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Biology II 01.1B Medical Milestones after 1850 1865 • English surgeon Joseph Lister begins using carbolic acid as an antiseptic in surgery. • His dramatic reduction in death rates leads to doctors routinely using antiseptics during surgery. 1870 • French scientist Louis Pasteur demonstrates that infectious disease is NOT caused by “bad air” but by microorganisms • He created the germ theory of disease. 1882 • German researcher Walter Flemming establishes that some mysterious material is passed to daughter cells when a parent cell divides. • His work is a foundation of modern cell biology. 1890 • Emil Behrig and Kitasato Shibasaburo develop a diphtheria antitoxin and discover antibodies. • Elie Metchnikoff puts forth the cellular theory of immunity. 1895 • German physicist Wilhelm Roentgen discovers X-rays. 1897 • German chemist Heinrich Dreser develops aspirin from plant extracts. 1901 Pathologist Karl Landsteiner discovers the human blood groups A, B, and O. 1910 • German chemist Paul Ehrlich and Japanese bacteriologist Sahachiro Hata chemically modify a toxic compound used to treat syphilis. 01.1 History of the Human Body 1 of 3 5/7/17 Biology II 1921 • Canadian physiologist Frederick Banting and his associate Charles Best isolate insulin. 1928 • Scottish bacteriologist Sir Alexander Fleming discovers that colonies of the Penicillium notatum produces a substance that destroys bacteria, thus discovering penicillin. 1944 • Scientist Oswald Avery performs experiments that provide key evidence that DNA is the molecule of inheritance. 1952 • Dr. Virginia Apgar develops a simple test based on appearance, pulse, grimace, activity, and respiration to see if a newborn is in need of medical attention. 1952 • U.S. physician Jonas Salk develops an effective vaccine for polio. 1953 • American James Watson and Briton Francis Crick discover double-helix structure of DNA. • They also discovered how it can replicate to pass on genetic information to new generations. 1950’s – 1960’s • 1954-U.S. physician Joseph Murray performs the first kidney transplant. • 1967-South African surgeon Christian Barnard performs the first human heart transplant. 1970’s • Englishman Sir Godfrey Newbold Hounsfield develops the technology for computer-assisted X-ray imaging. 01.1 History of the Human Body 2 of 3 5/7/17 Biology II 1973 • U.S. biochemists Stanley Cohen and Herbert Boyer successfully insert foreign genes into a bacterial cell, providing the foundation for all future genetic engineering. 1978 • In England, Louise Joy Brown became the first baby to be conceived by way of in vitro fertilization. 1970’s – 1980’s • 1977-magnetic resonance imaging revolutionizes diagnostic medicine • 1987-positron emission tomography became available for imaging brain abnormalities. 1996 • Researchers at the Roslin Institute in Edinberg, Scotland announce the birth of the ewe Dolly, the first animal to be cloned from an adult cell. 2003 The Human Genome Project consortium announces the completion of the overall sequence of the human genome. 2007 • Mario Capecchi, Sir Martin Evans, and Oliver Smithies win a Nobel Prize for their work in gene targeting in mice 2008 • Scientists at Advanced Cell Technology mitigate the ethical debate curbing stem cell research by developing human embryonic stem cell lines without the destruction of embryos. Remember to: Reduce, Recite, Reflect, & Review! Study Flashcards & Notes 3 x 5! 01.1 History of the Human Body 3 of 3 5/7/17