations, PM (biventricular) and ICD implants. NUMBER OF PUBLICATIONS AND ABSTRACTS From 1988 to 2007: 100, between national and international journals. LIST OF SOCIETIES Member of the A.I.A.C. (Associazione Italiana Aritmologia e Cardiostimolazione). Member of the ANMCO (Associazione Nazionale Medici Cardiologi Ospedalieri). 2 Publications 1) Salvo-D, Ferretti-PP, Versari-A, Serafini-D, Bottoni-N, Pantaloni-M, Borasi-G. Bullseye and 3D: Comparison between two methods for the display of myocardial perfusion in the evaluation of coronary stenosis. The Journal of Nuclear Medicine and Allied Sciences 1990; 34: 229-230. 2) Brignole-M; Menozzi-C; Lolli-G; Bottoni-N; Gaggioli-G. Long-term outcome of paced and nonpaced patients with severe carotid sinus syndrome. Am J Cardiol 1992; 69(12): 1039-1043. 3) Brignole-M; Menozzi-C; Gianfranchi-L; Bottoni-N; Lolli-G. The clinical and prognostic significance of the asystolic response during the head-up tilt test. Eur J Card Pacing Electrophysiol 1992; 2(2): 109-113. 4) Brignole-M; Menozzi-C; Gianfranchi-L; Lolli-G; Bottoni-N; Oddone-D. A controlled trial of acute and long-term medical therapy in tilt-induced neurally mediated syncope. Am J Cardiol 1992; 70(3): 339-342. 5) Brignole-M; Gianfranchi-L; Menozzi-C; Raviele-A; Oddone-D; Lolli-G; Bottoni-N. Role of autonomic reflexes in syncope associated with paroxysmal atrial fibrillation. J Am Coll Cardiol 1993; 22(4): 1123-1129. 6) Menozzi-C; Brignole-M; Lolli-G; Bottoni-N; Oddone-D; Gianfranchi-L; Gaggioli-G. Follow-up of asystolic episodes in patients with cardioinhibitory, neurally mediated syncope and VVI pacemaker. Am J Cardiol 1993; 72(15): 1152-1155. 7) Gaggioli-G; Bottoni-N; Brignole-M; Menozzi-C; Lolli-G; Oddone-D; Gianfranchi-L. Progression to second or third-degree atrioventricular block in patients electrostimulated for bundle branch block: A long-term study. (La progressione a blocco atrioventricolare di 2° e 3° grado nei pazienti elettrostimolati per blocco di branca e sincope: uno studio a lungo termine). G Ital Cardiol 1994; 24(4): 409-416. 8) Gianfranchi-L, Brignole-M, Menozzi-C, Bottoni-N, Bollini-R, Lolli-G, Oddone-D, Gaggioli-G. Sequential right-sided and left-sided radiofrequency catheter ablation of atrioventricular conduction in patients with atrial fibrillation. Cardiostimolazione 1994; 12 (3):253-254. 3 9) Menozzi-C; Brignole-M; Gianfranchi-L; Lolli-G; Oddone-D; Gaggioli-G; Bottoni-N. Radiofrequency catheter ablation and modulation of atrioventricular conduction in patients with atrial fibrillation. Pacing Clin Electrophysiol 1994; 17(11 II): 2143-2149. 10) Brignole-M; Gianfranchi-L; Menozzi-C; Bottoni-N; Bollini-R; Lolli-G; Oddone-D; Gaggioli-G. A new pacemaker for paroxysmal atrial fibrillation treated with radiofrequency ablation of the AV junction. Pacing Clin Electrophysiol 1994; 17(11 II): 1889-1894. 11) Brignole-M; Gianfranchi-L; Menozzi-C; Bottoni-N; Bollini-R; Lolli-G; Oddone-D; Gaggioli-G. Influence of atrioventricular junction radiofrequency ablation in patients with chronic atrial fibrillation and flutter on quality of life and cardiac performance. Am J Cardiol 1994; 74(3): 242-246. 12) Gaggioli-G; Brignole-M; Menozzi-C; Bottoni-N; Gianfranchi-L; Oddone-D; Lolli-G. Reappraisal of the vasodepressor reflex in carotid sinus syndrome. Am J Cardiol 1995; 75(7): 518-520. 13) Menozzi-C; Brignole-M; Tomasi-C; Lolli-G; Bottoni-N; Oddone-D; Gianfranchi-L. Carotid sinus syncope: The most frequent neurally mediated syncope in the elderly. Arch Gerontol Geriatr 1995; 20(1): 7-14. 14) Brignole-M; Menozzi-C; Bottoni-N; Gianfranchi-L; Lolli-G; Oddone-D; Gaggioli-G. Mechanisms of syncope caused by transient bradycardia and the diagnostic value of electrophysiologic testing and cardiovascular reflexivity maneuvers. Am J Cardiol 1995; 76(4): 273-278. 15) Brignole-M; Menozzi-C; Gianfranchi-L; Lolli-G; Oddone-G; Gaggioli-G; Bottoni-N. Single-session step-wise radiofrequency catheter modification of atrioventricular conduction in patients with paroxysmal atrial fibrillation. Eur J Cardiac Pacing Electrophysiology 1995; 5(1): 18-22. 16) Gaggioli-G; Brignole-M; Menozzi-C; Oddone-D; Gianfranchi-L; Bollini-R; Bottoni-N; Lolli-G. Rivalutazione della componente vasodepressiva nella sindrome del seno carotideo. [The re-evaluation of the vasodepressive component in the carotid sinus syndrome]. G Ital Cardiol 1995; 25(3): 327-33. 17) Gaggioli-G; Brignole-M; Menozzi-C; Devoto-G; Oddone-D; Gianfranchi-L; Gostoli-E; Bottoni-N; Lolli-G. A positive response to head-up tilt testing predicts syncopal recurrence in carotid sinus syndrome patients with permanent pacemakers. Am J Cardiol 1995; 76(10): 7202. 18) Menozzi-M, Brignole-M, Bottoni-N, Lolli-G, Oddone D, Gianfranchi-L, Gaggioli-G. La stimolazione cardiaca nelle sincopi vasovagali. Cardiostimolazione 1995; 13: 55-58. 4 19) Menozzi-C; Bottoni-N; Lolli-G; Tomasi-C. Epidemiology of syncope. Cerebrovasc Dis 1997; 7(5): 298. 20) Gaggioli-G; Bottoni-N; Mureddu-R; Foglia-Manzillo-G; Mascioli-G; Bartoli-P; Musso-G; Menozzi-C; Brignole-M. Effects of chronic vasodilator therapy to enhance susceptibility to vasovagal syncope during upright tilt testing. Am J Cardiol 1997; 80(8): 1092-4. 21) Brignole-M; Gaggioli-G; Menozzi-C; Gianfranchi-L; Bartoletti-A; Bottoni-N; Lolli-G; Oddone-D; Del-Rosso-A; Pellinghelli-G. Adenosine-induced atrioventricular block in patients with unexplained syncope: The diagnostic value of ATP testing. Circulation 1997; 96(11): 3921-3927. 22) Brignole-M; Menozzi-C; Gianfranchi-L; Musso-G; Mureddu-R; Bottoni-N; Lolli-G. Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation: A randomized, controlled study. Circulation 1998; 98(10): 953-960. 23) Brignole-M; Menozzi-C; Gaggioli-G; Musso-G; Foglia-Manzillo-G; Mascioli-G; FradellaG; Bottoni-N; Mureddu-R. Effects of long-term vasodilator therapy in patients with carotid sinus hypersensitivity. Am Heart J 1998; 136(2): 264-268. 24) Gianfranchi-L; Brignole-M; Menozzi-C; Lolli-G; Bottoni-N. Progression of permanent atrial fibrillation after atrioventricular junction ablation and dual-chamber pacemaker implantation in patients with paroxysmal atrial tachyarrhythmias. Am J Cardiol 1998; 81(3): 351-354. 25) Bottoni-N; Lolli-G; Tomasi-C; Calzolari-M; Menozzi-C. Syncope epidemiology in athletes. Int J Sports Cardiol 1999; 8(3): 117-119. 26) Davie-A; McMurray-J; Brignole-M; Gianfranchi-L; Menozzi-C; Bottoni-N; Lolli-G. Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation [1] (multiple letters). Circulation 1999; 99(22): 2966-2967. 27) Gianfranchi-L; Brignole-M; Menozzi-C; Lolli-G; Bottoni-N. Determinants of development of permanent atrial fibrillation and its treatment. Europace 1999; 1(1): 35-9. 28) Bartoletti-A; Gaggioli-G; Menozzi-C; Bottoni-N; Del-Rosso-A; Mureddu-R; Musso-G; Foglia-Manzillo-G; Bonfigli-B; Brignole-M. Head-up tilt testing potentiated with oral nitroglycerin: a randomized trial of the contribution of a drug-free phase and a nitroglycerin phase in the diagnosis of neurally mediated syncope. Europace 1999; 1(3): 183-6. 29) Brignole-M; Menozzi-C; Del-Rosso-A; Costa-S; Gaggioli-G; Bottoni-N; Bartoli-P; SuttonR. New classification of haemodynamics of vasovagal syncope: beyond the VASIS 5 classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study. Europace 2000; 2(1): 66-76. 30) Lupi-G; Brignole-M; Oddone-D; Bollini-R; Menozzi-C; Bottoni-N. Effects of left ventricular pacing on cardiac performance and on quality of life in patients with drug refractory heart failure. Am J Cardiol 2000; 86(11): 1267-1270. 31) Brignole-M; Gaggioli-G; Menozzi-C; Del-Rosso-A; Costa-S; Bartoletti-A; Bottoni-N; Lolli-G. Clinical features of adenosine sensitive syncope and tilt induced vasovagal syncope. Heart 2000; 83(1): 24-28. 32) Brignole-M; Menozzi-C; Moya-A; Garcia-Civera-R; Mont-L; Alvarez-M; Errazquin-F; Beiras-J; Bottoni-N; Donateo-P. Mechanism of syncope in patients with bundle branch block and negative electrophysiological test. Circulation 2001; 104(17): 2045-2050. 33) Bottoni-N; Donateo-P; Tomasi-C; Lolli-G; Oddone-D; Croci-F; Menozzi-C; Brignole-M. Comparison of the clinical and electrophysiological characteristics of symptomatic concealed and manifest accessory pathways. (Confronto delle caratteristiche cliniche ed elettrofisiologiche dei pazienti con via accessoria atrioventricolare occulta e manifesta). Ital Heart J Supplement 2001; 2(8): 888-893. 34) Alboni-P; Brignole-M; Menozzi-C; Raviele-A; Del-Rosso-A; Dinelli-M; Solano-A; Bottoni-N. Diagnostic value of history in patients with syncope with or without heart disease. J Am Coll Cardiol 2001; 37(7): 1921-1928. 35) Alboni-P; Tomasi-C; Menozzi-C; Bottoni-N; Paparella-N; Fuca-G; Brignole-M; CappatoR. Efficacy and safety of out-of-hospital self-administered single-dose oral drug treatment in the management of infrequent, well-tolerated paroxysmal supraventricular tachycardia. J Am Coll Cardiol 2001; 37(2): 548-553. 36) Croci-F; Brignole-M; Alboni-P; Menozzi-C; Raviele-A; Del-Rosso-A; Dinelli-M; SolanoA; Bottoni-N; Donateo-P. The application of a standardized strategy of evaluation in patients with syncope referred to three syncope units. Europace 2002; 4(4): 351-355. 37) Donateo-P; Brignole-M; Alboni-P; Menozzi-C; Raviele-A; Del-Rosso-A; Dinelli-M; Solano-A; Bottoni-N; Croci-F. A standardized conventional evaluation of the mechanism of syncope in patients with bundle branch block. Europace 2002; 4(4): 357-360. 38) Puggioni-E; Guiducci-V; Brignole-M; Menozzi-C; Oddone-D; Donateo-P; Croci-F; Solano-A; Lolli-G; Tomasi-C; Bottoni-N. Results and complications of the carotid sinus massage performed according to the "method of symptoms". Am J Cardiol 2002; 89(5): 599601. 6 39) Donateo-P; Brignole-M; Menozzi-C; Bottoni-N; Alboni-P; Dinelli-M; Del-Rosso-A; Croci-F; Oddone-D; Solano-A; Puggioni-E. Mechanism of syncope in patients with positive adenosine triphosphate tests. J Am Coll Cardiol 2003; 41(1): 93-98. 40) Bottoni-N; Tomasi-C; Donateo-P; Lolli-G; Muia-N; Croci-F; Oddone-D; Menozzi-C; Brignole-M. Clinical and electrophysiological characteristics in patients with atrioventricular reentrant and atrioventricular nodal reentrant tachycardia. Europace 2003; 5(3): 225-9. 41) Bottoni-N; Menozzi-C; Brignole-M. Management of patients with recurrent neuromediated syncope. Mediterranean-Journal-of-Pacing-and-Electrophysiology 2003; 5(2): 73-76. 42) Bottoni-N; Donateo-P; Quartieri-F; Tomasi-C; Oddone-D; Lolli-G; Menozzi-C; BrignoleM. Outcome after cavo-tricuspid isthmus ablation in patients with recurrent atrial fibrillation and drug-related typical atrial flutter. Am J Cardiol 2004; 94(4): 504-8. 43) Solano-A; Menozzi-C; Maggi-R; Donateo-P; Bottoni-N; Lolli-G; Tomasi-C; Croci-F; Oddone-D; Puggioni-E; Brignole-M. Incidence, diagnostic yield and safety of the implantable loop-recorder to detect the mechanism of syncope in patients with and without structural heart disease. Eur Heart J 2004; 25(13): 1116-9. 44) Alboni-P; Brignole-M; Menozzi-C; Raviele-A; Del-Rosso-A; Dinelli-M; Bettiol-K; Bottoni-N; Solano-A. Clinical spectrum of neurally mediated reflex syncopes. Europace 2004; 6(1): 55-62. 45) Brignole M, Menozzi C, Maggi R, Solano A, Donateo P, Bottoni N, Lolli G, Quartieri F, Croci F, Oddone D, Puggioni E. The usage and diagnostic yield of the implantable looprecorder in detection of the mechanism of syncope and in guiding effective antiarrhythmic therapy in older people. Europace 2005; 7:273-9. 46) Tomasi C, De Ponti R, Tritto M, Barilli AL, Bottoni N, Zardini M, Menozzi C, Spadacini G, Salerno-Uriarte JA. Simultaneous dual fast and slow pathway conduction upon induction of typical atrioventricular nodal reentrant tachycardia: electrophysiologic characteristics in a series of patients. J Cardiovasc Electrophysiol 2005;16:594-600. 47) Bottoni N, Donateo P, Quartieri F, Brignole M, Menozzi C. Two unusual cases of coincident atrioventricular nodal reentrant tachycardia and ventricular tachycardia. Ital Heart J 2005; 6 (9): 765-770. 48) De Ponti R, Verlato R, Bertaglia E, Del Greco M, Fusco A, Bottoni N, Drago F, Delise P, Ometto R, Mantovan R, Salerno-Uriarte JA and The SWEETT Investigators. Eelectroanatomic mapping using a novel setting of the window of interest to identify the diastolic pathway and guide ablation of atypical atrial macrore-entry: data from a multicenter prospective study. Heart Rhythm 2006; 3 (5) suppl: S75. 7 49) Bottoni N, Donateo P, Quartieri F, Lolli G, Maggi R, Oddone D, Brignole M, Menozzi C. Conservative approach in the ablation of atrioventricular nodal reentrant tachycardia. Europace 2006; 8 (Supplement 1): 218P/8. 50) Bottoni N, De Ponti R, Marazzi R, Quartieri F, Caravati F, De Sanctis V, Menozzi C, Salerno-Uriarte JA. Ablation of right ventricular outflow tract tachycardia based on electroanatomic mapping of isolate tachycardia beats. Europace 2006; 8 (Supplement 1): 262/2. 51) Bertaglia E, Zoppo F, Colella A, Bottoni N, Stabile G, Quartieri F, Zerbo F, D’Este D, Pascotto P. Left atrium ablation for atrial fibrillation: a multicentre perspective registry on procedural safety. Europace 2006; 8 (Supplement 1): 59PW/3. 52) Inama G, Della Bella P, Landolina M, Tritto M, Bottoni N on behalf of AIAC Council. Attività dei Laboratori di Elettrofisiologia Italiani nel 2005. G Ital Aritmol Cardiostim 2006;3:185-199. 53) Maggi R, Quartieri F, Donateo P, Bottoni N, Solano A, Lolli G, Tomasi C, Croci F, Oddone D, Puggioni E, Menozzi C and Brignole M. Comparative study of results of catheter ablation of ventricular tachycardia from different etiologies. Giornale Italiano di Cardiologia 2006; 7; 11:754-760. 54) De Ponti R, Verlato R, Bersaglia E, Del Greco M, Fusco A, Bottoni N, Drago F, Sciarpa L, Ometto R, Mantovan R, Salerno-Uriarte JA. Treatment of macro-re-entrant atrial tachycardia based on electroanatomic mapping: identification and ablation of the mid-diastolic isthmus. Europace 2007; doi:10.1093/europace/eum055. 8